Projects per year
Worldwide, newborn infants suffer death or permanent brain damage caused by diseases or clinical events arising before or around the time of birth causing reduced oxygen delivery and or blood flow to the brain. I do translational research aimed at developing effective treatment, improve treatment protocols and collect short and long term outcome for a detailed and large clinical database of newborns with HIE treated with therapeutic hypothermia. Current outcome results from our population based cohort is twice as good as they were in the the cooled group in the first large HT trials. Therapeutic hypothermia is the first and so far the only effective treatment after perinatal asphyxia. We have modified the protocol to start cooling very early and also include TH after postnatal collapse. TH resuces the occurence of later seizure disorder and reduced the severity of cerebral palsy - in our cohort 50% of CP children have a grade 1 CP. Mortality since 2007 has been 9%. We are awaiting the results from our small RCT adding xenon to TH in one group compared to TH only. our experimental models we have shown that adding the inert gas xenon to cooling we double the neuroprotection. We gave, for tthe first time in the world , xenon to a baby i 2010
For CV and a full list of publications, please visit my website here.
1. Circulation Physiology
- cerebral circulation and the influence of blood pressure, temperature and body positioning
- cerebral venous drainage
- positive pressure ventilation
- cardiovascular responses to tilting
- uterine and mammary circulation during normal pregnancy
- skin circulation and thermoregulation
- Physiological Method studies of Doppler velocity, electromagnetic Flowmetry, pletysmography, cerebral circulation, blood pressure and temperature.
- Models of human disease in; newborn asphyxia, intraventricular haemorrhage
I have developed 3 experimental models mimicking diseases leading to permanent handicap. We use these to understand disease mechanisms and repair processes, and develop treatments for injury caused by asphyxia or low brain blood flow.
Our clinical trials have confirmed effectiveness seen in the experimental models. Now, worldwide, we are applying hypothermia after perinatal asphyxia.
Adding Xenon inhalation to hypothermia doubles neuroprotection in both small and large newborn brain injury models. Our approved Xe delivery system, with safety data and long term survival results, precedes our clinical feasibility study which is now recruiting.
CoolCuddle: Do parents cuddling babies undergoing cooling therapy for hypoxic-ischaemic encephalopathy (HIE) affect the cooling process or intensive care? Refinement and evaluation of an intervention protocol
1/09/19 → 28/02/21
Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathySpencer, A. P. C., Brooks, J. C. W., Masuda, N., Byrne, H., Lee-Kelland, R., Jary, S., Thoresen, M., Tonks, J., Goodfellow, M., Cowan, F. M. & Chakkarapani, E., 10 Feb 2021, (E-pub ahead of print) In: NeuroImage: Clinical. 30, 14 p., 102582.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile8 Downloads (Pure)
Chakkarapani, E., Jary, S. L., Menassa, D., Scull-Brown, E. L., Frymoyer, A., Walløe, L. & Thoresen, M., 5 Jun 2021, (E-pub ahead of print) In: EClinicalMedicine. 9 p., 100892.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile
MRI combined with early clinical variables are excellent outcome predictors for newborn infants undergoing therapeutic hypothermia after perinatal asphyxiaThoresen, M., Jary, S., Walløe, L., Karlsson, M., Martinez-Biarge, M., Chakkarapani, E. & Cowan, F. M., 17 May 2021, (E-pub ahead of print) In: EClinicalMedicine. 12 p., 100885.
Research output: Contribution to journal › Article (Academic Journal) › peer-review2 Downloads (Pure)