Dr Marc W Van Der Kamp

M.Sc.(Wageningen), PhD(Bristol)

  • BS8 1TD

20072020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Research in my group involves the use of biomolecular simulation to investigate and predict the behaviour of biomolecules. Of particular interest are enzymes and their specificity, catalysis and dynamics. The main techniques used are combined quantum mechanical / molecular mechanical modelling (QM/MM) and molecular dynamics simulation. The current primary area of interest is the use and development of biomolecular simulation protocols to aid development of biocatalysts.

As a BBSRC David Phillips Fellow (affiliated with the BrisSynBio research centre), I will investigate biosynthetic enzymes that are responsible for a wide range of natural products, such as terpene and polyketide synthases. To efficiently tackle the chemical and structural complexity involved in the catalytic cycles of these enzymes, new simulation protocols and methods will be developed. By modifying enzymes according to predictions from simulation, in collaboration with experimentalists, the aim is to develop new biocatalysts for the sustainable production of high-value chemicals.

Other research interests are: enzymes involved in antibiotic resistance, computational simulation methods to aid drug design and fundamental principles of enzyme catalysis.

Structured keywords and research groupings

  • BcompB

Fingerprint Dive into the research topics where Marc W Van Der Kamp is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

  • 59 Article (Academic Journal)

Enzyme Evolution and the Temperature Dependence of Enzyme Catalysis

Arcus, V. L., Van Der Kamp, M. W., Pudney, C. R. & Mulholland, A. J., 4 Jun 2020, (Accepted/In press) In : Current Opinion in Structural Biology.

Research output: Contribution to journalArticle (Academic Journal)

  • Peptide cargo tunes a network of correlated motions in human leukocyte antigens

    Hopkins, J. R., Crean, R. M., Catici, D. A. M., Sewell, A. K., Arcus, V. L., Van Der Kamp, M. W., Cole, D. & Pudney, C. R., 5 Mar 2020, In : FEBS Journal. 17 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 27 Downloads (Pure)

    Datasets

    Activities

    • 1 Fellowship awarded competitively

    BBSRC David Phillips Fellowship

    Marc W Van der Kamp (Recipient)

    1 Dec 201530 Nov 2020

    Activity: Other activity typesFellowship awarded competitively