Mohamed Ghorbel

2024

Development of a Novel Hierarchically Biofabricated Blood Vessel Mimic Decorated with Three Vascular Cell Populations for the Reconstruction of Small-Diameter Arteries

Carrabba, M., Fagnano, M., Ghorbel, M., Rapetto, F., Su, B., De Maria, C., Vozzi, G., Biglino, G., Perriman, A. W., Caputo, M. & Madeddu, P. R., 14 Feb 2024, In: Advanced Functional Materials. 34, 7, 2300621.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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19 Downloads (Pure)

2023

6 Citations (Scopus)

110 Downloads (Pure)

Biological Scaffolds for Congenital Heart Disease

Harris, A. G., Salih, T. K. O., Ghorbel, M., Caputo, M., Biglino, G. & Carrabba, M., 2 Jan 2023, In: Bioengineering. 10, 1, p. 1-27 57.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

110 Downloads (Pure)

The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia

Skeffington, K. L., Mohamed Ahmed, E., Rapetto, F., Chanoit, G., Bond, A. R., Vardeu, A., Ghorbel, M. T., Suleiman, M-S. & Caputo, M., 7 Jun 2023, In: Frontiers in Cardiovascular Medicine. 10, 13 p., 1194645.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Warm versus cold blood cardioplegia in paediatric congenital heart surgery: a randomized trial

Stoica, S. C., Smartt, H. J. M., Heys, R. L., Sheehan, K., Walker-Smith, T. A. F., Parry, A., Beringer, R. M., Ttofi, I., Evans, R. N., Dabner, L. S., Ghorbel, M., Lansdowne, W., Reeves, B. C., Angelini, G. D., Rogers, C. A. & Caputo, M., 1 Apr 2023, In: European Journal of Cardio-Thoracic Surgery. 63, 4, 10 p., ezad041.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2021

Reconstruction of the swine pulmonary artery using a graft engineered with syngeneic cardiac pericytes

Alvino, V. V., Thomas, A. C., Ghorbel, M., Rapetto, F., Narayan, S., Kilcooley, M., Iacobazzi, D., Carrabba, M., Fagnano, M., Cathery, W. R., Avolio, E., Caputo, M. & Madeddu, P. R., 9 Sept 2021, In: Frontiers in Bioengineering and Biotechnology. 9, 15 p., 715717.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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5 Citations (Scopus)

136 Downloads (Pure)

2020

Changes in inflammation and oxidative stress signalling pathways in coarcted aorta triggered by bicuspid aortic valve and growth in young children

Skeffington, K. L., Bond, A. R., Bigotti, M. G., Abdul Ghani, S., Iacobazzi, D., Kang, S., Heesom, K. J., Wilson, M. C., Stoica, S. C., Martin, R., Caputo, M., Suleiman, M-S. & Ghorbel, M., 3 Sept 2020, In: Experimental and Therapeutic Medicine. 20, 5, p. 48 10 p., 48.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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96 Downloads (Pure)

Intermittent antegrade warm-blood versus cold-blood cardioplegia in children undergoing open heart surgery: a protocol for a randomised controlled study (Thermic-3)

Heys, R., Stoica, S., Angelini, G., Beringer, R., Evans, R., Ghorbel, M., Lansdowne, W., Parry, A., Pieles, G., Reeves, B., Rogers, C., Saxena, R., Sheehan, K., Smith, S., Walker-Smith, T., Tulloh, R. M. & Caputo, M., 14 Oct 2020, In: BMJ Open. 10, 10, p. e036974

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

In vitro and in vivo preclinical testing of pericyte-engineered grafts for the correction of congenital heart defects: Pericytes and heart defects

Alvino, V. V., Kilcooley, M., Thomas, A. C., Carrabba, M., Fagnano, M., Cathery, W. R., Avolio, E., Iacobazzi, D., Ghorbel, M., Caputo, M. & Madeddu, P. R., 11 Feb 2020, (E-pub ahead of print) In: Journal of the American Heart Association. 28 p., e014214.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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13 Citations (Scopus)

118 Downloads (Pure)

Safety and effectiveness of a new vascular conduit engineered with syngeneic cardiac pericytes for reconstruction the pulmonary artery in piglets

Alvino, V. V., Thomas, A. C., Ghorbel, M., Rapetto, F., Narayan, S., Kilcooley, M., Iacobazzi, D., Carrabba, M., Fagnano, M., Cathery, W. R., Avolio, E., Caputo, M. & Madeddu, P. R., 21 Dec 2020, (Submitted) In: Journal of the American Heart Association. JAHA/2020/020595.

Research output: Contribution to journal › Article (Academic Journal)

Wharton's Jelly-Mesenchymal Stem Cells- engineered conduit for pediatric translation in Heart Defect

Iacobazzi, D., Rapetto, F., Albertario, A., Swim, M. M., Narayan, S., Skeffington, K., Salih, T., Alvino, V. V., Madeddu, P., Ghorbel, M. T. & Caputo, M., 22 Jun 2020, (E-pub ahead of print) In: Tissue Engineering, Parts A, B, and C.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

219 Downloads (Pure)

2019

Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for In Vivo Vascular Repair

Swim, M., Albertario, A., Iacobazzi, D., Caputo, M. & Ghorbel, M., 1 Apr 2019, In: Tissue Engineering - Part A. 25, 7-8, p. 603-619 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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17 Citations (Scopus)

297 Downloads (Pure)

Bicuspid Aortic Valve Alters Aortic Protein Expression Profile in Neonatal Coarctation Patients

Skeffington, K. L., Bond, A. R., Abdul-Ghani, S., Iacobazzi, D., Kang, S-L., Heesom, K. J., Wilson, M. C., Ghorbel, M., Stoica, S., Martin, R., Suleiman, M. S. & Caputo, M., 16 Apr 2019, In: Journal of Clinical Medicine. 8, 4, 14 p., 517.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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3 Citations (Scopus)

214 Downloads (Pure)

Reconstruction of the pulmonary artery by a novel biodegradable conduit engineered with perinatal stem cell-derived vascular smooth muscle cells enables physiological vascular growth in a large animal model of congenital heart disease

Ghorbel, M. T., Jia, H., Swim, M. M., Iacobazzi, D., Albertario, A., Zebele, C., Holopherne-Doran, D., Hollander, A., Madeddu, P. & Caputo, M., 1 Oct 2019, In: Biomaterials. 217, 12 p., 119284.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

534 Downloads (Pure)

Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Albertario, A., Swim, M. M., Mohamed Ahmed, E., Iacobazzi, D., Yeong, M., Madeddu, P., Ghorbel, M. & Caputo, M., Jun 2019, In: JACC: Basic to Translational Science. 4, 3, p. 364-384 21 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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13 Citations (Scopus)

244 Downloads (Pure)

2018

Changes in contractile protein expression are linked to ventricular stiffness in infants with pulmonary hypertension or right ventricular hypertrophy due to congenital heart disease

Bond, A. R., Iacobazzi, D., Abdul-Ghani, S., Ghorbel, M., Heesom, K., Wilson, M., Gillett, C., George, S. J., Caputo, M., Suleiman, S. & Tulloh, R. M. R., 1 Feb 2018, In: Open Heart. 5, 1, 14 p., e000716.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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16 Citations (Scopus)

310 Downloads (Pure)

The cardiac proteome in patients with congenital ventricular septal defect: A comparative study between right atria and right ventricles

Bond, Iacobazzi, Abdul-Ghani, S., Ghorbel, Heesom, George, Caputo, Suleiman & Tulloh, 20 Mar 2018, (E-pub ahead of print) In: Journal of Proteomics.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

455 Downloads (Pure)

Thymus-Derived Mesenchymal Stem Cells for Tissue Engineering Clinical-Grade Cardiovascular Grafts

Iacobazzi, D., Swim, M. M., Albertario, A., Caputo, M. & Ghorbel, M. T., May 2018, In: Tissue Engineering, Part A. 24, 9-10, p. 794-808 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

2775 Downloads (Pure)

2017

Perivascular cells and tissue engineering: current applications and untapped potential

Avolio, E., Alvino, V. V., Ghorbel, M. T. & Campagnolo, P., 1 Mar 2017, In: Pharmacology and Therapeutics.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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57 Citations (Scopus)

347 Downloads (Pure)

2016

Cellular and molecular basis of RV hypertrophy in congenital heart disease

Iacobazzi, D., Suleiman, M-S., Ghorbel, M., George, S. J., Caputo, M. & Tulloh, R. M., Jan 2016, In: Heart. 102, 1, p. 12-17 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

24 Citations (Scopus)

Chronic hypoxia downregulates ZO-2 expression in children with cyanotic congenital heart defect

Jenkins, E. L., Caputo, M., Angelini, G. D. & Ghorbel, M., Jun 2016, In: ESC Heart Failure. 3, 2, p. 131-137 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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9 Citations (Scopus)

298 Downloads (Pure)

2015

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C., & 2 othersCaputo, M. & Madeddu, P., 2015, In: Journal of the American Heart Association. 4, 6

Research output: Contribution to journal › Article (Academic Journal) › peer-review

61 Citations (Scopus)

Gab1 is modulated by chronic hypoxia in children with cyanotic congenital heart defect and its overexpression reduces apoptosis in rat neonatal cardiomyocytes

Cherif, M., Caputo, M., Nakaoka, Y., Angelini, G. D. & Ghorbel, M., 19 May 2015, In: BioMed Research International. 2015, 9 p., 718492.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

466 Downloads (Pure)

Normothermic versus hypothermic cardiopulmonary bypass in children undergoing open heart surgery (thermic-2): study protocol for a randomized controlled trial

Baos, S., Sheehan, K., Culliford, L., Pike, K., Ellis, L., Parry, A., Stoica, S., Ghorbel, M., Caputo, M. & Rogers, C., 25 May 2015, In: JMIR Research Protocols. 4, 2, 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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359 Downloads (Pure)

Protein Phosphatase 1 Beta is Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration

Iacobazzi, D., Garaeva, I., Albertario, A., Cherif, M., Angelini, G. D., Caputo, M. & Ghorbel, M., May 2015, In: Cellular Physiology and Biochemistry. 36, 1, 11 p., 384-394.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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22 Citations (Scopus)

379 Downloads (Pure)

2014

Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury

Ghorbel, M., Patel, N., Sheikh, M., Angelini, G. D., Caputo, M. & Murphy, G., 21 Oct 2014, In: BMC Genomics. 15, 13 p., 916.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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12 Citations (Scopus)

316 Downloads (Pure)

Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgery

Caputo, M., Mokhtari, A., Miceli, A., Ghorbel, M. T., Angelini, G. D., Parry, A. J. & Suleiman, S. M., Sept 2014, In: Journal of Thoracic and Cardiovascular Surgery. 148, 3, p. 792-801.e8

Research output: Contribution to journal › Article (Academic Journal) › peer-review

51 Citations (Scopus)

2012

Chapter 10. Gene Expression Profiling - A New Approach in the Study of Congenital Heart Disease

Ghorbel, M., Angelini, G. D. & Caputo, M., 2012, Front Lines of Thoracic Surgery. Nazari, S. (ed.). InTechPublication

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

Controlled Reoxygenation Cardiopulmonary Bypass is Associated with Reduced Transcriptomic Changes in Cyanotic Tetralogy of Fallot Patients Undergoing Surgery

Ghorbel, M., Mokhtari, A. F., Sheikh, M., Angelini, G. D. & Caputo, M., 15 Nov 2012, In: Physiological Genomics. p. 1098-1106 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

17 Citations (Scopus)

2011

Common arterial trunk: review of surgical strategies and future research

di Siena, P. M., Ghorbel, MBT., Chen, Q., Yim, D. & Caputo, M., Dec 2011, In: Expert Review of Cardiovascular Therapy. 9(12), p. 1527 - 1538 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

18 Citations (Scopus)

Suppression subtractive hybridization

Ghorbel, M. T. & Murphy, D., 2011, In: Methods in Molecular Biology. 789, p. 237 - 259 23 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

2010

Off-pump coronary artery bypass surgery is associated with fewer gene expression changes in the human myocardium in comparison with on-pump surgery

Ghorbel, MBT., Cherif, M., Mokhtari, A., Bruno, VD., Caputo, M. & Angelini, G., 1 Jun 2010, In: Physiological Genomics. 42, 1, p. 67 - 75 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

Transcriptomic analysis of patients with tetralogy of Fallot reveals the effect of chronic hypoxia on myocardial gene expression

Ghorbel, MBT., Cherif, M., Jenkins, EL., Mokhtari, A., Kenny, D., Angelini, G. & Caputo, M., Aug 2010, In: Journal of Thoracic and Cardiovascular Surgery. 140(2), p. 337 - 345 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

45 Citations (Scopus)

2009

The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: a randomized controlled trial

Caputo, M., Mokhtari, A., Rogers, CA., Panayiotou, N., Chen, Q., Ghorbel, MBT., Angelini, G. & Parry, AJ., Jul 2009, In: Journal of Thoracic and Cardiovascular Surgery. 138, 1, p. 206 - 214 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

68 Citations (Scopus)

2008

Expression of long-term depression underlies visual recognition memory

Griffiths, SL., Scott, HL., Glover, CPJ., Bienemann, AS., Ghorbel, MBT., Uney, JB., Brown, MW., Warburton, EC. & Bashir, ZI., 24 Apr 2008, In: Neuron. 58, 2, p. 186 - 194 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

131 Citations (Scopus)

2006

Microarray screening of suppression subtractive hybridization-PCR cDNA libraries identifies novel RNAs regulated by dehydration in the rat supraoptic nucleus

Ghorbel, MBT., Sharman, GJ., Hindmarch, CCT., Becker, KG., Barret, T. & Murphy, D., Jan 2006, In: Physiological Genomics. 24 (2), p. 163 - 172 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

2005

Profile of changes in gene expression in cultured hippocampal neurones evoked by the GABA_B receptor agonist baclofen

Ghorbel, MBT., Becker, KG. & Henley, JM., Jun 2005, In: Physiological Genomics. 22 (1), p. 93 - 98 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)

2004

Deciphering the mechanisms of homeostatic plasticity in the hypothalamo-neurohypophyseal system--genomic and gene transfer strategies

Sharman, GJ., Ghorbel, MBT., Leroux, M., Beaucourt, SM., Wong, LF. & Murphy, D., 2004, In: Progress in Biophysics and Molecular Biology. 84(2-3), p. 151 - 182

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

2003

Cross-talk between hypoxic and circadian pathways: cooperative roles for hypoxia-inducible factor 1α and CLOCK in transcriptional activation of the vasopressin gene

Ghorbel, MBT., Coulson, JM. & Murphy, D., Mar 2003, In: Molecular and Cellular Neuroscience. 22 (3), p. 396 - 404 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

51 Citations (Scopus)

Microarray analysis reveals Interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system

Ghorbel, MBT., Sharman, GJ., Leroux, M., Donovan, DM., Becker, KG. & Murphy, D., 23 May 2003, In: Journal of Biological Chemistry. 278 (21), p. 19280 - 19285 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

61 Citations (Scopus)

Dr Mohamed Ghorbel

Research output

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