Professor Patricia E Kuwabara

B.A.(Johns Hopkins), Ph.D.(Penn.)

  • BS8 1TD

20022012

Research output per year

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Personal profile

Research interests

My lab used the nematode C. elegans as a model organism for biomedical studies. Our studies helped to establish that a signal transduction pathway sharing homology with the vertebrate Hedgehog/Patched (Hh/Ptc) signalling pathway underlies sexual cell fate decisions. These studies led to our current research on the role of PTC and PTC-related proteins in cell proliferation, osmolarity control and innate immunity. We are currently taking advantage of the local expertise at Bristol in mitochondrial biochemistry and using the genetic and cell biological tractability of C. elegans to explore the structure and function of mitochondrial protein transporters and their roles in lifespan extension. 

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Projects

Research Output

  • 11 Article (Academic Journal)
  • 1 Chapter in a book

A genome-wide collection of Mos1 transposon insertion mutants for the C. elegans research community

Vallin, E., Gallagher, J., Granger, L., Martin, E., Belougne, J., Maurizio, J., Duverger, Y., Scaglione, S., Borrel, C., Cortier, E., Abouzid, K., Carre-Pierrat, M., Gieseler, K., Ségalat, L., Kuwabara, P. E. & Ewbank, J. J., Feb 2012, In : PLoS ONE. 7, 2, p. e30482 - e30482 9 p.

Research output: Contribution to journalArticle (Academic Journal)

  • 30 Citations (Scopus)

    The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration

    Joyce, P. I., Satija, R., Chen, M. C. & Kuwabara, P. E., Mar 2012, In : PLoS Genetics. 8, 3, p. 1-16 e1002602.

    Research output: Contribution to journalArticle (Academic Journal)

  • 14 Citations (Scopus)

    C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain

    Soloviev, A., Gallagher, J., Marnef, A. & Kuwabara, P. E., Mar 2011, In : Developmental Biology. 351 , 2, p. 242 - 253 12 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 10 Citations (Scopus)

    Activities

    • 3 Participation in conference
    • 3 Editorial activity
    • 1 Advisory work for/on national or international committee or working group

    2015 C. elegans International Meeing

    Patricia E Kuwabara (Member of programme committee)

    24 Jun 201528 Jun 2015

    Activity: Participating in or organising an event typesParticipation in conference

    The 24th International Conference on Arginine and Pyrimidines

    Patricia E Kuwabara (Invited speaker)

    16 Jul 201419 Jul 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Genetics Society Spring Meeting 2012

    Patricia E Kuwabara (Organiser)

    20 Apr 2012

    Activity: Participating in or organising an event typesParticipation in conference