Dr Lucy A Crompton

B.Sc.(Manc.), MRes. (Imperial College London), PhD

  • BS8 1TD

20052020

Research output per year

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Personal profile

Research interests

My research career has focused on the application of stem cells for the study of neurodevelopment and neurodegeneration, and I now have over 12 years of experience in the culture of multiple types of stem cell and their differentiation into neural cells. My current research focuses on Parkinson’s disease and I am investigating how neuroinflammation, in particular the role of astrocytes contributes to Parkinson’s disease pathology. In brief I am using a hiPSC derived platform to study how astrocytes protect and support neurons but also how chronic disease generates neurotoxic astrocytes.

-The use of patient derived induced Pluripotent Stem Cells (iPSCs) to investigate Parkinsons disease and Alzheimer's disease.

- In particular my work looks at the role astrocytes play in these diseases.

- We generate specific subpopulations of neurons and astrocytes from the iPSCs and we use these to model the diseases.

- In particular I am interested in how astrocytes support neurons and why they can become neurotoxic and how this may pre-empt disease.

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Research Output

  • 10 Article (Academic Journal)
  • 1 Chapter in a book

A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 23 Jan 2020, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle (Academic Journal)

  • Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research

    Stathakos, P., Jimenez Moreno, N., Crompton, L., Nistor, P., Caldwell, M. & Lane, J., 5 Jan 2019, Autophagy. Humana Press, p. 257-280 23 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter in a book

    Open Access
    File
  • 55 Downloads (Pure)

    Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

    Hawkins, S. J., Crompton, L. A., Sood, A., Saunders, M., Boyle, N. T., Buckley, A., Minogue, A. M., McComish, S. F., Jiménez-Moreno, N., Cordero-Llana, O., Stathakos, P., Gilmore, C. E., Kelly, S., Lane, J. D., Case, C. P. & Caldwell, M. A., 2 Apr 2018, In : Nature Nanotechnology. p. 427-433 7 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 22 Citations (Scopus)
    377 Downloads (Pure)