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Personal profile

Research interests

I am a statistical epidemiologist within the MRC Integrative Epidemiology Unit with expertise in causal inference methods. The two main areas of my research are pharmacoepidemiology and Mendelian randomization.

I have applied and developed methods of using a statistical approach known as instrumental variable analysis to investigate the causal effects of prescription medications. For example, I have investigated the potential beneficial and adverse effects of anti-depressants, smoking cessation medications and anti-inflammatories. I have used data from large databases of electronic medical records such as the Clinical Practice Research Database and Hospital Episodes Statistics database.

A second area of my research involves developing methods for Mendelian randomization studies. Mendelian randomization uses individual genetic variants of known effects to make inferences about the causal effects of modifiable risk factors for disease. This approach can overcome problems which faced by traditional observational studies.

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Research Output

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Brumpton, B., Sanderson, E., Hartwig, F. P., Harrison, S., Cho, Y., Howe, L. D., Hughes, A., Havdahl, A., Howe, L., Morris, T., Windmeijer, F., Evans, D. M., Davey Smith, G., Hemani, G., Davies, N. M. & al., E., 12 Jun 2020, (Accepted/In press) In : Nature Communications.

Research output: Contribution to journalArticle (Academic Journal)

  • Can education be personalised using pupils' genetic data?

    Morris, T. T., Davies, N. M. & Davey Smith, G., 10 Mar 2020, In : eLife. 9, 18 p., e49962.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 24 Downloads (Pure)

    Can genetics reveal the causes and consequences of educational attainment?

    Munafò, M., Davies, N. M. & Davey Smith, G., 1 Feb 2020, In : Journal of the Royal Statistical Society: Series A. 183, 2, p. 681-688 8 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 61 Downloads (Pure)

    Supervised Work

    New uses for old drugs : Investigating whether antihypertensives can be repurposed for the prevention of dementia

    Author: Walker, V., 13 Sep 2019

    Supervisor: Davies, N. (Supervisor), Kehoe, P. (Supervisor) & Martin, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)