Professor Patricia E Kuwabara

B.A.(Johns Hopkins), Ph.D.(Penn.)

Fundamental Bioscience
Dynamic Cell Biology
William P. Coldrick Chair in Genomics, School of Biochemistry

EmailP.Kuwabara@bristol.ac.uk

BS8 1TD

Research output per year

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Personal profile

Research interests

My lab used the nematode C. elegans as a model organism for biomedical studies. Our studies helped to establish that a signal transduction pathway sharing homology with the vertebrate Hedgehog/Patched (Hh/Ptc) signalling pathway underlies sexual cell fate decisions. These studies led to our current research on the role of PTC and PTC-related proteins in cell proliferation, osmolarity control and innate immunity. We are currently taking advantage of the local expertise at Bristol in mitochondrial biochemistry and using the genetic and cell biological tractability of C. elegans to explore the structure and function of mitochondrial protein transporters and their roles in lifespan extension.

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Projects

2 Finished

THE ROLES OF C ELEGANS PATCHED FAMILY GENES IN CELL DIVISION

Kuwabara, P. E.

1/09/08 → 1/09/11

Project: Research

FUNCTIONAL ANALYSIS OF CELL SIGNALLING AND REGULATORY PROTEOLYSIS IN C. ELEGANS DEVELOPMENT AND REPRODUCTION

Kuwabara, P. E.

1/11/03 → 1/10/06

Project: Research

Research Output

11 Article (Academic Journal)
1 Chapter in a book

A genome-wide collection of Mos1 transposon insertion mutants for the C. elegans research community

Vallin, E., Gallagher, J., Granger, L., Martin, E., Belougne, J., Maurizio, J., Duverger, Y., Scaglione, S., Borrel, C., Cortier, E., Abouzid, K., Carre-Pierrat, M., Gieseler, K., Ségalat, L., Kuwabara, P. E. & Ewbank, J. J., Feb 2012, In : PLoS ONE. 7, 2, p. e30482 - e30482 9 p.

Research output: Contribution to journal › Article (Academic Journal)

30 Citations (Scopus)

The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration

Joyce, P. I., Satija, R., Chen, M. C. & Kuwabara, P. E., Mar 2012, In : PLoS Genetics. 8, 3, p. 1-16 e1002602.

Research output: Contribution to journal › Article (Academic Journal)

14 Citations (Scopus)

C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain

Soloviev, A., Gallagher, J., Marnef, A. & Kuwabara, P. E., Mar 2011, In : Developmental Biology. 351 , 2, p. 242 - 253 12 p.

Research output: Contribution to journal › Article (Academic Journal)

10 Citations (Scopus)

Activities

3 Participation in conference
3 Editorial activity
1 Advisory work for/on national or international committee or working group

2015 C. elegans International Meeing

Patricia E Kuwabara (Member of programme committee)

24 Jun 2015 → 28 Jun 2015

Activity: Participating in or organising an event types › Participation in conference

The 24th International Conference on Arginine and Pyrimidines

Patricia E Kuwabara (Invited speaker)

16 Jul 2014 → 19 Jul 2014

Activity: Participating in or organising an event types › Participation in conference

Genetics Society Spring Meeting 2012

Patricia E Kuwabara (Organiser)

20 Apr 2012

Activity: Participating in or organising an event types › Participation in conference