Professor Massimo Caputo

M.D.(Naples), M.Ch.(Bristol)

  • BS2 8HW

19952020

Research output per year

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Personal profile

Research interests

Research Interests:

Experimental

  • Transcriptomics and proteonomics in congenital heart disease
  • Identifying the optimal stem cell populations for vascular tissue regeneration used in congenital heart surgery
  • Regenerative stem cell biology for children with heart failure
  • Pulmonary hypertension
  • Bicuspid aortic valve and Marfan syndrome
  • Effect of oxidative stress in cardiomyocytes during different stages of postnatal development
  • The role of mitochondria in increased vulnerability to cardiac insults of hearts and cardiomyocytes isolated from mice fed Western style high-fat diet
  • The role of ventricular arrhythmias in sudden death associated with coronary artery disease
  • Effect of oxidative stress and the role of mitochondria in hearts with chronic coronary artery disease
  • The role of amino acids in cardioprotection
  • Lung protection in cardiopulmonary bypass and cardioplegic arrest

Clinical

  • Improving myocardial protection strategies in paediatric cardiac surgery
  • RCTs on different temperature and oxygen strategies during CPB in children undergoing cardiac surgery (Thermic and Oxic Trials)
  • Imaging and outcomes in adult congenital heart disease
  • Atrial arrhytmias in adult and congenital cardiac diseases
  • Age-related changes in excitation-contraction coupling in paediatric cardiomyocytes
  • Cardioprotection with propofol during adult open heart surgery

Current group members

  • Mohamed Ghorbel, Hua Lin, Sarah Martin, Jihad Hawi, Ben Littlejohns, Simon Duggan

Collaborators

  • UK
    Gianni Angelini, Paolo Madeddu, Andrew Halestrap, Elinor Griffiths, Raimondo Ascione, Jamie Jeremy, Barney Reeves, Andy James, Clive Orchard, Jules Hancox, Mervyn Miles, Claire Stewart.
  • Overseas
    Andrea Venturini (Italy), Hajime Imura (Japan), Nicola King (Australia), Malcolm Underwood (Hong Kong), Chris Howarth (UAE), Camille Nassar (Lebanon).

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Projects

Research Output

Open Access
File
  • 17 Downloads (Pure)

    Agrin-mediated cardiac regeneration: some open questions

    Bigotti, M. G., Skeffington, K. L., Jones, F. P., Caputo, M. & Brancaccio, A., 16 Jun 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 8 p., 594.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 8 Downloads (Pure)

    Anomalous Left Atrial Drainage of the Vena Cava in an Adult French Bulldog

    Borgeat, K., Lyraki, M., Keyte, S., Roper, D., Caputo, M. & Chanoit, G., 16 Apr 2020, In : CASE: Cardiovascular Imaging Case Reports. 6 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 9 Downloads (Pure)

    Supervised Work

    Antigenic, functional and molecular characterization of human cardiac pericytes from newborn and grown-up congenital heart disease patients

    Author: Judina, A., 25 Sep 2018

    Supervisor: Caputo, M. (Supervisor) & Madeddu, P. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Cardiac Survival Signalling, Oxidative Stress & Reperfusion Injury during Postnatal Development

    Author: Summers, K., 7 May 2019

    Supervisor: Suleiman, M. (Supervisor) & Caputo, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Normoxic versus Hyperoxic Cardiopulmonary Bypass In Cyanotic Paediatric Patients Undergoing Cardiac Surgery: A Controlled Randomised Trial

    Author: Mokhtari, A., 23 Sep 2014

    Supervisor: Caputo, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Medicine (MD)

    File