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Personal profile

Research interests

Lay Summary of Research:

Our work involves understanding how immune cells that live in the eye (called microglia) – the “guardian sentinels” that watch and survey for danger there – change their behaviour during models of uveitis (a group of autoimmune/autoinflammatory diseases of the eye that are the commonest cause of blindness in the working-age population). We characterise the microglial behaviour primarily by performing a technique called RNA-Sequencing.

The immune system needs to discriminate between foreign cells (e.g. bacteria that could cause an infection) and host cells (e.g. retinal cells that allow you to see) so that it attacks the correct targets; aberrant targeting of host cells is termed autoimmune or autoinflammatory disease (e.g. multiple sclerosis, asthma).

By using models that simulate uveitis, we hope to characterise how the microglia change in these models – the hope is this will ultimately allow us to find new “druggable” targets that will lead to better* treatments in the future.

*Better treatments could include those which reduced side effects, and/or those which treat patients with a better success rate.

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Research Output

  • 3 Article (Academic Journal)
  • 1 Conference Contribution (Conference Proceeding)
  • 1 Conference Abstract
  • 1 Conference Poster

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 disruption using CRISPR-Cas9

Wu, J., Bell, O. H., Copland, D. A., Young, A., Pooley, J. R., Maswood, R., Evans, R. S., Khaw, P., Ali, R. R., Dick, A. D. & Chu, C. J., 9 Jan 2020, In : Molecular Therapy. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 70 Downloads (Pure)

    Intravenous indocyanine green dye is insufficient for robust immune cell labelling in the human retina

    Bell, O. H., Carreño, E., Williams, E. L., Wu, J., Copland, D. A., Bora, M., Kobayter, L., Fruttiger, M., Sim, D. A., Lee, R. W. J., Dick, A. D. & Chu, C. J., 13 Feb 2020, In : PLoS ONE. 15, 2, 14 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 39 Downloads (Pure)
    Open Access
    File
  • 80 Downloads (Pure)

    Activities

    • 1 External Examination and Supervision

    Internal Reviewer for PhD

    Denize Atan (Examiner)

    2018

    Activity: Examination typesExternal Examination and Supervision