Professor Mark B Cannell

BSc(U.C.Lond.), PhD(U.C.Lond.), FRSNZ, FISHR

  • BS8 1TD

1987 …2020

Research output per year

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Research Output

3D localisation microscopy and 4D localisation microscopy and tracking methods and systems

Soeller, C., Baddeley, D. & Cannell, M., 20 Dec 2016, Patent No. US9523846 B2, Priority date 24 Sep 2010, Priority No. US 13/825,794

Research output: Patent

3D localization microscopy and 4D localization microscopy and tracking methods and systems

Cannell, M. B., Soeller, C. & Beddeley, D., 25 Feb 2020, US PATENT OFFICE, Patent No. US10571674B2, 28 Mar 2018, Priority date 24 Oct 2010, Priority No. NZ58819910

Research output: Patent

4D Super-Resolution Microscopy with Conventional Fluorophores and Single Wavelength Excitation in Optically Thick Cells and Tissues

Baddeley, D., Crossman, D., Rossberger, S., Cheyne, J., Montgomery, J., Isuru, D., Jayasinghe, ID., Cremer, C., Cannell, MB. & Soeller, C., 2011, In : PLoS ONE. 6, p. 1-10 10 p., e20645.

Research output: Contribution to journalArticle (Academic Journal)

94 Citations (Scopus)

A buffering SERCA pump in models of calcium dynamics

Higgins, E. R., Cannell, M. B. & Sneyd, J., 1 Jan 2006, In : Biophysical Journal. 91, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes

Sobie, E. A., Cannell, MB. & Bridge, J. H. B., Apr 2008, In : Biophysical Journal. 94, p. L54 - 56 2 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy

Zhang, L., Cannell, MB., Phillips, A. R. J., Cooper, G. J. S. & Ward, M-L., Aug 2008, In : Diabetes. 57, 8, p. 2158 - 2166 8 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

Bryant, S. M., Kong, C. H. T., Watson, J., Cannell, M. B., James, A. F. & Orchard, C. H., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 23–31 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Citations (Scopus)
327 Downloads (Pure)

A mode of thought in excitation-contraction coupling

Cannell, M. B. & Soeller, C., 1 Jan 2002, In : Biophysical Journal. 83, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Analysing cardiac excitation-contraction coupling with mathematical models of local control. Progress in biophysics and molecular biology

Soeller, C. & Cannell, M. B., 1 Jan 2004, In : Prog. Biophys. Mol. Biol.. 85, 2-3, p. 141-162 22 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, MB., May 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 964 - 971 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca[sup 2+] movements: Journal of Biomedical Optics

Soeller, C., Jacobs, M. D., Donaldson, P. J., Cannell, M. B., Jones, K. T. & Ellis-Davies, G. C. R., 1 Jan 2003, In : Journal of Biomedical Optics. 8, 3, p. 418 1 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
Open Access
File
91 Downloads (Pure)

Ca2+ entry via AMPA-type glutamate receptors triggers Ca2+-induced Ca2+ release from ryanodine receptors in rat spiral ganglion neurons

Morton-Jones, R. T., Cannell, MB. & Housley, G. D., Apr 2008, In : Cell Calcium. 43, p. 356 - 366 10 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Calcium Sparks - Elementary Events Underlying Excitation-Contraction Coupling in Heart-Muscle

Cheng, H., Lederer, W. J. & Cannell, M. B., 29 Jan 1993, In : Science. 262, 5134, p. 740-744 5 p.

Research output: Contribution to journalArticle (Academic Journal)

1509 Citations (Scopus)

Cardiac-specific overexpression of caveolin-3 preserves t-tubular I Ca during heart failure in mice

Kong, C. H. T., Bryant, S. M., Watson, J. J., Roth, D. M., Patel, H. H., Cannell, M. B., James, A. F. & Orchard, C. H., 1 May 2019, In : Experimental Physiology. 104, 5, p. 654-666 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
183 Downloads (Pure)

Caveolin-3 dependent loss of t-tubular ICa during hypertrophy and heart failure in mice

Bryant, S. M., Kong, C. H. T., Watson, J. J., Gadeberg, H. C., James, A. F., Cannell, M. B. & Orchard, C. H., 1 May 2018, In : Experimental Physiology. 103, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
261 Downloads (Pure)

Caveolin-3 KO Disrupts T-Tububle Structure and Decreases T-Tubular ICa Density in Mouse Ventricular Myocytes

Bryant, S., Kong, C., Watson, J., Gadeberg, H., Roth, D. M., Patel, H., Cannell, M., James, A. & Orchard, C., Nov 2018, In : AJP - Heart and Circulatory Physiology. 315, 5, p. H1101-H1111 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
163 Downloads (Pure)

Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2

Wier, W. G., Cannell, M. B., Berlin, J. R., Marbán, E. & Lederer, W. J., 16 Jan 1987, In : Science. 235, 4786, p. 325-328 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Zhang, H., Cannell, M. B., Kim, S. J., Watson, J. J., Norman, R., C. Calaghan, S., Orchard, C. & James, A. F., 29 Dec 2015, In : PLoS ONE. 10, 12, 17 p., e0144309.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
269 Downloads (Pure)

Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart

Kim, N., Cannell, MB. & Hunter, P. J., Sep 2010, In : Progress in Biophysics and Molecular Biology. 103, p. 28 - 34 6 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Changes in the organization of excitation-contraction coupling structures in failing human heart

Crossman, D. J., Ruygrok, P. R., Soeller, C. & Cannell, MB., Apr 2011, In : PLoS ONE. 6(3), p. e7901 - e7901 10 p., Electronic Journal.

Research output: Contribution to journalArticle (Academic Journal)

99 Citations (Scopus)

Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium

Winton, H. L., Wan, H., Cannell, M. B., Thompson, P. J., Garrod, D. R., Stewart, G. A. & Robinson, C., 30 Jul 1998, In : British Journal of Pharmacology. 124, 6, p. 1048-1059 12 p.

Research output: Contribution to journalArticle (Academic Journal)

72 Citations (Scopus)

Comparison of the organization of t-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, M. B., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 5, p. 469-476 7 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

Li, P., Wei, W., Cai, X., Soeller, C., Cannell, MB. & Holden, A. V., Aug 2010, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 368, p. 3953 - 3965 12 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination

Cannell, M. B., Kong, H. T., Imtiaz, M. & Laver, D. R., May 2013, In : Biophysical Journal. 104, 10, p. 2149-2159 10 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

Gomez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A. & Lederer, WJ., 1 Jan 1997, In : Science. 276, 5313, p. 800-806 7 p.

Research output: Contribution to journalArticle (Academic Journal)

607 Citations (Scopus)

Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca2+ sensitivity

Kaur, S., Kong, C., Cannell, M. & Ward, M., Jan 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 1, p. 88-94 6 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
179 Downloads (Pure)

Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node

Ju, Y-K., Lee, B. H., Lai, D., Woodcock, E. A., Hao, G-L., Lei, M., Cannell, MB. & Allen, D. G., 2011, In : Circulation Research. 109, p. 848 - 857 10 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells

Cannell, M. B. & Lederer, W. J., 1 Jan 1987, In : Science. 238, 4832, p. 1419-1423 5 p.

Research output: Contribution to journalArticle (Academic Journal)

232 Citations (Scopus)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca(2+) entry during the slow force response.

Shen, X., Cannell, M. B. & Ward, M-L., 1 Oct 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca2+ entry during the slow force response.

Sheng, X., Cannell, M. B. & Ward, M-L., 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 9 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Electrochemical detection of DNA hybridization amplified by nanoparticles. Biosensors & bioelectronics

Peng, H., Soeller, C., Cannell, M. B., Bowmaker, G. A., Cooney, R. P. & Travas-Sejdic, J., 15 Jan 2006, In : Biosens Bioelectron. 21, 9, p. 1727-1736 10 p.

Research output: Contribution to journalArticle (Academic Journal)

99 Citations (Scopus)

Estimation of the sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks

Soeller, C. & Cannell, M. B., 1 Jan 2002, In : Biophysical Journal. 82, 5, p. 2396-2414 19 p.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)

Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum. Annals of the New York Academy of Sciences

Lederer, W. J., Berlin, J. R., Cohen, N. M., Hadley, R. W., Bers, D. M. & Cannell, M. B., 1 Jan 1990, In : Annals of the New York Academy of Sciences. 588, 1 Embryonic Ori, p. 190-206 17 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Excitation-contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes

Cooper, P. J., Soeller, C. & Cannell, MB., Dec 2010, In : Journal of Molecular and Cellular Cardiology. 49, p. 911 - 917 6 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach

Kong, H. T., Laver, D. R. & Cannell, M. B., 2013, In : PLoS Computational Biology. 9, 2, p. 1-10 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
19 Citations (Scopus)
557 Downloads (Pure)

Functional imaging: gaining new insight from biophotonic imaging. Clinical and experimental pharmacology & physiology

Cannell, M. B., 1 Jan 2004, p. 883-884. 2 p.

Research output: Contribution to conferenceOther Conference Contribution

1 Citation (Scopus)

Functional imaging: New views on lens structure and function: Clinical and experimental pharmacology & physiology

Donaldson, PJ., Grey, AC., Merriman-Smith, BR., Sisley, AMG., Soeller, C., Cannell, MB. & Jacobs, MD., 1 Jan 2004, p. 890-895. 6 p.

Research output: Contribution to conferenceOther Conference Contribution

24 Citations (Scopus)

Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens. Investigative ophthalmology & visual science

Jacobs, M. D., Soeller, C., Sisley, A. M. G., Cannell, M. B. & Donaldson, P. J., 1 Jan 2004, In : Investigative Ophthalmology and Visual Science. 45, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Heterogeneity in transverse (t)-tubules in pig atria

Gadeberg, H., Bond, R., Kong, C., Cannell, M., Ascione, R., Chanoit, G. & James, A., 2014, In : Proceedings of The Physiological Society. 31

Research output: Contribution to journalArticle (Academic Journal)

Heterogeneity of T-Tubules in Pig Hearts

Gadeberg, H. C., Bond, R. C., Kong, C., Chanoit, G., Ascione, R., Cannell, M. & James, A., 9 Jun 2016, In : PLoS ONE. 11, 6, 16 p., e0156862.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
345 Downloads (Pure)

Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor

Shang, W., 31 Jan 2014, In : Circulation Research. 114, 3, p. 412-420 8 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

Increasing sensitivity of Ca2+ spark detection in noisy images by application of a matched-filter object detection algorithm

Kong, C. H., Soeller, C. & Cannell, MB., Dec 2008, In : Biophysical Journal. 95, p. 6016 - 6024 8 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms

Ju, Y-K., Woodcock, E., Allen, D. & Cannell, M. B., 17 Jun 2012, In : Journal of Molecular and Cellular Cardiology. 53, p. 375-381 6 p.

Research output: Contribution to journalReview article (Academic Journal)

16 Citations (Scopus)

Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes

Crespo, L. M., Grantham, C. J. & Cannell, M. B., 14 Jan 1990, In : Nature. 345, 6276, p. 618-621 4 p.

Research output: Contribution to journalArticle (Academic Journal)

145 Citations (Scopus)

Label-free electrochemical DNA sensor based on functionalised conducting copolymer: Biosensors & bioelectronics

Peng, H., Soeller, C., Vigar, N., Kilmartin, P. A., Cannell, M. B., Bowmaker, G. A., Cooney, R. P. & Travas-Sejdic, J., 1 Jan 2005, In : Biosens Bioelectron. 20, 9, p. 1821-1828 8 p.

Research output: Contribution to journalArticle (Academic Journal)

128 Citations (Scopus)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
161 Downloads (Pure)

Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media

Baddeley, D., Jayasinghe, I. J., Cremer, C., Cannell, MB. & Soeller, C., Jan 2009, In : Biophysical Journal. 96, p. 22 - 24 2 p.

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)