Projects per year
The Dillingham Laboratory is studying mechanistic aspects of DNA:protein interactions which underpin DNA replication, repair, recombination and segregation. At the moment we are especially interested in:
(1) DNA helicases as modular components of molecular machines
(2) The initiation of double-stranded DNA break repair and how it can be modulated for applications in cancer therapy and gene editing.
(3) The role of helicases in suppressing replication:transcription conflicts
(4) The mechanism of chromosome individualisation and segregation by ParB and SMC complexes
(5) DNA mimic proteins and their potential applications in medicine and biotechnology
Join our group! We are always interested in hearing from talented scientists who wish to join the laboratory. Please contact Mark for an informal discussion of the opportunities that are currently available.
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- 2 Active
1/06/21 → 31/05/24
1/06/19 → 31/05/22
CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repairWilkinson, O., Martín-González, A., Kang, H., Northall, S., Wigley, D. B., Moreno-Herrero, F. & Dillingham, M., 2 Jan 2019, In: eLife. 8, 22 p., e42129.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile11 Citations (Scopus)260 Downloads (Pure)
The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromereFisher, G. L. M., Pastrana, C. L., Higman, V. A., Koh, A., Taylor, J. A., Butterer, A., Craggs, T. D., Sobott, F., Murray, H., Crump, M. P., Moreno-Herrero, F. & Dillingham, M., 15 Dec 2017, In: eLife. 6, 25 p., e28086.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile27 Citations (Scopus)333 Downloads (Pure)
Krajewski, W. W., Fu, X., Wilkinson, M., Cronin, N. B., Dillingham, M. S. & Wigley, D. B., 17 Apr 2014, In: Nature. 508, 7496, p. 416-419 4 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review36 Citations (Scopus)