Projects per year
The molecular basis and evolution of host-parasite interactions in African trypanosomes.
There are multiple species of African trypanosome that can each infect multiple mammalian hosts. Together they are the causative agents of both human and animal African trypanosomiasis, with bovine trypanosomiasis acting as a major constraint to cattle farming across sub-Saharan Africa. Successful infection and transmission of African trypanosomes relies on their ability to detect, interact with, and adapt to their environment. As extracellular parasites, the trypanosome cell surface acts as the molecular interface between the parasite and its external environment and functions in nutrient acquisition, signalling, and countering host innate and adaptive immune attack. We aim to understand and exploit the molecular and cellular biology of the interaction between African trypanosomes and their external environment in the mammalian host.
BBSRC David Phillip FellowMay 2017 → Feb 2023
Post-doctoral research associate, Department of Biochemistry, University of Cambridge, Cambridge , Department of Chemistry, University of CambridgeMay 2014 → May 2017
Post-doctoral research associate, Institute of Immunology and Infection, University of EdinburghDec 2010 → Apr 2014
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse fliesMacleod, O. J. S., Bart, J-M., Macgregor, P., Peacock, L., Hester, S., Ravel, S., Sunter, J. D., Trevor, C., Rust, S., Vaughan, T. J., Minter, R., Mohammed, S., Gibson, W., Taylor, M. C., Higgins, M. K. & Carrington, M., 12 Mar 2020, In: Nature Communications. 11, 12 p., 1326 (2020).
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile5 Citations (Scopus)136 Downloads (Pure)
Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.Lane-Serff, H., Macgregor, P., Peacock, L., Macleod, O., Kay, C., Gibson, W., Higgins, M. & Carrington, M., 15 Apr 2016, In: eLife. 5, 20 p., e13044.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile10 Citations (Scopus)313 Downloads (Pure)