Projects per year
Personal profile
Research interests
My research is focused on developing quantitative tools to understand cell dynamics and engineering-inspired methodologies for controlling living system functions, with the final aim to both disentangle and to reprogram the complexity governing life.
My approach combines tools from different disciplines: control engineering, systems and synthetic biology, and computer science.
The interdisciplinary research group I lead works on 3 main research areas:
1. synthesis of controllers which can robustly engineer novel cellular functions while expanding the repertoire of redesigned phenotypes across organisms;
2. implementation of pipelines that can support whole-cell design and make synthetic biology design-build-test-learn cycles more predictable and efficient;
3. understanding of the endogenous processes which regulate higher organism gene expression in space and time for superior, nature-inspired design aims.
Structured keywords and research groupings
- Mathematics and Computational Biology
- Bristol BioDesign Institute
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Projects
Research output
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ChipSeg: an automatic tool to segment bacterial and mammalian cells cultured in microfluidic devices
De Cesare, I., Zamora Chimal, C. G., Postiglione, L., Khazim, M., Pedone, E., Shannon, B. M., Fiore, G., Perrino, G., Napolitano, S., di Bernardo, D., Savery, N. J., Grierson, C. S., Di Bernardo, M. & Marucci, L., 18 Jan 2021, In: ACS Omega. (2021) 6, 4, p. 2473–2476 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria
Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 6 Mar 2020, In: Journal of Biological Chemistry. 295, p. 3285-3300 16 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions
Aulicino, F., Pedone, E., Sottile, F., Lluis, F., Marucci, L. & Cosma, M. P., 8 Sep 2020, In: Stem Cell Reports. 15, 3, p. 646-661 16 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile
Datasets
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E Coli simulations JR
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator), Landon, S. (Creator) & Rightmyer, J. (Creator), University of Bristol, 5 Mar 2021
DOI: 10.5523/bris.1v58mpokwp9927bf6s36osb5k, http://data.bris.ac.uk/data/dataset/1v58mpokwp9927bf6s36osb5k
Dataset
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Data from whole-cell modelling (12-2019)
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 6 Dec 2019
DOI: 10.5523/bris.1jj0fszzrx9qf2ldcz654qp454, http://data.bris.ac.uk/data/dataset/1jj0fszzrx9qf2ldcz654qp454
Dataset
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Data from Understanding metabolic behaviour whole-cell model
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 20 Aug 2020
DOI: 10.5523/bris.3u1v7dy42fk332watjl81m13y0, http://data.bris.ac.uk/data/dataset/3u1v7dy42fk332watjl81m13y0
Dataset