19962020

Research output per year

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Personal profile

Research interests

Group webpages can be found here!  This has a more up to date list of publications than I can ever get the Bristol system to log!

My group's work has centred around the use of nuclear magnetic resonance spectroscopy to study protein structure and function. The most high profile of these are based in areas such as cancer, antibiotics and structure aided drug design that are of central importance to the well being of today's society.

A major highlight of our recent work has been the solution NMR structure of the domain 11 from the Insulin Growth factor receptor 2 and its interaction with IGF2. This milestone work has paved the way for CRUK and CRT funding (with Prof. Bass Hassan, University of Oxford) and it is an important step along the way to developing a therapeutic receptor to be used in the treatment of several different cancers. This work is currently the major theme within my laboratory alongside the application of NMR for screening potential small ligands for proteins of pharmaceutical interest (funded by UCB).

Finally we increasingly use X-ray crystallography for the structure determination of larger proteins and we have and have over ten collaborative NMR/X-ray projects running in the laboratory (funded by BBSRC, MRC and EPSRC).

Professor Crump is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis

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Projects

Research Output

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

Haines, A. S., Dong, X., Song, Z., Farmer, R., Williams, C., Hothersall, J., Ploskon, E., Wattana-amorn, P., Stephens, E. R., Yamada, E., Gurney, R., Takebayashi, Y., Masschelein, J., Cox, R. J., Lavigne, R., Willis, C. L., Simpson, T. J., Crosby, J., Winn, P. J., Thomas, C. M. & 1 others, Crump, M. P., Nov 2013, In : Nature Chemical Biology. 9, 11, p. 685-692 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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  • 33 Citations (Scopus)
    543 Downloads (Pure)

    An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

    Williams, C., Hoppe, H., Rezgui, D., Strickland, M., Forbes, B. E., Grutzner, F., Frago, S., Ellis, R. Z., Wattana-Amorn, P., Prince, S. N., Zaccheo, O. J., Mungall, A. J., Jones, Y., Nolan, C. M., Crump, M. P. & Hassan, A. B., Nov 2012, In : Science. 338, 6111, p. 1209-1213 5 p.

    Research output: Contribution to journalArticle (Academic Journal)

    25 Citations (Scopus)

    A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

    Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In : ACS Chemical Biology. 2020, 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Supervised Work

    Mechanisms for the Generation of Structural Diversity in Polyketide Biosynthesis

    Author: Walker, P., 7 May 2019

    Supervisor: Willis, C. (Supervisor), Race, P. (Supervisor) & Crump, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    The molecular basis of HicA dependent binding of HicB to DNA

    Author: Winter, A., 23 Jan 2019

    Supervisor: Crump, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Urea Based Synthetic Lectins: A Biomimetic Receptor for Glucose

    Author: Tromans, R., 25 Sep 2018

    Supervisor: Davis, A. (Supervisor) & Crump, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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