Projects per year
Personal profile
Research interests
Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.
Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.
We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.
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Projects
Design and in vivo assembly of switchable protein-protein interactions for transcription regulation
1/12/18 → 30/11/22
Project: Research
Design and in vivo assembly of switchable protein-protein interactions for transcription regulation
1/12/18 → 30/11/22
Project: Research, Parent
Research Output
De Novo Designed Protein-Interaction Modules for In-Cell Applications
Edgell, C. L., Smith, A. J., Beesley, J. L., Savery, N. J. & Woolfson, D. N., 6 Feb 2020, In : ACS Synthetic Biology. 9, p. 427-436 10 p., 2.Research output: Contribution to journal › Article (Academic Journal)
In vivo Feedback Control of an Antithetic Molecular-Titration Motif in Escherichia coli using Microfluidics
Shannon, B. M., Zamora Chimal, C. G., Postiglione, L., Salzano, D., Grierson, C. S., Marucci, L., Savery, N. J. & Di Bernardo, M., 20 Feb 2020, (Submitted) In : ACS Synthetic Biology.Research output: Contribution to journal › Article (Academic Journal)
Robust de novo designed homotetrameric coiled coils
Edgell, C. L., Savery, N. J. & Woolfson, D. N., 9 Mar 2020, In : Biochemistry. 6 p.Research output: Contribution to journal › Article (Academic Journal)
Supervised Work
De novo designed protein-protein interaction domains for synthetic biology applications in cells
Author: Edgell, C. L., 23 Jan 2019Supervisor: Woolfson, D. (Supervisor) & Savery, N. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Identification of CLP-1 atypical calpain substrates in Caenorhabditis elegans
Author: Newman, L., 23 Jan 2019Supervisor: Kuwabara, P. (Supervisor) & Savery, N. (Supervisor)
Student thesis: Master's Thesis › Master of Science (MSc)
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Transcription termination by a transcription-repair coupling factor
Author: Chambers, A. L., 2005Supervisor: Savery, N. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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