Projects per year
Personal profile
Research interests
Lucia's research is focused on developing quantitative tools to understand cell dynamics and engineering-inspired methodologies for controlling living system functions, with the final aim to both disentangle and reprogram the complexity governing life.
Her approach combines tools from different disciplines: control engineering, systems and synthetic biology, and computer science.
The interdisciplinary research group Lucia leads works on 3 main research areas:
1. synthesis of controllers which can robustly engineer novel cellular functions while expanding the repertoire of redesigned phenotypes across organisms;
2. implementation of pipelines that can support whole-cell design and make synthetic biology design-build-test-learn cycles more predictable and efficient;
3. understanding of the endogenous processes which regulate higher organism gene expression in space and time for superior, nature-inspired design aims.
Structured keywords and research groupings
- Mathematics and Computational Biology
- Bristol BioDesign Institute
Keywords
- synthetic biology
- systems biology
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Research output
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Development of a single layer microfluidic device for dynamic stimulation, culture and imaging of mammalian cells
Mustafa, A., Pedone, E., Regina, A. L., Erten, A. & Marucci, L., 16 Mar 2022Research output: Other contribution
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MODEL PREDICTIVE CONTROL OF CANCER CELLULAR DYNAMICS: A NEW STRATEGY FOR THERAPY DESIGN
Smart, B., Cesare, I. D., Renson, L. & Marucci, L., 16 Mar 2022Research output: Other contribution
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β-catenin perturbations control differentiation programs in mouse embryonic stem cells
Pedone, E., Failli, M., Gambardella, G., De Cegli, R., La Regina, A., di Bernardo, D. & Marucci, L., 18 Feb 2022, In: iScience. 25, 2, 22 p., 103756.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile15 Downloads (Pure)
Datasets
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Data from Understanding metabolic behaviour whole-cell model
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 20 Aug 2020
DOI: 10.5523/bris.3u1v7dy42fk332watjl81m13y0, http://data.bris.ac.uk/data/dataset/3u1v7dy42fk332watjl81m13y0
Dataset
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Data from whole-cell modelling (12-2019)
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 6 Dec 2019
DOI: 10.5523/bris.1jj0fszzrx9qf2ldcz654qp454, http://data.bris.ac.uk/data/dataset/1jj0fszzrx9qf2ldcz654qp454
Dataset
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E Coli simulations JR
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator), Landon, S. (Creator) & Rightmyer, J. (Creator), University of Bristol, 5 Mar 2021
DOI: 10.5523/bris.1v58mpokwp9927bf6s36osb5k, http://data.bris.ac.uk/data/dataset/1v58mpokwp9927bf6s36osb5k
Dataset