Professor Neil V Marrion

B.Sc., Ph.D.(Lond.)

Professor of Neuroscience, School of Physiology, Pharmacology & Neuroscience
Bristol Neuroscience

EmailN.V.Marrion@bristol.ac.uk

BS8 1TD

Research output per year

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Personal profile

Research interests

The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. The laboratory is actively pursuing the role of heteromeric channels undrlying the slow afterhypolarization in cortical and hippocampal neurons.The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding tby investigating the role of expression of tau protein isoforms in activation of calcium-activated potassium channels that regulate membrane excitability in hippocampal neurons.

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Projects

3 Finished

Determination of the SK channel composition contributing to atrial action potential duration

Ascione, R. & Marrion, N. V.

26/06/17 → 25/06/18

Project: Research

ION CHANNEL COUPLING IN CENTRAL NEURONS

Marrion, N. V.

1/04/00 → 1/10/05

Project: Research

ARE KCNQ2 AND KCNQ3 THE MOLECULAR CORRELATES OF THE MAMMALIAN M-CHANNEL

Marrion, N. V.

1/02/00 → 1/02/03

Project: Research

Research Output

41 Article (Academic Journal)
1 Chapter in a book
1 Conference Abstract

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In : Scientific Reports. 9, 15 p., 19825 (2019).

Research output: Contribution to journal › Article (Academic Journal)

Open Access

File

1 Citation (Scopus)

78 Downloads (Pure)

Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca²⁺-Activated Potassium Channels

Higham, J., Sahu, G., Wazen, R. M., Colarusso, P., Gregorie, A., Harvey, B. S. J., Goudswaard, L., Varley, G., Sheppard, D. N., Turner, R. W. & Marrion, N. V., 1 Jul 2019, In : Mol. Pharmacol. 96, 1, p. 115-126 12 p.

Research output: Contribution to journal › Article (Academic Journal)