Dr Paul R Race

BSc(Leeds), PhD(Birm.)

  • BS8 1TD

20082020

Research output per year

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Research Output

  • 31 Article (Academic Journal)
  • 2 Chapter in a book
  • 1 Review article (Academic Journal)
2020

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In : ACS Chemical Biology. 2020, 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology

Marucci, L., Barberis, M., Karr, J., Ray, O., Race, P. R., de Souza Andrade, M., Grierson, C. S., Hoffmann, S. A., Landon, S., Rech, E., Rees-Garbutt, J. P., Seabrook, R., Shaw, W. & Woods, C. J., 7 Aug 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 11 p., 942.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Downloads (Pure)

Enzyme-catalysed polymer cross-linking: Biocatalytic tools for chemical biology, materials science and beyond

Maddock, R. M. A., Pollard, G. J., Moreau, N. G., Perry, J. J. & Race, P. R., 8 Jul 2020, In : Biopolymers. 17 p., e23390.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Downloads (Pure)

Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics

Wang, L., Song, Z., Race, P. R., Spencer, J., Simpson, T. J., Crump, M. P. & Willis, C. L., 9 May 2020, In : Chemical Science. 11, p. 5221-5226 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
21 Downloads (Pure)

Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation

Nair, A. V., Robson, A., Ackrill, T. D., Till, M., Byrne, M. J., Back, C., Tiwari, K., Davies, J., Willis, C. L. & Race, P. R., 30 Jul 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle (Academic Journal)

The Bristol Sponge Microbiome Collection: A unique repository of deep-sea microorganisms and associated natural products

Williams, S., Stennett, H. L., Back, C., Tiwari, K., Ojeda Gomez, J., Challand, M. R., Hendry, K., Spencer, J., Essex-Lopresti, A., Willis, C. L., Curnow, P. & Race, P. R., 13 Aug 2020, In : Antibiotics. 9, 8, 189 p., 509.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Downloads (Pure)

The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture

Back, C., Higman, V. A., Le Vay, K., Patel, V. V., Parnell, A. E., Frankel, D., Jenkinson, H. F., Burston, S. G., Crump, M. P., Nobbs, A. H. & Race, P. R., 30 Mar 2020, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
66 Downloads (Pure)

Total Synthesis of Kalimantacin A

Davies, J. A., Bull, F. M., Walker, P. D., Weir, A. N. M., Lavigne, R., Masschelein, J., Simpson, T. J., Race, P. R., Crump, M. P. & Willis, C. L., 21 Aug 2020, In : Organic Letters. 22, 16, p. 6349-6353 5 p.

Research output: Contribution to journalArticle (Academic Journal)

2019

A Natural Diels-Alder Biocatalyst Enables Efficient [4 + 2] Cycloaddition Under Harsh Reaction Conditions

Marsh, C. O., Lees, N. R., Han, L-C., Byrne, M. J., Mbatha, S. Z., Maschio, L., Pagden-Ratcliffe, S., Duke, P., Stach, J. E. M., Curnow, P., Willis, C. L. & Race, P. R., 25 Aug 2019, In : ChemCatChem. 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
36 Downloads (Pure)

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis

Lees, N. R., Han, L-C., Byrne, M., Davies, J., Parnell, A., Moreland, P., Stach, J. E. M., Van der Kamp, M., Willis, C. & Race, P., 18 Feb 2019, In : Angewandte Chemie - International Edition. 58, 8, p. 2305-2309 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
78 Downloads (Pure)

Control of beta-Branching in Kalimantacin Biosynthesis: Application of 13C NMR to Polyketide Programming

Walker, P., Williams, C., Weir, A., Wang, L., Crosby, J., Race, P., Simpson, T., Willis, C. & Crump, M., 2 Sep 2019, In : Angewandte Chemie. 131, 36, p. 12576-12580 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Downloads (Pure)

Designer artificial membrane binding proteins direct stem cells to the myocardium

Xiao, W., Green, T. I. P., Liang, X., Cuahtecontzi Delint, R., Perry, G., Roberts, M. S., Le Vay, K., Back, C., Ascione, R., Wang, H., Race, P. & Perriman, A., 3 Jul 2019, In : Chemical Science. 10, 32, p. 7610 - 7618 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
135 Downloads (Pure)

Towards machine learning approaches for predicting the self-healing efficiency of materials

Wang, W., Moreau, N., Yuan, Y., Race, P. & Pang, W., 1 Oct 2019, In : Computational Materials Science. 168, p. 180-187 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
122 Downloads (Pure)
2018

A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis

Wang, L., Parnell, A., Williams, C., Bakar, N. A., Challand, M. R., van der Kamp, M. W., Simpson, T. J., Race, P. R., Crump, M. P. & Willis, C. L., Dec 2018, In : Nature Catalysis. 1, 12, p. 968-976 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
198 Downloads (Pure)

Cloning, Expression and Purification of Intact Polyketide Synthase Modules

Maschio, L., Parnell, A., Lees, N. R., Willis, C., Berger-Schaffitzel, C., Stach, J. E. M. & Race, P., 31 Oct 2018, (Accepted/In press) [forthcoming Methods in Enzymology volume]. Elsevier Inc., Vol. 617. p. 63-82 20 p. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway

Mohammad, H. H., Connolly, J. A., Song, Z., Hothersall, J., Race, P. R., Willis, C. L., Simpson, T. J., Winn, P. J. & Thomas, C. M., 16 Apr 2018, In : ChemBioChem. 19, 8, p. 836-841 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
262 Downloads (Pure)
2017

Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics

Thistlethwaite, I., Bull, F., Cui, C., Walker, P., Gao, S-S., Wang, L., Song, Z., Masschelein, J., Lavigne, R., Crump, M., Race, P., Simpson, T. & Willis, C., 1 Sep 2017, In : Chemical Science. 8, 9, p. 6196-6201 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
396 Downloads (Pure)

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics

Gao, S., Wang, L., Song, Z., Hothersall, J., Stevens, E. R., Connolly, J., Winn, P. J., Cox, R., Crump, M., Race, P., Simpson, T. & Willis, C., 27 Mar 2017, In : Angewandte Chemie - International Edition. 56, 14, p. 3930-3934 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
232 Downloads (Pure)

Studies of Recombinant TWA1 Reveal Constitutive Dimerization

Francis, O., Baker, G., Race, P. & Adams, J., 13 Jan 2017, In : Bioscience Reports. 37, 1, 12 p., BSR20160401.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
285 Downloads (Pure)

The Streptococcus gordonii adhesin CshA protein binds host fibronectin via a catch-clamp mechanism

Back, C., Sztukowska, M. N., Till, M., Lamont, R. J., Jenkinson, H. F., Nobbs, A. & Race, P., 3 Feb 2017, In : Journal of Biological Chemistry. 292, 5, p. 1538-1549 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
406 Downloads (Pure)
2016

BrisSynBio: a BBSRC/EPSRC-funded Synthetic Biology Research Centre

Sedgley, K. R., Race, P. R. & Woolfson, D. N., 9 Jun 2016, In : Biochemical Society Transactions. 44, 3, p. 389-391 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
243 Downloads (Pure)

Structural and Functional Analysis of Cell Wall-Anchored PolypeptideAdhesin BspA in Streptococcus agalactiae

Rego, S., Heal, T. J., Pidwill, G. R., Till, M., Robson, A., Lamont, R., Sessions, R. B., Jenkinson, H. F., Race, P. R. & Nobbs, A. H., 29 Jul 2016, In : Journal of Biological Chemistry. 291, 31, p. 15985-16000 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Citations (Scopus)
298 Downloads (Pure)

The Assembly Line Enzymology of Polyketide Biosynthesis

Race, P. & Till, M., Feb 2016, Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols. Evans, B. S. (ed.). Springer, p. 31-49 19 p. (Methods in Molecular Biology; vol. 1401).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
249 Downloads (Pure)

The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail

Byrne, M. J., Lees, N. R., Han, L. C., Van Der Kamp, M. W., Mulholland, A. J., Stach, J. E. M., Willis, C. L. & Race, P. R., 18 May 2016, In : Journal of the American Chemical Society. 138, 19, p. 6095-6098 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
77 Citations (Scopus)
478 Downloads (Pure)
2015

Iintegration of the Rac1- and actin-binding properties of coronin-1C

Tilley, F. C., Williamson, R. C., Race, P. R., Rendall, T. C. & Bass, M. D., 10 Apr 2015, In : Small GTPases. 6, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential

Cox, R., Abood, A., Al Fahad, A., Scott, A., Hosny, A. E-D., Hashem, A., Fattah, A., Race, P. & Simpson, T., 2015, In : RSC Advances. 5, 62, p. 49987-49995

Research output: Contribution to journalArticle (Academic Journal)

2014

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure

Williamson, R. C., Cowell, C. A. M., Hammond, C. L., Bergen, D. J. M., Roper, J. A., Feng, Y., Rendall, T. C. S., Race, P. R. & Bass, M. D., 1 Oct 2014, In : Journal of Cell Science. 127, Pt 19, p. 4292-307 16 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases

Till, M. & Race, P. R., May 2014, In : Biotechnology Letters. 36, 5, p. 877-88 12 p.

Research output: Contribution to journalReview article (Academic Journal)

2013

Improving the success rate of protein crystallization by random microseed matrix screening

Till, M., Robson, A., Byrne, M., Nair, A., Kolek, S., Shaw Stewart, P. & Race, P., 31 Aug 2013, In : Journal of Visualized Experiments. 78

Research output: Contribution to journalArticle (Academic Journal)

2011

Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC

Cuskin, F., Solovyova, AS., Lewis, RJ. & Race, PR., Apr 2011, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 4, p. 464 - 466 3 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2010

Solution stucture of the major (Spy0128) and minor (Spy0125 and Spy0130) pili subunits from Streptococcus pyogenes

Solovyova, AS., Pointon, JA., Race, PR., Smith, WD., Kehoe, MA. & Banfield, MJ., Feb 2010, In : European Biophysics Journal. 39, 3, p. 469 - 480 12 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2009

Crystal structure of Streptococcus pyogenes sortase A: Implications for sortase mechanism

Race, P. R., Bentley, M. L., Melvin, J. A., Crow, A., Hughes, R. K., Smith, W. D., Sessions, R. B., Kehoe, M. A., McCafferty, D. G. & Banfield, M. J., Mar 2009, In : Journal of Biological Chemistry. 284 , 11, p. 6924 - 6933 10 p.

Research output: Contribution to journalArticle (Academic Journal)

93 Citations (Scopus)

Crystal structures of Cif from bacterial pathogens Photohabdus luminescens and Burkholderia pseudomallei

Crow, A., Race, P. R., Jubelin, G., Varela Chavez, C., Escoubas, J-M., Oswald, E. & Banfield, M. J., May 2009, In : PLoS ONE. 4 , 5, p. 1-9 9 p., e5582.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
2008

Molecular architecture of the "stressosome", a signal integration and transduction hub

Marles-Wright, J., Grant, T., Delumeau, O., van Duinen, G., Firbank, S. J., Lewis, P. J., Murray, J. W., Newman, J. A., Quin, M. B., Race, P. R., Rohou, A., Tichelaar, W., van Heel, M. & Lewis, R. J., Oct 2008, In : Science. 322 , 5898, p. 92 - 96 5 p.

Research output: Contribution to journalArticle (Academic Journal)

108 Citations (Scopus)