Projects per year
To perform an action, one must use sensory information to plan the action, and then execute the required movements to achieve the goal. My lab studies a key part of the brain important for these processes – the basal ganglia. Our research focusses on understanding how different types of neuron in the basal ganglia encode behaviour and how this goes wrong in diseases like Parkinson’s. We use in vivo single-unit recording and labelling, optogenetic manipulation, and behavioural analyses to link the molecular profile of different neurons with their role in behaviour.
Paul graduated in Physiology and received his Ph.D. in Neuroscience from the University of Leicester. He completed his graduate studies in Professor Ian Forsythe's laboratory, examining the roles of presynaptic potassium channels at the calyx of Held in the auditory brainstem. In 2003, he moved to Los Angeles as an HFSP Long-Term Fellow to work with Professor Tom Otis, investigating how alcohol affects GABAA receptors in the cerebellum to cause motor impairment. Paul returned to the UK in 2006 to work with Professor Matt Nolan at the University of Edinburgh, studying how ion channel expression is tuned to control the function of grid cells. He then moved to the University of Oxford in 2011 to work alongside Prof’s. Peter Magill and Paul Bolam at the MRC Brain Network Dynamics Unit as a Career Development Fellow and then Senior Research Fellow of the Oxford Parkinson's Disease Centre. In 2018 Paul joined the University of Bristol as a lecturer in neuroscience.
- 6 Similar Profiles
3/12/20 → 2/12/23
13/08/18 → 11/02/21
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionSloan, M., Alegre-Abarrategui, J., Potgieter, D., Kaufmann, A. K., Exley, R., Deltheil, T., Threlfell, S., Connor-Robson, N., Brimblecombe, K., Wallings, R., Cioroch, M., Bannerman, D. M., Bolam, J. P., Magill, P. J., Cragg, S. J., Dodson, P. D. & Wade-Martins, R., 1 Mar 2016, In: Human Molecular Genetics. 25, 5, p. 951-963 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review34 Citations (Scopus)
Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonismDodson, P. D., Dreyer, J. K., Jennings, K. A., Syed, E. C. J., Wade-Martins, R., Cragg, S. J., Bolam, J. P. & Magill, P. J., 12 Apr 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 15, p. E2180-E2188 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile55 Citations (Scopus)229 Downloads (Pure)
Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidusDodson, P. D., Larvin, J. T., Duffell, J. M., Garas, F. N., Doig, N. M., Kessaris, N., Duguid, I. C., Bogacz, R., Butt, S. J. B. & Magill, P. J., 22 Apr 2015, In: Neuron. 86, 2, p. 501-513 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review69 Citations (Scopus)