Research output per year
Research output per year
Personal profile
Research interests
The Dillingham Laboratory is studying mechanistic aspects of DNA:protein interactions which underpin DNA replication, repair, recombination and segregation. At the moment we are especially interested in:
(1) DNA helicases as modular components of molecular machines
(2) The initiation of double-stranded DNA break repair and how it can be modulated for medical and biotech applications
(3) The role of helicases in suppressing replication:transcription conflicts
(4) The mechanism of chromosome individualisation and segregation by ParB and SMC complexes
(5) DNA mimic proteins and their potential applications in medicine and biotechnology
Join our group! We are always interested in hearing from talented scientists who wish to join the laboratory. Please contact Mark for an informal discussion of the opportunities that are currently available.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DNA binding and bridging by human CtIP in the healthy and diseased states
Lokanathan Balaji, S., De Bragança, S., Balaguer-Pérez, F., Northall, S., Wilkinson, O. J., Aicart-Ramos, C., Seetaloo, N., Sobott, F., Moreno-Herrero, F. & Dillingham, M. S., 26 Jun 2024, (E-pub ahead of print) In: Nucleic Acids Research. 52, 14, p. 8303-8319 17 p., gkae538.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Recent insights into eukaryotic double-strand DNA break repair unveiled by single-molecule methods
de Bragança, S., Dillingham, M. S. & Moreno-Herrero, F., 6 Oct 2023, In: Trends in genetics. 39, 12, p. 924-940 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus
Aulicino, F., Pelosse, M., Toelzer, C., Capin, J. M., Meysami, P., Dillingham, M. S., Berger-Schaffitzel, C. H., Saleem, M., Welsh, G. I., Berger, I. & et, A., 8 Jul 2022, (E-pub ahead of print) In: Nucleic Acids Research. 50, 13, p. 7783–7799 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile25 Citations (Scopus)130 Downloads (Pure)
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The interaction of HELB with RPA and its role in human fertility
Dillingham, M. S. (Principal Investigator)
1/06/24 → 31/05/27
Project: Research
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Bacteriophage control of host cell DNA transactions by small ORF proteins
Dillingham, M. S. (Principal Investigator)
1/06/24 → 31/05/27
Project: Research
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DNA Repair State Machines
Dillingham, M. S. (Principal Investigator)
1/05/23 → 30/04/27
Project: Research
Datasets
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Lokananthan_Balaji_Fig2-3
Dillingham, M. (Creator), Mendeley Data, 2024
DOI: 10.17632/nchzt38w4d.1, https://data.mendeley.com/datasets/nchzt38w4d and one more link, https://zenodo.org/records/10497389 (show fewer)
Dataset