Professor Richard J M Coward

M.B.,Ch.B., Ph.D.(Bristol), M.R.C.P.

  • BS1 3NY

20012020

Research output per year

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Research Output

  • 51 Article (Academic Journal)
  • 2 Review article (Academic Journal)
  • 1 Editorial (Academic Journal)
2020

An information theoretic approach to insulin sensing by human kidney podocytes

Pope, R. JP., Garner, K. L., Voliotis, M., Lay, A. C., Betin, V. MS., Tsaneva-Atanasova, K., Welsh, G. I., Coward, R. JM. & McArdle, C. A., 1 Aug 2020, In : Molecular and Cellular Endocrinology. 110976.

Research output: Contribution to journalArticle (Academic Journal)

A role for NPY-NPY2R signaling in albuminuric kidney disease

Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A. & 2 others, Welsh, G. I. & Coward, R. J. M., 19 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 12 p., 202004651.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Downloads (Pure)
2019

Aldosterone induces albuminuria via matrix metalloproteinase–dependent damage of the endothelial glycocalyx

Butler, M. J., Ramnath, R., Kadoya, H., Desposito, D., Riquier-Brison, A., Ferguson, J. K., Onions, K. L., Ogier, A. S., ElHegni, H., Coward, R. J., Welsh, G. I., Foster, R. R., Peti-Peterdi, J. & Satchell, S. C., Jan 2019, In : Kidney International. 95, 1, p. 94-107 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
117 Downloads (Pure)

An In Vitro Method to Analyze Glucose Uptake in Podocytes

Lay, A. C. & Coward, R. J., 8 Nov 2019, In : Methods in Molecular Biology. 2067, p. 139-143 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
133 Downloads (Pure)

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., Singh, S., Murphy, A., Scudamore, C. L., Marquez, E., Barrington, A. F., Pinto, V., Marchetti, M., Wong, L-F., Uney, J., Saleem, M. A., Mathieson, P. W., Patel, S., Walker, R. J., Woodgett, J. R. & 3 others, Quaggin, S. E., Welsh, G. I. & Coward, R. J. M., 2019, In : Nature Communications. 10, 1, 17 p., 403.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
357 Downloads (Pure)

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function

Hurcombe, J., Lay, A., Ni, L., Barrington, F., Woodgett, J. R., Quaggin, S. E., Welsh, G. & Coward, R., Aug 2019, In : FASEB BioAdvances. 1, 8, p. 498-510 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
114 Downloads (Pure)
2018

Advances in our understanding of the pathogenesis of hemolytic uremic syndromes

Bowen, E. E. & Coward, R. J., 1 Mar 2018, In : AJP - Renal Physiology. 314, 3, p. F454-F461

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
3 Citations (Scopus)
207 Downloads (Pure)

Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress

Garner, K. L., Betin, V. M. S., Pinto, V., Graham, M., Abgueguen, E., Barnes, M., Bedford, D. C., McArdle, C. A. & Coward, R. J. M., 2 Mar 2018, In : Scientific Reports. 8, 1, 3902.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
218 Downloads (Pure)

Preserving oral history: 50 years of paediatric nephrology in Europe

Tse, Y., Maxwell, H., Watson, A. R., Coward, R., Levtchenko, E., Christian, M. & European Society for Paediatric Nephrology, Nov 2018, In : Archives of Disease in Childhood. 103, 11, p. 1010-1012 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
253 Downloads (Pure)

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease.

Lay, A. C. & Coward, R. J. M., 21 Nov 2018, In : Frontiers in Endocrinology. 9, 9 p., 693.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
188 Downloads (Pure)
2017

DBA2J db/db mice are susceptible to early albuminuria and glomerulosclerosis that correlates with systemic insulin resistance

Østergaard, M. V., Ribeiro Pinto, V., Stevenson, K., Worm, J., Fink, L. N. & Coward, R., Feb 2017, In : AJP - Renal Physiology. 312, 2, p. F312-F321 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
218 Downloads (Pure)

Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Avenues

Oltean, S., Coward, R., Collino, M. & Baelde, H., 22 Nov 2017, In : BioMed Research International. 2017, 1 p., 3146524.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
File
5 Citations (Scopus)
232 Downloads (Pure)

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

Lay, A. C., Hurcombe, J., Betin, V., Barrington, F., Rollason, R., Ni, L., Gillam, L., Pearson, G. M. E., Østergaard, M. V., Hamidi, H., Lennon, R., Welsh, G. & Coward, R., 29 Aug 2017, In : Diabetologia.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
293 Downloads (Pure)

The molecular biology of pelvi-ureteric junction obstruction

Jackson, L., Woodward, M. & Coward, R. J., 13 Mar 2017, In : Pediatric Nephrology. p. 1-19 19 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
268 Downloads (Pure)

VEGF regulates local inhibitory complement proteins in the eye and kidney

Keir, L. S., Firth, R., Aponik, L., Feitelberg, D., Sakimoto, S., Aguilar, E., Welsh, G. I., Richards, A., Usui, Y., Satchell, S. C., Kuzmuk, V., Coward, R. J., Goult, J., Bull, K. R., Sharma, R., Bharti, K., Westenskow, P. D., Michael, I. P., Saleem, M. A. & Friedlander, M., 3 Jan 2017, In : Journal of Clinical Investigation. 127, 1, p. 199-214 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
52 Citations (Scopus)
234 Downloads (Pure)
2016

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms

Gnudi, L., Coward, R. J. M. & Long, D. A., 10 Nov 2016, In : Trends in Endocrinology and Metabolism. 27, 11, p. 820-830 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
111 Citations (Scopus)
326 Downloads (Pure)
2015

Clinical and Genetic Analysis of Patients with Cystinuria in the United Kingdom

Rhodes, H. L., Yarram-Smith, L., Rice, S. J., Tabaksert, A., Edwards, N., Hartley, A., Woodward, M. N., Smithson, S. L., Tomson, C., Welsh, G. I., Williams, M., Thwaites, D. T., Sayer, J. A. & Coward, R. J. M., 11 May 2015, In : Clinical Journal of the American Society of Nephrology.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Insulin signaling: implications for podocyte biology in diabetic kidney disease

Coward, R. & Fornoni, A., Jan 2015, In : Current Opinion in Nephrology and Hypertension. 24, 1, p. 104-10 7 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes

Santamaria, B., Marquez, E., Lay, A. C., Carew, R. M., González-Rodríguez, Á., Welsh, G. I., Ni, L., Hale, L. J., Ortiz, A., Saleem, M. A., Brazil, D. P., Coward, R. J. & Valverde, Á. M., Dec 2015, In : Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853, 12, p. 3224–3234 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Citations (Scopus)
418 Downloads (Pure)

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

Moore, S. F., Williams, C. M., Brown, E., Blair, T. A., Harper, M. T., Coward, R. J., Poole, A. W. & Hers, I., 22 Apr 2015, In : Cardiovascular Research.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)
2014

Genetics and the nephron

Marlais, M. & Coward, R. J., Apr 2014, In : Archives of Disease in Childhood: Education and Practice Edition. 99, 2, p. 73-9 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Initial Steroid Sensitivity in Children with Steroid-Resistant Nephrotic Syndrome Predicts Post-Transplant Recurrence

Ding, W. Y., Koziell, A., McCarthy, H. J., Bierzynska, A., Bhagavatula, M. K., Dudley, J. A., Inward, C. D., Coward, R. J., Tizard, J., Reid, C., Antignac, C., Boyer, O. & Saleem, M. A., 7 Feb 2014, In : Journal of the American Society of Nephrology.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
47 Citations (Scopus)

Paediatrics, insulin resistance and the kidney

Marlais, M. & Coward, R. J., 25 Jul 2014, In : Pediatric Nephrology.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Podocytes, signaling pathways, and vascular factors in diabetic kidney disease

Brosius, F. C. & Coward, R. J., May 2014, In : Advances in Chronic Kidney Disease. 21, 3, p. 304-10 7 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
2013

Glomerular involvement in the arthrogryposis, renal dysfunction and cholestasis syndrome

Holme, A., Hurcombe, J. A., Straatman-Iwanowska, A., Inward, C. D., Gissen, P. & Coward, R. J. M., 1 Apr 2013, In : Clinical Kidney Journal. 6, 2

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Insulin Directly Stimulates VEGF-A production in the Glomerular Podocyte

Hale, L. J., Hurcombe, J., Lay, A. C., Santamaría, B., Valverde, A. M., Saleem, M. A., Mathieson, P. W., Welsh, G. I. & Coward, R. J. M., 22 May 2013, In : AJP - Renal Physiology.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, AJ., Jeansson, M., Holly, J. M. P., Hardouin, SN. & Coward, R. J. M., May 2013, In : Journal of Pathology. 230, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Insulin signalling to the kidney in health and disease

Hale, L. J. & Coward, R. J. M., 2013, In : Clinical Science. 124, 6, p. 351-70 20 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Recent advances in our understanding of insulin signalling to the podocyte

Lay, A. C. & Coward, R. J., 27 Nov 2013, In : Nephrology Dialysis Transplantation.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Regulation of Hypoxia -Inducible Factor 2-Alpha is Essential for Integrity of the Glomerular Barrier

Ding, M., Coward, R. J. M., Jeansson, M., Kim, W. & Quaggin, S. E., 2013, In : AJP - Renal Physiology. 304, p. F120-F126

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
2012

Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome

Smith, H., Galmes, R., Gogolina, E., Straatman-Iwanowska, A., Reay, K., Banushi, B., Bruce, C. K., Cullinane, A. R., Romero, R., Chang, R., Ackermann, O., Baumann, C., Cangul, H., Cakmak Celik, F., Aygun, C., Coward, R., Dionisi-Vici, C., Sibbles, B., Inward, C., Ae Kim, C. & 4 others, Klumperman, J., Knisely, A. S., Watson, S. P. & Gissen, P., 2012, In : Human Mutation.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

The adaptor protein grb2 is not essential for the establishment of the glomerular filtration barrier

Bisson, N., Ruston, J., Jeansson, M., Vanderlaan, R., Hardy, W. R., Du, J., Hussein, S. M., Coward, R. J., Quaggin, S. E. & Pawson, T., 2012, In : PLoS ONE. 7, 11, p. e50996

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

The insulin receptor and the kidney

Hale, L. J. & Coward, R. J. M., 2012, In : Current Opinion in Nephrology and Hypertension.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)
2011

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Keir, L. & Coward, R. J. M., Apr 2011, In : Pediatric Nephrology. 26, 4, p. 523 - 533 11 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Podocytes as a target of insulin

Coward, R. J. M. & Saleem, M. A., Jan 2011, In : Current Diabetes Reviews. 7, 1, p. 22 - 27 6 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2010

Insulin signaling to the glomerular podocyte is critical for normal kidney function

Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenstädt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A. & Coward, R. J. M., 6 Oct 2010, In : Cell Metabolism. 12, 4, p. 329 - 340 12 p.

Research output: Contribution to journalArticle (Academic Journal)

264 Citations (Scopus)

Podocytes, glucose and insulin

Welsh, G. I. & Coward, R. J. M., Jul 2010, In : Current Opinion in Nephrology and Hypertension. 19, 4, p. 379 - 384 6 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Renal stones in paediatric practice

Humphreys, J. & Coward, R. J. M., Jun 2010, In : Paediatrics and Child Health. 20, 6, p. 279-285 7 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2009

An initial evaluation of post-cardiopulmonary bypass acute kidney injury in swine

Murphy, G. J., Lin, H., Coward, R. J., Toth, T., Holmes, R., Hall, D. & Angelini, G. D., Nov 2009, In : European Journal of Cardio-Thoracic Surgery. 36, 5, p. 849 - 855 7 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1

Lennon, R., Welsh, G. I., Singh, A., Satchell, S. C., Coward, R. J., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Sep 2009, In : Diabetologia. 52, 9, p. 1944 - 1952 9 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

Lennon, R., Pons, D., Sabin, M. A., Wei, C., Hamilton-Shield, J. P., Coward, R. J., Tavaré, J. M., Mathieson, P. W., Saleem, M. A. & Welsh, G. I., Nov 2009, In : Nephrology Dialysis Transplantation. 24, 11, p. 3288 - 3296 9 p.

Research output: Contribution to journalArticle (Academic Journal)

102 Citations (Scopus)
2008

A fair reason for failing to thrive

Connor, K., Lennon, R., McGraw, M. E. & Coward, R. J. M., Apr 2008, In : Archives of Disease in Childhood: Education and Practice Edition. 93, 2, p. 50 - 57 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

Lennon, R., Singh, A., Welsh, G. I., Coward, R. J., Satchell, S., Ni, L., Mathieson, P. W., Bakker, W. W. & Saleem, M. A., Nov 2008, In : Journal of the American Society of Nephrology. 19, 11, p. 2140 - 2149 10 p.

Research output: Contribution to journalArticle (Academic Journal)

82 Citations (Scopus)
2007

Eosinophilic glomerulonephritis in children in Southwestern Uganda

Walker, A., Ellis, J., Irama, M., Senkungu, J., Nansera, D., Axton, J., Coward, R. J., Peat, D. S., Bode, H. H. & Mathieson, P. W., Mar 2007, In : Kidney International. 71, 6, p. 569 - 573 5 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Meningococcal disease associated with an acute post-streptococcal complement deficiency

Daskas, N., Farmer, K., Coward, R. & Erlewyn-Lajeunesse, M., 2007, In : Pediatric Nephrology. 22, 5, p. 747-9 3 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Nephrin is critical for the action of insulin on human glomerular podocytes

Coward, R. J. M., Welsh, G. I., Koziell, A., Hussain, S., Lennon, R., Ni, L., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Apr 2007, In : Diabetes. 56, 4, p. 1127 - 1135 9 p.

Research output: Contribution to journalArticle (Academic Journal)

113 Citations (Scopus)
2006

Direct effects of dexamethasone on human podocytes

Xing, C-Y., Saleem, M. A., Coward, R. J., Ni, L., Witherden, I. R. & Mathieson, P. W., Sep 2006, In : Kidney International. 70, 6, p. 1038 - 1045 8 p.

Research output: Contribution to journalArticle (Academic Journal)

112 Citations (Scopus)
2005

The human glomerular podocyte is a novel target for insulin action

Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Nov 2005, In : Diabetes. 54, 11, p. 3095 - 3102 8 p.

Research output: Contribution to journalArticle (Academic Journal)

193 Citations (Scopus)