Projects per year
Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.
Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.
We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.
1/12/18 → 30/11/22
Project: Research, Parent
1/12/18 → 30/11/22
Pedone, E., De Cesare, I., Zamora-Chimal, C. G., Haener, D., Postiglione, L., La Regina, A., Shannon, B., Savery, N. J., Grierson, C. S., Di Bernardo, M., Gorochowski, T. E. & Marucci, L., 27 Apr 2021, ACS Synthetic Biology, (2021) 11 p.
Research output: Contribution to specialist publication › Article (Specialist Publication)
ChipSeg: an automatic tool to segment bacterial and mammalian cells cultured in microfluidic devicesDe Cesare, I., Zamora Chimal, C. G., Postiglione, L., Khazim, M., Pedone, E., Shannon, B. M., Fiore, G., Perrino, G., Napolitano, S., di Bernardo, D., Savery, N. J., Grierson, C. S., Di Bernardo, M. & Marucci, L., 18 Jan 2021, In: ACS Omega. (2021) 6, 4, p. 2473–2476 4 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile18 Downloads (Pure)
Brouwer, G. M., Bollins, J. M., Savery, N. J. & Strick, T. R., 13 Apr 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 15, 7 p., e2019630118.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile12 Downloads (Pure)