Professor Neil V Marrion

B.Sc., Ph.D.(Lond.)

  • BS8 1TD

19962019

Research output per year

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Personal profile

Research interests

The hippocampus is known to play a key role in the consolidation of memory and research has focused on the changes in membrane excitability that occur during the creation of memories. Neuronal excitability is regulated by the activation of both voltage- and calcium-dependent potassium currents. The Marrion laboratory uses a multidisciplinary approach to study how voltage-dependent potassium channels are activated and the functional relationship between ion channel subtypes that controls activation of calcium-activated potassium channels. In addition, the laboratory has pioneered a new technique to resolve the exocytosis of a single vesicle containing neurotransmitter. The understanding that learning and memory consolidation are controlled by the excitability of the CNS neurons has revolutionized our approach to disease states such as Alzheimer's disease and epilepsy. The Marrion laboratory is contributing to this understanding to permit an appreciation of how these processes are influential in particular CNS disease states.

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Projects

Research Output

  • 41 Article (Academic Journal)
  • 1 Chapter in a book
  • 1 Conference Abstract

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In : Scientific Reports. 9, 15 p., 19825 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 1 Citation (Scopus)
    65 Downloads (Pure)

    Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca2+-Activated Potassium Channels

    Higham, J., Sahu, G., Wazen, R. M., Colarusso, P., Gregorie, A., Harvey, B. S. J., Goudswaard, L., Varley, G., Sheppard, D. N., Turner, R. W. & Marrion, N. V., 1 Jul 2019, In : Mol. Pharmacol. 96, 1, p. 115-126 12 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 1 Citation (Scopus)
    Open Access
    File
  • 41 Downloads (Pure)

    Supervised Work

    Modulation of the herg potassium channel function by extracellular acidosis: single channel effects and underlying basis

    Author: Wilson, S., 20 Mar 2018

    Supervisor: Hancox, J. (Supervisor) & Marrion, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Resolution of channel movement underlying opening and closing of hERG1a potassium channels

    Author: Gregorie, A. E., 23 Jan 2020

    Supervisor: Miles, M. (Supervisor) & Marrion, N. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File