Dr Lucia Marucci

BSc, MSc, PhD

  • BS8 1UB

20092020

Research output per year

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Personal profile

Research interests

Cell decision-making is orchestrated by the complex interplay between intracellular dynamics and the extracellular environment. How do these components produce emergent phenotypes and affect cell decision-making? Can cell fate be directly engineered? Can mathematical models aid in the understanding the basis of living organism regulations and guide their re-engineering?

My multidisciplinary Systems and Synthetic Biology research group aims at answering these questions combining wet-lab experiments and computational research. The main aims are to:

i) get a quantitative understanding of the link between signalling pathway dynamics, cell-cycle and stem cell pluripotency. We combine tools from Systems and Synthetic Biology at population- and single-cell levels, and are currently setting-up a microscopy/microfluidics platform for real-time mammalian cells imaging and control;

ii) develop agent-based modelling tools for describing and predicting single-cell dynamics accounting for gene regulatory networks, cell morphology, cell growth and geometry of the environment;

iii) use in silico algorithms for rational minimal genome design, taking advantage of Whole-Cell models

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Projects

Research Output

  • 22 Article (Academic Journal)
  • 3 Review article (Academic Journal)
  • 2 Conference Contribution (Conference Proceeding)
  • 1 Letter (Academic Journal)

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions

Aulicino, F., Pedone, E., Sottile, F., Lluis, F., Marucci, L. & Cosma, M. P., 8 Sep 2020, In : Stem Cell Reports. 15, 3, p. 646-661 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 29 Downloads (Pure)

    Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology

    Marucci, L., Barberis, M., Karr, J., Ray, O., Race, P. R., de Souza Andrade, M., Grierson, C. S., Hoffmann, S. A., Landon, S., Rech, E., Rees-Garbutt, J. P., Seabrook, R., Shaw, W. & Woods, C. J., 7 Aug 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 11 p., 942.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 9 Downloads (Pure)

    Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model

    Ward, D., Montes Olivas, S., Fletcher, A., Homer, M. & Marucci, L., 10 Jan 2020, In : Computational and Structural Biotechnology Journal. 18, p. 230-240 11 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 1 Citation (Scopus)
    223 Downloads (Pure)

    Supervised Work

    A Viral Approach to Translatome Profiling of CA1 Neurons During Associative Recognition Memory Formation

    Author: Gaunt, J., 25 Sep 2018

    Supervisor: Uney, J. (Supervisor), Warburton, C. (Supervisor) & Marucci, L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Dynamics of Biomedical Networks

    Author: Godwin, S. E., 28 Nov 2019

    Supervisor: Marucci, L. (Supervisor) & Masuda, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Multiscale Modelling of Stem Cell Population Dynamics

    Author: Ward, D., 19 Mar 2019

    Supervisor: Marucci, L. (Supervisor) & Homer, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File