Projects per year
Personal profile
Research interests
My current principal areas of research are: i) prostate cancer aetiology (with a focus on metabolic factors such as the IGF system), predicting its progression and secondary and tertiary prevention of the disease via population-based screening and low-toxicity nutritional and lifestyle interventions; ii) the short- and long-term child and adult health effects of breastfeeding and early growth; and iii) uncovering unexpected beneficial and adverse effects of commonly prescribed drugs through pharmaco-epidemiological studies based on automated clinical databases such as the UK GPRD. I am lead principal investigator (with Jenny Donovan, Freddie Hamdy and David Neal) on a population-based cluster randomised controlled trial of PSA testing for prostate cancer (the CAP trial) that involves over 410,000 UK men and co-principal investigator (with Mike Kramer and Emily Oken) on the long-term follow-up of a cluster randomised controlled trial of a breastfeeding promotion intervention that involves over 17,000 children in the Republic of Belarus (the PROBIT trial). I am lead principal investigator (with Professor Caroline Relton) on a £4.1 million CRUK programme grant in Integrative Cancer Epidemiology, combining genetic, metabolomic and epigenetic technologies to understand causal risk factors, mechanistic targets and predictive biomarkers in a variety of cancers. In was co-PI with Dr Sarah Lewis on the WCRF funded project to develop systematic review methodology for mechanistic studies. I lead a cancer work-stream within the Bristol NIHR Biomedical Research Centre. I am interested in robustly assessing the causality of observational associations using instrumental variables analysis, working in collaboration with Frank Windmeijer, George Davey Smith, Tom Palmer and Neil Davies. With Willie Hamilton, Mike Stevens, Rachel Dommet and Theresa Redaniel, I have a developing interest in the presentation and diagnosis of childhood, teenage and young adult cancers in primary care.
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Network
Research output
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Fifteen-year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
Donovan, J. L., Lane, J. A., Metcalfe, C., Davis, M. J., Turner, E. L., Martin, R. M., Walsh, E. I., Peters, TJ. & Williams, N. J., 11 Mar 2023, In: New England Journal of Medicine.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment
Donovan, J. L., Hamdy, F. C., Lane, J. A., Young, G., Metcalfe, C., Walsh, E. I., Davis, M. J., Steuart-Feilding, T. A. H. M., Blazeby, J., Avery, K. N. L., Martin, R. M., Bollina, P., Doble, A., Doherty, A., Gillatt, D. A., Gnanapragasam, V., Hughes, O., Kockelbergh, R., Kynaston, H., Paul, A., & 14 others , 11 Mar 2023, In: NEJM Evidence. 2, 3, 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
Morales-Berstein, F., McCartney, D. L., Lu, A. T., Tsilidis, K. K., Bouras, E., Haycock, P., Burrows, K., Phipps, A. I., Buchanan, D. D., Cheng, I., Martin, R. M., Smith, G. D., Relton, C. L., Horvath, S., Marioni, R. E., Richardson, T. G. & Richmond, R. C., 29 Mar 2022, In: eLife. 11, 46 p., e75374.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile33 Downloads (Pure)
Datasets
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CPRD codes: ICD-10 equivalent code lists for dementia subtypes
Walker, V. M. (Creator), Davies, N. (Creator), Kehoe, P. G. (Creator), Martin, R. M. (Creator) & Payne, R. (Data Manager), University of Bristol, 27 Nov 2017
DOI: 10.5523/bris.2h4rmk9v7pw2k23h7vgf9tx1ea, http://data.bris.ac.uk/data/dataset/2h4rmk9v7pw2k23h7vgf9tx1ea
Dataset
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CPRD codes: neurodegenerative diseases and commonly prescribed drugs
Walker, V. M. (Creator), Davies, N. (Creator), Kehoe, P. G. (Creator), Martin, R. M. (Creator) & Payne, R. (Data Manager), University of Bristol, 2 Oct 2017
DOI: 10.5523/bris.1plm8il42rmlo2a2fqwslwckm2, http://data.bris.ac.uk/data/dataset/1plm8il42rmlo2a2fqwslwckm2
Dataset
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Additional file 2 of Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
Hazelwood, E. (Creator), Sanderson, E. C. M. (Creator), Tan, Y. (Creator), Ruth, K. S. (Creator), Frayling, T. M. (Creator), Dimou, N. (Creator), Gunter, M. J. (Creator), Dossus, L. (Creator), Newton, C. (Creator), Ryan, N. (Creator), Pournaras, D. J. (Creator), O’Mara, T. A. (Creator), Davey Smith, G. (Creator), Martin, R. M. (Creator) & Yarmolinsky, J. (Creator), figshare, 19 Apr 2022
DOI: 10.6084/m9.figshare.19613752, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Identifying_molecular_mediators_of_the_relationship_between_body_mass_index_and_endometrial_cancer_risk_a_Mendelian_randomization_analysis/19613752
Dataset