Paul B Martin

2024

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

Yarmolinsky, J., Robinson, J. W., Mariosa, D., Karhunen, V., Huang, J., Dimou, N. L., Murphy, N., Burrows, K., Bouras, E., Smith-Byrne, K., Lewis, S. J., Galesloot, T. E., Kiemeney, L. A., Vermeulen, S., Martin, P. B., Albanes, D., Hou, L., Newcomb, P. A., White, E. & Wolk, A. & 21 others, Wu, A. H., Le Marchand, L., Phipps, A. I., Buchanan, D. D., Consortium, I. L. C., The PRACTICAL, C., Zhao, S. S., Gill, D., Chanock, S. J., Purdue, M. P., Davey Smith, G., Brennan, P., Herzig, K.-H., Järvelin, M.-R., Amos, C. I., Hung, R. J., Dehghan, A., Johannson, M., Gunter, M. J., Tsilidis, K. & Martin, R. M., 31 Jan 2024, (E-pub ahead of print) In: EBioMedicine. 100, 21 p., 104991.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

2023

Live imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation

Ward, J. R. R. & Martin, P. B., 28 Sept 2023, In: Journal of Cell Science. 136, 18, jcs261225.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Parallel repair mechanisms in plants and animals

Byatt, T. C. & Martin, P. B., 1 Jan 2023, In: Disease Models and Mechanisms. 16, 1, dmm049801.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

2022

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

PRACTICAL Consortium, Bouras, E., Karhunen, V., Gill, D., Huang, J., Haycock, P. C., Gunter , M. J., Johansson, M. J., Brennan, P., Key, T. J., Lewis, S. J., Martin, R. M., Murphy, N., Platz, E. A., Travis , R. C., Yarmolinsky, J., Zuber, V., Martin, P. B., Katsoulis, M. & Freisling, H. & 19 others, Nøst, T. H., Schulze, M. B., Dossus, L., Hung, R. J., Amos, C. I., Ahola-Olli, A. V., Palaniswamy, S., Männikkö, M., Auvinen, J., Herzig, K.-H., Keinänen-Kiukaanniemi, S., Lehtimäki, T., Salomaa, V., Raitakari, O., Salmi, M., Jalkanen, S., Jarvelin, M.-R., Dehghan, A. & Tsilidis , K. K., 11 Jan 2022, In: BMC Medicine. 20, 1, 15 p., 3 (2022) .

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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74 Citations (Scopus)

102 Downloads (Pure)

Fluctuations of cell geometry and their non-equilibrium thermodynamics in living epithelial tissue

Olenik, M., Turley, J. M., Cross, S., Weavers, H., Martin, P. B., Chenchiah, I. V. & Liverpool, T. B., 18 Nov 2022, (Accepted/In press) In: Physical Review E.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Macrophage Reprogramming with Anti-miR223-Loaded Artificial Protocells Enhances In Vivo Cancer Therapeutic Potential

López-Cuevas, P., Xu, C., Severn, C. E., Oates, T. C. L., Cross, S. J., Toye, A. M., Mann, S. & Martin, P., 19 Dec 2022, In: Advanced Science. 9, 35, 20 p., 2202717.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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5 Citations (Scopus)

104 Downloads (Pure)

What good is maths in studies of wound healing?

Turley, J. M., Chenchiah, I. V., Liverpool, T. B., Weavers, H. & Martin, P. B., 19 Aug 2022, In: iScience. 25, 8, 10 p., 104778.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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4 Citations (Scopus)

69 Downloads (Pure)

Wound Healing Insights from Flies and Fish

George, A. V. A. & Martin, P. B., 11 Jul 2022, In: Cold Spring Harbor Perspectives in Biology. 14, 11, p. 1-17 17 p., a041217.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

2021

Modulating the inflammatory response to wounds and cancer through infection

Lopez Cuevas, F., Cross, S. & Martin, P. B., 30 Apr 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 676193.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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7 Citations (Scopus)

99 Downloads (Pure)

2020

Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish

Bevan, L., Lim, Z. W., Venkatesh, B., Riley, P. R., Martin, P. & Richardson, R., 1 Jun 2020, In: Cardiovascular Research. 116, 7, p. 1357-1371 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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87 Citations (Scopus)

510 Downloads (Pure)

2019

Cell migration by swimming: Drosophila adipocytes as a new in vivo model of adhesion-independent motility

Martin, P. B., Wood, W. J. & Franz, A., 4 Dec 2019, (E-pub ahead of print) In: Seminars in Cell and Developmental Biology. 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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4 Citations (Scopus)

261 Downloads (Pure)

Injury Activates a Dynamic Cytoprotective Network to Confer Stress Resilience and Drive Repair

Weavers, H., Wood, W. & Martin, P., 18 Nov 2019, In: Current Biology. 29, 22, p. 3851-3862.e4 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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27 Citations (Scopus)

237 Downloads (Pure)

Live imaging the foreign body response in zebrafish reveals how dampening inflammation reduces fibrosis

Gurevich, D. B., French, K. E., Collin, J. D., Cross, S. J. & Martin, P., 26 Sept 2019, In: Journal of Cell Science. 133, 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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26 Citations (Scopus)

154 Downloads (Pure)

Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation

Van Den Berg, M., MacCarthy-Morrogh, L., Carter, D., Morris, J., Ribeiro Bravo, I., Feng, Y. & Martin, P., 4 Jun 2019, In: Cell Reports. 27, 10, p. 2837-2846.e4 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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29 Citations (Scopus)

341 Downloads (Pure)

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

Burzynski, L. C., Humphry, M., Pyrillou, K., Wiggins, K. A., Chan, J. N. E., Figg, N., Kitt, L. L., Summers, C., Tatham, K. C., Martin, P. B., Bennett, M. R. & Clarke, M. C. H., 16 Apr 2019, In: Immunity. 50, 4, p. 1033-1042.e6 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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160 Citations (Scopus)

361 Downloads (Pure)

2018

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis

Greenhough, A., Bagley, C., Heesom, K., Gurevich, D., Gay, D., Bond, M., Collard, T., Paraskeva, C., Martin, P., Sansom, O. J., Malik, K. & Williams, A., 1 Nov 2018, In: EMBO Molecular Medicine. 10, 11, 13 p., e8699.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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67 Citations (Scopus)

443 Downloads (Pure)

Drosophila immune cells extravasate from vessels to wounds using Tre1 GPCR and Rho signaling

Thuma, L., Carter, D., Weavers, H. & Martin, P., 3 Sept 2018, In: Journal of Cell Biology. 217, 9, 12 p., 3045.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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24 Citations (Scopus)

365 Downloads (Pure)

Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection

Franz, A., Wood, W. & Martin, P., 26 Feb 2018, In: Developmental Cell. 44, 4, p. 460-470.e3 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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82 Citations (Scopus)

393 Downloads (Pure)

Host-Biomaterial Interactions in Zebrafish

Witherel, C. E., Gurevich, D., Collin, J. D., Martin, P. & Spiller, K. L., 9 Apr 2018, In: ACS Biomaterials Science and Engineering. 4, 4, p. 1233-1240 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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16 Citations (Scopus)

741 Downloads (Pure)

Live imaging of collagen deposition during skin development and repair in a collagen I – GFP fusion transgenic zebrafish line

Morris, J., Cross, S., Lu, Y., Kadler, K. E., Lu, Y., Dallas, S. & Martin, P., 1 Sept 2018, In: Developmental Biology. 441, 1, p. 4-11 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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35 Citations (Scopus)

347 Downloads (Pure)

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

Gurevich, D., Severn, C., Twomey, C., Greenhough, A., Cash, J., Toye, A., Mellor, H. & Martin, P., 2 Jul 2018, In: EMBO Journal. 37, 13, 23 p., e97786.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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182 Citations (Scopus)

529 Downloads (Pure)

Long-term in vivo tracking of inflammatory cell dynamics within drosophila pupae

Weavers, H., Franz, A., Wood, W. & Martin, P., 14 Jun 2018, In: Journal of Visualized Experiments. 2018, 136, 10 p., e57871.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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8 Citations (Scopus)

349 Downloads (Pure)

Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds

de Kerckhove, M., Tanaka, K., Umehara, T., Okamoto, M., Kanematsu, S., Hayashi, H., Yano, H., Nishiura, S., Tooyama, S., Matsubayashi, Y., Komatsu, T., Park, S., Okada, Y., Takahashi, R., Kawano, Y., Hanawa, T., Iwasaki, K., Nozaki, T., Torigoe, H. & Ikematsu, K. & 5 others, Suzuki, Y., Tanaka, K., Martin, P., Shimokawa, I. & Mori, R., 1 Oct 2018, In: EMBO Molecular Medicine. 10, 10, 21 p., e9024.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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38 Citations (Scopus)

262 Downloads (Pure)

2017

Inflammation and metabolism in tissue repair and regeneration

Eming, S. A., Wynn, T. A. & Martin, P., 9 Jun 2017, In: Science. 356, 6342, p. 1026-12030 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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831 Citations (Scopus)

2659 Downloads (Pure)

Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Wood, W. & Martin, P., 6 Feb 2017, In: Developmental Cell. 40, 3, p. 221-233 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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68 Citations (Scopus)

457 Downloads (Pure)

MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton

Tanaka, K., Kim, S. E., Yano, H., Matsumoto, G., Ohuchida, R., Ishikura, Y., Araki, M., Araki, K., Park, S., Komatsu, T., Hayashi, H., Ikematsu, K., Tanaka, K., Hirano, A., Martin, P., Shimokawa, I. & Mori, R., Apr 2017, In: Journal of Investigative Dermatology. 137, 4, p. 931–940 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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44 Citations (Scopus)

334 Downloads (Pure)

2016

Accurate Reconstruction of Cell and Particle Tracks from 3D Live Imaging Data

Liepe, J., Sim, A., Weavers, H., Ward, L., Martin, P. & Stumpf, M. H., 27 Jul 2016, In: Cell Systems. 3, 1, p. 102-107 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

344 Downloads (Pure)

Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response

Weavers, H., Evans, I. R., Martin, P. & Wood, W., 16 Jun 2016, In: Cell. 165, 7, p. 1658-1671 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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153 Citations (Scopus)

593 Downloads (Pure)

Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient

Weavers, H., Liepe, J., Sim, A., Wood, W., Martin, P. & Stumpf, M. H., 8 Aug 2016, In: Current Biology. 26, 15, p. 1975-1989 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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42 Citations (Scopus)

488 Downloads (Pure)

2015

Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization

Nunan, R., Campbell, J., Mori, R., Pitulescu, M. E., Jiang, W. G., Harding, K. G., Adams, R. H., Nobes, C. D. & Martin, P. B., 17 Nov 2015, In: Cell Reports. 13, 7, p. 1380–1395 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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59 Citations (Scopus)

479 Downloads (Pure)

Imaging innate immune responses at tumour initiation: new insights from fish and flies

Feng, Y. & Martin, P., Sept 2015, In: Nature Reviews Cancer. 15, 9, p. 556-62 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

38 Citations (Scopus)

The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

Antonio, N., Bønnelykke-Behrndtz, M. L., Ward, L. C., Collin, J., Christensen, I. J., Steiniche, T., Schmidt, H., Feng, Y. & Martin, P., 2 Sept 2015, In: EMBO Journal. 34, 17, p. 2219-2236 18 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

200 Citations (Scopus)

2014

Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity

Nunan, R., Harding, K. G. & Martin, P., Nov 2014, In: Disease Models and Mechanisms. 7, 11, p. 1205-13 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

342 Citations (Scopus)

Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation

Razzell, W., Wood, W. & Martin, P., May 2014, In: Development (Cambridge). 141, 9, p. 1814-1820 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Reduced FOXO1 Expression Accelerates Skin Wound Healing and Attenuates Scarring

Mori, R., Tanaka, K., de Kerckhove, M., Okamoto, M., Kashiyama, K., Tanaka, K., Kim, S., Kawata, T., Komatsu, T., Park, S., Ikematsu, K., Hirano, A., Martin, P. & Shimokawa, I., Sept 2014, In: American Journal of Pathology. 184, 9, p. 2465-79 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

55 Citations (Scopus)

Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring

Cash, J. L., Bass, M. D., Campbell, J., Barnes, M., Kubes, P. & Martin, P. B., 16 Jun 2014, In: Current Biology. 24, 12, p. 1406-14 9 p.

Research output: Contribution to journal › Article (Academic Journal)

57 Citations (Scopus)

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P. & Tomic-Canic, M., 3 Dec 2014, In: Science Translational Medicine. 6, 265, p. 265sr6

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2204 Citations (Scopus)

2013

Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release

Razzell, W., Evans, I. R., Martin, P. & Wood, W. J., 4 Mar 2013, In: Current Biology. 23, 5, p. 424-9 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

250 Citations (Scopus)

Inflammation drives wound hyperpigmentation in zebrafish by recruiting pigment cells to sites of tissue damage

Lévesque, M., Feng, Y., Jones, R. A. & Martin, P., Mar 2013, In: Disease Models and Mechanisms. 6, 2, p. 508-15 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

69 Citations (Scopus)

Modelling of human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using in vivo live imaging

Jones, R. A., Feng, Y., Worth, A. J., Thrasher, A. J., Burns, S. O. & Martin, P., 15 Sept 2013, In: Journal of Cell Science. 126, Pt 18, p. 4077-84 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)

Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing

Smart, N., Dubé, K. N., Bollini, S., Evans, H. G., Taams, L. S., Richardson, R., Lévesque, M., Martin, P., Mills, K., Riegler, J., Price, A. N., Lythgoe, M. F. & Riley, P. R., 2013, In: Nature Communications. 4, p. 2081

Research output: Contribution to journal › Article (Academic Journal) › peer-review

64 Citations (Scopus)

2012

Embryonic clutch control

Razzell, W. & Martin, P., Mar 2012, In: Science. 335(#6073), p. 1181 - 1182 2 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Knockdown of osteopontin reduces the inflammatory response and subsequent size of postsurgical adhesions in a murine model.

Andrews, S. N., Ford, D. J. & Martin, P. B., 2012, In: American Journal of Pathology. 181, 4, p. 1165-1172

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.

Feng, Y., Renshaw, S. & Martin, P. B., May 2012, In: Current Biology. 22, 13, p. 1253-1259 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

87 Citations (Scopus)

Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis

Williams, C., Feng, Y., Martin, P. & Poole, A., Dec 2012, In: Journal of Thrombosis and Haemostasis. 9(12), p. 2457 - 2465 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

11 Citations (Scopus)

2011

A Syndecan-4 hair trigger initiates wound healing through Caveolin- and RhoG-regulated integrin endocytosis

Bass, M. D., Williamson, R. C., Nunan, R. D., Humphries, J. D., Byron, A., Morgan, M. R., Martin, P. & Humphries, M. J., Oct 2011, In: Developmental Cell. 21, 5, p. 681 - 693 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

115 Citations (Scopus)

Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion

Kadir, S., Astin, J. W., tahtamouni, L., Martin, P. & Nobes, C. D., Apr 2011, In: Journal of Cell Science. 124, p. 2642 - 2653 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

52 Citations (Scopus)

Swatting flies: modelling wound healing and inflammation in Drosophila

Razzell, W., Wood, W. & Martin, P., Sept 2011, In: Disease Models and Mechanisms. 4, 5, p. 569 - 574 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

68 Citations (Scopus)

White wave analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion

Matsubayashi, Y., Razzel, W. & Martin, P., Apr 2011, In: Journal of Cell Science. 24 (7), p. 1017 - 1021 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

46 Citations (Scopus)

2010

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo

Stramer, B., Moreira, S., Millard, T., Evans, I., Huang, C.-Y., Sabet, O., Milner, M., Dunn, G., Martin, P. & Wood, W., 17 May 2010, In: Journal of Cell Biology. 189, 4, p. 681 - 689 9 p., S1 - S4.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

100 Citations (Scopus)

Professor Paul B Martin

Research output

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