Projects per year
Personal profile
Research interests
The Dillingham Laboratory is studying mechanistic aspects of DNA:protein interactions which underpin DNA replication, repair, recombination and segregation. At the moment we are especially interested in:
(1) DNA helicases as modular components of molecular machines
(2) The initiation of double-stranded DNA break repair and how it can be modulated for medical and biotech applications
(3) The role of helicases in suppressing replication:transcription conflicts
(4) The mechanism of chromosome individualisation and segregation by ParB and SMC complexes
(5) DNA mimic proteins and their potential applications in medicine and biotechnology
Join our group! We are always interested in hearing from talented scientists who wish to join the laboratory. Please contact Mark for an informal discussion of the opportunities that are currently available.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structure: Function Correlation in the Human DNA Repair Factor CtIP
1/06/21 → 31/05/24
Project: Research
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Single-molecule DNA repair by homologous recombination in live bacterial cells
1/06/19 → 31/05/22
Project: Research
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CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair
Wilkinson, O., Martín-González, A., Kang, H., Northall, S., Wigley, D. B., Moreno-Herrero, F. & Dillingham, M., 2 Jan 2019, In: eLife. 8, 22 p., e42129.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Citations (Scopus)336 Downloads (Pure) -
The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere
Fisher, G. L. M., Pastrana, C. L., Higman, V. A., Koh, A., Taylor, J. A., Butterer, A., Craggs, T. D., Sobott, F., Murray, H., Crump, M. P., Moreno-Herrero, F. & Dillingham, M., 15 Dec 2017, In: eLife. 6, 25 p., e28086.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile36 Citations (Scopus)436 Downloads (Pure) -
Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites
Krajewski, W. W., Fu, X., Wilkinson, M., Cronin, N. B., Dillingham, M. S. & Wigley, D. B., 17 Apr 2014, In: Nature. 508, 7496, p. 416-419 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
40 Citations (Scopus)