Research output per year
Research output per year
Research output
- 48 results
Search results
-
2024
Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model
Miller, C. J., Trichilo, S., Pickering, E., Martelli, S., Dall'Ara, E., Delisser, P., Meakin, L. B. & Pivonka, P., 1 Mar 2024, In: Bone. 180, p. 116994 116994.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
2023
The effect of flushing of the common bile duct on hepatobiliary markers and short-term outcome in dogs undergoing cholecystectomy for the management of gall bladder mucocele: A randomized controlled prospective study
Hernon, T., Friend, E. J., Chanoit, G. P. A., Black, V. & Meakin, L. B., 20 Mar 2023, (Accepted/In press) In: Veterinary Surgery.Research output: Contribution to journal › Article (Academic Journal) › peer-review
-
The effect of flushing of the common bile duct on hepatobiliary markers and short-term outcomes in dogs undergoing cholecystectomy for the management of gall bladder mucocele: A randomized controlled prospective study
Hernon, T. L., Friend, E. J., Chanoit, G., Black, V. & Meakin, L. B., 21 Jul 2023, In: Veterinary Surgery. 52, 5, p. 697-703 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access8 Citations (Scopus) -
2022
Computed tomographic staging of dogs with anal sac adenocarcinoma
Sutton, D., Hernon, T., Hezzell, M. J., Meakin, L. B., Gould, S., Bradley, K. J. & Major, A. C., 17 Jan 2022, In: Journal of Small Animal Practice. 63, 1, p. 27-33 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
9 Citations (Scopus) -
2021
Cortical Thickness Adaptive Response to Mechanical Loading Depends on Periosteal Position and Varies Linearly With Loading Magnitude
Miller, C. J., Trichilo, S., Pickering, E., Martelli, S., Delisser, P., Meakin, L. B. & Pivonka, P., 18 Jun 2021, In: Frontiers in Bioengineering and Biotechnology. 9, p. 671606 671606.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile15 Citations (Scopus)81 Downloads (Pure) -
Influence of muscle-sparing lateral thoracotomy on postoperative pain and lameness – a randomized clinical trial
Nutt, A. E., Knowles, T. G., Nutt, N. G., Murrell, J. C., Carwardine, D. R., Meakin, L. B. & Chanoit, G. P. A., Aug 2021, In: Veterinary Surgery. 50, 6, p. 1227-1236 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile5 Citations (Scopus)159 Downloads (Pure) -
Long-term outcome of female dogs treated for intramural ectopic ureters with cystoscopic-guided laser ablation
Hoey, C. S. F. K., Friend, E., Meakin, L. B. & Chanoit, G. P., Oct 2021, In: Veterinary Surgery. 50, 7, p. 1449-1462 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
13 Citations (Scopus) -
Necrotising fasciitis and an associated fatal peri-adrenal abscess
Matiasovic, M., Brooks Brownlie, H. & Meakin, L. B., Aug 2021, In: Journal of Small Animal Practice. 62, 8, p. 712 1 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
-
Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom
Anderson, T., Beever, L., Hall, J., Moores, A. P., Llanos, C., Adams, R., Meakin, L., Coppola, M., Bowlt-Blacklock, K., Holmes, M. A. & Barnes, D., Sept 2021, In: Journal of Small Animal Practice. 62, 9, p. 744-749 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
7 Citations (Scopus) -
2020
Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice
Galea, G. L., Delisser, P. J., Meakin, L., Price, J. S. & Windahl, S. H., 1 Apr 2020, In: Bone. 133, 9 p., 115255.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile12 Citations (Scopus)96 Downloads (Pure) -
Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2
Galea, G. L., Paradise, C. R., Meakin, L. B., Camilleri, E. T., Taipaleenmaki, H., Stein, G. S., Lanyon, L. E., Price, J. S., van Wijnen, A. J. & Dudakovic, A., 1 Dec 2020, In: Gene. 763S, p. 100027 9 p., 100027.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile20 Citations (Scopus)104 Downloads (Pure) -
Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results
Main, R. P., Shefelbine, S. J., Meakin, L. B., Silva, M. J., van der Meulen, M. C. H. & Willie, B. M., 1 Feb 2020, In: Journal of Orthopaedic Research. 38, 2, p. 233-252 20 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile56 Citations (Scopus)99 Downloads (Pure) -
2019
Outcomes of dogs treated for extrahepatic congenital portosystemic shunts with thin film banding or ameroid ring constrictor
Matiasovic, M., Chanoit, G. P. A., Meakin, L. B. & Tivers, M. S., 4 Jul 2019, In: Veterinary Surgery. 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile26 Citations (Scopus)256 Downloads (Pure) -
Penetrating thoracic wound with cardiac trauma
McGrath, C., Smith, C. & Meakin, L. B., 1 Dec 2019, In: Veterinary Record Case Reports.Research output: Contribution to journal › Article (Academic Journal) › peer-review
1 Citation (Scopus) -
2017
Electrosurgery reduces blood loss and immediate postoperative inflammation compared to cold instruments for midline celiotomy in dogs: A randomized controlled trial
Meakin, L., Murrell, J., Doran, I., Knowles, T., Tivers, M. & Chanoit, G., May 2017, In: Veterinary Surgery. 46, 4, p. 515–519 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile10 Citations (Scopus)496 Downloads (Pure) -
Indicator gloves not better than double standard gloves
Tikka, C., Verbeek, J., Meakin, L. & Langley-Hobbs, S., 1 Feb 2017, In: Veterinary Surgery. 46, 2, p. 187-188 2 p.Research output: Contribution to journal › Letter (Academic Journal)
-
Mechanical properties of 6 finger-trap suture techniques
Earley, N. F., Meakin, L. B., Parsons, K. J., Tarlton, J. & Hall, J. L., Aug 2017, In: Veterinary Surgery. 46, 6, p. 765-772 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Modulating Skeletal Responses to Mechanical Loading by Targeting Estrogen Receptor Signaling: Exploitation for Medical Benefit
Galea, G. & Meakin, L., Jan 2017, Mechanobiology. Rawlinson, S. (ed.). Wiley-Blackwell, p. 115-129 7 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
-
Old age and the associated impairment of bones’ adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle
Galea, G., Meakin, L., Harris, M., Delisser, P., Lanyon, L., Harris, S. & Price, J., 30 Jan 2017, In: Gene. 599, p. 36–52 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile39 Citations (Scopus)327 Downloads (Pure) -
Parathyroid hormone’s enhancement of bones’ osteogenic response to loading is affected by ageing in a dose- and time-dependent manner
Meakin, L. B., Todd, H., Delisser, P. J., Galea, G. L., Moustafa, A., Lanyon, L. E., Windahl, S. H. & Price, J. S., May 2017, In: Bone. 98, p. 59–67 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile25 Citations (Scopus)344 Downloads (Pure) -
Reliability of CT measurement of induced radioulnar step in dogs using a circle superimposition technique
Burton, N. J., Meakin, L., Hosworth, A. & Parsons, K. J., 14 Nov 2017, (E-pub ahead of print) In: Journal of Small Animal Practice.Research output: Contribution to journal › Article (Academic Journal) › peer-review
6 Citations (Scopus) -
2016
Colored Indicator Undergloves Increase the Detection of Glove Perforations by Surgeons During Small Animal Orthopedic Surgery: A Randomized Controlled Trial
Meakin, L., Gilman, O. P., Parsons, K., Burton, N. & Langley-Hobbs, S., Aug 2016, In: Veterinary Surgery. 45, 6, p. 709-714 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile19 Citations (Scopus)453 Downloads (Pure) -
2015
Disuse rescues the age-impaired adaptive response to external loading in mice
Meakin, L. B., Delisser, P. J., Galea, G., Lanyon, L. E. & Price, J., Nov 2015, In: Osteoporosis International. 26, 11, p. 2703-2708 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Citations (Scopus)276 Downloads (Pure) -
Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice
Meakin, L. B., Udeh, C., Galea, G. L., Lanyon, L. E. & Price, J. S., Dec 2015, In: Bone. 81, p. 47-52 6 p.Research output: Contribution to journal › Special issue (Academic Journal) › peer-review
Open AccessFile18 Citations (Scopus)362 Downloads (Pure) -
Planar Cell Polarity Aligns Osteoblast Division in Response to Substrate Strain
Galea, G., Meakin, L. B., Savery, D., Taipaleenmaki, H., Delisser, P. J., Stein, G., Copp, A., van Wijnen, A., Lanyon, L. E. & Price, J., 16 Feb 2015, In: Journal of Bone and Mineral Research. 30, 3, p. 423-435 13 p., 2377.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile22 Citations (Scopus)457 Downloads (Pure) -
Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading
Galea, G. L., Hannuna, S., Meakin, L. B., Delisser, P. J., Lanyon, L. E. & Price, J. S., 23 Apr 2015, In: Frontiers in Endocrinology. 6, 52, 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile32 Citations (Scopus)429 Downloads (Pure) -
Risedronate and Mechanical Loading Have Additive Effects Increasing Bone Mass in Cortical, but Not Cancellous, Bone in Aged Mice
Delisser, P., Todd, H., Meakin, L., Galea, G., Lanyon, L., Windahl, S. & Price, J., 8 Oct 2015.Research output: Contribution to conference › Conference Poster › peer-review
-
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
Todd, H., Galea, G. L., Meakin, L. B., Delisser, P. J., Lanyon, L. E., Windahl, S. H. & Price, J. S., 9 Oct 2015, In: PLoS ONE. 10, 10, 16 p., e0140260.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile35 Citations (Scopus)361 Downloads (Pure) -
2014
Age-Related Impairment of Bones' Adaptive Response to Loading in Mice is Associated with Sex-Related Deficiencies in Osteoblasts But No Change in Osteocytes
Meakin, L. B., Galea, G., Sugiyama, T., Lanyon, L. E. & Price, J., 21 Jul 2014, In: Journal of Bone and Mineral Research. 29, 8, p. 1859-1871 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile90 Citations (Scopus)333 Downloads (Pure) -
Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice
Gilbert, S. J., Meakin, L. B., Bonnet, C. S., Nowell, M. A., Ladiges, W. C., Morton, J., Duance, V. C. & Mason, D. J., 17 Oct 2014, In: Frontiers in Endocrinology. 5, 13 p., 174.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile20 Citations (Scopus)433 Downloads (Pure) -
Protein kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity*
Galea, G. L., Meakin, L. B., Williams, C. M., Hulin-Curtis, S. L., Lanyon, L. E., Poole, A. W. & Price, J. S., 12 Sept 2014, In: Journal of Biological Chemistry. 289, 37, p. 25509-25522 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile29 Citations (Scopus)504 Downloads (Pure) -
The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone
Meakin, L. B., Price, J. S. & Lanyon, L. E., 1 Oct 2014, In: Frontiers in Endocrinology. 5, 13 p., 154.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile104 Citations (Scopus)383 Downloads (Pure) -
2013
Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.
Windahl, S., Saxon, L., Borjesson, A., Lagerquist, M., Frenkel, B., Henning, P., Lerner, U., Galea, G., Meakin, L. B., Engdahl, C., Sjogren, K., Antal, M., Krust, A., Chambon, P., Lanyon, L. E., Price, J. & Ohlsson, C., Feb 2013, In: Journal of Bone and Mineral Research. 28, 2, p. 291-301Research output: Contribution to journal › Article (Academic Journal) › peer-review
85 Citations (Scopus)19 Downloads (Pure) -
Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β
Galea, G. L., Meakin, L. B., Sugiyama, T., Zebda, N., Sunters, A., Taipaleenmaki, H., Stein, G. S., van Wijnen, A. J., Lanyon, L. E. & Price, J. S., 29 Mar 2013, In: Journal of Biological Chemistry. 288, 13, p. 9035-9048 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile107 Citations (Scopus)393 Downloads (Pure) -
Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight
Meakin, L. B., Sugiyama, T., Galea, G. L., Browne, W. J., Lanyon, L. E. & Price, J. S., May 2013, In: Bone. 54, 1, p. 113-117 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile62 Citations (Scopus)324 Downloads (Pure) -
Prevalence, outcome and risk factors for postoperative pyothorax in 232 dogs undergoing thoracic surgery
Meakin, L. B., Salonen, L., Baines, S., Brockman, D., Gregory, S., Halfacree, Z., Lipscomb, V. & Lee, K., Jun 2013, In: Journal of Small Animal Practice. 54, 6, p. 313-317 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
14 Citations (Scopus)28 Downloads (Pure) -
Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis
Hayes, A. J., Reynolds, S., Nowell, M. A., Meakin, L. B., Habicher, J., Ledin, J., Bashford, A., Caterson, B. & Hammond, C. L., 24 Sept 2013, In: PLoS ONE. 8, 9, e75787.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile65 Citations (Scopus)486 Downloads (Pure) -
2012
Age-Related Impairment of the Mechanostat is Sex Specific and Associated with Impaired Cell-Cycle Progression and Decreased Mechanosensitivity
Meakin, L. B., Galea, G., Sugiyama, T., Lanyon, L. E. & Price, J., 2012, Journal of Bone & Mineral Research.Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)
-
Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition
Sugiyama, T., Meakin, L. B., Browne, W. J., Galea, G., Price, J. S. & Lanyon, L. E., Aug 2012, In: Journal of Bone and Mineral Research. 27, 8, p. 1784-93 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
182 Citations (Scopus) -
Customary Activity as a Potential Confounding Variable in Experiments on Mechanically-Adaptive Bone Remodelling Using Unilateral Loading
Meakin, L. B., Sugiyama, T., Galea, G., Lanyon, L. E. & Price, J., 2012, Journal of Bone & MIneral Research.Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)
-
ERα and ERβ differentially regulate the effects of estradiol and mechanical strain on proliferation and Sost expression
Galea, G., Meakin, L. B., Sugiyama, T., Van Wijnen, A., Lanyon, L. E. & Price, J., 2012, Journal of Bone & MIneral Research.Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)
-
Estrogen Receptors α and β Have Different Gender-Dependent Effects on the Adaptive Responses to Load Bearing in Cancellous and Cortical Bone
Saxon, L., Galea, G., Meakin, L. B., Price, J. & Lanyon, L. E., Mar 2012, In: Endocrinology. 153, 5, p. 2254-2266 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
65 Citations (Scopus)16 Downloads (Pure) -
Planar Cell Polarity Signaling directs Osteoblast Proliferation and Wolff's Law for Dynamic Strain
Galea, G., Meakin, L. B., Taipaleenmaki, H., Zebda, N., Sugiyama, T., Stein, G., Lanyon, L. E., Van Wijnen, A. & Price, J., 2012, Journal of Bone & Mineral Research.Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)
-
Protein Kinase C α Deletion Age-dependently Alters Bone Architecture in Female Mice, Impairs Osteoblast Responsiveness to Estrogen and Strain and Replicates Features of Gaucher Disease
Galea, G., Sugiyama, T., Meakin, L. B., Williams, C. M., Curtis, S. L., Lanyon, L. E., Poole, A. W. & Price, J., 2012, Journal of Bone & Mineral Research.Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)
-
The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice
Sugiyama, T., Meakin, L., Galea, G., Lanyon, L. & Price, J., 14 Feb 2012, In: Osteoporosis International. 24, 1, p. 383-388 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile13 Citations (Scopus)266 Downloads (Pure) -
2011
Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice
Sugiyama, T., Meakin, L., Galea, G., Jackson, B., Lanyon, L. E., Ebetino, F., Russell, R. & Price, J., Jul 2011, In: Bone. 49, 1, p. 133 - 139 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile38 Citations (Scopus)314 Downloads (Pure) -
Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading
Price, J. S., Sugiyama, T., Galea, G. L., Meakin, L. B., Sunters, A. & Lanyon, L. E., Jun 2011, In: Current Osteoporosis Reports. 9, 2, p. 76-82 7 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
62 Citations (Scopus)26 Downloads (Pure) -
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
Galea, G., Sunters, A., Meakin, L., Zaman, G., Sugiyama, T., Lanyon, L. & Price, J., 4 Aug 2011, In: FEBS Letters. 585, 15, p. 2450 - 2454 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile82 Citations (Scopus)374 Downloads (Pure)