Professor M C Galan

B.Sc. (Alicante, Spain), M.Phil. (Strathclyde, Scotland), Ph.D. (CCRC, Georgia, USA)

  • BS8 1TS

20002020

Research output per year

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Personal profile

Research interests

In our lab we are interested in employing synthetic organic chemistry as a tool to probe and manipulate the structure and function of biologically relevant molecules to study biological problems and potentially discover treatments for diseases.

Carbohydrates have emerged as important factors of molecular recognition in biology and medicine. Understanding the roles of these complex molecules, which are found on the surface of cells as part of glycoproteins or glycolipids is of great importance. However, the synthesis of these oligosaccharide structures is still a challenging task.

Our current research interests focus on the development of new synthetic techniques for the facile synthesis of oligosaccharide libraries and glycoconjugates drug analogues.

We are also interested in the development of multivalent platforms to study carbohydrate-protein interactions in the context of disease.

Dr Galan is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis

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Projects

Research Output

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

Huang, K., Marchesi, A., Hollingsworth, K., Both, P., Mattey, A. P., Pallister, E., Ledru, H., Charnock, S. J., Galan, M. C., Turnbull, W. B., Parmeggiani, F. & Flitsch, S. L., 30 Mar 2020, In : Organic and Biomolecular Chemistry. 2020, 18, p. 3142-3148 7 p.

Research output: Contribution to journalArticle (Academic Journal)

  • Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

    Valverde, P., Vendeville, J-B., Hollingsworth, K., Mattey, A. P., Keenan, T., Chidwick, H., Ledru, H., Huonnic, K., Huang, K., Light, M. E., Turner, N., Jiménez-Barbero, J., Galan, M. C., Fascione, M. A., Flitsch, S., Turnbull, W. B. & Linclau, B., 29 Apr 2020, In : Chemical communications (Cambridge, England). (2020) 56, p. 6408-6411

    Research output: Contribution to journalArticle (Academic Journal)

  • Chemo-selective Rh-catalysed hydrogenation of azides into amines

    Ghirardello, M., Ledru, H., Sau, A. & Galan, M. C., 6 Feb 2020, In : Carbohydrate Research. 489, p. 107948 4 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
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    Datasets

    Ultrafast Chemical Dynamics: Guanine-Cytosine Photochemistry

    Coulter, P. (Creator), Roberts, G. (Creator), Grubb, M. (Creator), Orr-Ewing, A. J. (Creator), Marroux, H. (Creator), Roettger, K. (Creator), Roettger, K. (Contributor), Galan, M. C. (Contributor), Roberts, G. (Contributor), Marroux, H. (Contributor), Bohnke, H. (Contributor), Orr-Ewing, A. J. (Contributor), Henderson, A. (Contributor), Grubb, M. (Contributor), Coulter, P. (Contributor) & Temps, F. (Contributor), University of Bristol, 21 May 2015

    Dataset

    Activities

    • 1 Fellowship awarded competitively

    Career Acceleration Fellowship - Novel ionic-based tools for glycoscience.

    M C Galan (Recipient)

    31 Mar 201231 Mar 2017

    Activity: Other activity typesFellowship awarded competitively