Professor Nigel J Savery

B.Sc., Ph.D.(Birm.)

  • BS8 1TD

19962020

Research output per year

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Personal profile

Research interests

Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.

Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.

We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.

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Projects

Research Output

De Novo Designed Protein-Interaction Modules for In-Cell Applications

Edgell, C. L., Smith, A. J., Beesley, J. L., Savery, N. J. & Woolfson, D. N., 6 Feb 2020, In : ACS Synthetic Biology. 9, p. 427-436 10 p., 2.

Research output: Contribution to journalArticle (Academic Journal)

  • In vivo Feedback Control of an Antithetic Molecular-Titration Motif in Escherichia coli using Microfluidics

    Shannon, B. M., Zamora Chimal, C. G., Postiglione, L., Salzano, D., Grierson, C. S., Marucci, L., Savery, N. J. & Di Bernardo, M., 20 Feb 2020, (Submitted) In : ACS Synthetic Biology.

    Research output: Contribution to journalArticle (Academic Journal)

    Robust de novo designed homotetrameric coiled coils

    Edgell, C. L., Savery, N. J. & Woolfson, D. N., 9 Mar 2020, In : Biochemistry. 6 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Supervised Work

    De novo designed protein-protein interaction domains for synthetic biology applications in cells

    Author: Edgell, C. L., 23 Jan 2019

    Supervisor: Woolfson, D. (Supervisor) & Savery, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Identification of CLP-1 atypical calpain substrates in Caenorhabditis elegans

    Author: Newman, L., 23 Jan 2019

    Supervisor: Kuwabara, P. (Supervisor) & Savery, N. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Transcription termination by a transcription-repair coupling factor

    Author: Chambers, A. L., 2005

    Supervisor: Savery, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File