Projects per year
Prefrontal Cortex Circuits: The prefrontal cortex is involved in high-level cognition and functions as an important junction between cortical and limbic brain regions. My research aims to understand the properties of the long-range and local connections that mediate prefrontal circuits, focusing on how connectivity depends on presynaptic and postsynaptic neuronal identity. I am also interested in understanding how the components of cortical circuits and their connectivity vary across individual regions, particularly how prefrontal circuits differ to those in sensory cortices.
Circuit Development: Central to deciphering the complex connectivity that underlies cortical function are the mechanisms that give rise to cortical connectivity during development. This is particularly important because a number of neuropsychiatric disorders, such as schizophrenia, are thought to occur due to failure of these developmental processes. To better understand prefrontal development, I aim to determine how the properties of prefrontal circuits change as we grow, with particular focus on changes during the period of adolescence.
Neuromodulation: Neuromodulators play an integral role in prefrontal cortex function. I study how individual components of prefrontal circuits are impacted by neuromodulation and the overall impact on circuit dynamics. Dopamine is thought to be involved in a range of neuropsychiatric disorders, and I aim to understand how aberrant prefrontal dopamine causes deficits in neural signaling within the PFC and associated brain regions.
- 1 Similar Profiles
1/11/22 → 31/03/23
PFCmap: 8067 H2020 MSC: 898460 -PFCmap - MSCA-IF-2019 - Development of neural circuits in the prefrontal cortex —
1/01/21 → 31/12/22
Anastasiades, P. G., Collins, D. & Carter, A., 13 Nov 2020, (E-pub ahead of print) In: Neuron. 109, 2, p. p314-330.E4 22 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile24 Downloads (Pure)
Collins, D., Anastasiades, P. G., Marlin, J. & Carter, A., 5 Apr 2018, In: Neuron. 98, 2, p. 237-239
Research output: Contribution to journal › Article (Academic Journal) › peer-review103 Citations (Scopus)
Anastasiades, PG., Marques-Smith, A., Lyngholm, D., Lickiss, T., Raffiq, S., Kätzel, D., Miesenböck, G. & Butt, SJ., 4 Feb 2016, In: Nature Communications. 7, 10584.
Research output: Contribution to journal › Article (Academic Journal) › peer-review47 Citations (Scopus)