Linda Wooldridge

2025

Hybrid B and T-cell immunity associates with protection against breakthrough infection after SARS-CoV-2 vaccination in ALSPAC participants

Baum, H. E., Santopaolo, M., Francis, O., Milodowski, E. J., Entwistle, K., Oliver, E. H., Hitchings, B. E., Diamond, D., Thomas, A., Mitchell, R. E., Kibble, M. M., Gupta, K., Di Bartolo, N. D., Klenerman, P., Brown, A., Morales-Aza, M. B., Oliver, J. L., Berger, I., Toye, A. M. & Finn, A. H. R. & 11 others, Goenka, A., Davidson, A. D., Ring, S. M., Molloy, L. C., Lewcock, M., Northstone, K., Roth, F., Timpson, N. J., Wooldridge, L., Halliday, A. & Rivino, L., 8 May 2025, (Accepted/In press) In: Journal of Infectious Diseases.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2023

Antibodies generated<i>in vitro</i>and<i>in vivo</i>elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

Buzas, D., Bunzel, H. A., Staufer, O., Milodowski, E., Edmonds, G., Bufton, J., Vidana, B., Yadav, S., Gupta, K., Fletcher, C., Williamson, M. K., Harrison, A., Borucu, U., Capin, J., Francis, O., Balchin, G., Hall, S., Vega, M. V., Fabien, D. & Vincentelli, R. & 16 others, Roe, J., Wooldridge, L., Burt, R., Anderson, R., Mulholland, A., Hare, J., Bailey, M., Davidson, A., Finn, A., Morgan, D., Mann, J., Spatz, J., Garzoni, F., Berger-Schaffitzel, C. H., Berger, I. & Group, B. U., 17 Mar 2023

Research output: Other contribution

High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs

Knezevic, L., Wachsmann, T. L. A., Francis, O., Dockree, T., Bridgeman, J. S., Wouters, A., de Wet, B., Cole, D. K., Clement, M., McLaren, J. E., Gostick, E., Ladell, K., Llewellyn-Lacey, S., Price, D. A., van den Berg, H. A., Tabi, Z., Sessions, R. B., Heemskerk, M. H. M. & Wooldridge, L., 28 Jun 2023, (E-pub ahead of print) In: Journal of Biological Chemistry. 299, 8, p. 104981 104981.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

5 Citations (Scopus)

In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

Buzas, D., Bunzel, A. H., Staufer, O., Milodowski, E. J., Edmunds, G. L., Bufton, J. C., Vidana mateo, B. V., Yadav, S. K. N., Gupta, K., Fletcher, C., Williamson, M. K., Harrison, A., Borucu, U., Capin, J., Francis, O., Balchin, G., Hall, S., Vega, M. V., Durbesson, F. & Lingappa, S. & 17 others, Vincentelli, R., Roe, J., Wooldridge, L., Burt, R., Anderson, R. J. L., Mulholland, A. J., Bristol uncover group, W. M. P. H. D., Hare, J., Bailey, M., Davidson, A. D., Finn, A., Morgan, D., Mann, J., Spatz, J., Garzoni, F., Schaffitzel, C. & Berger, I., 17 Oct 2023, In: Antibody Therapeutics. 6, 4, p. 277-297

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

Santopaolo, M., Gregorova, M., Hamilton, F. W., Arnold, D. T., Long, A. E., Lacey, A., Halliday, A., Baum, H. E., Hamilton, K., Milligan, R., Oliver, E. H., Pearce, O. E., Knezevic, L., Morales-Aza, M. B., Milne, A. J., Milodowski, E. J., Jones, E., Lazarus, R., Goenka, A. & Finn, A. H. R. & 5 others, Maskell, N. A., Davidson, A. D., Gillespie, K. M., Wooldridge, L. & Rivino, L., 13 Jun 2023, (E-pub ahead of print) In: eLife. 12, e85009.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

28 Citations (Scopus)

T Cells: Ready and waiting to go

Wooldridge, L. & Rivino, L., 6 Jan 2023, In: eLife. 12, 3 p., e85080.

Research output: Contribution to journal › Comment/debate (Academic Journal)

Open Access

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1 Citation (Scopus)

80 Downloads (Pure)

2022

Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2

Halliday, A., Long, A. E., Baum, H. E., Thomas, A., Shelley, K. L., Oliver, E. H., Gupta, K., Francis, O., Kavanagh Williamson, M., Di Bartolo, N. D., Randell, M. J., Ben Khoud, Y., Kelland, I., Mortimer, G. L. M., Ball, O. E., Plumptre, C., Chandler, M. A., Obst, U., Secchi, M. & Piemonti, L. & 27 others, Lampasona, V., Smith, J., Gregorova, M., Knezevic, L., Metz, J., Barr, R. S., Morales-Aza, M. B., Oliver, J. L., Collingwood, L., Hitchings, B. E., Ring, S. M., Wooldridge, L., Rivino, L., Timpson, N. J., McKernon, J., Muir, P., Hamilton, F. W., Arnold, D. T., Woolfson, D. N., Goenka, A., Davidson, A. D., Toye, A. M., Berger, I., Bailey, M., Gillespie, K. M., Williams, A. J. K. & Finn, A., 9 Nov 2022, In: Frontiers in Immunology. 13, 20 p., 968317.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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2 Citations (Scopus)

90 Downloads (Pure)

Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19

Rice, C. M., Lewis, P., Ponce-Garcia, F. M., Gibbs, W., Groves, S., Cela, D., Hamilton, F., Arnold, D., Hyams, C., Oliver, E., Barr, R., Goenka, A., Davidson, A., Wooldridge, L., Finn, A., Rivino, L. & Amulic, B., 13 Dec 2022, (E-pub ahead of print) In: Life Science Alliance. 6, 2, p. 1-13 e202201658.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

103 Downloads (Pure)

2021

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

Clement, M., Knezevic, L., Dockree, T., McLaren, J. E., Ladell, K., Miners, K. L., Llewellyn-Lacey, S., Rubina, A., Francis, O., Cole, D. K., Sewell, A. K., Bridgeman, J. S., Price, D. A., van den Berg, H. A. & Wooldridge, L., 20 Jul 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 29, 5 p., e2019639118.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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9 Citations (Scopus)

14 Downloads (Pure)

Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells

Man, S., Wooldridge, L., Rizkallah, P. J. & al., E., 15 Aug 2021, In: Journal of Immunology. 207, 4, p. 1009-1017 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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5 Citations (Scopus)

9 Downloads (Pure)

Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2

Goenka, A., Halliday, A., Gregorova, M., Milodowski, E. J., Thomas, A., Kavanagh Williamson, M., Baum, H. E., Oliver, E. H., Long, A. E., Knezevic, L., Gupta, K., Di Bartolo, N. D., Berger, I., Toye, A. M., Bernatoniene, J., Bailey, M., Gillespie, K. M., Davidson, A. D., Wooldridge, L. & Rivino, L. & 1 others, Finn, A., 20 Jul 2021, In: Cell Reports Medicine. 2, 7, 13 p., 100327.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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27 Citations (Scopus)

108 Downloads (Pure)

2020

GPU-Accelerated Discovery of Pathogen Derived Molecular Mimics of a T-cell Insulin Epitope

Whalley, T., Dolton, G., Brown, P. E., Wall, A., Wooldridge, L., van den Burg, H., Fuller, A., Hopkins, J. R., Crowther, M. D., Attaf, M., Knight, R. R., Cole, D. K., Peakman, M., Sewell, A. K. & Szomolay, B., 28 Feb 2020, In: Frontiers in Immunology. 11, 18 p., 296.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

158 Downloads (Pure)

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia

Gregorova, M., Morse, D., Brignoli, T., Steventon, J., Hamilton, F., Albur, M., Arnold, D., Thomas, M., Halliday, A., Baum, H., Rice, C., Avison, M. B., Davidson, A. D., Santopaolo, M., Oliver, E., Goenka, A., Finn, A., Wooldridge, L., Amulic, B. & Boyton, R. J. & 10 others, Altmann, D. M., Butler, D. K., McMurray, C., Stockton, J., Nicholls, S., Cooper, C., Loman, N., Cox, M. J., Rivino, L. & Massey, R. C., 31 Dec 2020, In: eLife. 9, 13 p., e63430.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

108 Downloads (Pure)

2018

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

Lissina, A., McLaren, J. E., Ilander, M., Andersson, E., Lewis, C. S., Clement, M., Herman, A., Ladell, K., Llewellyn-Lacey, S., Miners, K., Gostick, E., Melenhorst, J. J., Barrett, A. J., Price, D. A., Mustjoki, S. & Wooldridge, L., 7 Feb 2018, (E-pub ahead of print) In: Scientific Reports. 8, 1, 12 p., 2534.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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2 Citations (Scopus)

315 Downloads (Pure)

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs

Bijen, H. M., van der Steen, D. M., Hagedoorn, R. S., Wouters, A. K., Wooldridge, L., Falkenburg, J. H. F. & Heemskerk, M. H. M., 2 May 2018, In: Molecular Therapy. 26, 5, p. 1206-1214 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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34 Citations (Scopus)

264 Downloads (Pure)

2017

CD8⁺ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

Dockree, T., Holland, C., Bailey, M. & Wooldridge, L., 10 Jan 2017, In: Immunology and Cell Biology. 95, 1, p. 68–76 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

366 Downloads (Pure)

Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase

Cole, D. K., Wooldridge, L. & Sewell, A. K., 20 Jan 2017, In: Journal of Biological Chemistry. 292, p. 802-813 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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22 Citations (Scopus)

322 Downloads (Pure)

2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Cole, D. K., Bulek, A. M., Dolton, G., Schauenberg, A. J., Szomolay, B., Rittase, W., Trimby, A., Jothikumar, P., Fuller, A., Skowera, A., Rossjohn, J., Zhu, C., Miles, J. J., Peakman, M., Wooldridge, L., Rizkallah, P. J. & Sewell, A. K., 1 Jun 2016, In: Journal of Clinical Investigation. 126, 6, p. 2191-2204 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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117 Citations (Scopus)

475 Downloads (Pure)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

Szomolay, B., Liu, J., Brown, P., Clement, M., Llewellyn-Lacey, S., Dolton, G., Ekeruche-Makinde, J., Lissina, A., Schauenburg, A. J. A., Sewell, A. K., Burrows, S. R., Roederer, M., Price, D. A., Wooldridge, L. & van den Berg, H. A., Jul 2016, In: Immunology and Cell Biology. 94, 6, p. 573–582 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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22 Citations (Scopus)

303 Downloads (Pure)

Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures

Grant, E. J., Josephs, T. M., Valkenburg, S. A., Wooldridge, L., Hellard, M., Rossjohn, J., Bharadwaj, M., Kedzierska, K. & Gras, S., 18 Nov 2016, In: Journal of Biological Chemistry. 291, 47, p. 24335-24351 18 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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23 Citations (Scopus)

289 Downloads (Pure)

Targeted suppression of autoreactive CD8⁺ T-cell activation using blocking anti-CD8 antibodies

Clement, M., Pearson, J., Gras, S., van den Berg, H. A., Lissina, A., Llewellyn-Lacey, S., Willis, M., Dockree, T., McLaren, J. E., Ekeruche-Makinde, J., Gostick, E., Robertson, N. P., Rossjohn, J., Burrows, S. R., Price, D. A., Wong, S., Peakman, M., Skowera, A. & Wooldridge, L., 17 Oct 2016, In: Scientific Reports. 6, 14 p., 35332.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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26 Citations (Scopus)

407 Downloads (Pure)

2015

Clinical research: Developing an appropriate career structure

Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N., Clegg, P., Emes, R., England, G., Corr, S. A., Piercy, R., Mulcahy, G., Wood, J., Walker, B. & Argyle, D., 28 Nov 2015, In: Veterinary Record. 177, 21, p. 544-547 4 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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403 Downloads (Pure)

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

A Neller, M., Ladell, K., McLaren, J. E., K Matthews, K., Gostick, E., M Pentier, J., Dolton, G., JA Schauenburg, A., Koning, D., Costa, A., Watkins, T., Venturi, V., Smith, C., Khanna, R., Miners, K., Clement, M., Wooldridge, L., Cole, D. K., van Baarle, D. & Sewell, A. K. & 3 others, Burrows, S. R., Price, D. A. & Miles, J. J., Aug 2015, In: Immunology and Cell Biology. 93, 7, p. 625-633 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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39 Citations (Scopus)

291 Downloads (Pure)

2014

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations

Hill, B. J., Darrah, P. A., Ende, Z., Ambrozak, D. R., Quinn, K. M., Darko, S., Gostick, E., Wooldridge, L., Van Den Berg, H. A., Venturi, V., Larsen, M., Davenport, M. P., Seder, R. A., Price, D. A. & Douek, D. C., 1 Dec 2014, In: Journal of Immunology. 193, 11, p. 5626-5636 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

2013

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

van den Berg, H. A., Ladell, K., Miners, K., Laugel, B., Llewellyn-Lacey, S., Clement, M., Cole, D. K., Gostick, E., Wooldridge, L., Sewell, A. K., Bridgeman, J. S. & Price, D. A., 2013, In: Frontiers in Immunology. 4, p. 250

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy

Szomolay, B., Williams, T., Wooldridge, L. & van den Berg, H. A., 2013, In: Frontiers in Immunology. 4, p. 329

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

Knight, R. R., Kronenberg, D., Zhao, M., Huang, G. C., Eichmann, M., Bulek, A., Wooldridge, L., Cole, D. K., Sewell, A. K., Peakman, M. & Skowera, A., Jan 2013, In: Diabetes. 62, 1, p. 205-13 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

52 Citations (Scopus)

Individual MHCI-restricted T-cell receptors are characterized by a unique peptide recognition signature

Wooldridge, L., 23 Jul 2013, In: Frontiers in Immunology. 4, 6 p., 199.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

301 Downloads (Pure)

Peptide length determines the outcome of TCR/peptide-MHCI engagement

Ekeruche-Makinde, J., Miles, J. J., van den Berg, H. A., Skowera, A., Cole, D. K., Dolton, G., Schauenburg, A. J. A., Tan, M. P., Pentier, J. M., Llewellyn-Lacey, S., Miles, K. M., Bulek, A. M., Clement, M., Williams, T., Trimby, A., Bailey, M., Rizkallah, P., Rossjohn, J., Peakman, M. & Price, D. A. & 3 others, Burrows, S. R., Sewell, A. K. & Wooldridge, L., 14 Feb 2013, In: Blood. 121, 7, p. 1112-1123 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

87 Citations (Scopus)

The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses

Xu, W., Watts, D. M., Costanzo, M. C., Tang, X., Venegas, L. A., Jiao, F., Sette, A., Sidney, J., Sewell, A. K., Wooldridge, L., Makino, S., Morrill, J. C., Peters, C. J. & Kan-Mitchell, J., 2013, In: PLoS ONE. 8, 3, p. e59210

Research output: Contribution to journal › Article (Academic Journal) › peer-review

29 Citations (Scopus)

2012

A single autoimmune T cell receptor recognizes more than a million different peptides

Wooldridge, L., Ekeruche-Makinde, J., van den Berg, H. A., Skowera, A., Miles, J. J., Tan, M. P., Dolton, G., Clement, M., Llewellyn-Lacey, S., Price, D. A., Peakman, M. & Sewell, A. K., 6 Jan 2012, In: Journal of Biological Chemistry. 287, 2, p. 1168-1177 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

342 Citations (Scopus)

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

Bulek, A. M., Cole, D. K., Skowera, A., Dolton, G., Gras, S., Madura, F., Fuller, A., Miles, J. J., Gostick, E., Price, D. A., Drijfhout, J. W., Knight, R. R., Huang, G. C., Lissin, N., Molloy, P. E., Wooldridge, L., Jakobsen, B. K., Rossjohn, J., Peakman, M. & Rizkallah, P. J. & 1 others, Sewell, A. K., Mar 2012, In: Nature Immunology. 13, 3, p. 283-9 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

150 Citations (Scopus)

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

Ekeruche-Makinde, J., Clement, M., Cole, D. K., Edwards, E. S. J., Ladell, K., Miles, J. J., Matthews, K. K., Fuller, A., Lloyd, K. A., Madura, F., Dolton, G. M., Pentier, J., Lissina, A., Gostick, E., Baxter, T. K., Baker, B. M., Rizkallah, P. J., Price, D. A., Wooldridge, L. & Sewell, A. K., 26 Oct 2012, In: Journal of Biological Chemistry. 287, 44, p. 37269-81 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

42 Citations (Scopus)

The molecular determinants of CD8 co-receptor function

Cole, D. K., Laugel, B., Clement, M., Price, D. A., Wooldridge, L. & Sewell, A. K., Oct 2012, In: Immunology. 137, 2, p. 139-48 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

54 Citations (Scopus)

2011

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Clement, M., Ladell, K., Ekeruche-Makinde, J., Miles, J. J., Edwards, E. S. J., Dolton, G., Williams, T., Schauenburg, A. J. A., Cole, D. K., Lauder, S. N., Gallimore, A. M., Godkin, A. J., Burrows, S. R., Price, D. A., Sewell, A. K. & Wooldridge, L., 15 Jul 2011, In: Journal of Immunology. 187, 2, p. 654-663 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Escape from highly effective public CD8+ T-cell clonotypes by HIV

Iglesias, M. C., Almeida, J. R., Fastenackels, S., van Bockel, D. J., Hashimoto, M., Venturi, V., Gostick, E., Urrutia, A., Wooldridge, L., Clement, M., Gras, S., Wilmann, P. G., Autran, B., Moris, A., Rossjohn, J., Davenport, M. P., Takiguchi, M., Brander, C., Douek, D. C. & Kelleher, A. D. & 2 others, Price, D. A. & Appay, V., 25 Aug 2011, In: Blood Reviews. 118, 8, p. 2138-49 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

98 Citations (Scopus)

2010

CD8 controls T cell cross-reactivity

Wooldridge, L., Laugel, B., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. A. & Sewell, A. K., 15 Oct 2010, In: Journal of Immunology. 185, 8, p. 4625-4632 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

69 Citations (Scopus)

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs

Wooldridge, L., Clement, M., Lissina, A., Edwards, E. S. J., Ladell, K., Ekeruche, J., Hewitt, R. E., Laugel, B., Gostick, E., Cole, D. K., Debets, R., Berrevoets, C., Miles, J. J., Burrows, S. R., Price, D. A. & Sewell, A. K., 1 Apr 2010, In: Journal of Immunology. 184, 7, p. 3357-66 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

2009

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

Lissina, A., Ladell, K., Skowera, A., Clement, M., Edwards, E., Seggewiss, R., van den Berg, H. A., Gostick, E., Gallagher, K., Jones, E., Melenhorst, J. J., Godkin, A. J., Peakman, M., Price, D. A., Sewell, A. K. & Wooldridge, L., 1 Jan 2009, In: Journal of Immunological Methods. 340, 1, p. 11-24 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

130 Citations (Scopus)

Tricks with tetramers: how to get the most from multimeric peptide-MHC

Lissina, A., Wooldridge, L., Cole, D. K., van den Berg, H. A., Price, D. A. & Sewell, A. K., Feb 2009, In: Immunology. 126, 2, p. 147-64 18 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

148 Citations (Scopus)

2008

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

Melenhorst, J. J., Scheinberg, P., Chattopadhyay, P. K., Lissina, A., Gostick, E., Cole, D. K., Wooldridge, L., van den Berg, H. A., Bornstein, E., Hensel, N. F., Douek, D. C., Roederer, M., Sewell, A. K., Barrett, A. J. & Price, D. A., 30 Sept 2008, In: Journal of Immunological Methods. 338, 1-2, p. 31-9 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

31 Citations (Scopus)

Profound inhibition of antigen-specific T-cell effector functions by dasatinib

Weichsel, R., Dix, C., Wooldridge, L., Clement, M., Fenton-May, A., Sewell, A. K., Zezula, J., Greiner, E., Gostick, E., Price, D. A., Einsele, H. & Seggewiss, R., 15 Apr 2008, In: Clinical Cancer Research. 14, 8, p. 2484-91 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

129 Citations (Scopus)

2007

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

Wooldridge, L., Lissina, A., Vernazza, J., Gostick, E., Laugel, B., Hutchinson, S. L., Mirza, F., Dunbar, P. R., Boulter, J. M., Glick, M., Cerundolo, V., van den Berg, H. A., Price, D. A. & Sewell, A. K., May 2007, In: European Journal of Immunology. 37, 5, p. 1323-33 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

57 Citations (Scopus)

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

Gostick, E., Cole, D. K., Hutchinson, S. L., Wooldridge, L., Tafuro, S., Laugel, B., Lissina, A., Oxenius, A., Boulter, J. M., Price, D. A. & Sewell, A. K., Feb 2007, In: European Journal of Immunology. 37, 2, p. 479-86 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

2003

Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface

Wooldridge, L., Hutchinson, S. L., Choi, E. M., Lissina, A., Jones, E., Mirza, F., Dunbar, P. R., Price, D. A., Cerundolo, V. & Sewell, A. K., 15 Dec 2003, In: Journal of Immunology. 171, 12, p. 6650-60 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

46 Citations (Scopus)

High avidity antigen-specific CTL identified by CD8-independent tetramer staining

Choi, E.M.-L., Chen, J.-L., Wooldridge, L., Salio, M., Lissina, A., Lissin, N., Hermans, I. F., Silk, J. D., Mirza, F., Palmowski, M. J., Dunbar, P. R., Jakobsen, B. K., Sewell, A. K. & Cerundolo, V., 15 Nov 2003, In: Journal of Immunology. 171, 10, p. 5116-23 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

77 Citations (Scopus)

Professor Linda Wooldridge

Research output

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