Professor Paolo R Madeddu

  • BS2 8HW


Research output per year

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Personal profile

Research interests

The overall goal of my present and future research consists of developing more effective strategies to treat limb and myocardial ischaemia. My research also addresses diabetes-related microvascular complications, in particular impaired angiogenesis and wound healing. To achieve these aims, our group is applying state of the art concepts in the new field of therapeutic angiogenesis, which postulates that local delivery of growth factors that can promote clinically valuable increase in blood flow. Such growth factors are either delivered as proteins or as gene therapy. My own contribution has been the identification of novel angiogenic factors, in particular human tissue kallikrein and nerve growth factor, and developing platforms for translational research to bring these discoveries from the bench to the bedside. More recently, the idea has emerged that therapeutic angiogenesis can also be achieved using stem cell transplantation. We are currently engaged in studies aimed at challenging the therapeutic potentiality of human stem cells (embryonic, foetal, and adult) for the regeneration of wounded tissues in murine models of myocardial infarction and ischaemic diabetic wounds. In particular, we have funded plans to bring human pericytes to a first in man clinical trial by 2015.

A recent biography is available in the AHA Journal Circulation "European perspectives" at the URL

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Research Output

A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Non-Structural Protein 1

Cheung, Y. P., Mastrullo, V., Maselli, D., Butsabong, T., Madeddu, P. R., Maringer, K. & Campagnolo, P., 5 Aug 2020, In : mSphere. 5, 4, 11 p., e00258-20.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
  • 38 Downloads (Pure)

    Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

    Santopaolo, M., Sullivan, N., Thomas, A. C., Alvino, V. V., Nicholson, L. B., Gu, Y., Spinetti, G., Kallikourdis, M., Blom, A. W. & Madeddu, P. R., 3 Jul 2020, (Submitted) In : Cardiovascular Diabetology.

    Research output: Contribution to journalArticle (Academic Journal)

  • Angiogenesis in Tissue Engineering: As Nature Intended?

    Mastrullo, V., Cathery, W., Velliou, E., Madeddu, P. & Campagnolo, P., 20 Mar 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 13 p., 188.

    Research output: Contribution to journalReview article (Academic Journal)

    Open Access
  • 37 Downloads (Pure)


    • 2 Editorial activity
    • 2 Advisory work for/on national or international committee or working group
    • 1 Membership or peer review panel or committee

    ANR France (External organisation)

    Paolo R Madeddu (Contributor)


    Activity: Membership typesMembership or peer review panel or committee

    Medical Research Council (External organisation)

    Paolo R Madeddu (Member)


    Activity: Membership typesAdvisory work for/on national or international committee or working group

    Arteriosclerosis, Thrombosis, and Vascular Biology (Journal)

    Paolo R Madeddu (Editorial board member)


    Activity: Publication peer-review and editorial work typesEditorial activity