Robert J P Pope

2024

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

Hurcombe, J. A., Barrington, F., Marchetti, M., Betin, V. M. S., Bowen, E. E., Lay, A. C., Ni, L., Dayalan, L., Pope, R. J. P., Brinkkoetter, P. T., Holzenberger, M., Welsh, G. I. & Coward, R. J. M., 17 May 2024, In: iScience. 27, 5, 18 p., 109749.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

Lay, A. C., Tran, V. D. T., Nair, V., Betin, V. M. S., Hurcombe, J. A., Barrington, A. F., Pope, R. J. P., Burdet, F., Mehl, F., Kryvokhyzha, D., Ahmad, A., C. Sinton, M., Lewis, P., Wilson, M. C., Menon, R., Otto, E. A., Heesom, K. J., C. Looker, H., Nelson, R. G. & Ju, W. & 4 others, Kretzler, M., Satchell, S. C., Lopez-Gomez, M. J. & Coward , R. J. M., 19 Nov 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 19 p., 10018.

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Open Access

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4 Citations (Scopus)

13 Downloads (Pure)

2023

Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation

Bowen, E. E., Hurcombe, J. A., Barrington, F., Keir, L. S., Farmer, L. K., Wherlock, M. D., Ortiz-Sandoval, C. G., Bruno, V., Bohorquez-Hernandez, A., Diatlov, D., Rostam-Shirazi, N., Wells, S., Stewart, M., Teboul, L., Lay, A. C., Butler, M. J., Pope, R. J. P., Larkai, E. M. S., Morgan, B. P. & Moppett, J. & 6 others, Satchell, S. C., Welsh, G. I., Walker, P. D., Licht, C., Saleem, M. A. & Coward, R. J. M., 10 Nov 2023, In: Med (New York, N.Y.). 4, 11, p. 761-777.e8

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

2021

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

Lay, A. C., Hale, L. J., Stowell-Connolly, H., Pope, R. J. P., Nair, V., Ju, W., Marquez, E., Rollason, R., Hurcombe, J. A., Hayes, B., Roberts, T., Gillam, L., Allington, J., Nelson, R. G., Kretzler, M., Holly, J. M. P., Perks, C. M., McArdle, C. A., Welsh, G. I. & Coward, R. J. M., Jul 2021, In: Diabetologia. 64, 7, p. 1690-1702 13 p.

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Open Access

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25 Citations (Scopus)

101 Downloads (Pure)

2020

An information theoretic approach to insulin sensing by human kidney podocytes

Pope, R. J., Garner, K. L., Voliotis, M., Lay, A. C., Betin, V. M., Tsaneva-Atanasova, K., Welsh, G. I., Coward, R. J. & McArdle, C. A., 1 Aug 2020, In: Molecular and Cellular Endocrinology. 518, 110976.

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Open Access

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4 Citations (Scopus)

64 Downloads (Pure)

2013

Galanin stimulates neurite outgrowth from sensory neurons by inhibition of Cdc42 and Rho GTPases and activation of cofilin

Hobson, S., Vanderplank, P. A., Pope, R. J. P., Kerr, N. C. H. & Wynick, D., 2013, In: Journal of Neurochemistry. 127, 2, p. 199-208 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

28 Citations (Scopus)

RhoG regulates platelet granule secretion and thrombus formation in mice

Goggs, R., Harper, M. T., Pope, R. J., Savage, J. S., Williams, C. M., Mundell, S. J., Heesom, K. J., Bass, M., Mellor, H. & Poole, A. W., 8 Oct 2013, In: Journal of Biological Chemistry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

34 Citations (Scopus)

2012

ARF6-Dependent Regulation of P2Y Receptor Traffic and Function in Human Platelets

Kanamarlapudi, V., Owens, S. E., Saha, K., Pope, R. J. & Mundell, S. J., 2012, In: PLoS ONE. 7, 8, p. e43532

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization

Nisar, S. P., Cunningham, M., Saxena, K., Pope, R. J., Kelly, E. & Mundell, S. J., 13 Jul 2012, In: Journal of Biological Chemistry. 287, 29, p. 24505-24515 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

32 Citations (Scopus)

2010

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice

Pope, R., Holmes, F., Kerr, N. & Wynick, D., Oct 2010, In: Molecular Pain. 6

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage

Kerr, N., Pintzas, A., Holmes, F., Hobson, S., Pope, R., Wallace, M., Wasylyk, C., Wasylyk, B. & Wynick, D., 2010, In: Molecular and Cellular Neuroscience. 44, p. 165 - 177

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

2009

A role for galanin in human and experimental inflammatory demyelination

Wraith, D., Pope, R., Butzkueven, H., Holder, H., Vanderplank, P., Lowrey, P., Day, M., Gundlach, A., Kilpatrick, T., Scolding, N. & Wynick, D., 8 Sept 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 36, p. 15466 - 15471 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

2008

Galanin acts as a trophic factor to the central and peripheral nervous systems

Hobson, S., Bacon, A., Elliott-Hunt, C., Holmes, F., Kerr, N., Pope, R., Vanderplank, P. & Wynick, D., 2008, In: Cellular and Molecular Life Sciences. 65, p. 1806 - 1812

Research output: Contribution to journal › Article (Academic Journal) › peer-review

51 Citations (Scopus)

2007

Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage

Elliott-Hunt, C., Pope, R., Vanderplank, P. & Wynick, D., Feb 2007, In: Journal of Neurochemistry. 100 (3), p. 780 - 789 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

89 Citations (Scopus)

2006

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour

Hobson, S., Holmes, F., Kerr, N., Pope, R. & Wynick, D., Nov 2006, In: Journal of Neurochemistry. 99 (3), p. 1000 - 1010 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

81 Citations (Scopus)

2004

Galanin acts as a neuroprotective factor to the hippocampus

Elliott-Hunt, C., Marsh, B., Bacon, A., Pope, R., Vanderplank, P. & Wynick, D., 6 Apr 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101 (14), p. 5105 - 5110 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

123 Citations (Scopus)

2003

Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior

Holmes, F., Bacon, A., Pope, R., Vanderplank, P., Kerr, N., Sukumaran, M., Pachnis, V. & Wynick, D., 13 May 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100 (10), p. 6180 - 6185 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

67 Citations (Scopus)

2001

Endogenous galanin potentiates spinal nociceptive processing following inflammation

Kerr, B., Gupta, Y., Pope, R., Thompson, S., Wynick, D. & McMahon, S., Sept 2001, In: PAIN. 93 (3), p. 267 - 277 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

44 Citations (Scopus)

Dr Robert J P Pope

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