Dr Paula MacGregor

PhD, MRes, BSc

    • BS8 1TQ

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    Personal profile

    Research interests

    The molecular basis and evolution of host-parasite interactions in African trypanosomes.

     

    There are multiple species of African trypanosome that can each infect multiple mammalian hosts. Together they are the causative agents of both human and animal African trypanosomiasis, with bovine trypanosomiasis acting as a major constraint to cattle farming across sub-Saharan Africa. Successful infection and transmission of African trypanosomes relies on their ability to detect, interact with, and adapt to their environment. As extracellular parasites, the trypanosome cell surface acts as the molecular interface between the parasite and its external environment and functions in nutrient acquisition, signalling, and countering host innate and adaptive immune attack. We aim to understand and exploit the molecular and cellular biology of the interaction between African trypanosomes and their external environment in the mammalian host.

    External positions

    BBSRC David Phillip Fellow

    May 2017Feb 2023

    Post-doctoral research associate, University of Cambridge

    May 2014May 2017

    Post-doctoral research associate, Institute of Immunology and Infection, University of Edinburgh

    Dec 2010Apr 2014

    Keywords

    • African trypanosomes
    • Parasite
    • Molecular biology
    • Host-parasite interactions
    • Cell surface
    • Kinetoplastids
    • Trypanosoma brucei
    • Trypanosoma congolense
    • Parasitology

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