Projects per year
The overall aim of my research is to understand the contributions the mammalian cerebellum makes to the control of voluntary limb movements.
The cerebellum is the largest motor structure within the brain and to succeed in this aim would substantially increase knowledge of the way in which movements are controlled, as well as shed light on the functional organization of a major neural structure and the pathways linking it to other parts of the nervous system.
In particular, the climbing fibre pathways connecting the inferior olive (a brainstem nucleus) to the cerebellum play a vital but enigmatic role in the regulation of movements. In the short to medium term a key aim of my work is to test and refine the hypothesis that these connections provide 'error signals' to the cerebellum during performance of both new and well-rehearsed movements.
1/01/19 → 30/06/23
1/01/17 → 31/07/21
Apps, R. & Hawkes, R., Sep 2009, In: Nature Reviews Neuroscience. 10, 9, p. 670-681 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review288 Citations (Scopus)
Cerminara, N. L., Aoki, H., Loft, M., Sugihara, I. & Apps, R., 16 Oct 2013, In: Journal of Neuroscience. 33, 42, p. 16427-16442 16 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile28 Citations (Scopus)645 Downloads (Pure)
Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in ratsDrake, R. A. R., Lumb, B. M., Apps, R. & Pickering, A. E., 8 Feb 2021, In: eLife. 10, p. 1-22 22 p., e65156.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Downloads (Pure)
1 Jul 2018 → 2 Jul 2018
Activity: Participating in or organising an event types › Participation in workshop, seminar, course