Professor Mark S Dillingham

B.Sc.(Bristol), Ph.D.(Oxon.)

  • BS8 1TD

19962020

Research output per year

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Research Output

  • 64 Article (Academic Journal)
2020

Bulk and single-molecule analysis of a bacterial DNA2-like helicase-nuclease reveals a single-stranded DNA looping motor

Wilkinson, O. J., Carrasco, C., Aicart Ramos, C., Moreno-Herrero, F. & Dillingham, M. S., 4 Jul 2020, In : Nucleic Acids Research. 15 p., gkaa562.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Downloads (Pure)
2019

CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

Wilkinson, O., Martín-González, A., Kang, H., Northall, S., Wigley, D. B., Moreno-Herrero, F. & Dillingham, M., 2 Jan 2019, In : eLife. 8, 22 p., e42129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
281 Downloads (Pure)

Direct removal of RNA polymerase barriers to replication by accessory replicative helicases

Hawkins, M., Dimude, J. U., Howard, J. A. L., Smith, A., Dillingham, M., Savery, N., Rudolph, C. J. & McGlynn, P., 4 Jun 2019, In : Nucleic Acids Research. 47, 10, p. 5100-5113 14 p., gkz170.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
161 Downloads (Pure)

ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

Madariaga-Marcos, J., Pastrana, C. L., Fisher, G. L., Dillingham, M. S. & Moreno-Herrero, F., 25 Mar 2019, In : eLife. 8, 19 p., e43812.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
167 Downloads (Pure)
2018

Force determination in lateral magnetic tweezers combined with TIRF microscopy

Madariaga-Marcos, J., Hormeño, S., Pastrana, C. L., Fisher, G. L. M., Dillingham, M. S. & Moreno-Herrero, F., 7 Mar 2018, In : Nanoscale. 10, 9, p. 4579-4590 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)

The 2B subdomain of Rep helicase links translocation along DNA with protein displacement

Brüning, J. G., Howard, J. A. L., Myka, K. K., Dillingham, M. S. & McGlynn, P., 28 Sep 2018, In : Nucleic Acids Research. 46, 17, p. 8917-8925 9 p., gky673.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
202 Downloads (Pure)

The molecular basis of protein toxin HicA– dependent binding of the protein antitoxin HicB to DNA

Winter, A. J., Williams, C., Isupov, M. N., Crocker, H., Gromova, M., Marsh, P., Wilkinson, O. J., Dillingham, M. S., Harmer, N. J., Titball, R. W. & Crump, M. P., 14 Dec 2018, In : Journal of Biological Chemistry. 293, 50, p. 19429-19440 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
352 Downloads (Pure)
2017

Inhibiting translation elongation can aid genome duplication in Escherichia coli

Myka, K. K., Hawkins, M., Syeda, A. H., Gupta, M. K., Meharg, C., Dillingham, M. S., Savery, N. J., Lloyd, R. G. & McGlynn, P., 17 Mar 2017, In : Nucleic Acids Research. 45, 5, p. 2571-2584 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
329 Downloads (Pure)

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

Fisher, G. L. M., Pastrana, C. L., Higman, V. A., Koh, A., Taylor, J. A., Butterer, A., Craggs, T. D., Sobott, F., Murray, H., Crump, M. P., Moreno-Herrero, F. & Dillingham, M., 15 Dec 2017, In : eLife. 6, 25 p., e28086.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
350 Downloads (Pure)

The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase

Sanders, K., Lin, C. L., Smith, A. J., Cronin, N., Fisher, G., Eftychidis, V., McGlynn, P., Savery, N. J., Wigley, D. B. & Dillingham, M. S., 20 Apr 2017, In : Nucleic Acids Research. 45, 7, p. 3875-3887 13 p., gkx074.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
229 Downloads (Pure)
2016

Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination

Gilhooly, N. S., Carrasco, C., Gollnick, B., Wilkinson, M., Wigley, D. B., Moreno-Herrero, F. & Dillingham, M. S., 7 Apr 2016, In : Nucleic Acids Research. 44, 6, p. 2727-2741 15 p., gkv1543.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
298 Downloads (Pure)

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

Wilkinson, M., Troman, L., Wan Ahmad Kamil, W. N. I., Chaban, Y., Avison, M. B., Dillingham, M. S. & Wigley, D. B., 23 Dec 2016, In : eLife. 5, 12 p., e22963.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
306 Downloads (Pure)
2015

Probing DNA Helicase Kinetics with Temperature-Controlled Magnetic Tweezers

Gollnick, B., Carrasco, C., Zuttion, F., Gilhooly, N. S., Dillingham, M. S. & Moreno-Herrero, F., 18 Mar 2015, In : Small. 11, 11, p. 1273-1284 12 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
1 Downloads (Pure)

Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation

Taylor, J. A., Pastrana, C. L., Butterer, A., Pernstich, C., Gwynn, E. J., Sobott, F., Moreno-Herrero, F. & Dillingham, M. S., 8 Jan 2015, In : Nucleic Acids Research.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)
2014

Engineering a reagentless biosensor for single-stranded DNA to measure real-time helicase activity in Bacillus

Green, M., Gilhooly, N. S., Abedeen, S., Scott, D. J., Dillingham, M. S. & Soultanas, P., 11 Jun 2014, In : Biosensors and Bioelectronics. 61C, p. 579-586 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase-nuclease

Gilhooly, N. S. & Dillingham, M. S., 15 Mar 2014, In : Nucleic Acids Research.

Research output: Contribution to journalArticle (Academic Journal)

Single molecule approaches to monitor the recognition and resection of double-stranded DNA breaks during homologous recombination

Carrasco, C., Dillingham, M. S. & Moreno-Herrero, F., 22 Feb 2014, In : DNA Repair.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites

Krajewski, W. W., Fu, X., Wilkinson, M., Cronin, N. B., Dillingham, M. S. & Wigley, D. B., 17 Apr 2014, In : Nature. 508, 7496, p. 416-419 4 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2013

AFM volumetric methods for the characterization of proteins and nucleic acids

Fuentes-Perez, M. E., Dillingham, M. S. & Moreno-Herrero, F., 2013, In : Methods.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD

Chisty, L. T., Toseland, C. P., Fili, N., Mashanov, G. I., Dillingham, M. S., Molloy, J. E. & Webb, M. R., 27 Mar 2013, In : Nucleic Acids Research.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

On the mechanism of recombination hotspot scanning during double-stranded DNA break resection

Carrasco, C., Gilhooly, N. S., Dillingham, M. S. & Moreno-Herrero, F., 24 Jun 2013, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Superfamily 1 helicases 

Gilhooly, N. S., Gwynn, E. J. & Dillingham, M. S., 2013, In : Frontiers in Bioscience (Scholar edition). 5, p. 206-216 11 p., S367.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

The Conserved C-Terminus of the PcrA/UvrD Helicase Interacts Directly with RNA Polymerase

Gwynn, E. J., Smith, A. J., Guy, C. P., Savery, N. J., McGlynn, P. & Dillingham, M. S., 2013, In : PLoS ONE. 8, 10, p. e78141

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)
2012

Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control

Yang, L., Handa, N., Liu, B., Dillingham, M. S., Wigley, D. B. & Kowalczykowski, S. C., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8907-12 6 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

A New Method for inferring hidden Markov models from noisy time sequences

Kelly, D. E., Dillingham, M., Hudson, A. J. & Wiesner, K., Jan 2012, In : PLoS ONE. 7, 1, 19 p., e29703.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

How to build a DNA unwinding machine

Szczelkun, M. D. & Dillingham, M. S., 2012, In : Structure. 20, 7, p. 1127-8 2 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex

Saikrishnan, K., Yeeles, J. T., Gilhooly, N. S., Krajewski, W. W., Dillingham, M. S. & Wigley, D. B., Mar 2012, In : EMBO Journal. 31, 6, p. 1568 - 1578 11 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Iron-sulphur clusters in nucleic acid processing enzymes

White, M. F. & Dillingham, MS., Feb 2012, In : Current Opinion in Structural Biology. 22, 1, p. 94 - 100 7 p.

Research output: Contribution to journalArticle (Academic Journal)

99 Citations (Scopus)

Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzyme

Handa, N., Yang, L., Dillingham, M. S., Kobayashi, I., Wigley, D. B. & Kowalczykowski, S. C., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8901-6 6 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

The conflict between DNA replication and transcription

McGlynn, P., Savery, N. J. & Dillingham, M. S., 2012, In : Molecular Microbiology. 85, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

Using DNA as a fiducial marker to study SMC complex interactions with the atomic force microscope

Fuentes-Perez, M. E., Gwynn, E. J., Dillingham, M. S. & Moreno-Herrero, F., Feb 2012, In : Biophysical Journal. 102, 4, p. 839 - 848 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
2011

A single-molecule approach to visualize the unwinding activity of DNA helicases

Fili, N., Toseland, CP., Dillingham, MS., Webb, MR. & Molloy, JE., 2011, In : Methods in Molecular Biology. 778, p. 193-214 22 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Recombination hotspots and single-stranded DNA binding proteins couple DNA translocation to DNA unwinding by the AddAB helicase-nuclease

Yeeles, J., van Aelst, K., Dillingham, M. S. & Moreno-Herrero, F., Jun 2011, In : Molecular Cell. 42, 6, p. 806 - 816 11 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Superfamily I helicases as modular components of DNA-processing machines

Dillingham, M. S., Apr 2011, In : Biochemical Society Transactions. 39, 2, p. 413 - 423 11 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain

Yeeles, J., Gwynn, E. J., Webb, M. R. & Dillingham, M. S., Mar 2011, In : Nucleic Acids Research. 39, 6, p. 2271 - 2285 15 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
2010

The processing of double-stranded DNA breaks for recombinational repair by helicase-nuclease complexes

Yeeles, J. T. P. & Dillingham, M. S., Mar 2010, In : DNA Repair. 9, 3, p. 276 - 285 10 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)

Visualizing helicases unwinding DNA at the single molecule level

Fili, N., Mashanov, G. I., Toseland, C. P., Batters, C., Wallace, M. I., Yeeles, J. T. P., Dillingham, M. S., Webb, M. R. & Molloy, J. E., Apr 2010, In : Nucleic Acids Research. 38, 13, p. 4448 - 4457 10 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)
2009

An iron-sulfur cluster is essential for the binding of broken DNA by AddAB-type helicase-nucleases

Yeeles, J. T. P., Cammack, R. & Dillingham, M. S., Mar 2009, In : Journal of Biological Chemistry. 284, 12, p. 7746 - 7755 10 p.

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

Rep provides a second motor at the replisome to promote duplication of protein-bound DNA

Guy, C. P., Atkinson, J., Gupta, M. K., Mahdi, A. A., Gwynn, E. J., Rudolph, C. J., Moon, P. B., van Knippenberg, I. C., Cadman, C. J., Dillingham, M. S., Lloyd, R. G. & McGlynn, P., Nov 2009, In : Molecular Cell. 36, 4, p. 654 - 666 13 p.

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair

Manelyte, L., Guy, C. P., Smith, R. M., Dillingham, M. S., McGlynn, P. & Savery, N. J., Nov 2009, In : DNA Repair. 8, 11, p. 1300 - 1310 11 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
2008

Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity

Dillingham, M. S., Tibbles, K. L., Hunter, J. L., Bell, J. C., Kowalczykowski, S. C. & Webb, M. R., Oct 2008, In : Biophysical Journal. 95, 7, p. 3330 - 3339 10 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Protein modification for single molecule fluorescence microscopy

Dillingham, M. S. & Wallace, M. I., Aug 2008, In : Organic and Biomolecular Chemistry. 6, 17, p. 3031 - 3037 7 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

RecBCD enzyme and the repair of double-stranded DNA breaks

Dillingham, M. S. & Kowalczykowski, S. C., Dec 2008, In : Microbiology and Molecular Biology Reviews. 72, 4, p. 642-71, Table of Contents 30 p.

Research output: Contribution to journalArticle (Academic Journal)

313 Citations (Scopus)
2007

A dual-nuclease mechanism for DNA break processing by AddAB-type helicase-nucleases

Yeeles, J. T. P. & Dillingham, M. S., Aug 2007, In : Journal of Molecular Biology. 371, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Directional loading and stimulation of PcrA helicase by the replication initiator protein RepD

Zhang, W., Dillingham, MS., Thomas, CD., Allen, S., Roberts, CJ. & Soultanas, P., Aug 2007, In : Journal of Molecular Biology. 371, 2, p. 336 - 348 13 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

Structure and mechanism of helicases and nucleic acid translocases

Singleton, M. R., Dillingham, M. S. & Wigley, D. B., Jul 2007, In : Annual Review of Biochemistry. 76, p. 23 - 50 28 p.

Research output: Contribution to journalArticle (Academic Journal)

777 Citations (Scopus)
2006

Replicative helicases: A staircase with a twist

Dillingham, MS., Oct 2006, In : Current Biology. 16, 19, p. R844 - R847 4 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation

Chédin, F., Handa, N., Dillingham, M. S. & Kowalczykowski, S. C., Jul 2006, In : Journal of Biological Chemistry. 281, 27, p. 18610 - 18617 8 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
2005

Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme

Dillingham, M. S., Webb, M. R. & Kowalczykowski, S. C., 2005, In : Journal of Biological Chemistry. 280, 44, p. 37069-77 9 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Translocation by the RecB motor is an absolute requirement for {chi}-recognition and RecA protein loading by RecBCD enzyme

Spies, M., Dillingham, M. S. & Kowalczykowski, S. C., 2005, In : Journal of Biological Chemistry. 280, 44, p. 37078-87 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)