Projects per year
Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.
Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.
We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.
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1/12/18 → 30/11/22
Project: Research, Parent
1/12/18 → 30/11/22
1/02/20 → 31/03/22
Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loopsUrrutia-Irazabal, I., Ault, J. R., Sobott, F., Savery, N. J. & Dillingham, M. S., 19 Jul 2021, In: eLife. 10, e68829.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)30 Downloads (Pure)
Pedone, E., De Cesare, I., Zamora-Chimal, C. G., Haener, D., Postiglione, L., La Regina, A., Shannon, B., Savery, N. J., Grierson, C. S., Di Bernardo, M., Gorochowski, T. E. & Marucci, L., 27 Apr 2021, ACS Synthetic Biology, 10, 5, p. 979-989 11 p.
Research output: Contribution to specialist publication › Article (Specialist Publication)Open AccessFile3 Citations (Scopus)29 Downloads (Pure)
ChipSeg: an automatic tool to segment bacterial and mammalian cells cultured in microfluidic devicesDe Cesare, I., Zamora Chimal, C. G., Postiglione, L., Khazim, M., Pedone, E., Shannon, B. M., Fiore, G., Perrino, G., Napolitano, S., di Bernardo, D., Savery, N. J., Grierson, C. S., Di Bernardo, M. & Marucci, L., 18 Jan 2021, In: ACS Omega. (2021) 6, 4, p. 2473–2476 4 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile172 Downloads (Pure)