Projects per year
To perform an action, one must use sensory information to plan the action, and then execute the required movements to achieve the goal. My lab studies a key part of the brain important for these processes – the basal ganglia. Our research focusses on understanding how different types of neuron in the basal ganglia encode behaviour and how this goes wrong in diseases like Parkinson’s. We use in vivo single-unit recording and labelling, imaging, optogenetic manipulation, and behavioural analyses to link the molecular profile of different neurons with their role in behaviour.
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3/12/20 → 2/12/23
1/12/20 → 30/11/23
13/08/18 → 11/02/21
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatumReynolds, J. N. J., Avvisati, R., Dodson, P. D., Fisher, S. D., Oswald, M. J., Wickens, J. R. & Zhang, Y-F., 11 Mar 2022, In: Nature Communications. 13, 1, p. 1296 1296.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile6 Citations (Scopus)2 Downloads (Pure)
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionSloan, M., Alegre-Abarrategui, J., Potgieter, D., Kaufmann, A. K., Exley, R., Deltheil, T., Threlfell, S., Connor-Robson, N., Brimblecombe, K., Wallings, R., Cioroch, M., Bannerman, D. M., Bolam, J. P., Magill, P. J., Cragg, S. J., Dodson, P. D. & Wade-Martins, R., 1 Mar 2016, In: Human Molecular Genetics. 25, 5, p. 951-963 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review44 Citations (Scopus)