Professor Mark B Cannell

BSc(U.C.Lond.), PhD(U.C.Lond.), FRSNZ, FISHR

  • BS8 1TD

1987 …2020

Research output per year

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Research Output

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Article (Academic Journal)
2020
Open Access
File
91 Downloads (Pure)
2019

Cardiac-specific overexpression of caveolin-3 preserves t-tubular I Ca during heart failure in mice

Kong, C. H. T., Bryant, S. M., Watson, J. J., Roth, D. M., Patel, H. H., Cannell, M. B., James, A. F. & Orchard, C. H., 1 May 2019, In : Experimental Physiology. 104, 5, p. 654-666 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
180 Downloads (Pure)
2018

Caveolin-3 dependent loss of t-tubular ICa during hypertrophy and heart failure in mice

Bryant, S. M., Kong, C. H. T., Watson, J. J., Gadeberg, H. C., James, A. F., Cannell, M. B. & Orchard, C. H., 1 May 2018, In : Experimental Physiology. 103, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
258 Downloads (Pure)

Caveolin-3 KO Disrupts T-Tububle Structure and Decreases T-Tubular ICa Density in Mouse Ventricular Myocytes

Bryant, S., Kong, C., Watson, J., Gadeberg, H., Roth, D. M., Patel, H., Cannell, M., James, A. & Orchard, C., Nov 2018, In : AJP - Heart and Circulatory Physiology. 315, 5, p. H1101-H1111 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
162 Downloads (Pure)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
159 Downloads (Pure)

Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure

Bryant, S. M., Kong, C. H. T., Cannell, M. B., Orchard, C. H. & James, A. F., 1 Apr 2018, In : AJP - Heart and Circulatory Physiology. 314, 3, p. H521-H529

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
158 Downloads (Pure)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
311 Downloads (Pure)

Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes

Kong, C., Rog-Zielinska, E., Kohl, P., Orchard, C. & Cannell, M., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. E7073-E7080 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
211 Downloads (Pure)

Species differences in the morphology of T-tubule openings in cardiomyocytes

Rog-Zielinska, E., Kong, C. H. T., Zgierski-Johnston, C. M., Verkade, P., Mantell, J., Cannell, M. & Kohl, P., 1 Nov 2018, In : EP-Europace. 20, Supp 3, p. iii120-iii124 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
125 Downloads (Pure)

The Effects of Aging on the Regulation of T-Tubular i Ca by Caveolin in Mouse Ventricular Myocytes

Kong, C. H. T., Bryant, S. M., Watson, J. J., Gadeberg, H. C., Roth, D. M., Patel, H. H., Cannell, M. B., Orchard, C. H. & James, A. F., 9 May 2018, In : Journals of Gerontology, Series A. 73, 6, p. 711-719 9 p., glx242.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
224 Downloads (Pure)
2017

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
179 Downloads (Pure)

Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method

Kong, C. H. T., Rog-Zielinska, E. A., Kohl, P., Orchard, C. & Cannell, M. B., 1 Jul 2017, In : Journal of Molecular and Cellular Cardiology. 108, p. 1-7 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
243 Downloads (Pure)
2016

Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca2+ sensitivity

Kaur, S., Kong, C., Cannell, M. & Ward, M., Jan 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 1, p. 88-94 6 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Heterogeneity of T-Tubules in Pig Hearts

Gadeberg, H. C., Bond, R. C., Kong, C., Chanoit, G., Ascione, R., Cannell, M. & James, A., 9 Jun 2016, In : PLoS ONE. 11, 6, 16 p., e0156862.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
344 Downloads (Pure)
2015

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

Bryant, S. M., Kong, C. H. T., Watson, J., Cannell, M. B., James, A. F. & Orchard, C. H., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 23–31 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Citations (Scopus)
327 Downloads (Pure)

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload

Zhang, H., Cannell, M. B., Kim, S. J., Watson, J. J., Norman, R., C. Calaghan, S., Orchard, C. & James, A. F., 29 Dec 2015, In : PLoS ONE. 10, 12, 17 p., e0144309.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
268 Downloads (Pure)

Na+ channel function, regulation, structure, trafficking and sequestration

Chen-Izu, Y., Shaw, R. M., Pitt, G. S., Yarov-Yarovoy, V., Sack, J. T., Abriel, H., Aldrich, R. W., Belardinelli, L., Cannell, M. B., Catterall, W. A., Chazin, W. J., Chiamvimonvat, N., Deschenes, I., Grandi, E., Hund, T. J., Izu, L. T., Maier, L. S., Maltsev, V. A., Marionneau, C., Mohler, P. J. & 5 others, Rajamani, S., Rasmusson, R. L., Sobie, E. A., Clancy, C. E. & Bers, D. M., 15 Mar 2015, In : Journal of Physiology. 593, 6, p. 1347-60 14 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

The involvement of TRPC3 channels in sinoatrial arrhythmias

Ju, Y-K., Lee, B. H., Trajanovska, S., Hao, G., Allen, D. G., Lei, M. & Cannell, M. B., 25 Mar 2015, In : Frontiers in Physiology. 6, 12 p., 86.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
195 Downloads (Pure)

T-tubule disease: Relationship between t-tubule organization and regional contractile performance in human dilated cardiomyopathy

Crossman, D. J., Young, A. A., Ruygrok, P. N., Nason, G. P., Baddelely, D., Soeller, C. & Cannell, M. B., 1 Jul 2015, In : Journal of Molecular and Cellular Cardiology. 84, C, p. 170-178 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
34 Citations (Scopus)
301 Downloads (Pure)
2014

Heterogeneity in transverse (t)-tubules in pig atria

Gadeberg, H., Bond, R., Kong, C., Cannell, M., Ascione, R., Chanoit, G. & James, A., 2014, In : Proceedings of The Physiological Society. 31

Research output: Contribution to journalArticle (Academic Journal)

Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor

Shang, W., 31 Jan 2014, In : Circulation Research. 114, 3, p. 412-420 8 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)
2013

Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination

Cannell, M. B., Kong, H. T., Imtiaz, M. & Laver, D. R., May 2013, In : Biophysical Journal. 104, 10, p. 2149-2159 10 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca(2+) entry during the slow force response.

Shen, X., Cannell, M. B. & Ward, M-L., 1 Oct 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca2+ entry during the slow force response.

Sheng, X., Cannell, M. B. & Ward, M-L., 2013, In : Journal of Molecular and Cellular Cardiology. 63, p. 37-46 9 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach

Kong, H. T., Laver, D. R. & Cannell, M. B., 2013, In : PLoS Computational Biology. 9, 2, p. 1-10 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
19 Citations (Scopus)
556 Downloads (Pure)

Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

Zhang, L., Ward, M-L., Phillips, A. RJ., Zhang, S., Kennedy, J., Barry, B., Cannell, M. B. & Cooper, G. JS., 28 Aug 2013, In : Cardiovascular Diabetology. 12, 1, 17 p., 123.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
21 Citations (Scopus)
291 Downloads (Pure)

Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry

Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B. & Winterbourn, C. C., 1 May 2013, In : Free Radical Biology and Medicine. 58, p. 109-117 9 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

Laver, D. R., Kong, H. T., Imtiaz, M. & Cannell, M. B., 2013, In : Journal of Molecular and Cellular Cardiology. 54, p. 98-100 2 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)
2012

Comparison of the organization of t-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, M. B., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 5, p. 469-476 7 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Local control in cardiac E--C coupling

Cannell, M. B. & Kong, C. H. T., 1 Feb 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 298-303 6 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Nanoscale Organization of Junctophilin-2 and Ryanodine Receptors within Peripheral Couplings of Rat Ventricular Cardiomyocytes

Jayasinghe, ID., Kong, C., Wehrens, X., Cannell, M. B. & Soeller, C., 2012, In : Biophysical Journal. 102, p. 19-21 3 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
2011

4D Super-Resolution Microscopy with Conventional Fluorophores and Single Wavelength Excitation in Optically Thick Cells and Tissues

Baddeley, D., Crossman, D., Rossberger, S., Cheyne, J., Montgomery, J., Isuru, D., Jayasinghe, ID., Cremer, C., Cannell, MB. & Soeller, C., 2011, In : PLoS ONE. 6, p. 1-10 10 p., e20645.

Research output: Contribution to journalArticle (Academic Journal)

94 Citations (Scopus)

Changes in the organization of excitation-contraction coupling structures in failing human heart

Crossman, D. J., Ruygrok, P. R., Soeller, C. & Cannell, MB., Apr 2011, In : PLoS ONE. 6(3), p. e7901 - e7901 10 p., Electronic Journal.

Research output: Contribution to journalArticle (Academic Journal)

99 Citations (Scopus)

Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node

Ju, Y-K., Lee, B. H., Lai, D., Woodcock, E. A., Hao, G-L., Lei, M., Cannell, MB. & Allen, D. G., 2011, In : Circulation Research. 109, p. 848 - 857 10 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Mapping system for coregistration of cardiac mri and ex vivo tissue sampling

Young, A. A., Crossman, D. J., Ruygrok, P. N. & Cannell, MB., Nov 2011, In : Journal of Magnetic Resonance Imaging. 34, p. 1065 - 1071 6 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Mechanisms of reduced contractility in an animal model of hypertensive heart failure

Ward, M-L., Crossman, D. J. & Cannell, MB., Oct 2011, In : Clinical and Experimental Pharmacology and Physiology. 38, p. 711 - 716 6 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Three dimensional sub-100 nm super-resolution imaging of biological samples using a phase ramp in the objective pupil

Baddeley, D., Cannell, MB. & Soeller, C., Jun 2011, In : Nano Research. 4, 6, p. s89 - s98 9 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)
2010

A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes

Jayasinghe, I. D., Crossman, D. J., Soeller, C. & Cannell, MB., May 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 964 - 971 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart

Kim, N., Cannell, MB. & Hunter, P. J., Sep 2010, In : Progress in Biophysics and Molecular Biology. 103, p. 28 - 34 6 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

Li, P., Wei, W., Cai, X., Soeller, C., Cannell, MB. & Holden, A. V., Aug 2010, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 368, p. 3953 - 3965 12 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Excitation-contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes

Cooper, P. J., Soeller, C. & Cannell, MB., Dec 2010, In : Journal of Molecular and Cellular Cardiology. 49, p. 911 - 917 6 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat

Ward, M-L., Crossman, D. J., Loisell, D. S. & Cannell, MB., Nov 2010, In : Pflügers Archiv: European Journal of Physiology. 460, p. 991 - 1001 10 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Visualization of localization microscopy data

Baddeley, D., Cannell, MB. & Soeller, C., Feb 2010, In : Microscopy and Microanalysis. 16, p. 64 - 72 8 p.

Research output: Contribution to journalArticle (Academic Journal)

79 Citations (Scopus)
2009

Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media

Baddeley, D., Jayasinghe, I. J., Cremer, C., Cannell, MB. & Soeller, C., Jan 2009, In : Biophysical Journal. 96, p. 22 - 24 2 p.

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

Baddeley, D., Jayasinghe, I. D., Lam, L., Rossberger, S., Cannell, MB. & Soeller, C., Dec 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22275 - 22280 5 p.

Research output: Contribution to journalArticle (Academic Journal)

191 Citations (Scopus)

Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes

Jayasinghe, I. D., Cannell, MB. & Soeller, C., Nov 2009, In : Biophysical Journal. 97, p. 2664 - 2673 9 p.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Pulling on the heart strings: a new mechanism within Starling's law of the heart?

Cannell, MB., Mar 2009, In : Circulation Research. 104, p. 715 - 716 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion

Kumar, V., KItaef, N., Hampton, MB., Cannell, MB. & Winterbourn, CC., Mar 2009, In : FEBS Letters. 583, p. 997 - 1000 3 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signalling in rat ventricular myocytes

Soeller, C., Jayasinghe, I. D., Li, P., Holdem, A. V. & Cannell, MB., May 2009, In : Experimental Physiology. 94, p. 496 - 508 12 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)
2008

Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes

Sobie, E. A., Cannell, MB. & Bridge, J. H. B., Apr 2008, In : Biophysical Journal. 94, p. L54 - 56 2 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)