Professor Mark B Cannell

BSc(U.C.Lond.), PhD(U.C.Lond.), FRSNZ, FISHR

  • BS8 1TD

1987 …2020

Research output per year

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Research Output

2020

3D localization microscopy and 4D localization microscopy and tracking methods and systems

Cannell, M. B., Soeller, C. & Beddeley, D., 25 Feb 2020, US PATENT OFFICE, Patent No. US10571674B2, 28 Mar 2018, Priority date 24 Oct 2010, Priority No. NZ58819910

Research output: Patent

Open Access
File
102 Downloads (Pure)
2019

Cardiac-specific overexpression of caveolin-3 preserves t-tubular I Ca during heart failure in mice

Kong, C. H. T., Bryant, S. M., Watson, J. J., Roth, D. M., Patel, H. H., Cannell, M. B., James, A. F. & Orchard, C. H., 1 May 2019, In : Experimental Physiology. 104, 5, p. 654-666 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
192 Downloads (Pure)

Multiphoton microscopy

Cannell, M. & Cox, G., 2019, Fundamentals of fluorescence imaging. Cox, G. (ed.). Singapore: Jenny Stanford Publishing Pte. Ltd., p. 63-80 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Practical aspects of localization microscopy

Cannell, M., Soeller, C. & Baddeley, D., 2019, Fundamentals of fluorescence imaging. Cox, G. (ed.). Singapore: Jenny Stanford Publishing Pte. Ltd., p. 347-381 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2018

Caveolin-3 dependent loss of t-tubular ICa during hypertrophy and heart failure in mice

Bryant, S. M., Kong, C. H. T., Watson, J. J., Gadeberg, H. C., James, A. F., Cannell, M. B. & Orchard, C. H., 1 May 2018, In : Experimental Physiology. 103, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
265 Downloads (Pure)

Caveolin-3 KO Disrupts T-Tububle Structure and Decreases T-Tubular ICa Density in Mouse Ventricular Myocytes

Bryant, S., Kong, C., Watson, J., Gadeberg, H., Roth, D. M., Patel, H., Cannell, M., James, A. & Orchard, C., Nov 2018, In : AJP - Heart and Circulatory Physiology. 315, 5, p. H1101-H1111 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
172 Downloads (Pure)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
165 Downloads (Pure)

Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure

Bryant, S. M., Kong, C. H. T., Cannell, M. B., Orchard, C. H. & James, A. F., 1 Apr 2018, In : AJP - Heart and Circulatory Physiology. 314, 3, p. H521-H529

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
161 Downloads (Pure)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
325 Downloads (Pure)

Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes

Kong, C., Rog-Zielinska, E., Kohl, P., Orchard, C. & Cannell, M., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. E7073-E7080 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
214 Downloads (Pure)

Species differences in the morphology of T-tubule openings in cardiomyocytes

Rog-Zielinska, E., Kong, C. H. T., Zgierski-Johnston, C. M., Verkade, P., Mantell, J., Cannell, M. & Kohl, P., 1 Nov 2018, In : EP-Europace. 20, Supp 3, p. iii120-iii124 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
132 Downloads (Pure)

The Effects of Aging on the Regulation of T-Tubular i Ca by Caveolin in Mouse Ventricular Myocytes

Kong, C. H. T., Bryant, S. M., Watson, J. J., Gadeberg, H. C., Roth, D. M., Patel, H. H., Cannell, M. B., Orchard, C. H. & James, A. F., 9 May 2018, In : Journals of Gerontology, Series A. 73, 6, p. 711-719 9 p., glx242.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
230 Downloads (Pure)
2017

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
183 Downloads (Pure)

Modelling Calcium-Induced-Calcium-Release from Measurements of RyR Gating

Laver, D. R., Kong, C. H. & Cannell, M. B., 3 Feb 2017, p. 540a-541a.

Research output: Contribution to conferenceConference Poster

Quenching the spark: Termination of CICR in the sub-microscopic space of the dyad

Cannell, M. B. & Kong, C. HT., 2 Oct 2017, In : Journal of General Physiology. 149, 10, p. 837-845 9 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
5 Citations (Scopus)
198 Downloads (Pure)

Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method

Kong, C. H. T., Rog-Zielinska, E. A., Kohl, P., Orchard, C. & Cannell, M. B., 1 Jul 2017, In : Journal of Molecular and Cellular Cardiology. 108, p. 1-7 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
247 Downloads (Pure)
2016

3D localisation microscopy and 4D localisation microscopy and tracking methods and systems

Soeller, C., Baddeley, D. & Cannell, M., 20 Dec 2016, Patent No. US9523846 B2, Priority date 24 Sep 2010, Priority No. US 13/825,794

Research output: Patent

Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca2+ sensitivity

Kaur, S., Kong, C., Cannell, M. & Ward, M., Jan 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 1, p. 88-94 6 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Heterogeneity of T-Tubules in Pig Hearts

Gadeberg, H. C., Bond, R. C., Kong, C., Chanoit, G., Ascione, R., Cannell, M. & James, A., 9 Jun 2016, In : PLoS ONE. 11, 6, 16 p., e0156862.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
347 Downloads (Pure)

The involvement of TRPC3 channels in sinoatrial arrhythmias

Ju, Y-K., Lee, B. H., Trajanovska, S., Hao, G., Allen, D. G., Lei, M. & Cannell, M. B., Jun 2016, Ca2+ Signaling and Heart Rhythm. Lei, M., Huang, C., Solaro, RJ. & Ke, Y. (eds.). Frontiers in Bioscience, p. 26-37 12 p. 86. (Frontiers Research Topics; vol. 6).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
217 Downloads (Pure)
2015

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

Bryant, S. M., Kong, C. H. T., Watson, J., Cannell, M. B., James, A. F. & Orchard, C. H., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 23–31 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
29 Citations (Scopus)
338 Downloads (Pure)

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Zhang, H., Cannell, M. B., Kim, S. J., Watson, J. J., Norman, R., C. Calaghan, S., Orchard, C. & James, A. F., 29 Dec 2015, In : PLoS ONE. 10, 12, 17 p., e0144309.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
275 Downloads (Pure)

Na+ channel function, regulation, structure, trafficking and sequestration

Chen-Izu, Y., Shaw, R. M., Pitt, G. S., Yarov-Yarovoy, V., Sack, J. T., Abriel, H., Aldrich, R. W., Belardinelli, L., Cannell, M. B., Catterall, W. A., Chazin, W. J., Chiamvimonvat, N., Deschenes, I., Grandi, E., Hund, T. J., Izu, L. T., Maier, L. S., Maltsev, V. A., Marionneau, C., Mohler, P. J. & 5 others, Rajamani, S., Rasmusson, R. L., Sobie, E. A., Clancy, C. E. & Bers, D. M., 15 Mar 2015, In : Journal of Physiology. 593, 6, p. 1347-60 14 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

The involvement of TRPC3 channels in sinoatrial arrhythmias

Ju, Y-K., Lee, B. H., Trajanovska, S., Hao, G., Allen, D. G., Lei, M. & Cannell, M. B., 25 Mar 2015, In : Frontiers in Physiology. 6, 12 p., 86.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
201 Downloads (Pure)

T-tubule disease: Relationship between t-tubule organization and regional contractile performance in human dilated cardiomyopathy

Crossman, D. J., Young, A. A., Ruygrok, P. N., Nason, G. P., Baddelely, D., Soeller, C. & Cannell, M. B., 1 Jul 2015, In : Journal of Molecular and Cellular Cardiology. 84, C, p. 170-178 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
35 Citations (Scopus)
308 Downloads (Pure)
2014

Heterogeneity in transverse (t)-tubules in pig atria

Gadeberg, H., Bond, R., Kong, C., Cannell, M., Ascione, R., Chanoit, G. & James, A., 2014, In : Proceedings of The Physiological Society. 31

Research output: Contribution to journalArticle (Academic Journal)

Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor

Shang, W., 31 Jan 2014, In : Circulation Research. 114, 3, p. 412-420 8 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)
2013

Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination

Cannell, M. B., Kong, H. T., Imtiaz, M. & Laver, D. R., May 2013, In : Biophysical Journal. 104, 10, p. 2149-2159 10 p.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca(2+) entry during the slow force response.

Shen, X., Cannell, M. B. & Ward, M-L., 1 Oct 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca2+ entry during the slow force response.

Sheng, X., Cannell, M. B. & Ward, M-L., 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 9 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach

Kong, H. T., Laver, D. R. & Cannell, M. B., 2013, In : PLoS Computational Biology. 9, 2, p. 1-10 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
19 Citations (Scopus)
568 Downloads (Pure)

Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

Zhang, L., Ward, M-L., Phillips, A. RJ., Zhang, S., Kennedy, J., Barry, B., Cannell, M. B. & Cooper, G. JS., 28 Aug 2013, In : Cardiovascular Diabetology. 12, 1, 17 p., 123.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
21 Citations (Scopus)
298 Downloads (Pure)

Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry

Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B. & Winterbourn, C. C., 1 May 2013, In : Free Radical Biology and Medicine. 58, p. 109-117 9 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

Laver, D. R., Kong, H. T., Imtiaz, M. & Cannell, M. B., 2013, In : Journal of Molecular and Cellular Cardiology. 54, p. 98-100 2 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)
2012

Comparison of the organization of t-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, M. B., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 5, p. 469-476 7 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms

Ju, Y-K., Woodcock, E., Allen, D. & Cannell, M. B., 17 Jun 2012, In : Journal of Molecular and Cellular Cardiology. 53, p. 375-381 6 p.

Research output: Contribution to journalReview article (Academic Journal)

16 Citations (Scopus)

Local control in cardiac E--C coupling

Cannell, M. B. & Kong, C. H. T., 1 Feb 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 298-303 6 p.

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)

Local control in cardiac excitation-contraction coupling

Cannell, M. B. & Kong, H. T., 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 298-303 5 p.

Research output: Contribution to journalReview article (Academic Journal)

Nanoscale Organization of Junctophilin-2 and Ryanodine Receptors within Peripheral Couplings of Rat Ventricular Cardiomyocytes

Jayasinghe, ID., Kong, C., Wehrens, X., Cannell, M. B. & Soeller, C., 2012, In : Biophysical Journal. 102, p. 19-21 3 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)
2011

4D Super-Resolution Microscopy with Conventional Fluorophores and Single Wavelength Excitation in Optically Thick Cells and Tissues

Baddeley, D., Crossman, D., Rossberger, S., Cheyne, J., Montgomery, J., Isuru, D., Jayasinghe, ID., Cremer, C., Cannell, MB. & Soeller, C., 2011, In : PLoS ONE. 6, p. 1-10 10 p., e20645.

Research output: Contribution to journalArticle (Academic Journal)

95 Citations (Scopus)

Changes in the organization of excitation-contraction coupling structures in failing human heart

Crossman, D. J., Ruygrok, P. R., Soeller, C. & Cannell, MB., Apr 2011, In : PLoS ONE. 6(3), p. e7901 - e7901 10 p., Electronic Journal.

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)

Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node

Ju, Y-K., Lee, B. H., Lai, D., Woodcock, E. A., Hao, G-L., Lei, M., Cannell, MB. & Allen, D. G., 2011, In : Circulation Research. 109, p. 848 - 857 10 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Mapping system for coregistration of cardiac mri and ex vivo tissue sampling

Young, A. A., Crossman, D. J., Ruygrok, P. N. & Cannell, MB., Nov 2011, In : Journal of Magnetic Resonance Imaging. 34, p. 1065 - 1071 6 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Mechanisms of reduced contractility in an animal model of hypertensive heart failure

Ward, M-L., Crossman, D. J. & Cannell, MB., Oct 2011, In : Clinical and Experimental Pharmacology and Physiology. 38, p. 711 - 716 6 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Three dimensional sub-100 nm super-resolution imaging of biological samples using a phase ramp in the objective pupil

Baddeley, D., Cannell, MB. & Soeller, C., Jun 2011, In : Nano Research. 4, 6, p. s89 - s98 9 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)
2010

A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, MB., May 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 964 - 971 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart

Kim, N., Cannell, MB. & Hunter, P. J., Sep 2010, In : Progress in Biophysics and Molecular Biology. 103, p. 28 - 34 6 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

Li, P., Wei, W., Cai, X., Soeller, C., Cannell, MB. & Holden, A. V., Aug 2010, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 368, p. 3953 - 3965 12 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Excitation-contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes

Cooper, P. J., Soeller, C. & Cannell, MB., Dec 2010, In : Journal of Molecular and Cellular Cardiology. 49, p. 911 - 917 6 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)