Professor Paolo R Madeddu

  • BS2 8HW

19992020

Research output per year

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Research Output

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Article (Academic Journal)
2020

Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

Santopaolo, M., Sullivan, N., Thomas, A. C., Alvino, V. V., Nicholson, L. B., Gu, Y., Spinetti, G., Kallikourdis, M., Blom, A. W. & Madeddu, P. R., 3 Jul 2020, (Submitted) In : Diabetologia.

Research output: Contribution to journalArticle (Academic Journal)

Circulating BPIFB4 levels associate with and influence the abundance of reparative monocytes and macrophages in long living individuals

Ciaglia, E., Montella, F., Lopardo, V., Scala, P., Ferrario, A., Cattaneo, M., Carrizzo, A., Malovini, A., Madeddu, P. R., Vecchione, C. & Puca, A. A., 29 May 2020, In : Frontiers in Immunology. 11, 8 p., 1034.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)

Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes

Sangalli, E., Tagliabue, E., La Sala, L., Pratichizzo, F., Uccellatore, A., Spada, D., Lorino, F., de Candia, P., Lupini, S., Cantone, L., Favero, C., Madeddu, P. R., Bollati, V., Genovese, S. & Spinetti, G., 23 Apr 2020, In : Frontiers in Endocrinology. 11, 8 p., 254.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Downloads (Pure)

Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1

Garoffolo, G., Ruiter, M. S., Piola, M., Brioschi, M., Thomas, A. C., Agrifoglio, M., Polvani, G., Coppadoro, L., Zoli, S., Saccu, C., Spinetti, G., Banfi, C., Fiore, G. B., Madeddu, P., Soncini, M. & Pesce, M., 3 Feb 2020, In : Theranostics. 10, 6, p. 2597-2611 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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35 Downloads (Pure)

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

Faulkner, A. R. M., Tamiato, A., Cathery, W. R., Rampin, A., Caravaggi, C. M., Jover Garcia, E., Allen, S., Mellor, H. H., Hauton, D., Heather, L. C., Spinetti, G. & Madeddu, P. R., 30 Jul 2020, In : Diabetologia.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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Open Access
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36 Downloads (Pure)

MicroRNA-21/PDCD4 proapoptotic signaling from circulating CD34+ cells to vascular endothelial cells: a potential contributor to adverse cardiovascular outcomes in patients with critical limb ischemia

Spinetti, G., Sangalli, E., Tagliabue, E., Maselli, D., Colpani, O., Ferland-Mccollough, D., Carnelli, F., Orlando, P., Paccagnella, A., Furlan, A., Stefani, P. M., Sambado, L., Sambataro, M. & Madeddu, P. R., 1 Jul 2020, In : Diabetes Care. 43, 7, p. 1520-1529 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Downloads (Pure)

Multi-omics analysis of diabetic heart disease in the db/db model reveals potential targets for treatment by a longevity-associated gene

Faulkner, A. R. M., Dang, Z., Avolio, E., Thomas, A. C., Batstone, T. E., Lloyd, G. R., Weber, R., Najdekr, L., Jankevics, A., Dunn, W., Spinetti, G., Vecchione, C., Puca, A. A. & Madeddu, P. R., 21 May 2020, In : Cells. 9, 5, 5 p., 1283.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
21 Downloads (Pure)
2019

Bone marrow pericyte dysfunction in individuals with type 2 diabetes

Mangialardi, G., Ferland-McCollough, D., Maselli, D., Santopaolo, M., Cordaro, A., Spinetti, G., Sambataro, M., Sullivan, N., Blom, A. & Madeddu, P., 1 Jul 2019, In : Diabetologia. 62, 7, p. 1275-1290 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
185 Downloads (Pure)

LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.

Malavolta, M., Dato, S., Villa, F., De Rango, F., Iannone, F., Ferrario, A., Maciag, A., Ciaglia, E., D'amato, A., Carrizzo, A., Basso, A., Orlando, F., Provinciali, M., Madeddu, P. R., Passarino, G., Vecchione, C., Rose, G. & Puca, A. A., 28 Aug 2019, In : Aging. 11, 16, p. 6555-6568 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
119 Downloads (Pure)

miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia

Besnier, M., Shantikumar, S., Anwar, M., Dixit, P., Chamorro-Jorganes, A., Sweaad, W., Sala-Newby, G., Madeddu, P., Thomas, A. C., Howard, L., Mushtaq, S., Petretto, E., Caporali, A. & Emanueli, C., 6 Sep 2019, In : Molecular Therapy - Nucleic Acids. 17, p. 49-62 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
127 Downloads (Pure)

Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia

Dang, Z., Avolio, E., Albertario, A., Sala-Newby, G., Thomas, A., Wang, N., Emanueli, C. & Madeddu, P., 1 Jul 2019, In : Diabetologia. 62, 7, p. 1297-1311 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
288 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
241 Downloads (Pure)

Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity

Spencer, H. L., Jover, E., Cathery, W., Avolio, E., Rodriguez-Arabaolaza, I., Thomas, A. C., Alvino, V. V., Sala-Newby, G., Dang, Z., Fagnano, M., Reni, C., Rowlinson, J., Vono, R., Spinetti, G., Beltrami, A. P., Gargioli, C., Caporali, A., Angelini, G. & Madeddu, P., 1 Jun 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 6, p. 1113-1124 12 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism

Puca, A. A., Carrizzo, A., Spinelli, C. C., Damato, A., Ambrosio, M., Villa, F., Ferrario, A., Maciąg, A., Fornai, F., Lenzi, P., Valenti, V., di Nonno, F., Accarino, G., Madonna, M., Forte, M., Calì, G., Baragetti, A., Norata, G. D., Catapano, A. L., Cattaneo, M. & 10 others, Izzo, R., Trimarco, V., Montella, F., Versaci, F., Auricchio, A., Frati, G., Sciarretta, S., Madeddu, P., Ciaglia, E. & Vecchione, C., 10 Jul 2019, In : European Heart Journal. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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183 Downloads (Pure)

Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Albertario, A., Swim, M. M., Mohamed Ahmed, E., Iacobazzi, D., Yeong, M., Madeddu, P., Ghorbel, M. & Caputo, M., Jun 2019, In : JACC: Basic to Translational Science. 4, 3, p. 364-384 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
107 Downloads (Pure)
2018

Cell Sources for Tissue Engineering Strategies to Treat Calcific Valve Disease

Fagnano, M., Jover Garcia, E., Madeddu, P. & Angelini, G., 6 Nov 2018, In : Frontiers in Cardiovascular Medicine. 5, 27 p., 155.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
278 Downloads (Pure)

MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes

Ferland-McCollough, D., Maselli, D., Spinetti, G., Sambataro, M., Sullivan, N., Blom, A. & Madeddu, P., 1 Jul 2018, In : Diabetes. 67, 7, p. 1380-1394 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
169 Downloads (Pure)

MicroRNA-532 regulates pericyte function through targeting the transcription regulator BACH1 and Angiopoietin-1

Slater, S., Jover, E., Martello, A., Rodriguez-Arabaolaza, I., Alvino, V. V., Satchell, S., Madeddu, P., Spinetti, G., Caporali, A., Vono, R. & Mitić, T., 1 Sep 2018, In : Molecular Therapy. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
155 Downloads (Pure)

miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia

Besnier, M., Gasparino, S., Vono, R., Sangalli, E., Facoetti, A., Bollati, V., Cantone, L., Zaccagnini, G., Maimone, B., Fuschi, P., Da Silva, D., Schiavulli, M., Aday, S., Caputo, M., Madeddu, P., Emanueli, C., Martelli, F. & Spinetti, G., 5 Jul 2018, In : Molecular Therapy. 26, 7, p. 1694-1705 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
132 Downloads (Pure)

Transplantation of allogeneic pericytes improves myocardial vascularization and reduces interstitial fibrosis in a swine model of reperfused acute myocardial infarction

Alvino, V. V., Fernandez-Jimenez, R., Rodriguez-Arabaolaza, I., Slater, S., Mangialardi, G., Avolio, E., Spencer, H., Culliford, L., Hassan, S., Sueiro Ballesteros, L., Herman, A., Ayaon-Albarran, A., Galan-Arriola, C., Sanchez-Gonzalez, J., Hennessey, H., Delmege, C., Ascione, R., Emanueli, C., Angelini, G., Ibanez, B. & 1 others, Madeddu, P., Jan 2018, In : Journal of the American Heart Association. 7, 2, 43 p., e006727.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
293 Downloads (Pure)
2017

The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling

Riu, F., Slater, S. C., Garcia, E. J., Rodriguez-Arabaolaza, I., Alvino, V., Avolio, E., Mangialardi, G., Cordaro, A., Satchell, S., Zebele, C., Caporali, A., Angelini, G. & Madeddu, P., 14 Jul 2017, In : Scientific Reports. 7, 13 p., 5443.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
408 Downloads (Pure)

The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy

Spinetti, G., Sangalli, E., Specchia, C., Villa, F., Spinelli, C., Pipolo, R., Carrizzo, A., Greco, S., Voellenkle, C., Vecchione, C., Madeddu, P., Martelli, F. & Puca, A. A., 22 Jan 2017, In : Aging. 9, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
210 Downloads (Pure)
2016

Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia

Vono, R., Fuoco, C., Testa, S., Pirró, S., Maselli, D., McCollough, D. F., Sangalli, E., Pintus, G., Giordo, R., Finzi, G., Sessa, F., Cardani, R., Gotti, A., Losa, S., Cesareni, G., Rizzi, R., Bearzi, C., Cannata, S., Spinetti, G., Gargioli, C. & 1 others, Madeddu, P., Dec 2016, In : Diabetes. 65, 12, p. 3691-3704 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Citations (Scopus)
214 Downloads (Pure)

Bone Marrow-Derived Stem Cells: A Mixed Blessing in the Multifaceted World of Diabetic Complications

Mangialardi, G. & Madeddu, P., 1 May 2016, In : Current diabetes reports. 16, 5, 12 p., 43.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
292 Downloads (Pure)

Diabetes Stimulates Osteoclastogenesis by Acidosis-Induced Activation of Transient Receptor Potential Cation Channels

Reni, C., Mangialardi, G., Meloni, M. & Madeddu, P., 29 Jul 2016, In : Scientific Reports. 6, 12 p., 30639.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
351 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
209 Downloads (Pure)

Pericyte Seeded Dual Peptide Scaffold with Improved Endothelialization for Vascular Graft Tissue Engineering

Campagnolo, P., Gormley, A. J., Chow, L. W., Guex, A. G., Parmar, P. A., Puetzer, J. L., Steele, J. A. M., Breant, A., Madeddu, P. & Stevens, M. M., 7 Dec 2016, In : Advanced Healthcare Materials. 5, 23, p. 3046-3055 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
163 Downloads (Pure)

Pleiotropic action of CpG-ODN on endothelium and macrophages attenuates angiogenesis through distinct pathways

Wu, J., Su, W., Powner, M. B., Liu, J., Copland, D. A., Fruttiger, M., Madeddu, P., Dick, A. D. & Liu, L., 25 Aug 2016, In : Scientific Reports. 6, 15 p., 31873.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
394 Downloads (Pure)

The genetics of exceptional longevity identifies new druggable targets forvascular protection and repair

Puca, A. A., Spinetti, G., Vono, R., Vecchione, C. & Madeddu, P. R., Dec 2016, In : Pharmacological Research. 114, p. 169-174 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
238 Downloads (Pure)

Vascular stem cells: Potential for clinical application

Slater, S. C., Carrabba, M. & Madeddu, P., Jun 2016, In : British Medical Bulletin. 118, 1, p. 133-143 11 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2015

A journey from basic stem cell discovery to clinical application: the case of adventitial progenitor cells

Spencer, H. L., Slater, S. C., Rowlinson, J., Morgan, T., Culliford, L. A., Guttridge, M., Emanueli, C., Angelini, G. & Madeddu, P., 2015, In : Regenerative Medicine. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart

Meloni, M., Cesselli, D., Caporali, A., Mangialardi, G., Avolio, E., Reni, C., Fortunato, O., Martini, S., Madeddu, P., Valgimigli, M., Nikolaev, E., Kaczmarek, L., Angelini, G. D., Beltrami, A. P. & Emanueli, C., 10 Sep 2015, In : Molecular Therapy.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair

Avolio, E., Meloni, M., Spencer, H. L., Riu, F., Katare, R., Mangialardi, G., Oikawa, A., Rodriguez-Arabaolaza, I., Dang, Z., Mitchell, K., Reni, C., Alvino, V. V., Rowlinson, J., Livi, U., Cesselli, D., Angelini, G., Emanueli, C., Beltrami, A. P. & Madeddu, P., 8 May 2015, In : Circulation Research. 116, 10, p. e81-e94

Research output: Contribution to journalArticle (Academic Journal)

69 Citations (Scopus)

Data supporting the activation of autophagy genes in the diabetic heart

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., Emanueli, C., Madeddu, P. & Katare, R., Dec 2015, In : Data in Brief. 5, p. 269-75 7 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Enhancing Stem Cell Mobility: New Hope for Treatment of Cardiovascular Complications in Patients With Diabetes?

Spinetti, G., Mangialardi, G., Specchia, C. & Madeddu, P., Aug 2015, In : Diabetes. 64, 8, p. 2704-7 4 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia

Gubernator, M., Slater, S. C., Spencer, H. L., Spiteri, I., Sottoriva, A., Riu, F., Rowlinson, J., Avolio, E., Katare, R., Mangialardi, G., Oikawa, A., Reni, C., Campagnolo, P., Spinetti, G., Touloumis, A., Tavaré, S., Prandi, F., Pesce, M., Hofner, M., Klemens, V. & 3 others, Emanueli, C., Angelini, G. & Madeddu, P., Mar 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 3, p. 675-88 14 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C. & 2 others, Caputo, M. & Madeddu, P., 2015, In : Journal of the American Heart Association. 4, 6

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Extending flaps lifts an infarcted heart toward repair

Angelini, G., Caputo, M. & Madeddu, P., Feb 2015, In : Molecular Therapy. 23, 2, p. 223-5 3 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis

Villa, F., Carrizzo, A., Spinelli, C. C., Ferrario, A., Malovini, A., Maciąg, A., Damato, A., Auricchio, A., Spinetti, G., Sangalli, E., Dang, Z., Madonna, M., Ambrosio, M., Sitia, L., Bigini, P., Calì, G., Schreiber, S., Perls, T., Fucile, S., Mulas, F. & 5 others, Nebel, A., Bellazzi, R., Madeddu, P., Vecchione, C. & Puca, A. A., 31 Jul 2015, In : Circulation Research. 117, 4, p. 333-345 13 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction

Ascione, R., Rowlinson, J., Avolio, E., Katare, R., Meloni, M., Spencer, H. L., Mangialardi, G., Norris, C., Kränkel, N., Spinetti, G., Emanueli, C. & Madeddu, P., 11 Apr 2015, In : Stem Cell Research and Therapy. 6, p. 53

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
10 Downloads (Pure)

p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia

Caporali, A., Meloni, M., Nailor, A., Mitić, T., Shantikumar, S., Riu, F., Sala-Newby, G. B., Rose, L., Besnier, M., Katare, R., Voellenkle, C., Verkade, P., Martelli, F., Madeddu, P. & Emanueli, C., 13 Aug 2015, In : Nature Communications. 6, 8024.

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)
9 Downloads (Pure)

Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes

Dang, Z., Maselli, D., Spinetti, G., Sangalli, E., Carnelli, F., Rosa, F., Seganfreddo, E., Canal, F., Furlan, A., Paccagnella, A., Paiola, E., Lorusso, B., Specchia, C., Albiero, M., Cappellari, R., Avogaro, A., Falco, A., Quaini, F., Ou, K., Rodriguez-Arabaolaza, I. & 4 others, Emanueli, C., Sambataro, M., Fadini, G. P. & Madeddu, P., 10 Oct 2015, In : Diabetologia. 58, 11, p. 2653-62 10 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
12 Downloads (Pure)
24 Citations (Scopus)
1 Citation (Scopus)

Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., Emanueli, C., Madeddu, P. & Katare, R., 10 Aug 2015, In : International Journal of Cardiology. 202, p. 13-20 8 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)