Projects per year
Why do some individuals suffer long term pain while others don't?
I am interested in neurophysiological mechanism that impart vulnerability to develop chronic pain conditions. One potentially important factor is the correct functioning of endogenous pain modulatory circuits that link the brain and spinal cord to powerfully affect pain processing. Currently, I am investigating the causal link between injury induced brain network reorganisation and the development of the pain state in pre-clinical animal models of persistent pain. I try to take findings from clinical studies in human patients (e.g. fMRI studies) and investigate 1 - whether the pre-clinical models are able to recreate these features and 2 - how they causally relate to sensory, affective and cognitive disturbances that develop following injury.
Structured keywords and research groupings
- Tactile Action Perception
- Pain & Nociception
- Chronic Pain
- Brain and Behaviour
- In Vivo System
- Affective & Behavioural neuroscience
- 1 Similar Profiles
- 4 Article (Academic Journal)
Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary HypersensitivityDrake, R. A. R., Leith, J. L., Almahasneh, F., Martindale, J., Wilson, A. W., Lumb, B. M. & Donaldson, L. F., 31 Aug 2016, In: Journal of Neuroscience. 36, 35, p. 9026 –9040 15 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile5 Citations (Scopus)325 Downloads (Pure)
The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic painHulse, R. P., Drake, R. A. R., Bates, D. O. & Donaldson, L. F., Dec 2016, In: Neurobiology of Disease. 96, p. 186-200 15 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile17 Citations (Scopus)396 Downloads (Pure)
The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent inputDrake, R. A. R., Hulse, R. P., Lumb, B. M. & Donaldson, L. F., 15 Aug 2014, In: Journal of Physiology. 592, Pt 16, p. 3611-24 14 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review12 Citations (Scopus)