Raquel Granell

2025

Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts

CADSET Clinical Research Collaboration of the European Respiratory Society, Ullah, A., Granell, R., Lowe, L., Fontanella, S., Arshad, S. H., Murray, C. S., Turner, S., Custovic, A. & et al., 1 Mar 2025, In: Lancet Child and Adolescent Health. 9, 3, p. 172-183 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

2024

Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

Hernandez-Pacheco, N., Kilanowski, A., Kumar, A., Curtin, J. A., Olvera, N., Kress, S., Bertels, X., Lahousse, L., Bhatta, L., Granell, R., Marí, S., Bilbao, J. R., Sun, Y., Tingskov Pedersen, C.-E., Karramass, T., Thiering, E., Dardani, C., Kebede Merid, S., Wang, G. & Hallberg, J. & 35 others, Koch, S., Garcia-Aymerich, J., Esplugues, A., Torrent, M., Ibarluzea, J., Lowe, L., Simpson, A., Gehring, U., Vermeulen, R. C. H., Roberts, G., Bergström, A., Vonk, J. M., Felix, J. F., Duijts, L., Bønnelykke, K., Timpson, N., Brusselle, G., Brumpton, B. M., Langhammer, A., Turner, S., Holloway, J. W., Arshad, S. H., Ullah, A., Custovic, A., Cullinan, P., Murray, C. S., van den Berge, M., Kull, I., Schikowski, T., Wedzicha, J. A., Koppelman, G., Faner, R., Agustí, À., Standl, M. & Melén, E., 24 Sept 2024, In: EClinicalMedicine. 75, 102731.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Genome-wide association study of preserved ratio impaired spirometry (PRISm)

Higbee, D. H., Lirio, A., Hamilton, F., Granell, R., Wyss, A. B., London, S. J., Bartz, T. M., Gharib, S. A., Cho, M. H., Wan, E., Silverman, E., Crapo, J. D., Lominchar, J. V. T., Hansen, T., Grarup, N., Dantoft, T., Kårhus, L., Linneberg, A., O’Connor, G. T. & Dupuis, J. & 25 others, Xu, H., De Vries, M. M., Hu, X., Rich, S. S., Barr, R. G., Manichaikul, A., Wijnant, S. R. A., Brusselle, G. G., Lahousse, L., Li, X., Hernández Cordero, A. I., Obeidat, M., Sin, D. D., Harris, S. E., Redmond, P., Taylor, A. M., Cox, S. R., Williams, A. T., Shrine, N., John, C., Guyatt, A. L., Hall, I. P., Smith, G. D., Tobin, M. D. & Dodd, J. W., Jan 2024, In: European Respiratory Journal. 63, 1, 12 p., 2300337.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

10 Citations (Scopus)

Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk

Granell, R., Haider, S., Deliu, M., Ullah, A., Mahmoud, O., Fontanella, S., Lowe, L., Simpson, A., Dodd, J. W., Arshad, S. H., Murray, C. S., Roberts, G., Hughes, A., Park, C., Holloway, J. W. & Custovic, A., 16 Jul 2024, In: Thorax. 79, p. 770-777 thorax-2023-220485.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

5 Citations (Scopus)

2023

A history of asthma may be associated with grandparents' exposures to stress and cigarette smoking.

Golding, J., Tunstall, H. E., Gregory, S., Granell, R., Dodd, J., Iles-Caven , Y. L., Watkins, S. H. & Suderman, M. J., 22 Sept 2023, In: Frontiers in Toxicology. 5, 1253442.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing

Granell, R., Curtin, J., Haider, S., Kitaba, N. T., Mathie, S. A. & Custovic, A., 25 May 2023, In: eLife. 12, 57 p., e84315.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

50 Downloads (Pure)

Lung function and cognitive ability in children: a UK birth cohort study

Grenville, J., Granell, R. & Dodd, J., 2 May 2023, In: BMJ Open Respiratory Research. 10, 1, e001528.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Nick, S. & Granell, R., 13 Mar 2023, In: Nature Genetics. 55, p. 410-422 19 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

71 Citations (Scopus)

TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility

Margaritte-Jeannin, P., Vernet, R., Budu-Aggrey, A., Ege, M., Madore, A.-M., Linhard, C., Mohamdi, H., Mutius, E. V., Granell, R., Demenais, F., Laprise, C., Bouzigon, E. & Dizier, M.-H., 7 Sept 2023, (E-pub ahead of print) In: Allergy, Asthma & Immunology Research. 15, E59.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2022

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

STELAR/UNICORN investigators, Tutino, M., Granell, R., Curtin, J. A., Haider, S., Fontanella, S., Murray, C. S., Roberts, G., Arshad, S. H., Turner, S., Morris, A. P., Custovic, A. & Simpson, A., 20 Oct 2022, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology. 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

210 Downloads (Pure)

Early-life and health behaviour influences on lung function in early-adulthood

Mahmoud, O., Granell, R., Peralta, G., Garcia-Aymerich, J., Jarvis, D., Henderson, A. J. & Sterne, J. A. C., 20 Oct 2022, (E-pub ahead of print) In: European Respiratory Journal. 62 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

42 Downloads (Pure)

Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150,000 European children

Van Meel, E., Mensink-Bout, S. M., den Dekker, H. T., Ahluwalia, T. S., Granell, R. & Duijts, L., 29 Apr 2022, (E-pub ahead of print) In: European Respiratory Journal. 60, 4, 2102395.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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51 Citations (Scopus)

45 Downloads (Pure)

Evolution of Eczema, Wheeze and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies

Haider, S., Fontanella, S., Granell, R. & Custovic, A., 10 Jun 2022, (Accepted/In press) In: American Journal of Respiratory and Critical Care Medicine. 206, 8, p. 950-960 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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38 Citations (Scopus)

47 Downloads (Pure)

Mid-childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C-reactive protein

Peralta, G. P., Granell, R., Bédard, A., Carsin, A. E., Fuertes, E., Howe, L. D., Márquez, S., Jarvis, D. L. & Garcia-Aymerich, J., 4 Dec 2022, In: Pediatric Allergy and Immunology. 33, 12, 8 p., e13894.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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3 Citations (Scopus)

56 Downloads (Pure)

Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates

Haider, S., Granell, R., Curtin, J., Fontanella, S., Custovic, A. & Cucco, A., 20 Jan 2022, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine. 205, 8, p. 883-893 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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30 Citations (Scopus)

99 Downloads (Pure)

Multi-ancestry genome-wide association study of asthma exacerbations

Herrera-Luis, E., Ortega, V., Ampleford, E., Sio, Y. Y., Granell, R., Lethem, R., Pino-Yanes, M. & et, A., 8 Jun 2022, In: Pediatric Allergy and Immunology. 33, 6, 17 p., e13802.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

49 Downloads (Pure)

Nonlinear effects of environment on childhood asthma susceptibility

Kothalawala, D., Weiss, V., Kadalayil, L., Granell, R., Curtin, J. & Holloway, J. W., 25 Apr 2022, In: Pediatric Allergy and Immunology. 33, 4, e13777.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

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2 Citations (Scopus)

67 Downloads (Pure)

Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK Biobank cohort analysis

Higbee, D. H., Granell, R., Davey Smith, G. & Dodd, J., 1 Feb 2022, In: Lancet Respiratory Medicine. 10, 2, p. 149-157 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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133 Citations (Scopus)

1436 Downloads (Pure)

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

Hartley, A. E., Sanderson, E. C. M., Granell, R., Paternoster, L., Zheng, J., Davey Smith, G., Southam, L., Hatzikotoulas, K., Boer, C. G., van Meurs, J. B. J., Zeggini, E., Gregson, C. L. & Tobias, J. H., 10 Aug 2022, In: International Journal of Epidemiology. 51, 4, 14 p., dyab251.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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34 Citations (Scopus)

117 Downloads (Pure)

2021

Dietary intake of vitamin A, lung function, and incident asthma in childhood

Talaei, M., Hughes, D. A., Mahmoud, O., Emmett, P. M., Granell, R., Guerra, S. & Shaheen, S. O., Oct 2021, In: The European respiratory journal. 58, 4

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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20 Citations (Scopus)

141 Downloads (Pure)

Examining the possible causal relationship between lung function, COPD and Alzheimer’s disease: a Mendelian randomisation study

Higbee, D. H., Granell, R., Walton, E., Korologou-Linden, R. S., Davey Smith, G. & Dodd, J., 7 Jul 2021, In: BMJ Open Respiratory Research. 8, 1, 8 p., :e000759.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

75 Downloads (Pure)

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

Hernandez-Pacheco, N., Granell, R. & Maitland-van der Zee, A., 13 May 2021, In: European Respiratory Journal. 57, 5, 2003388.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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25 Citations (Scopus)

141 Downloads (Pure)

High Insulin in Early Childhood is Associated with Subsequent Asthma Risk Independent of Body Mass Index

Carr, T., Granell, R., Stern, D. A., Guerra, S., Wright, A., Henderson, A. J., Halonen, M. & Martinez, F., 14 Oct 2021, In: Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

68 Downloads (Pure)

Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema

Margaritte-Jeannin, P., Budu-Aggrey, A., Ege, M., Madore, A.-M., Linhard, C., Mohamdi, H., von Mutius, E., Granell, R., Demenais, F., Laprise, C., Bouzigon, E. & Dizier, M.-H., 22 Jun 2021, (E-pub ahead of print) In: Clinical and Experimental Allergy. 52, 1, p. 70-81 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

71 Downloads (Pure)

Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma

Talaei, M., Sdona, E., Calder, P., Jones, L. R., Emmett, P. M., Granell, R., Bergstrom, A., Melén, E. & Shaheen, S. O., 1 Sept 2021, In: ERJ Open Research. 58, 3, 2003633.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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26 Citations (Scopus)

107 Downloads (Pure)

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Higbee, D. H., Granell, R., Hemani, G., Davey Smith, G. & Dodd, J., Dec 2021, In: BMC Pulmonary Medicine. 21, 1, 246.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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24 Citations (Scopus)

71 Downloads (Pure)

Lung function and cardiovascular disease: a two-sample Mendelian randomisation study

Higbee, D. H., Granell, R., Sanderson, E. C. M., Davey Smith, G. & Dodd, J., Sept 2021, In: European Respiratory Journal. 58, 3, 2003196.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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48 Citations (Scopus)

494 Downloads (Pure)

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Fawcett, K. R., Timpson, N. J., Granell, R. & Ring, S. M., 10 May 2021, In: ERJ Open Research. 7, 2, 11 p., 00049-2021.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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16 Citations (Scopus)

61 Downloads (Pure)

Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

CADSET Clinical Research Collaboration, 6 Dec 2021, (E-pub ahead of print) In: ERJ Open Research. 7, 4, 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

77 Downloads (Pure)

The impact of asthma on mental health and wellbeing during COVID-19 lockdown

Higbee, D. H., Nava, G. W., Kwong , A. S. F., Dodd, J. & Granell, R., 29 Jul 2021, In: European Respiratory Journal. 58, 1, 4 p., 2004497.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

File

15 Citations (Scopus)

72 Downloads (Pure)

Trimester effects of source-specific PM 10 on birth weight outcomes in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Yingxin, C., hodgson, S., Gulliver, J., Granell, R., Henderson, A. J. W., Cai, Y. & Hansell, A. L., 7 Jan 2021, In: Environmental Health. 20, 1

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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55 Downloads (Pure)

Variants associated with HHIP expression have sex-differential effects on lung function

Fawcett, K., Granell, R. & Wain, L. V., 24 May 2021, In: Wellcome Open Research. 5, p. 1-20 20 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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1 Citation (Scopus)

76 Downloads (Pure)

2020

Age-of-onset information helps identify 76 genetic variants associated with allergic disease

Ferreira, M. A. R., Granell, R., Brumpton, B. M., Paternoster, L. & al., E., 30 Jun 2020, In: PLoS Genetics.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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28 Citations (Scopus)

104 Downloads (Pure)

Confirmed causal effect of obesity on asthma and new insights on potential underlying shared genetic mechanisms.

Granell, R. & Rodriguez, S., 1 Feb 2020, In: Journal of Allergy and Clinical Immunology. 145, 2, p. 484-486 3 p.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

67 Downloads (Pure)

Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

Higbee, D. H., Granell, R., Walton, E., Korologou-Linden, R., Smith, G. D. & Dodd, J. W., 1 Sept 2020, (Unpublished) In: British Medical Journal (1857-1980). 8, 7 p.

Research output: Contribution to journal › Article (Academic Journal)

File

65 Downloads (Pure)

Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis.

Hartley, A., Hardcastle, S. A., Paternoster, L., McCloskey, E., Poole, K. E. S., Javaid, M. K., Aye, M., Moss, K., Granell, R., Gregory, J., Williams, M., Tobias, J. H. & Gregson, C. L., 1 Sept 2020, In: Osteoarthritis and Cartilage. p. 1180-1190 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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20 Citations (Scopus)

51 Downloads (Pure)

Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort

Cai, Y., Hansell, A. L., Granell, R., Blangiardo, M., Zottoli, M., Fecht, D., Gulliver, J., Henderson, A. J. & Elliott, P., 1 Jul 2020, In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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54 Citations (Scopus)

123 Downloads (Pure)

Residential greenspace and lung function up to 24 years of age: The ALSPAC birth cohort

Fuertes, E., Markevych, I., Thomas, R., Boyd, A., Granell, R., Mahmoud, O., Heinrich, J., Garcia-Aymerich, J., Roda, C., Henderson, J. & Jarvis, D., 1 Jul 2020, In: Environment International. 140, 11 p., 105749.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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51 Citations (Scopus)

161 Downloads (Pure)

The effect of catch-up growth in the first year of life on later wheezing phenotypes

Kotecha, S. J., Lowe, J., Granell, R., Watkins, W. J., Henderson, A. J. & Kotecha, S., 25 Jun 2020, (E-pub ahead of print) In: European Research Journal.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

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4 Citations (Scopus)

78 Downloads (Pure)

WITHDRAWN: Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

Higbee, D. H., Granell, R., Smith, G. D. & Dodd, J. W., 20 Oct 2020, medRxiv.

Research output: Other contribution

2019

Causes of variability in latent phenotypes of childhood wheeze

Oksel, C., Granell, R., Mahmoud, O., Custovic, A., Henderson, J. & STELAR and Breathing Together investigators, 1 May 2019, In: Journal of Allergy and Clinical Immunology. 143, 5, p. 1783-1790.e11 19 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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42 Citations (Scopus)

308 Downloads (Pure)

Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study

Peralta, G., Fuertes, E., Granell, R., Mahmoud, O., Roda, C., Serra, I., Jarvis, D., Henderson, J. & Garcia-Aymerich, J., 1 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 75-83 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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46 Citations (Scopus)

234 Downloads (Pure)

Comparison of the associations of early life factors on wheezing-phenotypes in preterm-born children and term-born children

Kotecha, S., Watkins, J. W., Lowe, J., Granell, R., Henderson, J. & Kotecha, S., 1 Mar 2019, In: American Journal of Epidemiology. 188, 3, p. 527-536 10 p., kwy268.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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25 Citations (Scopus)

341 Downloads (Pure)

Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis

Clark, H., Granell, R., Curtin, J. A., Belgrave, D. C. M., Simpson, A., Murray, C., Henderson, A. J., Custovic, A. & Paternoster, L., 23 Aug 2019, In: Clinical and Experimental Allergy. 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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31 Citations (Scopus)

237 Downloads (Pure)

Distinguishing wheezing phenotypes from infancy to adolescence: a pooled analysis of five birth cohorts

Oksel, C., Granell, R., Haider, S., Fontanella, S., Simpson, A., Turner, S., Devereux, G., Arshad, H., Murrey, C. S., Roberts, G., Holloway, J., Cullinan, P., Henderson, J. & Custovic, A., Jul 2019, In: Annals of the American Thoracic Society. 16, 7, p. 868-876 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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80 Citations (Scopus)

350 Downloads (Pure)

Genetic and observational evidence supports a causal role of sex hormones on the development of asthma

Arathimos, R., Granell, R., Haycock, P., Richmond, R., Yarmolinsky, J., Relton, C. & Tilling, K., 1 Jul 2019, In: Thorax. 74, 7, p. 633-642 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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28 Citations (Scopus)

249 Downloads (Pure)

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

the 23 and Me Research Team, eQTLGen Consortium & BIOS Consortium, 4 Apr 2019, In: American Journal of Human Genetics. 104, 4, p. 665-684 20 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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185 Citations (Scopus)

249 Downloads (Pure)

Genome-wide interaction study of early-life smoking exposure on time-to-asthma onset in childhood

Sugier, P.-E., Sarnowski, C., Granell, R., Laprise, C., Ege, M., Margaritte-Jeannin, P., Dizier, M.-H., Minelli, C., Moffatt, M. F., Lathrop, M., Cookson, W. O. C. M., Henderson, J., von Mutius, E., Kogevinas, M., Demenais, F. & Bouzigon, E., Oct 2019, In: Clinical and Experimental Allergy. 49, 10, p. 1342-1351 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

147 Downloads (Pure)

Physical activity trajectories during childhood and lung function at 15 years: Findings from the ALSPAC cohort

Roda, C., Mahmoud, O., Peralta, G., Fuertes, E., Granell, R., Serra, I., Henderson, A. J. W., Jarvis, D. & Garcia-Aymerich, J., 3 Jul 2019, In: International Journal of Epidemiology. 11 p., dyz128.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

225 Downloads (Pure)

Respiratory Phenotypes during Childhood and Early Life Exposures

Granell, R., 1 Jan 2019, In: American Journal of Respiratory and Critical Care Medicine. 199, 1, p. 7-9 3 p.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

Open Access

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342 Downloads (Pure)

Dr Raquel Granell

Research output

Search results