Projects per year
Personal profile
Research interests
Why do some individuals suffer long term pain while others don't?
I am interested in neurophysiological mechanism that impart vulnerability to develop chronic pain conditions. One potentially important factor is the correct functioning of endogenous pain modulatory circuits that link the brain and spinal cord to powerfully affect pain processing. Currently, I am investigating the causal link between injury induced brain network reorganisation and the development of the pain state in pre-clinical animal models of persistent pain. I try to take findings from clinical studies in human patients (e.g. fMRI studies) and investigate 1 - whether the pre-clinical models are able to recreate these features and 2 - how they causally relate to sensory, affective and cognitive disturbances that develop following injury.
Structured keywords and research groupings
- Tactile Action Perception
- Pain & Nociception
- Chronic Pain
- Neurophysiology
- Brain and Behaviour
- In Vivo System
- Affective & Behavioural neuroscience
Keywords
- In Vivo Systems
- Neurophysiology
- Pain & Nociception
- Chronic pain
- Affective & Behavioural Neuroscience
- Electrophysiology
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- 1 Similar Profiles
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Sex, stress & Pain; exploring sex differences in the cortical control of chronic pain
1/11/22 → 31/10/25
Project: Research
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Research output
- 6 Article (Academic Journal)
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Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats
Drake, R. A. R., Lumb, B. M., Apps, R. & Pickering, A. E., 8 Feb 2021, In: eLife. 10, p. 1-22 22 p., e65156.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile9 Citations (Scopus)98 Downloads (Pure) -
Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity
Drake, R. A. R., Leith, J. L., Almahasneh, F., Martindale, J., Wilson, A. W., Lumb, B. M. & Donaldson, L. F., 31 Aug 2016, In: Journal of Neuroscience. 36, 35, p. 9026 –9040 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile6 Citations (Scopus)372 Downloads (Pure) -
Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour
Lawrenson, C. L., Paci, E., Pickford, J., Drake, R. A. R., Lumb, B. M. & Apps, R., 15 Mar 2022, In: eLife. 11, 30 p., e76278.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Citations (Scopus)16 Downloads (Pure)
Activities
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Weizmann Institute of Science
Robert A R Drake (Visiting researcher)
15 May 2022 → 28 Jul 2022Activity: Visiting an external institution types › Visiting an external academic institution
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Building Bridges Along The Psychiatric Drug Discovery Pipeline
Robert A R Drake (Advisor)
22 Feb 2022Activity: Talk or presentation types › Partnerships and collaboration/co-production
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Psychedelics & Chronic Pain Discussion
Robert A R Drake (Advisor)
2 Jun 2021Activity: Talk or presentation types › Community engagement, including convening focus/advisory groups