Dr Lucia Marucci

BSc, MSc, PhD

  • BS8 1UB

20092020

Research output per year

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Personal profile

Research interests

Cell decision-making is orchestrated by the complex interplay between intracellular dynamics and the extracellular environment. How do these components produce emergent phenotypes and affect cell decision-making? Can cell fate be directly engineered? Can mathematical models aid in the understanding the basis of living organism regulations and guide their re-engineering?

My multidisciplinary Systems and Synthetic Biology research group aims at answering these questions combining wet-lab experiments and computational research. The main aims are to:

i) get a quantitative understanding of the link between signalling pathway dynamics, cell-cycle and stem cell pluripotency. We combine tools from Systems and Synthetic Biology at population- and single-cell levels, and are currently setting-up a microscopy/microfluidics platform for real-time mammalian cells imaging and control;

ii) develop agent-based modelling tools for describing and predicting single-cell dynamics accounting for gene regulatory networks, cell morphology, cell growth and geometry of the environment;

iii) use in silico algorithms for rational minimal genome design, taking advantage of Whole-Cell models

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Projects

8032 EP/S01876X/1

Marucci, L.

1/10/1930/09/24

Project: Research, Parent

Research Output

  • 18 Article (Academic Journal)
  • 3 Review article (Academic Journal)
  • 2 Conference Contribution (Conference Proceeding)
  • 1 Letter (Academic Journal)

Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model

Ward, D., Montes Olivas, S., Fletcher, A., Homer, M. & Marucci, L., 10 Jan 2020, In : Computational and Structural Biotechnology Journal. 18, p. 230-240 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 210 Downloads (Pure)

    Designing Minimal Genomes Using Whole-Cell Models

    Rees-Garbutt, J., Chalkley, O., Landon, S., Purcell, O., Marucci, L. & Grierson, C., 11 Feb 2020, In : Nature Communications. 11, 12 p., 836 (2020).

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 42 Downloads (Pure)

    Dual druggable genome siRNA and compound screening approaches identify novel modulators of parkin recruitment to mitochondria

    Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 7 Jan 2020, In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 58 Downloads (Pure)

    Datasets

    Supervised Work

    A Viral Approach to Translatome Profiling of CA1 Neurons During Associative Recognition Memory Formation

    Author: Gaunt, J., 25 Sep 2018

    Supervisor: Uney, J. (Supervisor), Warburton, C. (Supervisor) & Marucci, L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Dynamics of Biomedical Networks

    Author: Godwin, S. E., 28 Nov 2019

    Supervisor: Marucci, L. (Supervisor) & Masuda, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Multiscale Modelling of Stem Cell Population Dynamics

    Author: Ward, D., 19 Mar 2019

    Supervisor: Marucci, L. (Supervisor) & Homer, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File