Projects per year
Examination of the properties of nociceptive neurons, identifying neurons as nociceptive or non-nociceptive according to their responses to natural stimuli. Properties examined include membrane properties, firing patterns, ion channels and receptors determined immunocytochemically or by voltage clamp techniques. We are carefully examining how these properties alter in models of chronic pain, and thus how they may contrinute to chronic pain. This information is intended to help the much needed development of novel analgesics.
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, Aβ-nociceptors, moderate pressure receptors and their receptive field depthsLawson, S. N., Fang, X. & Djouhri, L., 16 Oct 2019, In: Current Opinion in Physiology. 11, p. 125-146 22 p.
Research output: Contribution to journal › Review article (Academic Journal) › peer-reviewOpen AccessFile2 Citations (Scopus)52 Downloads (Pure)
Expression and properties of hyperpolarization-activated current (Ih) in vivo in rat DRG neurons with known sensory functionsGao, L., McMullan, S., Djouhri, L., Acosta, C., Harper, A. A. & Lawson, S. N., 2012, In: Journal of Physiology.
Research output: Contribution to journal › Article (Academic Journal) › peer-review39 Citations (Scopus)
Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviourMarsh, B., Acosta, C., Djouhri, L. & Lawson, S. N., 2012, In: Molecular and Cellular Neuroscience. 49, 3, p. 375-86 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review77 Citations (Scopus)