If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article (Academic Journal)
2020

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. Å., Cho, Y., Howe, L. D., Hughes, A., Boomsma, D. I., Havdahl, A., Hopper, J. L., Neale, M., Nivard, M. G., Pedersen, N. L., Reynolds, C., Tucker-Drob, E. M., Howe, L., Morris, T., Lin, S. & 14 others, The Within-family Consortium, the 23 and Me Research Team, Auton, A., Windmeijer, F., Chen, W-M., Bjørngaard, J. H., Hveem, K., Willer, C. J., Evans, D. M., Kaprio, J. A., Davey Smith, G., Åsvold, B. O., Hemani, G. & Davies, N. M., 14 Jul 2020, In : Nature Communications. 11, 13 p., 3519 (2020) .

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Downloads (Pure)

Can education be personalised using pupils' genetic data?

Morris, T. T., Davies, N. M. & Davey Smith, G., 10 Mar 2020, In : eLife. 9, 18 p., e49962.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
32 Downloads (Pure)

Can genetics reveal the causes and consequences of educational attainment?

Munafò, M., Davies, N. M. & Davey Smith, G., 1 Feb 2020, In : Journal of the Royal Statistical Society: Series A. 183, 2, p. 681-688 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
68 Downloads (Pure)

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

Dardani, C., Howe, L. J. M. S., Mukhopadhyay, N., Stergiakouli, E., Wren, Y. E., Humphries, K. J., Davies, A. J. V., Ho, K. M., Weinberg, S., Marazita, M., Mangold, E., Ludwig, K., Relton, C. L., Davey Smith, G., Lewis, S. J., Sandy, J. R., Davies, N. M. & Sharp, G. C., 6 May 2020, In : International Journal of Epidemiology. 12 p., dyaa047.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File

Comparison of antihypertensive drug classes for dementia prevention

Walker, V., Davies, N. M., Martin, R. M. & Kehoe, P. G., 6 Jun 2020, (Accepted/In press) In : Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

Early childhood general anesthesia and neurodevelopmental outcomes in the ALSPAC birth cohort

Walkden, G., Gill, H., Davies, N. M., Peters, A. E., Wright, I. & Pickering, A. E., 27 Jul 2020, (Accepted/In press) In : Anesthesiology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
68 Downloads (Pure)

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

Dixon, P. C., Harrison, S., Hollingworth, W., Davies, N. M. & Davey Smith, G., 11 Jul 2020, (Unpublished) In : medRxiv.

Research output: Contribution to journalArticle (Academic Journal)

Integrating Family-Based and Mendelian Randomization Designs

Hwang, L-D., Davies, N. M., Warrington, N. M. & Evans, D. M., 2 Mar 2020, In : Cold Spring Harbor perspectives in medicine.

Research output: Contribution to journalArticle (Academic Journal)

Mendelian Randomization analysis of the causal effect of adiposity on hospital costs

Dixon, P., Hollingworth, W., Harrison, S., Davies, N. M. & Davey Smith, G., 1 Mar 2020, In : Journal of Health Economics. 70, 22 p., 102300.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
43 Downloads (Pure)

Population phenomena inflate genetic associations of complex social traits

Morris, T. T., Davies, N. M., Hemani, G. & Davey Smith, G., 15 Apr 2020, In : Science Advances. 6, 16, 13 p., eaay0328.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
29 Downloads (Pure)
Open Access
File
23 Downloads (Pure)
2019

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

de Vries, P. S., Sabater-Lleal, M., Huffman, J. E., Marten, J., Song, C., Pankratz, N., Bartz, T. M., de Haan, H. G., Delgado, G. E., Eicher, J. D., Martinez-Perez, A., Ward-Caviness, C. K., Brody, J. A., Chen, M-H., de Maat, M. P. M., Frånberg, M., Gill, D., Kleber, M. E., Rivadeneira, F., Soria, J. M. & 25 others, Tang, W., Tofler, G. H., Uitterlinden, A. G., van Hylckama Vlieg, A., Seshadri, S., Boerwinkle, E., Davies, N. M., Giese, A-K., Ikram, M. K., Kittner, S. J., McKnight, B., Psaty, B. M., Reiner, A. P., Sargurupremraj, M., Taylor, K. D., Fornage, M., Hamsten, A., März, W., Rosendaal, F. R., Souto, J. C., Dehghan, A., Johnson, A. D., Morrison, A. C., O'Donnell, C. J. & Smith, N. L., 28 Feb 2019, In : Blood. 133, 9, p. 967-977 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
38 Citations (Scopus)
282 Downloads (Pure)

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: Results from a collaborative meta-analysis

Hartwig, F. P., Davies, N. M., Horta, B. L., Ahluwalia, T. S., Bisgaard, H., Bønnelykke, K., Caspi, A., Moffitt, T. E., Poulton, R., Sajjad, A., Tiemeier, H. W., Dalmau-Bueno, A., Guxens, M., Bustamante, M., Santa-Marina, L., Parker, N., Paus, T., Pausova, Z., Lauritzen, L., Schnurr, T. M. & 7 others, Michaelsen, K. F., Hansen, T., Oddy, W., Pennell, C. E., Warrington, N. M., Davey Smith, G. & Victora, C. G., 1 Feb 2019, In : International Journal of Epidemiology. 48, 1, p. 45-57 13 p., dyy273.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
203 Downloads (Pure)

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization and within-family study in UK Biobank

Howe, L. D., Kanayalal, R., Harrison, S., Beaumont, R. N., Davies, A. R., Frayling, T., Davies, N. M., Hughes, A. M. M., Jones, S. E., Sassi, F., Wood, A. R. & Tyrrell, J., 4 Dec 2019, In : International Journal of Epidemiology. 12 p., dyz240.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
134 Downloads (Pure)

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

Howe, L. J., Lawson, D. J., Davies, N. M., St. Pourcain, B., Lewis, S. J., Davey Smith, G. & Hemani, G., 19 Nov 2019, In : Nature Communications. 10, 10 p., 5039 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
135 Downloads (Pure)

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Hill, W. D., Davies, N. M., Ritchie, S. J., Skene, N. G., Bryois, J., Bell, S., Di Angelantonio, E., Roberts, D. J., Xueyi, S., Davies, G., Liewald, D. C. M., Porteous, D. J., Hayward, C., Butterworth, A. S., McIntosh, A. M., Gale, C. R. & Deary, I. J., 16 Dec 2019, In : Nature Communications. 10, 1, p. 5741

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Genome-Wide Association Trans-Ethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels

INVENT Consortium; MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC), Sabater-Lleal, M., Huffman, J. E., de Vries, P. S., Marten, J., Mastrangelo, M. A., Song, C., Pankratz, N., Ward-Caviness, C. K., Yanek, L. R., Trompet, S., Delgado, G. E., Guo, X., Bartz, T. M., Martinez-Perez, A., Germain, M., de Haan, H. G., Ozel, A. B., Polasek, O., Smith, A. V. & 31 others, Eicher, J. D., Reiner, A. P., Tang, W., Davies, N. M., Stott, D. J., Rotter, J. I., Tofler, G. H., Boerwinkle, E., de Maat, M. P. M., Kleber, M. E., Welsh, P., Brody, J. A., Chen, M-H., Vaidya, D., Soria, J. M., Suchon, P., van Hylckama Vlieg, A., Desch, K. C., Kolcic, I., Joshi, P. K., Launer, L. J., Harris, T. B., Campbell, H., Rudan, I., Becker, D. M., Li, J. Z., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Franco, O. H. & Cushman, M., 29 Jan 2019, In : Circulation. 139, 5, p. 620-635 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
196 Downloads (Pure)

Is Population Structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson, D., Davies, N., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N., 27 Apr 2019, In : Human Genetics. 19 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
182 Downloads (Pure)
Open Access
File
90 Downloads (Pure)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

Davies, N., Hill, W. D., Anderson, E., Sanderson, E., Deary, I. J. & Davey Smith, G., 17 Sep 2019, In : eLife. 8, 22 p., e43990.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
157 Downloads (Pure)

On the Use of the Lasso for Instrumental Variables Estimation with Some Invalid Instruments

Windmeijer, F., Farbmacher, H., Davies, N. & Davey Smith, G., 25 Sep 2019, In : Journal of the American Statistical Association. 114, 527, p. 1339-1350 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
294 Downloads (Pure)

Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders

Taylor, G., Itani, T., Thomas, K., Rai, D., Jones, T., Windmeijer, F., Martin, R., Munafo, M., Davies, N. & Taylor, A., 10 Jul 2019, In : Nicotine and Tobacco Research. 11 p., ntz072.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
170 Downloads (Pure)
Open Access
File
281 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
226 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
225 Downloads (Pure)

Selection bias when estimating average treatment effects using one-sample instrumental variable analysis

Hughes, R. A., Davies, N. M., Davey Smith, G. & Tilling, K., 1 May 2019, In : Epidemiology. 30, 3, p. 350-357 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
190 Downloads (Pure)

The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes: Mendelian Randomization in UK Biobank

Harrison, S., Davies, A. R., Dickson, M., Tyrrell, J., Green, M. J., Katikireddi, S. V., Campbell, D., Munafo, M. R., Dixon, P. C., Jones, H. E., Rice, F., Davies, N. M. & Howe, L. D., 8 Oct 2019, (Submitted) In : medRxiv.

Research output: Contribution to journalArticle (Academic Journal)

Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study

Carter, A., Gill, D., Davies, N., Taylor, A., Tillmann, T., Vaucher, J., Wootton, R., Munafo, M., Hemani, G., Malik, R., Seshadri, S., Woo, D., Burgess, S., Davey Smith, G., Holmes, M. V., Tzoulaki, I., Howe, L. & Dehghan, A., 22 May 2019, In : BMJ. 365, 12 p., l1855.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
326 Downloads (Pure)
Open Access
File
265 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
162 Downloads (Pure)

Within family Mendelian randomization studies

Davies, N. M., Howe, L., Brumpton, B., Havdahl, A., Evans, D. M. & Smith, G. D., 22 Oct 2019, In : Human Molecular Genetics.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)
2018

A systematic review and meta-analysis of effects of early life non-cognitive skills on academic, psychosocial, cognitive and health outcomes

Smithers, L. G., Sawyer, A. C. P., Chittleborough, C., Davies, N., Davey Smith, G. & Lynch, J., 5 Nov 2018, In : Nature Human Behaviour. 2, 11, p. 867-880 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
167 Downloads (Pure)

Bias in Mendelian randomization due to assortative mating

Hartwig, F., Davies, N. & Davey Smith, G., 3 Jul 2018, In : Genetic Epidemiology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
228 Downloads (Pure)

Confounding by ill-health in the observed association between BMI and mortality: evidence from the HUNT Study using offspring BMI as an instrument

Carslake, D., Davey Smith, G., Gunnell, D., Davies, N., Nilsen, TI. & Romundstad, P., Jun 2018, In : International Journal of Epidemiology. 47, 3, p. 760-770 11 p., dyx246.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
308 Downloads (Pure)

Education and myopia: assessing the direction of causality by mendelian randomisation

Mountjoy, E., Davies, N. M., Plotnikov, D., Smith, G. D., Rodriguez, S., Williams, C. E., Guggenheim, J. A. & Atan, D., 6 Jun 2018, In : BMJ. 361, 11 p., k2022.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
42 Citations (Scopus)
232 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
271 Downloads (Pure)
Open Access
File
28 Citations (Scopus)
297 Downloads (Pure)

Infant feeding and growth: Putting the horse before the cart

Kramer, M. S., Davies, N., Oken, E., Martin, R. M., Dahhou, M., Zhang, X. & Yang, S., Apr 2018, In : American Journal of Clinical Nutrition. 107, 4, p. 635-639 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
307 Downloads (Pure)

Outcome trends and safety measures after 30 years of laparoscopic cholecystectomy: a systematic review and pooled data analysis

Pucher, P. H., Brunt, L. M., Davies, N., Linsk, A., Munshi, A., Rodriguez, H. A., Fingerhut, A., Fanelli, R. D., Asbun, H., Aggarwal, R. & on behalf of the SAGES Safe Cholecystectomy Task Force, 1 May 2018, In : Surgical Endoscopy. 32, 5, p. 2175-2183 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
30 Citations (Scopus)
346 Downloads (Pure)

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Davies, N., Holmes, M. & Davey Smith, G., 12 Jul 2018, In : BMJ. 362, 11 p., k601.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
124 Citations (Scopus)
331 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
220 Downloads (Pure)
Open Access
File
17 Citations (Scopus)
260 Downloads (Pure)

Testing the validity of value-added measures of educational progress with genetic data

Morris, T., Davies, N., Dorling, D., Richmond, R. & Davey Smith, G., 1 Oct 2018, In : British Educational Research Journal. 44, 5, p. 725-747 23 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
282 Downloads (Pure)

The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records

Davies, N. M., Taylor, G. M. J., Taylor, A. E., Jones, T., Martin, R. M., Munafò, M. R., Windmeijer, F. & Thomas, K. H., 1 Jun 2018, In : Addiction. 113, 6, p. 1105-1116 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
241 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
200 Downloads (Pure)
2017

Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study

Brunner, C., Davies, N. M., Martin, R., Eeles, R., Easton, D., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Wiklund, F., Grönberg, H., Haiman, C. A., Schleutker, J., Nordestgaard, B. G., Travis, R. C., Neal, D. E., Donovan, J., Pashayan, N., Khaw, K-T. & 15 others, Stanford, J. L., Blot, W. J., Thibodeau, S., Maier, C., Kibel, A. S., Cybulski, C., Cannon-Albright, L., Brenner, H., Park, J., Kaneva, R., Batra, J., Teixeira, M. R., Pandha, H., the PRACTICAL Consortium & Zuccolo, L., 1 Jan 2017, In : International Journal of Cancer. 140, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
304 Downloads (Pure)

An epigenome-wide association study meta-analysis of educational attainment

Karlsson Linnér, R., Marioni, R. E., Rietveld, C. A., Simpkin, A. J., Davies, N. M., Watanabe, K., Armstrong, N. J., Auro, K., Baumbach, C., Bonder, M. J., Buchwald, J., Fiorito, G., Ismail, K., Iurato, S., Joensuu, A., Karell, P., Kasela, S., Lahti, J., McRae, A. F., Mandaviya, P. R. & 31 others, Seppälä, I., Wang, Y., Baglietto, L., Binder, E. B., Harris, S. E., Hodge, A. M., Horvath, S., Hurme, M., Johannesson, M., Latvala, A., Mather, K. A., Medland, S. E., Metspalu, A., Milani, L., Milne, R. L., Pattie, A., Pedersen, N. L., Peters, A., Polidoro, S., Räikkönen, K., Severi, G., Starr, J. M., Stolk, L., Waldenberger, M., Eriksson, J. G., Esko, T., Franke, L., Gieger, C., Relton, C., Davey Smith, G. & BIOS Consortium, 31 Oct 2017, In : Molecular Psychiatry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
24 Citations (Scopus)
445 Downloads (Pure)

Breastfeeding effects on DNA methylation in the offspring: A systematic literature review

Pires Hartwig, F., de Mola, C. L., Davies, N., Victora, C. G. & Relton, C., 3 Mar 2017, In : PLoS ONE. 12, 4, 18 p., e0173070.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
275 Downloads (Pure)