Research Interests:

Experimental

• Transcriptomics and proteonomics in congenital heart disease
• Identifying the optimal stem cell populations for vascular tissue regeneration used in congenital heart surgery
• Regenerative stem cell biology for children with heart failure
• Pulmonary hypertension
• Bicuspid aortic valve and Marfan syndrome
• Effect of oxidative stress in cardiomyocytes during different stages of postnatal development
• The role of mitochondria in increased vulnerability to cardiac insults of hearts and cardiomyocytes isolated from mice fed Western style high-fat diet
• The role of ventricular arrhythmias in sudden death associated with coronary artery disease
• Effect of oxidative stress and the role of mitochondria in hearts with chronic coronary artery disease
• The role of amino acids in cardioprotection
• Lung protection in cardiopulmonary bypass and cardioplegic arrest

Clinical

• Improving myocardial protection strategies in paediatric cardiac surgery
• RCTs on different temperature and oxygen strategies during CPB in children undergoing cardiac surgery (Thermic and Oxic Trials)
• Imaging and outcomes in adult congenital heart disease
• Atrial arrhytmias in adult and congenital cardiac diseases
• Age-related changes in excitation-contraction coupling in paediatric cardiomyocytes
• Cardioprotection with propofol during adult open heart surgery

Current group members

• Mohamed Ghorbel, Hua Lin, Sarah Martin, Jihad Hawi, Ben Littlejohns, Simon Duggan

Collaborators

• UK
  Gianni Angelini, Paolo Madeddu, Andrew Halestrap, Elinor Griffiths, Raimondo Ascione, Jamie Jeremy, Barney Reeves, Andy James, Clive Orchard, Jules Hancox, Mervyn Miles, Claire Stewart.
• Overseas
  Andrea Venturini (Italy), Hajime Imura (Japan), Nicola King (Australia), Malcolm Underwood (Hong Kong), Chris Howarth (UAE), Camille Nassar (Lebanon).