Projects per year
Personal profile
Research interests
Prefrontal Cortex Circuits: The prefrontal cortex is involved in high-level cognition and functions as an important junction between cortical and limbic brain regions. My research aims to understand the properties of the long-range and local connections that mediate prefrontal circuits, focusing on how connectivity depends on presynaptic and postsynaptic neuronal identity. I am also interested in understanding how the components of cortical circuits and their connectivity vary across individual regions, particularly how prefrontal circuits differ to those in sensory cortices.
Circuit Development: Central to deciphering the complex connectivity that underlies cortical function are the mechanisms that give rise to cortical connectivity during development. This is particularly important because a number of neuropsychiatric disorders, such as schizophrenia, are thought to occur due to failure of these developmental processes. To better understand prefrontal development, I aim to determine how the properties of prefrontal circuits change as we grow, with particular focus on changes during the period of adolescence.
Neuromodulation: Neuromodulators play an integral role in prefrontal cortex function. I study how individual components of prefrontal circuits are impacted by neuromodulation and the overall impact on circuit dynamics. Dopamine is thought to be involved in a range of neuropsychiatric disorders, and I aim to understand how aberrant prefrontal dopamine causes deficits in neural signaling within the PFC and associated brain regions.
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PFCmap: 8067 H2020 MSC: 898460 -PFCmap - MSCA-IF-2019 - Development of neural circuits in the prefrontal cortex —
1/01/21 → 31/12/22
Project: Research
Research output
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Mediodorsal and Ventromedial Thalamus Engage Distinct L1 Circuits in the Prefrontal Cortex
Anastasiades, P. G., Collins, D. & Carter, A., 13 Nov 2020, (E-pub ahead of print) In: Neuron. 109, 2, p. p314-330.E4 22 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile26 Downloads (Pure) -
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Collins, D., Anastasiades, P. G., Marlin, J. & Carter, A., 5 Apr 2018, In: Neuron. 98, 2, p. 237-239Research output: Contribution to journal › Article (Academic Journal) › peer-review
105 Citations (Scopus) -
GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex.
Anastasiades, PG., Marques-Smith, A., Lyngholm, D., Lickiss, T., Raffiq, S., Kätzel, D., Miesenböck, G. & Butt, SJ., 4 Feb 2016, In: Nature Communications. 7, 10584.Research output: Contribution to journal › Article (Academic Journal) › peer-review
48 Citations (Scopus)