Projects per year
The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. The laboratory is actively pursuing the role of heteromeric channels undrlying the slow afterhypolarization in cortical and hippocampal neurons.The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding tby investigating the role of expression of tau protein isoforms in activation of calcium-activated potassium channels that regulate membrane excitability in hippocampal neurons.
- 1 Similar Profiles
Dive into details
Select a country/territory to view shared publications and projects
- 3 Finished
26/06/17 → 25/06/18
1/02/00 → 1/02/03
Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In: Scientific Reports. 9, 15 p., 19825 (2019).
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile5 Citations (Scopus)62 Downloads (Pure)
Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca2+-Activated Potassium ChannelsHigham, J., Sahu, G., Wazen, R. M., Colarusso, P., Gregorie, A., Harvey, B. S. J., Goudswaard, L., Varley, G., Sheppard, D. N., Turner, R. W. & Marrion, N. V., 1 Jul 2019, In: Mol. Pharmacol. 96, 1, p. 115-126 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review8 Citations (Scopus)
Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF StudyShamsaldeen, Y., Culliford, L., Clout, M., James, A., Ascione, R., Hancox, J. & Marrion, N., 14 May 2019, In: Biochemical and Biophysical Research Communications. 512, 4, p. 684-690 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Citations (Scopus)130 Downloads (Pure)