Research output per year
Research output per year
Personal profile
Research interests
Lucia's research is focused on developing quantitative tools to understand cell dynamics and engineering-inspired methodologies for controlling living system functions, with the final aim to both disentangle and reprogram the complexity governing life.
Her approach combines tools from different disciplines: control engineering, systems and synthetic biology, and computer science.
The interdisciplinary research group Lucia leads works on 3 main research areas:
1. synthesis of controllers which can robustly engineer novel cellular functions while expanding the repertoire of redesigned phenotypes across organisms;
2. implementation of pipelines that can support whole-cell design and make synthetic biology design-build-test-learn cycles more predictable and efficient;
3. understanding of the endogenous processes which regulate higher organism gene expression in space and time for superior, nature-inspired design aims.
Research Groups and Themes
- Mathematics and Computational Biology
- Bristol BioDesign Institute
- Engineering Mathematics Research Group
Keywords
- synthetic biology
- systems biology
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Collaborations and top research areas from the last five years
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Research output
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Knowledge preservation in the era of big science and AI: strategies for sustainable scientific research
Rainford, P. F., Occhipinti, A., Wang, B., Stepney, S., Angione, C., Verma, S., Marucci, L., Sharma, K., Harris, S. A., Füchslin, R. M., Klipp, E., Grierson, C. S., Weyland, M. S., Mogre, A., Fellermann, H., Doan, L. M. T., Gherman, I. M., Pyne, A. L. B., Rudge, T. J. & Berrelleza, V. M. V. & 1 others, , 5 May 2026, In: Nature Communications. 17, 1, 12 p., 4069.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open Access -
Accelerated design of Escherichia coli reduced genomes using a whole-cell model and machine learning
Gherman, I. M., Sharma, K., Rees-Garbutt, J., Pang, W., Abdallah, Z. S., Gorochowski, T. E., Grierson, C. S. & Marucci, L., 15 Oct 2025, In: Cell Systems. 16, 10, p. 1-23 23 p., 101392.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access4 Citations (Scopus) -
In silico modelling of organ-on-a-chip devices: an overview
Wang, Y., Marucci, L. & Homer, M. E., 27 Jan 2025, In: Frontiers in Bioengineering and Biotechnology. 12, 1520795.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open Access11 Citations (Scopus)
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EEBio: Efficient Engineering and Control of Predictable and Reliable Biosystems
Marucci, L. (Principal Investigator)
1/03/24 → 28/02/30
Project: Research
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AI In Bioscience Network Proposal
Marucci, L. (Principal Investigator)
1/08/23 → 31/07/28
Project: Research
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Datasets
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ML surrogates for minimal genome design
Marucci, L. (Creator), Grierson, C. (Creator), Rees, J. (Creator), Gherman, I. (Creator), Gorochowski, T. (Creator) & Abdallah, Z. (Creator), University of Bristol, 16 May 2024
DOI: 10.5523/bris.2wnzwzenfn4tt2iva9xxmb7ayh, http://data.bris.ac.uk/data/dataset/2wnzwzenfn4tt2iva9xxmb7ayh
Dataset
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Code for metabolic flux analysis
Marucci, L. (Creator), Grierson, C. (Creator), Chalkley, O. (Creator), Rees, J. (Creator), Breese, A. (Creator), Landon, S. (Creator), Rightmyer, J. (Creator), Gherman, I. M. (Creator), Harrison, C. (Creator) & Pedone, E. (Creator), University of Bristol, 24 Nov 2021
DOI: 10.5523/bris.879w4p1r8iy32ef9vcwftq9ts, http://data.bris.ac.uk/data/dataset/879w4p1r8iy32ef9vcwftq9ts
Dataset
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Data from minimal gene set whole-cell modelling
Marucci, L. (Creator), Grierson, C. (Creator), Chalkley, O. (Creator), Rees, J. (Creator) & Rightmyer, J. (Creator), University of Bristol, 30 Apr 2021
DOI: 10.5523/bris.356boayld729v2snyncfoltt0w, http://data.bris.ac.uk/data/dataset/356boayld729v2snyncfoltt0w
Dataset