Projects per year
Personal profile
Research interests
Research in my group involves the use of biomolecular simulation to investigate and predict the behaviour of biomolecules. Of particular interest are enzymes and their specificity, catalysis and dynamics. The main techniques used are combined quantum mechanical / molecular mechanical modelling (QM/MM) and molecular dynamics simulation. The current primary area of interest is the use and development of biomolecular simulation protocols to aid development of biocatalysts.
As a BBSRC David Phillips Fellow (affiliated with the BrisSynBio research centre), I will investigate biosynthetic enzymes that are responsible for a wide range of natural products, such as terpene and polyketide synthases. To efficiently tackle the chemical and structural complexity involved in the catalytic cycles of these enzymes, new simulation protocols and methods will be developed. By modifying enzymes according to predictions from simulation, in collaboration with experimentalists, the aim is to develop new biocatalysts for the sustainable production of high-value chemicals.
Other research interests are: enzymes involved in antibiotic resistance, computational simulation methods to aid drug design and fundamental principles of enzyme catalysis.
Structured keywords and research groupings
- BcompB
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Projects
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Multi-scale enzyme modelling for SynBio: optimizing biocatalysts for selective synthesis of bioactive compounds
1/12/15 → 31/05/21
Project: Research
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Simulating Catalysis: Multiscale Embedding Of Machine Learning Potentials
1/05/21 → 30/04/24
Project: Research
Research output
- 67 Article (Academic Journal)
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Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance
Koh, A., Gibbon, M. J., Van Der Kamp, M. W., Pudney, C. R. & Gebhard, S., 1 Jan 2021, In: Molecular Microbiology. 115, 1, p. 157-174 18 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
Redesigning the molecular choreography to prevent hydroxylation in germacradien-11-ol synthase catalysis
et al., 7 Jan 2021, In: ACS Catalysis. 11, p. 1033–1041 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Enlighten2: molecular dynamics simulations of protein-ligand systems made accessible
Zinovjev, K. & Van Der Kamp, M. W., 15 Oct 2020, In: Bioinformatics. 36, 20, p. 5104-5106 3 p., btaa643.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Datasets
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Simulation of Functional Motions in Enzymes
Woods, C. J. (Creator), Van Der Kamp, M. W. (Creator), McGeagh, J. (Contributor) & Mulholland, A. J. (Data Manager), University of Bristol, 14 Jul 2015
DOI: 10.5523/bris.1klro7qjw27xi19qrcs1bb2nt6, http://data.bris.ac.uk/data/dataset/1klro7qjw27xi19qrcs1bb2nt6
Dataset
Activities
- 1 Fellowship awarded competitively
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BBSRC David Phillips Fellowship
Marc W Van der Kamp (Recipient)
1 Dec 2015 → 30 Nov 2020Activity: Other activity types › Fellowship awarded competitively