Projects per year
Personal profile
Research interests
My lab used the nematode C. elegans as a model organism for biomedical studies. Our studies helped to establish that a signal transduction pathway sharing homology with the vertebrate Hedgehog/Patched (Hh/Ptc) signalling pathway underlies sexual cell fate decisions. These studies led to our current research on the role of PTC and PTC-related proteins in cell proliferation, osmolarity control and innate immunity. We are currently taking advantage of the local expertise at Bristol in mitochondrial biochemistry and using the genetic and cell biological tractability of C. elegans to explore the structure and function of mitochondrial protein transporters and their roles in lifespan extension.
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- 1 Similar Profiles
Projects
- 2 Finished
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FUNCTIONAL ANALYSIS OF CELL SIGNALLING AND REGULATORY PROTEOLYSIS IN C. ELEGANS DEVELOPMENT AND REPRODUCTION
1/11/03 → 1/10/06
Project: Research
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Maintenance of Complex I and its super-complexes by NDUF-11 is essential for mitochondrial structure, function and health
Knapp-Wilson, A. L., C. Pereira, G., Buzzard, E. J., Ford, H. C., Neal, C. R., Verkade, P., Halestrap, A. P., Gold, V. A. M., Kuwabara, P. E. & Collinson, I. R., 28 May 2021, (Accepted/In press) In: Journal of Cell Science.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile25 Downloads (Pure) -
A genome-wide collection of Mos1 transposon insertion mutants for the C. elegans research community
Vallin, E., Gallagher, J., Granger, L., Martin, E., Belougne, J., Maurizio, J., Duverger, Y., Scaglione, S., Borrel, C., Cortier, E., Abouzid, K., Carre-Pierrat, M., Gieseler, K., Ségalat, L., Kuwabara, P. E. & Ewbank, J. J., Feb 2012, In: PLoS ONE. 7, 2, p. e30482 - e30482 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
33 Citations (Scopus) -
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration
Joyce, P. I., Satija, R., Chen, M. C. & Kuwabara, P. E., Mar 2012, In: PLoS Genetics. 8, 3, p. 1-16 e1002602.Research output: Contribution to journal › Article (Academic Journal) › peer-review
15 Citations (Scopus)
Activities
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2015 C. elegans International Meeing
Patricia E Kuwabara (Member of programme committee)
24 Jun 2015 → 28 Jun 2015Activity: Participating in or organising an event types › Participation in conference
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The 24th International Conference on Arginine and Pyrimidines
Patricia E Kuwabara (Invited speaker)
16 Jul 2014 → 19 Jul 2014Activity: Participating in or organising an event types › Participation in conference
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Genetics Society Spring Meeting 2012
Patricia E Kuwabara (Organiser)
20 Apr 2012Activity: Participating in or organising an event types › Participation in conference