Professor Paolo R Madeddu

  • BS2 8HW

19992020

Research output per year

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Personal profile

Research interests

The overall goal of my present and future research consists of developing more effective strategies to treat limb and myocardial ischaemia. My research also addresses diabetes-related microvascular complications, in particular impaired angiogenesis and wound healing. To achieve these aims, our group is applying state of the art concepts in the new field of therapeutic angiogenesis, which postulates that local delivery of growth factors that can promote clinically valuable increase in blood flow. Such growth factors are either delivered as proteins or as gene therapy. My own contribution has been the identification of novel angiogenic factors, in particular human tissue kallikrein and nerve growth factor, and developing platforms for translational research to bring these discoveries from the bench to the bedside. More recently, the idea has emerged that therapeutic angiogenesis can also be achieved using stem cell transplantation. We are currently engaged in studies aimed at challenging the therapeutic potentiality of human stem cells (embryonic, foetal, and adult) for the regeneration of wounded tissues in murine models of myocardial infarction and ischaemic diabetic wounds. In particular, we have funded plans to bring human pericytes to a first in man clinical trial by 2015.

A recent biography is available in the AHA Journal Circulation "European perspectives" at the URL http://circ.ahajournals.org/content/126/7/f37.full.pdf?ijkey=QdK5BJZZAQMZzVQ&keytype=ref

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Projects

Research Output

Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo, V., Cathery, W., Velliou, E., Madeddu, P. & Campagnolo, P., 20 Mar 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 13 p., 188.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
  • 24 Downloads (Pure)

    Bone Marrow as a Target and Accomplice of Vascular Complications in Diabetes

    Santopaolo, M., Sambataro, M., Spinetti, G. & Madeddu, P., Mar 2020, In : Diabetes/Metabolism Research and Reviews. 36, S1, 6 p., e3240.

    Research output: Contribution to journalReview article (Academic Journal)

  • Bone marrow fat: friend or foe in people with diabetes mellitus?

    Santopaolo, M., Gu, Y., Spinetti, G. & Madeddu, P. R., 27 Apr 2020, In : Clinical Science. 134, 8, p. 1031 – 1048 18 p.

    Research output: Contribution to journalReview article (Academic Journal)

  • Activities

    • 2 Editorial activity
    • 2 Advisory work for/on national or international committee or working group
    • 1 Membership or peer review panel or committee

    ANR France (External organisation)

    Paolo R Madeddu (Contributor)

    2014

    Activity: Membership typesMembership or peer review panel or committee

    Arteriosclerosis, Thrombosis, and Vascular Biology (Journal)

    Paolo R Madeddu (Editorial board member)

    2014

    Activity: Publication peer-review and editorial work typesEditorial activity

    Circulation Research (Journal)

    Paolo R Madeddu (Editorial board member)

    2014

    Activity: Publication peer-review and editorial work typesEditorial activity

    Supervised Work

    Antigenic, functional and molecular characterization of human cardiac pericytes from newborn and grown-up congenital heart disease patients

    Author: Judina, A., 25 Sep 2018

    Supervisor: Caputo, M. (Supervisor) & Madeddu, P. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Biomimetic Gelatin Nanofibrous Scaffolds for the Mechanical Modulation of Cardiac Pericyte Fate

    Author: Naduthottathil, M. R., 1 Oct 2019

    Supervisor: Davis, S. (Supervisor), Su, B. (Supervisor) & Madeddu, P. R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Novel approaches of scaffold fabrication for vascular tissue engineering

    Author: Carrabba, M., 19 Mar 2019

    Supervisor: Madeddu, P. (Supervisor) & Drinkwater, B. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File