Projects per year
Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.
Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.
We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.
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1/12/18 → 30/11/22
Project: Research, Parent
1/02/20 → 31/03/22
1/12/18 → 30/11/22
Rhys, G. G., Cross, J. A., Dawson, W. M., Thompson, H. F., Shanmugaratnam, S., Savery, N. J., Dodding, M. P., Höcker, B. & Woolfson, D. N., 1 Sep 2022, In: Nature Chemical Biology. 18, 9, p. 999-1004 6 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review1 Citation (Scopus)52 Downloads (Pure)
Naudin, E. A., Albanese, K. I., Smith, A. J., Mylemans, B., Baker, E. G., Savery, N. J., Woolfson, D. N. & Smith, A. J., 20 Sep 2022, In: Chemical Science. 13, 38, p. 11330-11340 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loopsUrrutia-Irazabal, I., Ault, J. R., Sobott, F., Savery, N. J. & Dillingham, M. S., 19 Jul 2021, In: eLife. 10, e68829.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile8 Citations (Scopus)38 Downloads (Pure)