Professor Paolo R Madeddu

  • BS2 8HW

19992020

Research output per year

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Research Output

2020

Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo, V., Cathery, W., Velliou, E., Madeddu, P. & Campagnolo, P., 20 Mar 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 13 p., 188.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
20 Downloads (Pure)

Bone Marrow as a Target and Accomplice of Vascular Complications in Diabetes

Santopaolo, M., Sambataro, M., Spinetti, G. & Madeddu, P., Mar 2020, In : Diabetes/Metabolism Research and Reviews. 36, S1, 6 p., e3240.

Research output: Contribution to journalReview article (Academic Journal)

Bone marrow fat: friend or foe in people with diabetes mellitus?

Santopaolo, M., Gu, Y., Spinetti, G. & Madeddu, P. R., 27 Apr 2020, In : Clinical Science. 134, 8, p. 1031 – 1048 18 p.

Research output: Contribution to journalReview article (Academic Journal)

Circulating BPIFB4 levels associate with and influence the abundance of reparative monocytes and macrophages in long living individuals

Ciaglia, E., Montella, F., Lopardo, V., Scala, P., Ferrario, A., Cattaneo, M., Carrizzo, A., Malovini, A., Madeddu, P. R., Vecchione, C. & Puca, A. A., 29 May 2020, In : Frontiers in Immunology. 11, 8 p., 1034.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Downloads (Pure)

Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes

Sangalli, E., Tagliabue, E., La Sala, L., Pratichizzo, F., Uccellatore, A., Spada, D., Lorino, F., de Candia, P., Lupini, S., Cantone, L., Favero, C., Madeddu, P. R., Bollati, V., Genovese, S. & Spinetti, G., 23 Apr 2020, In : Frontiers in Endocrinology. 11, 8 p., 254.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Downloads (Pure)

Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1

Garoffolo, G., Ruiter, M. S., Piola, M., Brioschi, M., Thomas, A. C., Agrifoglio, M., Polvani, G., Coppadoro, L., Zoli, S., Saccu, C., Spinetti, G., Banfi, C., Fiore, G. B., Madeddu, P., Soncini, M. & Pesce, M., 3 Feb 2020, In : Theranostics. 10, 6, p. 2597-2611 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
25 Downloads (Pure)

Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease.

Fadini, G. P., Spinetti, G., Santopaolo, M. & Madeddu, P. R., 1 Jan 2020, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 1, p. 34–44 11 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
29 Downloads (Pure)

MicroRNA-21/PDCD4 proapoptotic signaling from circulating CD34+ cells to vascular endothelial cells: a potential contributor to adverse cardiovascular outcomes in patients with critical limb ischemia

Spinetti, G., Sangalli, E., Tagliabue, E., Maselli, D., Colpani, O., Ferland-Mccollough, D., Carnelli, F., Orlando, P., Paccagnella, A., Furlan, A., Stefani, P. M., Sambado, L., Sambataro, M. & Madeddu, P. R., 1 Jul 2020, In : Diabetes Care. 43, 7, p. 1520-1529 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Downloads (Pure)

Multi-omics analysis of diabetic heart disease in the db/db model reveals potential targets for treatment by a longevity-associated gene

Faulkner, A. R. M., Dang, Z., Avolio, E., Thomas, A. C., Batstone, T. E., Lloyd, G. R., Weber, R., Najdekr, L., Jankevics, A., Dunn, W., Spinetti, G., Vecchione, C., Puca, A. A. & Madeddu, P. R., 21 May 2020, In : Cells. 9, 5, 5 p., 1283.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Downloads (Pure)
2019

Bone marrow pericyte dysfunction in individuals with type 2 diabetes

Mangialardi, G., Ferland-McCollough, D., Maselli, D., Santopaolo, M., Cordaro, A., Spinetti, G., Sambataro, M., Sullivan, N., Blom, A. & Madeddu, P., 1 Jul 2019, In : Diabetologia. 62, 7, p. 1275-1290 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
183 Downloads (Pure)

Correction to: Bone marrow pericyte dysfunction in individuals with type 2 diabetes (Diabetologia, (2019), 62, 7, (1275-1290), 10.1007/s00125-019-4865-6)

Mangialardi, G., Ferland-McCollough, D., Maselli, D., Santopaolo, M., Cordaro, A., Spinetti, G., Sambataro, M., Sullivan, N., Blom, A. & Madeddu, P., 1 May 2019, In : Diabetologia. 62, 7, p. 1315–1315 1 p.

Research output: Contribution to journalComment/debate (Academic Journal)

LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.

Malavolta, M., Dato, S., Villa, F., De Rango, F., Iannone, F., Ferrario, A., Maciag, A., Ciaglia, E., D'amato, A., Carrizzo, A., Basso, A., Orlando, F., Provinciali, M., Madeddu, P. R., Passarino, G., Vecchione, C., Rose, G. & Puca, A. A., 28 Aug 2019, In : Aging. 11, 16, p. 6555-6568 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
112 Downloads (Pure)

miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia

Besnier, M., Shantikumar, S., Anwar, M., Dixit, P., Chamorro-Jorganes, A., Sweaad, W., Sala-Newby, G., Madeddu, P., Thomas, A. C., Howard, L., Mushtaq, S., Petretto, E., Caporali, A. & Emanueli, C., 6 Sep 2019, In : Molecular Therapy - Nucleic Acids. 17, p. 49-62 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
124 Downloads (Pure)

Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia

Dang, Z., Avolio, E., Albertario, A., Sala-Newby, G., Thomas, A., Wang, N., Emanueli, C. & Madeddu, P., 1 Jul 2019, In : Diabetologia. 62, 7, p. 1297-1311 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
267 Downloads (Pure)

Personalized Cardiovascular Regenerative Medicine: Targeting the Extreme Stages of Life

Madeddu, P. R., Avolio, E., Alvino, V. V., Santopaolo, M. & Spinetti, G., 27 Nov 2019, In : Frontiers in Cardiovascular Medicine. 6, 7 p., 177.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
57 Downloads (Pure)
Open Access
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2 Citations (Scopus)
228 Downloads (Pure)

Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity

Spencer, H. L., Jover, E., Cathery, W., Avolio, E., Rodriguez-Arabaolaza, I., Thomas, A. C., Alvino, V. V., Sala-Newby, G., Dang, Z., Fagnano, M., Reni, C., Rowlinson, J., Vono, R., Spinetti, G., Beltrami, A. P., Gargioli, C., Caporali, A., Angelini, G. & Madeddu, P., 1 Jun 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 6, p. 1113-1124 12 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism

Puca, A. A., Carrizzo, A., Spinelli, C. C., Damato, A., Ambrosio, M., Villa, F., Ferrario, A., Maciąg, A., Fornai, F., Lenzi, P., Valenti, V., di Nonno, F., Accarino, G., Madonna, M., Forte, M., Calì, G., Baragetti, A., Norata, G. D., Catapano, A. L., Cattaneo, M. & 10 others, Izzo, R., Trimarco, V., Montella, F., Versaci, F., Auricchio, A., Frati, G., Sciarretta, S., Madeddu, P., Ciaglia, E. & Vecchione, C., 10 Jul 2019, In : European Heart Journal. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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172 Downloads (Pure)

Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Albertario, A., Swim, M. M., Mohamed Ahmed, E., Iacobazzi, D., Yeong, M., Madeddu, P., Ghorbel, M. & Caputo, M., Jun 2019, In : JACC: Basic to Translational Science. 4, 3, p. 364-384 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
104 Downloads (Pure)
2018

Cell Sources for Tissue Engineering Strategies to Treat Calcific Valve Disease

Fagnano, M., Jover Garcia, E., Madeddu, P. & Angelini, G., 6 Nov 2018, In : Frontiers in Cardiovascular Medicine. 5, 27 p., 155.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
275 Downloads (Pure)

Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation

Cathery, W., Faulkner, A., Maselli, D. & Madeddu, P., Sep 2018, In : Stem Cells. 36, 9, p. 1295-1310 16 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
15 Citations (Scopus)
172 Downloads (Pure)

Current Strategies for the manufacture of Small Size Tissue Engineering Vascular Graft

Carrabba, M. & Madeddu, P., 17 Apr 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 12 p., 41.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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23 Citations (Scopus)
154 Downloads (Pure)

MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes

Ferland-McCollough, D., Maselli, D., Spinetti, G., Sambataro, M., Sullivan, N., Blom, A. & Madeddu, P., 1 Jul 2018, In : Diabetes. 67, 7, p. 1380-1394 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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14 Citations (Scopus)
162 Downloads (Pure)

MicroRNA-532 regulates pericyte function through targeting the transcription regulator BACH1 and Angiopoietin-1

Slater, S., Jover, E., Martello, A., Rodriguez-Arabaolaza, I., Alvino, V. V., Satchell, S., Madeddu, P., Spinetti, G., Caporali, A., Vono, R. & Mitić, T., 1 Sep 2018, In : Molecular Therapy. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
152 Downloads (Pure)

miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia

Besnier, M., Gasparino, S., Vono, R., Sangalli, E., Facoetti, A., Bollati, V., Cantone, L., Zaccagnini, G., Maimone, B., Fuschi, P., Da Silva, D., Schiavulli, M., Aday, S., Caputo, M., Madeddu, P., Emanueli, C., Martelli, F. & Spinetti, G., 5 Jul 2018, In : Molecular Therapy. 26, 7, p. 1694-1705 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
130 Downloads (Pure)

Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs

Vono, R., Jover Garcia, E., Spinetti, G. & Madeddu, P., 20 Sep 2018, In : Antioxidants and Redox Signaling. 29, 9, p. 864-879 16 p., ARS-2017-7294-ver9-Vono_1P.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
16 Citations (Scopus)
238 Downloads (Pure)

Pericytes and cardiac stem cells: common features and peculiarities: Common features and peculiarities

Beltrami, A. P. & Madeddu, P., 1 Jan 2018, In : Pharmacological Research. 127, p. 101-109 9 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
9 Citations (Scopus)
187 Downloads (Pure)

Transplantation of allogeneic pericytes improves myocardial vascularization and reduces interstitial fibrosis in a swine model of reperfused acute myocardial infarction

Alvino, V. V., Fernandez-Jimenez, R., Rodriguez-Arabaolaza, I., Slater, S., Mangialardi, G., Avolio, E., Spencer, H., Culliford, L., Hassan, S., Sueiro Ballesteros, L., Herman, A., Ayaon-Albarran, A., Galan-Arriola, C., Sanchez-Gonzalez, J., Hennessey, H., Delmege, C., Ascione, R., Emanueli, C., Angelini, G., Ibanez, B. & 1 others, Madeddu, P., Jan 2018, In : Journal of the American Heart Association. 7, 2, 43 p., e006727.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
285 Downloads (Pure)
2017
Open Access
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197 Downloads (Pure)

Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

Ellison-Hughes, G. M. & Madeddu, P., 1 Mar 2017, In : Pharmacology and Therapeutics. 171, 2017, p. 1-12 12 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
9 Citations (Scopus)
231 Downloads (Pure)

The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling

Riu, F., Slater, S. C., Garcia, E. J., Rodriguez-Arabaolaza, I., Alvino, V., Avolio, E., Mangialardi, G., Cordaro, A., Satchell, S., Zebele, C., Caporali, A., Angelini, G. & Madeddu, P., 14 Jul 2017, In : Scientific Reports. 7, 13 p., 5443.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
397 Downloads (Pure)

The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy

Spinetti, G., Sangalli, E., Specchia, C., Villa, F., Spinelli, C., Pipolo, R., Carrizzo, A., Greco, S., Voellenkle, C., Vecchione, C., Madeddu, P., Martelli, F. & Puca, A. A., 22 Jan 2017, In : Aging. 9, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
206 Downloads (Pure)
2016

Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia

Vono, R., Fuoco, C., Testa, S., Pirró, S., Maselli, D., McCollough, D. F., Sangalli, E., Pintus, G., Giordo, R., Finzi, G., Sessa, F., Cardani, R., Gotti, A., Losa, S., Cesareni, G., Rizzi, R., Bearzi, C., Cannata, S., Spinetti, G., Gargioli, C. & 1 others, Madeddu, P., Dec 2016, In : Diabetes. 65, 12, p. 3691-3704 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Citations (Scopus)
209 Downloads (Pure)

Bone Marrow-Derived Stem Cells: A Mixed Blessing in the Multifaceted World of Diabetic Complications

Mangialardi, G. & Madeddu, P., 1 May 2016, In : Current diabetes reports. 16, 5, 12 p., 43.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
290 Downloads (Pure)

Diabetes Stimulates Osteoclastogenesis by Acidosis-Induced Activation of Transient Receptor Potential Cation Channels

Reni, C., Mangialardi, G., Meloni, M. & Madeddu, P., 29 Jul 2016, In : Scientific Reports. 6, 12 p., 30639.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
349 Downloads (Pure)
Open Access
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15 Citations (Scopus)
206 Downloads (Pure)

In vivo enhancement of arteriogenesis using human cell-seeded scaffolds

Carrabba, M., De Maria, C., Madeddu, P. & Vozzi, G., 2016.

Research output: Contribution to conferenceConference Abstract

Novel ultrasound-based seeding method for adventitial progenitor cells onto composite scaffolds.

Carrabba, M., Vozzi, G., Drinkwater, B. & Madeddu, P., 2016.

Research output: Contribution to conferenceConference Abstract

Pericyte Seeded Dual Peptide Scaffold with Improved Endothelialization for Vascular Graft Tissue Engineering

Campagnolo, P., Gormley, A. J., Chow, L. W., Guex, A. G., Parmar, P. A., Puetzer, J. L., Steele, J. A. M., Breant, A., Madeddu, P. & Stevens, M. M., 7 Dec 2016, In : Advanced Healthcare Materials. 5, 23, p. 3046-3055 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Citations (Scopus)
159 Downloads (Pure)

Pleiotropic action of CpG-ODN on endothelium and macrophages attenuates angiogenesis through distinct pathways

Wu, J., Su, W., Powner, M. B., Liu, J., Copland, D. A., Fruttiger, M., Madeddu, P., Dick, A. D. & Liu, L., 25 Aug 2016, In : Scientific Reports. 6, 15 p., 31873.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
389 Downloads (Pure)

The bone marrow pericyte: An orchestrator of vascular niche

Mangialardi, G., Cordaro, A. & Madeddu, P., 25 Nov 2016, In : Regenerative Medicine. 11, 8, p. 883-895 13 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
14 Citations (Scopus)
209 Downloads (Pure)

The genetics of exceptional longevity identifies new druggable targets forvascular protection and repair

Puca, A. A., Spinetti, G., Vono, R., Vecchione, C. & Madeddu, P. R., Dec 2016, In : Pharmacological Research. 114, p. 169-174 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
231 Downloads (Pure)

The Peter Principle in Cardiovascular Cell Therapy

Spinetti, G. & Madeddu, P., 9 Dec 2016, In : Circulation Research. 119, 12, p. 1283-1285 3 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Vascular stem cells: Potential for clinical application

Slater, S. C., Carrabba, M. & Madeddu, P., Jun 2016, In : British Medical Bulletin. 118, 1, p. 133-143 11 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2015

A journey from basic stem cell discovery to clinical application: the case of adventitial progenitor cells

Spencer, H. L., Slater, S. C., Rowlinson, J., Morgan, T., Culliford, L. A., Guttridge, M., Emanueli, C., Angelini, G. & Madeddu, P., 2015, In : Regenerative Medicine. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart

Meloni, M., Cesselli, D., Caporali, A., Mangialardi, G., Avolio, E., Reni, C., Fortunato, O., Martini, S., Madeddu, P., Valgimigli, M., Nikolaev, E., Kaczmarek, L., Angelini, G. D., Beltrami, A. P. & Emanueli, C., 10 Sep 2015, In : Molecular Therapy.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair

Avolio, E., Meloni, M., Spencer, H. L., Riu, F., Katare, R., Mangialardi, G., Oikawa, A., Rodriguez-Arabaolaza, I., Dang, Z., Mitchell, K., Reni, C., Alvino, V. V., Rowlinson, J., Livi, U., Cesselli, D., Angelini, G., Emanueli, C., Beltrami, A. P. & Madeddu, P., 8 May 2015, In : Circulation Research. 116, 10, p. e81-e94

Research output: Contribution to journalArticle (Academic Journal)

68 Citations (Scopus)