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Research Output

  • 41 Article (Academic Journal)
  • 3 Conference Contribution (Conference Proceeding)
  • 1 Conference Poster
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Article (Academic Journal)
2020

Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea

Buckner, N., Kemp, K. C., Scott, H. L., Shi, G., Rivers, C. A., Gialeli, A., Wong, L-F., Cordero Llana, O., Allen, N., Wilkins, A. & Uney, J. B., 24 Jun 2020, In : Brain Pathology. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Downloads (Pure)
Open Access
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54 Downloads (Pure)

Dual druggable genome siRNA and compound screening approaches identify novel modulators of parkin recruitment to mitochondria

Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 7 Jan 2020, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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85 Downloads (Pure)

Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury

Prager, J., Adams, C. F., Delaney, A. M., Chanoit, G., Tarlton, J. F., Wong, L-F., Chari, D. M. & Granger, N., 17 Jul 2020, In : Journal of Tissue Engineering. 11, p. 2041731420934806

Research output: Contribution to journalArticle (Academic Journal)

2019

Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs

Ito, D., Carwardine, D., Prager, J., Wong, L. F., Kitagawa, M., Jeffery, N. & Granger, N., 6 Mar 2019, In : PLoS ONE. 14, 3, 20 p., e0213252.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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169 Downloads (Pure)

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., Singh, S., Murphy, A., Scudamore, C. L., Marquez, E., Barrington, A. F., Pinto, V., Marchetti, M., Wong, L-F., Uney, J., Saleem, M. A., Mathieson, P. W., Patel, S., Walker, R. J., Woodgett, J. R. & 3 others, Quaggin, S. E., Welsh, G. I. & Coward, R. J. M., 2019, In : Nature Communications. 10, 1, 17 p., 403.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Citations (Scopus)
353 Downloads (Pure)
2017

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Simeoli, R., Montague, K., Jones, H. R., Castaldi, L., Chambers, D., Kelleher, J. H., Vacca, V., Pitcher, T., Grist, J., Al-Ahdal, H., Wong, L-F., Perretti, M., Lai, J., Mouritzen, P., Heppenstall, P. & Malcangio, M., 24 Nov 2017, In : Nature Communications. 8, 17 p., 1778.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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56 Citations (Scopus)
234 Downloads (Pure)

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo

McMillan, K. J., Murray, T. K., Bengoa-Vergniory, N., Cordero-Llana, O., Cooper, J., Buckley, A., Wade-Martins, R., Uney, J. B., O'Neill, M. J., Wong, L. F. & Caldwell, M. A., 4 Oct 2017, In : Molecular Therapy. 25, 10, p. 2404-2414 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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223 Downloads (Pure)

Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections

Barker, G., Banks, P., Scott, H., Wong, L-F., Bashir, Z., Uney, J., Warburton, C., Banks, P. J. & Scott Ralph, G., Feb 2017, In : Nature Neuroscience. 20, 2, p. 242–250 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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42 Citations (Scopus)
426 Downloads (Pure)

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

Carwardine, D., Prager, J., Neeves, J., Muir, E. M., Uney, J., Granger, N. & Wong, L-F., 11 Dec 2017, In : PLoS ONE. 12, 12, p. e0188967

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
242 Downloads (Pure)
2016

A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method

Ponnusamy, V., Kapellou, O., Yip, E., Evanson, J., Wong, L-F., Michael-Titus, A., Yip, P. K. & Shah, D. K., May 2016, In : Pediatric Research. 79, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Citations (Scopus)
304 Downloads (Pure)

Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC

Carwardine, D., Wong, L-F., Fawcett, J., Muir, E. & Granger, N., 15 Aug 2016, In : Journal of the Neurological Sciences. 367, p. 311-318 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
272 Downloads (Pure)
2015

Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease

Cordero-Llana, Ó., Houghton, B. C., Rinaldi, F., Taylor, H., Yáñez-Muñoz, R. J., Uney, J. B., Wong, L-F. & Caldwell, M. A., Feb 2015, In : Molecular Therapy. 23, 2, p. 244-54 11 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)
2012

Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo

Ellis, S., Fong-Wong, L., Iqball, S., Thoree, V., Mitrophanous, K. A. & Binley, K., 2012, In : Molecular Therapy - Nucleic Acids. 1, p. e60

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex

Scott, H. L., Tamagnini, F., Narduzzo, K. E., Howarth, J. L., Bok-Lee, Y., Wong, L-F., Brown, M. W., Warburton, E. C., Bashir, Z. I. & Uney, J. B., Oct 2012, In : European Journal of Neuroscience. 36, 7, p. 2941-8

Research output: Contribution to journalArticle (Academic Journal)

86 Citations (Scopus)

MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating

Scott, H., Howarth, J., Lee, Y. B., Wong, L-F., Bantounas, I., Phylactou, L., Verkade, P. & Uney, J. B., 27 Apr 2012, In : Journal of Biological Chemistry. 287, 18, p. 14726-14733 8 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
2011

A stable producer cell line for the manufacture of a lentiviral vector for gene therapy of Parkinson's disease

Stewart, HJ., Wong, LF., Strickland, IT., Chipchase, D., Kelleher, M., Stevenson, L., Thoree, V., McCarthy, J., Scott Ralph, G., Mitrophanous, KA. & Radcliffe, PA., Mar 2011, In : Human Gene Therapy. 22(3), p. 357 - 369 12 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons

Strickland, IT., Holmes, FE., Richards, LJ., Wynick, D., Uney, JB. & Wong, LF., 10 Aug 2011, In : PLoS ONE. 6, 8, p. e23423 - e23423 8 p.

Research output: Contribution to journalArticle (Academic Journal)

105 Citations (Scopus)

Connexin 36 expression regulates neuronal differentiation from neural progenitor cells

Hartfield, EM., Rinaldi, F., Glover, CP., Wong, LF., Caldwell, MA. & Uney, JB., Mar 2011, In : PLoS ONE. 9;6(3), p. e14746 - e14746 1 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Connexin 36 Expression Regulates Neuronal Differentiation From Neural Progenitor cells

Wong, LF. & Caldwell, MA., Mar 2011, In : PLoS ONE. 6(3), p. e14746 - e14746 1 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)
2010

Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat

Ping, KY., Wong, LF., Sears, TA., Yáñez-Muñoz, RJ. & McMahon, SB., 22 Jun 2010, In : PLoS Biology. 8, 6, e1000399.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)
2006

Gene therapy for neurodegenerative and ocular diseases using lentiviral vectors

Ralph, GS., Binley, K., Wong, LF., Azzouz, M. & Mazarakis, ND., Jan 2006, In : Clinical Science. 110 (1), p. 37 - 46 10 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth

So, PL., Yip, PK., Bunting, S., Wong, LF., Mazarakis, ND., Hall, S., McMahon, SB., Maden, M. & Corcoran, J., Oct 2006, In : Developmental Biology. 298 (1), p. 167 - 175 9 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Lentiviral vector expressing retinoic acid receptor β2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord

Yip, PK., Wong, LF., Pattinson, D., Battaglia, A., Grist, J., Bradbury, EJ., Maden, M., McMahon, SB. & Mazarakis, ND., Nov 2006, In : Human Molecular Genetics. 15 (21), p. 3107 - 3118 12 p.

Research output: Contribution to journalArticle (Academic Journal)

66 Citations (Scopus)

Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications

Wong, LF., Goodhead, L., Prat, C., Mitrophanous, KA., Kingsman, SM. & Mazarakis, ND., Jan 2006, In : Human Gene Therapy. 17 (1), p. 1 - 9 9 p.

Research output: Contribution to journalArticle (Academic Journal)

146 Citations (Scopus)

Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF

Pezet, S., Krzyzanowska, A., Wong, LF., Grist, J., Mazarakis, ND., Georgievka, B. & McMahon, SB., Jun 2006, In : Molecular Therapy. 13 (6), p. 1101 - 1109 9 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

The transcription factor retinoic acid receptor β2 promotes functional regeneration of sensory axons into the adult rat spinal cord

Wong, LF., Yip, PK., Battaglia, A., Grist, J., Corcoran, J., Maden, M., Azzouz, M., Kingsman, SM., Kingsman, AJ., Mazarakis, ND. & McMahon, SB., Feb 2006, In : Nature Neuroscience. 9 (2), p. 243 - 250 8 p.

Research output: Contribution to journalArticle (Academic Journal)

114 Citations (Scopus)
2005

Glial-mediated neuroprotection: evidence for the protective role of the NO-cGMP pathway via neuron-glial communication in the peripheral nervous system

Thippeswamy, T., McKay, JS., Morris, R., Quinn, J., Wong, L-F. & Murphy, D., 2005, In : Glia. 49, p. 197 - 210 14 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human parkinsonism in a rat lesion model

Dowd, E., Monville, C., Torres, E., Wong, LF., Azzouz, M., Mazarakis, ND. & Dunnett, SB., 2005, In : European Journal of Neuroscience. 22(10), p. 2587 - 2595

Research output: Contribution to journalArticle (Academic Journal)

73 Citations (Scopus)

Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus

Wong, L-F., Ralph, G. S., Walmsley, LE., Bienemann, AS., Parham, S., Kingsman, SM., Uney, JB. & Mazarakis, ND., Jan 2005, In : Molecular Therapy. 11 (1), p. 89 - 95 7 p.

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

Ralph, GS., Radcliffe, PA., Day, DM., Carthy, JM., Leroux, MA., Lee, DC., Wong, LF., Bilsland, LG., Greensmith, L., Kingsman, SM., Mitrophanous, KA., Mazarakis, ND. & Azzouz, M., 2005, In : Nature Medicine. 11(4), p. 429 - 433

Research output: Contribution to journalArticle (Academic Journal)

394 Citations (Scopus)
2004

Deciphering the mechanisms of homeostatic plasticity in the hypothalamo-neurohypophyseal system--genomic and gene transfer strategies

Sharman, GJ., Ghorbel, MBT., Leroux, M., Beaucourt, SM., Wong, LF. & Murphy, D., 2004, In : Progress in Biophysics and Molecular Biology. 84(2-3), p. 151 - 182

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector

Azzouz, M., Ralph, S., Wong, LF., Day, D., Askham, Z., Barber, RD., Mitrophanous KA, N. V., Kingsman, SM. & Mazarakis, ND., 2004, In : NeuroReport. 15(6), p. 985 - 990

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)

Transduction patterns of pseudotyped lentiviral vectors in the nervous system

Wong, LF., Azzouz, M., Walmsley, LE., Askham, Z., Wilkes, FJ., Mitrophanous, KA., Kingsman, SM. & Mazarakis, ND., Jan 2004, In : Molecular Therapy. 9 (1), p. 101 - 111 11 p.

Research output: Contribution to journalArticle (Academic Journal)

118 Citations (Scopus)
2003
7 Citations (Scopus)

cAMP-dependent protein kinase A mediation of vasopressin gene expression in the hypothalamus of the osmotically challenged rat

Wong, L. F., Harding, T., Uney, J. & Murphy, D., 1 Sep 2003, In : Molecular and Cellular Neuroscience. 24, 1, p. 82-90 9 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin

Bienemann, AS., Martin-Rendon, E., Cosgrave, AS., Glover, CPJ., Wong, LF., Kingsman, SM., Mitrophanous, KA., Marzarakis, ND. & Uney, JB., May 2003, In : Molecular Therapy. 7 (5), p. 588 - 596 9 p.

Research output: Contribution to journalArticle (Academic Journal)

2002

Genetic and pharmacological dissection of pathways involved in the angiotensin II-mediated depression of baroreflex function

Wong, LF., Polson, JW., Murphy, D., Paton, JFR. & Kasparov, S., Oct 2002, In : FASEB Journal. 16 (12), p. 1595 - 1601 7 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)
2001
143 Citations (Scopus)
2000

Gene transfer strategies for the physiologist

Wong, L. F., Wells, S. & Murphy, D., Nov 2000, In : Experimental Physiology. 85, 6, p. 735-45 11 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)