Projects per year
Personal profile
Research interests
Research in my group involves the use of biomolecular simulation to investigate and predict the behaviour of biomolecules. Of particular interest are enzymes and their specificity, catalysis and dynamics. The main techniques used are combined quantum mechanical / molecular mechanical modelling (QM/MM) and molecular dynamics simulation. The current primary area of interest is the use and development of biomolecular simulation protocols to aid development of biocatalysts.
As a BBSRC David Phillips Fellow (affiliated with the BrisSynBio research centre), I will investigate biosynthetic enzymes that are responsible for a wide range of natural products, such as terpene and polyketide synthases. To efficiently tackle the chemical and structural complexity involved in the catalytic cycles of these enzymes, new simulation protocols and methods will be developed. By modifying enzymes according to predictions from simulation, in collaboration with experimentalists, the aim is to develop new biocatalysts for the sustainable production of high-value chemicals.
Other research interests are: enzymes involved in antibiotic resistance, computational simulation methods to aid drug design and fundamental principles of enzyme catalysis.
Structured keywords and research groupings
- BcompB
Keywords
- BrisSynBio
- Centre for Computational Chemistry
- enzyme catalysis
- Computational and Theoretical Chemistry
- Bristol Computational Biochemistry
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Resistance to β-lactam antibiotics: Exploring the mechanism and inhibition of Class C β-lactamases
1/02/23 → 31/01/25
Project: Research
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Simulating Catalysis: Multiscale Embedding Of Machine Learning Potentials
1/05/21 → 30/04/24
Project: Research
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Simulating catalysis: Multiscale embedding of machine learning potentials
1/05/21 → 30/04/24
Project: Research, Parent
Research output
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Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution
Frohlich, C., Bunzel, H. A., Buda, K., Mulholland, A. J., Kamp, M. W. V. D., Johnsen, P. J., Leiros, H-K. S. & Tokuriki, N., 29 Jun 2023Research output: Other contribution
Open Access -
Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases
Zorn, K., Back, C. R., Barringer, R., Chadimová, V., Manzo‐Ruiz, M., Mbatha, S. Z., Mobarec, JC., Williams, S. E., Kamp, M. W. V. D., Race, P. R., Willis, C. L. & Hayes, M. A., 12 Jun 2023, In: ChemBioChem. 24, 14, e202300382.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Promiscuous recognition of MR1 drives self-reactive Mucosal-Associated Invariant T cell responses
Chancellor, A., Simmons, R. A., Crean, R. M., Van der Kamp, M. W., De Libero, G. & Lepore, M., 4 Sept 2023, In: Journal of Experimental Medicine. 220, 9, e20221939.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure)
Datasets
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Selected simulation input and output for patchoulol synthase and germacradien-11-ol synthase
Van der Kamp, M. W. (Creator), Johns, S. (Creator) & Walters, R. K. (Creator), Zenodo, 20 Apr 2023
DOI: 10.5281/zenodo.7824978, https://zenodo.org/record/7824978
Dataset
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Molcular Dynamics Data for Therapeutic High Affinity T Cell Receptor Targeting a KRAS G12D Cancer Neoantigen
Van der Kamp, M. W. (Creator) & Hartt, A. M. (Creator), Zenodo, 12 Jul 2022
DOI: 10.5281/zenodo.6818253, https://zenodo.org/record/6818253
Dataset
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Molcular Dynamics Data for Therapeutic High Affinity T Cell Receptor Targeting a KRAS G12D Cancer Neoantigen
Van der Kamp, M. W. (Creator) & Hartt, A. M. (Creator), Zenodo, 12 Jul 2022
DOI: 10.5281/zenodo.6839257, https://zenodo.org/record/6839257
Dataset
Activities
- 1 Fellowship awarded competitively
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BBSRC David Phillips Fellowship
Marc W Van der Kamp (Recipient)
1 Dec 2015 → 30 Nov 2020Activity: Other activity types › Fellowship awarded competitively