Projects per year
Personal profile
Research interests
Molecular Modelling in Biochemistry
Molecular modelling is a very useful tool in the design and interpretation of experiments. This is well recognised in Bristol, where most research groups have used this technique, to a greater or lesser extent.
Molecular modelling can also be thought of as a subset of Bioinformatics and, as we pass into the "post-genomic sequence era", this field will play an ever more important role in scientific research.
Computer hardware advances continue to follow Moore’s law, formulated in the 1960s, which states that machine speed’s roughly double every 18 months. This is allowing the application of evermore sophisticated modelling techniques to routine problems. The following molecular modelling techniques and projects are actively pursued in the School of Biochemistry:
- homology modelling
- ligand/drug design
- mutant design
- molecular mechanics/dynamics
- semi-empirical molecular orbital calculations
- protein structure prediction.
More information about my research.
More information about the Bristol University Docking Engine (BUDE).
Keywords
- BcompB
Fingerprint
- 1 Similar Profiles
Network
Projects
- 3 Finished
-
-
-
MOLECULAR DYNAMICS SIMULATIONS OF NATIVE PROTEINS AND FOLDING INTERMEDIATES AND CORRELATION WITH NMR PROTECTION
1/01/00 → 1/07/00
Project: Research
Research output
-
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
Jimenez Moreno, N., Kollareddy, M., Stathakos, P., Moss, J. J., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. & Lane, J. D., 4 Apr 2023, In: Journal of Cell Biology. 222, 5Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Carfentanil is a β-arrestin-biased agonist at the μ opioid receptor
Ramos-Gonzalez, N., Groom, S., Sutcliffe, K. J., Bancroft, S., Bailey, C. P., Sessions, R. B., Henderson, G. & Kelly, E., 2 Apr 2023, (E-pub ahead of print) In: British Journal of Pharmacology.Research output: Contribution to journal › Article (Academic Journal) › peer-review
-
Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking
Elseginy, S. A., Oliveira, S., Shoemark, D. K. & Sessions, R. B., 18 May 2022, (E-pub ahead of print) In: RSC medicinal chemistry. 13, 8, p. 929-943 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Citations (Scopus)7 Downloads (Pure)