Personal profile
Research interests
I am a psychiatric genetic epidemiologist, interested in understanding and preventing mental illness. My research is highly interdisciplinary, combining methodologies from behavior genetics, epidemiology and longitudinal modelling. Currently, my research focus has three core areas:
1) Longitudinal modeling of mental illness over the life-course: applying novel modeling techniques to better understand how mental health develops with age.
2) Leveraging genetic data to better understand the development of mental illness: using Mendelian randomisation to identify risk factors for mental illness and comparing transmitted and non-transmitted genetic variants to understand the intergenerational transmission of mental illness from parents to children.
3) Identifying predictors of mental illness progression: combining longitudinal modeling of mental illness with genetic causal inference techniques to find robust predictors of favorable outcomes for those with mental illness.
External positions
Research Fellow, Lovisenberg Diaconal Hospital
Research Groups and Themes
- Mental Health Data Science
- TARG
Keywords
- mental health
- wellbeing
- genetics
- health behaviours
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Collaborations and top research areas from the last five years
Research output
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Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study
Wootton, R. E., Crowley, J. J., Pol-Furster, J., Holmberg, A., Rück, C., Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, Mataix-Cols, D. & Fernández de la Cruz, L., 13 Jan 2026, (E-pub ahead of print) In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Maternal migraine and offspring ADHD: triangulating the evidence
Luo, Y., Dardani, C., Wootton, R. E., Gkatzionis, A. & Stergiakouli , E., 14 Feb 2026, In: BMC Medicine. 24, 1, 12 p., 167.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Symptom and Age Dependent Causal Effects of Body Size on Bipolar Disorder: A Mendelian Randomisation Study
Monson, A. H. R., Power, G. M., Haworth , C. M. A. & Wootton, R. E., 27 Mar 2026, (Submitted) In: General Psychiatry.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Datasets
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Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with “cigarette smoking initiation” really capturing?
Reed, Z. (Creator), Wootton, R. (Creator), Khouja, J. (Creator), Richardson, T. (Creator), Sanderson, E. (Creator), Smith, G. D. (Creator) & Munafo, M. (Creator), University of Bristol, 19 Mar 2024
DOI: 10.5523/bris.3bkvq4bbwzqwc2iovjpmyzffdt, http://data.bris.ac.uk/data/dataset/3bkvq4bbwzqwc2iovjpmyzffdt
Dataset
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Study Data Dictionary from Cognitive functioning in anxiety and depression: results from the ALSPAC cohort
Suddell, S. (Creator), Mahedy, L. (Creator), Skirrow, C. (Creator), Penton-Voak, I. S. (Creator), Munafò, M. R. (Creator) & Wootton, R. E. (Creator), The Royal Society, 27 Jul 2023
DOI: 10.6084/m9.figshare.23789453, https://rs.figshare.com/articles/dataset/Study_Data_Dictionary_from_Cognitive_functioning_in_anxiety_and_depression_results_from_the_ALSPAC_cohort/23789453
Dataset
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Observational Analysis Script from Cognitive functioning in anxiety and depression: results from the ALSPAC cohort
Suddell, S. (Creator), Mahedy, L. (Creator), Skirrow, C. (Creator), Penton-Voak, I. S. (Creator), Munafò, M. R. (Creator) & Wootton, R. E. (Creator), The Royal Society, 27 Jul 2023
DOI: 10.6084/m9.figshare.23789456, https://rs.figshare.com/articles/dataset/Observational_Analysis_Script_from_Cognitive_functioning_in_anxiety_and_depression_results_from_the_ALSPAC_cohort/23789456
Dataset