Projects per year
Personal profile
Research interests
Cell decision-making is orchestrated by the complex interplay between intracellular dynamics and the extracellular environment. How do these components produce emergent phenotypes and affect cell decision-making? Can cell fate be directly engineered? Can mathematical models aid in the understanding the basis of living organism regulations and guide their re-engineering?
My multidisciplinary Systems and Synthetic Biology research group aims at answering these questions combining wet-lab experiments and computational research. The main aims are to:
i) get a quantitative understanding of the link between signalling pathway dynamics, cell-cycle and stem cell pluripotency. We combine tools from Systems and Synthetic Biology at population- and single-cell levels, and are currently setting-up a microscopy/microfluidics platform for real-time mammalian cells imaging and control;
ii) develop agent-based modelling tools for describing and predicting single-cell dynamics accounting for gene regulatory networks, cell morphology, cell growth and geometry of the environment;
iii) use in silico algorithms for rational minimal genome design, taking advantage of Whole-Cell models
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Projects
Research Output
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions
Aulicino, F., Pedone, E., Sottile, F., Lluis, F., Marucci, L. & Cosma, M. P., 8 Sep 2020, In : Stem Cell Reports. 15, 3, p. 646-661 16 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology
Marucci, L., Barberis, M., Karr, J., Ray, O., Race, P. R., de Souza Andrade, M., Grierson, C. S., Hoffmann, S. A., Landon, S., Rech, E., Rees-Garbutt, J. P., Seabrook, R., Shaw, W. & Woods, C. J., 7 Aug 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 11 p., 942.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model
Ward, D., Montes Olivas, S., Fletcher, A., Homer, M. & Marucci, L., 10 Jan 2020, In : Computational and Structural Biotechnology Journal. 18, p. 230-240 11 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Datasets
Data from Understanding metabolic behaviour whole-cell model
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 20 Aug 2020
DOI: 10.5523/bris.3u1v7dy42fk332watjl81m13y0, http://data.bris.ac.uk/data/dataset/3u1v7dy42fk332watjl81m13y0
Dataset
Data from whole-cell modelling (12-2019)
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 6 Dec 2019
DOI: 10.5523/bris.1jj0fszzrx9qf2ldcz654qp454, http://data.bris.ac.uk/data/dataset/1jj0fszzrx9qf2ldcz654qp454
Dataset
Supervised Work
A Viral Approach to Translatome Profiling of CA1 Neurons During Associative Recognition Memory Formation
Author: Gaunt, J., 25 Sep 2018Supervisor: Uney, J. (Supervisor), Warburton, C. (Supervisor) & Marucci, L. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File
Dynamics of Biomedical Networks
Author: Godwin, S. E., 28 Nov 2019Supervisor: Marucci, L. (Supervisor) & Masuda, N. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File
Multiscale Modelling of Stem Cell Population Dynamics
Author: Ward, D., 19 Mar 2019Supervisor: Marucci, L. (Supervisor) & Homer, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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