Projects per year
Personal profile
Research interests
Cell decision-making is orchestrated by the complex interplay between intracellular dynamics and the extracellular environment. How do these components produce emergent phenotypes and affect cell decision-making? Can cell fate be directly engineered? Can mathematical models aid in the understanding the basis of living organism regulations and guide their re-engineering?
My multidisciplinary Systems and Synthetic Biology research group aims at answering these questions combining wet-lab experiments and computational research. The main aims are to:
i) get a quantitative understanding of the link between signalling pathway dynamics, cell-cycle and stem cell pluripotency. We combine tools from Systems and Synthetic Biology at population- and single-cell levels, and are currently setting-up a microscopy/microfluidics platform for real-time mammalian cells imaging and control;
ii) develop agent-based modelling tools for describing and predicting single-cell dynamics accounting for gene regulatory networks, cell morphology, cell growth and geometry of the environment;
iii) use in silico algorithms for rational minimal genome design, taking advantage of Whole-Cell models
Fingerprint Dive into the research topics where Lucia Marucci is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 9 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Research Output
Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model
Ward, D., Montes Olivas, S., Fletcher, A., Homer, M. & Marucci, L., 10 Jan 2020, In : Computational and Structural Biotechnology Journal. 18, p. 230-240 11 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Designing Minimal Genomes Using Whole-Cell Models
Rees-Garbutt, J., Chalkley, O., Landon, S., Purcell, O., Marucci, L. & Grierson, C., 11 Feb 2020, In : Nature Communications. 11, 12 p., 836 (2020).Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Dual druggable genome siRNA and compound screening approaches identify novel modulators of parkin recruitment to mitochondria
Scott, H. L., Buckner, N., Fernandez-Albert, F., Pedone, E., Postiglione, L., Shi, G., Allen, N., Wong, L-F., Magini, L., Marucci, L., O’Sullivan, G., Cole, S., Powell, J., Maycox, P. & Uney, J. B., 7 Jan 2020, In : Journal of Biological Chemistry.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Datasets
Data from whole-cell modelling (12-2019)
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 6 Dec 2019
DOI: 10.5523/bris.1jj0fszzrx9qf2ldcz654qp454, http://data.bris.ac.uk/data/dataset/1jj0fszzrx9qf2ldcz654qp454
Dataset
Supervised Work
A Viral Approach to Translatome Profiling of CA1 Neurons During Associative Recognition Memory Formation
Author: Gaunt, J., 25 Sep 2018Supervisor: Uney, J. (Supervisor), Warburton, C. (Supervisor) & Marucci, L. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File
Dynamics of Biomedical Networks
Author: Godwin, S. E., 28 Nov 2019Supervisor: Marucci, L. (Supervisor) & Masuda, N. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File
Multiscale Modelling of Stem Cell Population Dynamics
Author: Ward, D., 19 Mar 2019Supervisor: Marucci, L. (Supervisor) & Homer, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File