Genomes are replicated, repaired, modified and transcribed by a diverse range of protein:protein and protein:nucleic acid complexes.

Research in my laboratory aims to understand the mechanisms by which such complexes cooperate to control the frequency and accuracy with which individual genes are expressed.

We are studying transcription-coupled DNA repair processes and the effect of DNA damage on transcription, using a combination of biochemical and genetic techniques. In collaboration with colleagues from Engineering Maths and Biological Sciences we are also developing synthetic gene regulatory networks that perform designed functions.