Dr Mark P Dodding

BSC, PHD

  • BS8 1TD

20052020

Research output per year

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Personal profile

Research interests

Research in our lab aims to understand the molecular mechanisms and signaling pathways that control the distribution and dynamics of subcellular components, focusing on structure, function, molecular mechanism and regulation of the key biomolecular machines and multiprotein complexes that regulate cellular organisation. We also seek to apply that knowledge to develop novel chemical tools to manipulate these systems. We take a multi-disciplinary approach that combines advanced cell imaging with cell biology, biophysics and structural approaches to define the molecular basis of these dynamic processes.

Our first major contribution was to show, how a microtubule motor motor, in this case kinesin-1, recognises the some of the cargo that it carries (Science. 2013.19, 356-9). We have since gone onto show how cargo engagement can regulate the activity of the motor (PNAS. 2016. 113, 2418-23) and identifed new cargo recognition mechanism (eLife. 2018). An important focus us now in this area is to use this information to develop small molecules that can manipulate this mechanism and to understand whether such molecules may be of therapeutic use. Our proof-of-concept study describing the first such compound, kinesore, was recently published (PNAS. 2017. 114, 13738-13743).

In another research theme, we have studied how the spatial organisation of the lysosomal membrane compartment is regulated by metabolic state, and in doing so, implicated a tumour suppressor protein called Folliculin in controlling inter-organelle contacts between lysosomes and the Golgi apparatus (EMBO Reports. 2016. 17, 823-41). Our continuing work in this area is focusing on understanding how the architecture of the lysosomal membrane compartment is re-established after cell division.

External positions

Visiting Senior Lecturer, King's College London

2 Oct 2017 → …

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Projects

Research Output

  • 20 Article (Academic Journal)
  • 2 Review article (Academic Journal)
  • 1 Editorial (Academic Journal)

In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen

Paul, D. M., Mantell, J. M., Borucu, U., Coombs, J., Surridge, K. J., Squire, J. M., Verkade, P. & Dodding, M. P., 1 Jun 2020, In : Journal of Cell Biology. 219, 9, 14 p., e201911154.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 24 Downloads (Pure)

    A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

    Randall, T. S., Yip, Y. Y., Wallock-Richards, D. J., Pfisterer, K., Sanger, A., Ficek, W., Steiner, R. A., Beavil, A. J., Parsons, M. & Dodding, M. P., 26 Dec 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. 13738-13743 6 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 8 Citations (Scopus)
    240 Downloads (Pure)

    Structural basis for kinesin-1:cargo recognition

    Pernigo, S., Lamprecht, A., Steiner, R. A. & Dodding, M. P., 19 Apr 2013, In : Science. 340, 6130, p. 356-9 4 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 43 Citations (Scopus)

    Prizes

    Lister Institute of Preventative Medicine Research Prize

    Dodding, Mark P (Recipient), 2018

    Prize: Prizes, Medals, Awards and Grants