Professor Sarah J George

Search results

• 2023

  Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice

  Reolizo, L. M. P., Williams, H., Frankow, A., Li, Z., Gaston, K. L., Jayaraman, P-S., Johnson, J. L. & George, S. J., 26 Jan 2023, (E-pub ahead of print) In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 3, p. 456-473 18 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Proline 100%
  • Artery Intima Proliferation 36%
  • Vascular Smooth Muscle Cell 36%
  • Saphenous Vein 36%
  • Protein 27%
• 2022

  A novel small diameter nanotextile arterial graft is associated with surgical feasibility and safety and increased transmural endothelial ingrowth in pig

  Josef, J., Bruno, V. D., Sulaiman, N., Ward, A., Johnson, T. W., Baby, H. M., Nair, S. V., Menon, D., George, S. J. & Ascione, R., 8 Feb 2022, In: Journal of Nanobiotechnology. 20, 1, p. 1-13 13 p., 71.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Blood Vessel Graft 100%
  • Enalapril Maleate 66%
  • Pig 66%
  • Patient 33%
  • Tissues 33%
  46 Downloads (Pure)

• Development and Preliminary Testing of Porcine Blood-Derived Endothelial-like Cells for Vascular Tissue Engineering Applications: Protocol Optimisation and Seeding of Decellularised Human Saphenous Veins

  Bond, A. R., Bruno, V. D., Johnson, J. L., George, S. J. & Ascione, R., 14 Jun 2022, In: International Journal of Molecular Sciences. 23, 12, p. 1-22 22 p., 6633.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cells 100%
  • Blood 80%
  • Endothelial Cell 60%
  • Development 40%
  • Cell Marker 40%
  19 Downloads (Pure)

• Hybrid coronary revascularization versus coronary artery bypass grafting for multivessel coronary artery disease: Hybrid coronary revascularisation vs bypass grafting

  Dixon, L. K., Akberali, U., Di Tommaso, E., George, S. J., Johnson, T. W. & Bruno, V. D., 15 Jul 2022, In: International Journal of Cardiology. 359, p. 20-27 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Hybrid 100%
  • Heart Muscle Revascularization 100%
  • Coronary Artery Bypass Graft 54%
  • Survival 27%
  • Mortality 27%

• Next-Generation and Single-Cell Sequencing Approaches to Study Atherosclerosis and Vascular Inflammation Pathophysiology: A Systematic Review

  McQueen, L. W., Ladak, S. S., Abbasciano, R., George, S. J., Suleiman, M-S., Angelini, G. D., Murphy, G. J. & Zakkar, M., 28 Mar 2022, In: Frontiers in Cardiovascular Medicine. 9, 19 p., 849675.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cells 100%
  • Diseases 50%
  • Atherosclerosis 50%
  • Pathophysiology 37%
  • Next Generation Sequencing 37%
  3 Citations (Scopus)

  41 Downloads (Pure)

• Pro-inflammatory role of Wnt/b-catenin signaling in endothelial dysfunction

  Wadey, K. S., Somos, A., Leyden, G., Blythe, H. C., Chan, J., Hutchinson, L., Poole, A. W., Frankow, A., Johnson, J. L. & George, S. J., 14 Dec 2022, (Accepted/In press) In: Frontiers in Cardiovascular Medicine.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Catenin 100%
  • Tumor Necrosis Factor 62%
  • Therapeutic Procedure 37%
  • Endothelial Cell 37%
  • Endothelial Dysfunction 37%
• 2021

  Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

  Mansell, DS., Bruno, V. D., Sammut, E., Chiribiri, A., Johnson, T. W., Khaliulin, I., Baz Lopez, D., Gill, HS., Fraser, KH., Murphy, M., Krieg, T., Suleiman, M-S., George, S. J., Ascione, R. & Cookson, AN., 15 Sep 2021, In: Scientific Reports. 11, 1, 18322.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Myocardial Infarction 100%
  • Ventricular Remodeling 83%
  • Secreted Frizzled-Related Protein 1 50%
  • Time 33%
  • Protein 33%
  2 Citations (Scopus)

  35 Downloads (Pure)

• Aneurysm severity is suppressed by deletion of CCN4: CCN4 in aneurysms

  Williams, H., Wadey, K. S., Frankow, A., Blythe, H. C., Forbes, T., Johnson, J. L. & George, S. J., Sep 2021, In: Journal of Cell Communication and Signaling. 15, 3, p. 421-432 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Aneurysm 100%
  • Apolipoprotein E 50%
  • Apolipoprotein E Knockout Mouse 50%
  • Programmed Cell Death 30%
  • Apoptosis 30%
  4 Citations (Scopus)

  8 Downloads (Pure)

• Disparate Effects of MMP and TIMP Modulation on Coronary Atherosclerosis and Associated Myocardial Fibrosis

  Kremastiotis, G., Handa, I., Jackson, C., George, S. J. & Johnson, J. L., 30 Nov 2021, In: Scientific Reports. 11, 16 p., 23081.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Metalloprotease Inhibitor 100%
  • Cardiac Fibrosis 100%
  • Matrix Metalloproteinase 60%
  • Combination Therapy 40%
  • Pathology 40%
  35 Downloads (Pure)

• Effective decellularisation of human saphenous veins for biocompatible arterial tissue engineering applications: Bench optimisation and feasibility in vivo testing

  Sulaiman, N. S., Bond, A. R., Bruno, V. D., Joseph, J., Johnson, J. L., Suleiman, M-S., George, S. J. & Ascione, R., 29 Mar 2021, In: Journal of Tissue Engineering. 12, 14 p., 2041731420987529.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Sodium Dodecyl Sulfate 100%
  • Decellularization 100%
  • Dodecyl Sulfate Sodium 100%
  • In Vivo 100%
  • Tissue Engineering 66%
  2 Citations (Scopus)

  40 Downloads (Pure)

• Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells

  Ward, A., Sala-Newby, G., Ladak, S., Angelini, G., Caputo, M., Suleiman, M-S., Evans, P., George, S. & Zakkar, M., 25 Apr 2021, (E-pub ahead of print) In: Perfusion.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Shear Stress 100%
  • Upregulation 50%
  • Endothelial Cell 37%
  • Hemodynamic 37%
  • Cells 37%
  72 Downloads (Pure)
• 2020

  A Protocol for a Novel Human Ex Vivo Model of Aneurysm

  Bianco, R., Di Gregoli, K., Caputo, M., George, S. J. & Johnson, J. L., 18 Dec 2020, In: STAR Protocols. 1, 3, p. 100108 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Ex Vivo 100%
  • Aneurysm 100%
  • Aortic Rupture 100%
  • Experience 50%
  • Combination Therapy 50%
  45 Downloads (Pure)

• Galectin-3 identifies a subset of macrophages with a potential beneficial role in atherosclerosis: Macrophage galectin-3 prevents plaque progression

  Di Gregoli, K., Somerville, M., Bianco, R., Thomas, A. C., Frankow, A., Newby, A. C., George, S. J., Jackson, C. L. & Johnson, J. L., 28 May 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 6, p. 1491-1509 19 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Galectin 3 100%
  • Galectin-3 100%
  • Apolipoprotein E Knockout Mouse 41%
  • Mouse 16%
  • Gene 16%
  130 Downloads (Pure)

• NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium

  Ward, A. O., Angelini, G. D., Caputo, M., Evans, P. C., Johnson, J. L., Suleiman, M. S., Tulloh, R. M., George, S. J. & Zakkar, M., 15 Sep 2020, In: Scientific Reports. 10, 10 p., 15133 (2020).

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Shear Stress 100%
  • Serositis 55%
  • Saphenous Vein 44%
  • Monocyte 33%
  • Ex Vivo 33%
  17 Citations (Scopus)

  44 Downloads (Pure)

• Therapeutic potential of inhibiting mitochondrial fission to reduce abdominal aortic aneurysms

  Forbes, T. & George, S. J., 17 Jul 2020, (Accepted/In press) In: Cardiovascular Research. 3 p., cvaa227.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File
  20 Downloads (Pure)
• 2019

  Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases

  Akoumianakis, I., Sanna, F., Margaritis, M., Badi, I., Akawi, N., Herdman, L., Coutinho, P., Fagan, H., Antonopoulos, A. S., Oikonomou, E. K., Thomas, S., Chiu, A. P., Chuaiphichai, S., Kotanidis, C. P., Christodoulides, C., Petrou, M., Krasopoulos, G., Sayeed, R., Lv, L., Hale, A., & 7 othersNaeimi Kararoudi, M., McNeill, E., Douglas, G., George, S., Tousoulis, D., Channon, K. M. & Antoniades, C., 18 Sep 2019, In: Science Translational Medicine. 11, 510, 17 p., eaav5055.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • WNT5A 100%
  • Frizzled 37%
  • RAC1 37%
  • Human 25%
  • Oxidative Stress 25%
  40 Citations (Scopus)

  376 Downloads (Pure)

• Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells

  Brown, B. A., Connolly, G. M., Mill, C. E. J., Williams, H., Angelini, G. D., Johnson, J. L. & George, S. J., Feb 2019, In: Aging Cell. 18, 1, 14 p., e12844.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vascular Smooth Muscle Cell 100%
  • Survival 88%
  • Protein 77%
  • Age 55%
  • Signal Transduction 55%
  17 Citations (Scopus)

  285 Downloads (Pure)

• The Human-Specific and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling

  Mahmoud, A., Ballantyne, M., Miscianinov, V., Pinel, K., Hung, J., Scanlon, J., Iyinikkel, J., Kaczynski, J., Tavares, A., Bradshaw, A., Mills, N., Newby, D., Caporali, A., Gould, G., George, S., Vlitsky, I., Sluimer, J., Rodor, J. & Baker, A., 24 Jul 2019, In: Circulation Research. 125 (2019), 5, p. 535 - 551 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Electric Potential 100%
  • Vascular Smooth Muscle Cell 75%
  • Smooth Muscle Cell 75%
  • Combination Therapy 50%
  • Cell Cycle 50%
  73 Citations (Scopus)

  146 Downloads (Pure)
• 2018

  Changes in contractile protein expression are linked to ventricular stiffness in infants with pulmonary hypertension or right ventricular hypertrophy due to congenital heart disease

  Bond, A. R., Iacobazzi, D., Abdul-Ghani, S., Ghorbel, M., Heesom, K., Wilson, M., Gillett, C., George, S. J., Caputo, M., Suleiman, S. & Tulloh, R. M. R., 1 Feb 2018, In: Open Heart. 5, 1, 14 p., e000716.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Right Ventricle 100%
  • Protein 44%
  • Tetralogy of Fallot 44%
  • Infant 33%
  • Calcium Signaling 33%
  14 Citations (Scopus)

  288 Downloads (Pure)

• Lung function, inflammation, and endothelin-1 in congenital heart disease-associated pulmonary arterial hypertension

  Low, A., George, S., Howard, L., Bell, N., Millar, A. & Tulloh, R. M. R., 1 Feb 2018, In: Journal of the American Heart Association. 7, 4, e007249.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Pulmonary Hypertension 91%
  • Interleukins 11%
  • Serum 10%
  17 Citations (Scopus)

  264 Downloads (Pure)

• Role of smooth muscle cells in coronary artery bypass grafting failure

  Wadey, K., Lopes, J., Bendeck, M. & George, S., 15 Mar 2018, In: Cardiovascular Research. 114, 4, p. 601–610 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vein Graft 100%
  • Artery Intima Proliferation 80%
  • Atherosclerotic Plaque 60%
  • Atherosclerosis 60%
  • Cell Proliferation 40%
  58 Citations (Scopus)

  260 Downloads (Pure)

• The cardiac proteome in patients with congenital ventricular septal defect: A comparative study between right atria and right ventricles

  Bond, Iacobazzi, Abdul-Ghani, S., Ghorbel, Heesom, George, Caputo, Suleiman & Tulloh, 20 Mar 2018, (E-pub ahead of print) In: Journal of Proteomics.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Right Ventricle 100%
  • Ventricular Septal Defect 40%
  • Atrium 40%
  • Patient 30%
  • Tissues 30%
  5 Citations (Scopus)

  397 Downloads (Pure)
• 2017

  Activation and inflammation of the venous endothelium in vein graft disease

  Ward, A. O., Caputo, M., Angelini, G. D., George, S. J. & Zakkar, M., 24 Aug 2017, (E-pub ahead of print) In: Atherosclerosis.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Arterial Circulation 100%
  45 Citations (Scopus)

  454 Downloads (Pure)

• Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression

  Lyon, C., Williams, H., Bianco, R., Simmonds, S., Brown, B., Wadey, K., Smith, F., Johnson, J. & George, S., 11 Dec 2017, In: Scientific Reports. 7, 11 p., 17342.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Programmed Cell Death 100%
  • Vascular Smooth Muscle Cell 77%
  • Matrilysin 77%
  • Abdominal Aortic Aneurysm 55%
  • Nerve Cell Adhesion Molecule 44%
  10 Citations (Scopus)

  284 Downloads (Pure)

• Carotid artery ligation induced intimal thickening and profliferation is unaffeted by ageing

  Brown, B., Williams, H., Bond, A., Angelini, G., Johnson, J. & George, S., 29 Nov 2017, (E-pub ahead of print) In: Journal of Cell Communication and Signaling. 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Age 100%
  • Mouse 100%
  • Cell Proliferation 50%
  • Artery Intima Proliferation 50%
  • Restenosis 50%
  269 Downloads (Pure)

• Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

  Hussain, A., Suleiman, M. S., George, S. J., Loubani, M. & Morice, A., Nov 2017, In: Open Cardiovascular Medicine Journal. 11, p. 1-13 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hypoxic Pulmonary Vasoconstriction 100%
  • Lung Vasoconstriction 100%
  • Patient 33%
  • Development 33%
  • Isotopes of Calcium 33%
  17 Citations (Scopus)

  316 Downloads (Pure)

• MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin

  Di Gregoli, K., Mohamad Anuar, N. N., Bianco, R., White, S. J., Newby, A. C., George, S. J. & Johnson, J. L., 6 Jan 2017, In: Circulation Research. 120, 1, p. 49-65 40 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Aneurysm 100%
  • Elastin 71%
  • Atherosclerosis 71%
  • Atherosclerotic Plaque 57%
  • Tissue Inhibitor of Metalloproteinase 3 57%
  106 Citations (Scopus)

  354 Downloads (Pure)

• Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism

  Wadey, K. S., Brown, B., Sala-Newby, G. B., Jayaraman, P. S., Gaston, K. & George, S. J., 1 Dec 2017, In: Vascular Pharmacology. 99, p. 34-44 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Homeodomain 100%
  • Proline 89%
  • Cell Cycle 30%
  • Cell Cycle Progression 20%
  • Protein Kinase 20%
  9 Citations (Scopus)

  221 Downloads (Pure)

• Targeting Wnt/β-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation

  Curtis, S., Williams, H., Wadey, K., Sala-Newby, G. & George, S., 17 Jun 2017, In: Molecular Therapy - Methods and Clinical Development. 5, p. 191-199 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Nerve Cell Adhesion Molecule 100%
  • Artery Intima Proliferation 62%
  • T Cell 37%
  • Catenin 37%
  • Programmed Cell Death 25%
  11 Citations (Scopus)

  4016 Downloads (Pure)
• 2016

  Cellular and molecular basis of RV hypertrophy in congenital heart disease

  Iacobazzi, D., Suleiman, M-S., Ghorbel, M., George, S. J., Caputo, M. & Tulloh, R. M., Jan 2016, In: Heart. 102, 1, p. 12-17 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Base 100%
  • Persistent Truncus Arteriosus 100%
  • Patient 50%
  • Comprehension 50%
  • Combination Therapy 50%
  23 Citations (Scopus)

• Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion

  Di Gregoli, K., George, S. J., Jackson, C. L., Newby, A. C. & Johnson, J. L., 1 Feb 2016, In: Cardiovascular Research. 109, 2, p. 318-330 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Apolipoprotein E 100%
  • Tissue Inhibitor of Metalloproteinase 2 77%
  • Macrophage 77%
  • Tissue Inhibitor of Metalloproteinase 1 66%
  • Monocyte 55%
  36 Citations (Scopus)

  407 Downloads (Pure)

• Effect of decellularization protocol of human saphenous veins on cytotoxicity and matrix component

  Sulaiman, N., Satta, S., George, S., Suleiman, S. & Ascione, R., 1 Jan 2016, In: Atherosclerosis. 244, p. e11-e12

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cells 100%
  • Vein Graft 100%
  • Cytotoxicity 100%
  • Decellularization 100%
  • Development 50%

• Improving cellularisation of tissue endgineered vascular grafts using functionalised peptide hydrogels

  Schumacker, N. W., Angelini, G., George, S. & Ascione, R., 1 Jan 2016, In: Atherosclerosis. 244, p. e10

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Blood Vessel Graft 100%
  • Tissues 33%
  • Surgery 33%
  • Peptide 33%
  • Coronary Artery Bypass Graft 33%

• Response to Weintraub and Garratt

  Zakkar, M., George, S. J. & Ascione, R., 3 May 2016, In: Circulation. 133, 18, p. 1826 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File
  249 Downloads (Pure)

• Should chronic total occlusion be treated with coronary artery bypass grafting? Chronic total occlusion should be treated with coronary artery bypass grafting

  Zakkar, M., George, S. J. & Ascione, R., 3 May 2016, In: Circulation. 133, 18, p. 1807-1816 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Coronary Artery Bypass Graft 100%
  • Chronic Total Occlusion 100%
  11 Citations (Scopus)

  858 Downloads (Pure)

• Suppression of neointima formation by targeting β-catenin/TCF pathway

  Williams, H., Slater, S. & George, S., Dec 2016, In: Bioscience Reports. 36, 6, 7 p., e00427.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Catenin 100%
  • T Cell 77%
  • Neointima 77%
  • Cells 33%
  • Promoter Region 22%
  7 Citations (Scopus)

  271 Downloads (Pure)

• Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration

  Williams, H., Mill, C., Monk, B., Curtis, S., Johnson, J. & George, S., 1 Jul 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 7, p. 1417-1424 23 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Signal Transduction 100%
  • Synapsin I 100%
  • Protein 100%
  • Artery Intima Proliferation 69%
  • Cell Migration 53%
  38 Citations (Scopus)

  356 Downloads (Pure)
• 2015

  Soluble N-cadherin: A novel inhibitor of VSMC proliferation and intimal thickening

  Lyon, C. A., Wadey, K. S. & George, S. J., 14 Nov 2015, In: Vascular Pharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cell Proliferation 100%
  • Artery Intima Proliferation 83%
  • Vascular Smooth Muscle Cell 83%
  • Endothelial Cell 83%
  • Cell Migration 66%
  7 Citations (Scopus)
• 2014

  EC4, a truncation of soluble N-cadherin, reduces vascular smooth muscle cell apoptosis and markers of atherosclerotic plaque instability

  Lyon, C. A., Johnson, J. L., White, S., Sala-Newby, G. B. & George, S. J., 8 Jan 2014, In: Molecular Therapy - Methods and Clinical Development. 1, 14004.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Nerve Cell Adhesion Molecule 100%
  • Plaque 85%
  • Antiapoptotic 85%
  • Programmed Cell Death 71%
  • Instability 57%
  6 Citations (Scopus)

• EC4, a Truncation of Soluble N-cadherin Reduces Vascular Smooth Muscle Cell Apoptosis and Markers of Atherosclerotic Plaque Instability.

  Lyon, C. A., Johnson, J. L., White, S. J., Sala-Newby, G. & George, S. J., 2014, In: Molecular Therapy - Methods and Clinical Development. 1, 1-14004.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

• The Effect of Ageing on Vascular Smooth Muscle Cell Behaviour - A Mini-Review

  Monk, B. A. & George, S. J., 3 Dec 2014, In: Gerontology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Vascular Smooth Muscle Cell 100%
  • Cell Function 80%
  • Age 60%
  • Aging 40%
  • Comprehension 20%

• Wnt5a-Induced Wnt1-Inducible Secreted Protein-1 Suppresses Vascular Smooth Muscle Cell Apoptosis Induced by Oxidative Stress

  Mill, C., Monk, B. A., Williams, H., Simmonds, S. J., Jeremy, J. Y., Johnson, J. L. & George, S. J., 11 Sep 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Protein 100%
  • Synapsin I 69%
  • Vascular Smooth Muscle Cell 60%
  • Catenin 60%
  • Programmed Cell Death 40%
  30 Citations (Scopus)
• 2013

  miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation

  McDonald, R. A., White, K. M., Wu, J., Cooley, B. C., Robertson, K. E., Halliday, C. A., McClure, J. D., Francis, S., Lu, R., Kennedy, S., George, S. J., Wan, S., van Rooij, E. & Baker, A. H., 25 Mar 2013, In: European Heart Journal.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Neointima 100%
  • Vein 80%
  • microRNA 80%
  • Vein Graft 60%
  • Engraftment 60%
  54 Citations (Scopus)
• 2012

  Tissue-engineered vascular graft remodeling in a growing lamb model: expression of matrix metalloproteinases

  Cummings, I., George, S., Kelm, J., Schmidt, D., Emmert, M. Y., Weber, B., Zünd, G. & Hoerstrup, S. P., Jan 2012, In: European Journal of Cardio-Thoracic Surgery. 41, 1, p. 167-72 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Tissues 100%
  • Engineered Tissue 75%
  • Blood Vessel Graft 75%
  • Matrix Metalloproteinase 50%
  • In Vitro 25%
  33 Citations (Scopus)

• Wnt signalling in smooth muscle cells and its role in cardiovascular disorders

  Mill, C. & George, S. J., 2012, In: Cardiovascular Research. 95, 2, p. 233-40 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Smooth Muscle Cell 100%
  • Cardiovascular Disease 50%
  • Programmed Cell Death 50%
  • Cell Proliferation 50%
  • Wnt Protein 50%
  104 Citations (Scopus)
• 2011

  A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E-Knockout Mice

  Johnson, JL., Devel, L., Czarny, B., George, SJ., Jackson, CL., Rogakos, V., Beau, F., Yiotakis, A., Newby, AC. & Dive, V., Mar 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 528 - 535 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Macrophage Elastase 100%
  • Plaque 57%
  • Macrophage 57%
  • Atherosclerotic Plaque 42%
  • Apolipoprotein E 42%
  129 Citations (Scopus)

• Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice

  Johnson, J. L., Dwivedi, A., Somerville, M., George, S. J. & Newby, A. C., Sep 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 9, p. e35 - e44 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Stromelysin 100%
  • Neointima 100%
  • Vascular Smooth Muscle Cell 80%
  • Plaque 40%
  • Cell Migration 40%
  119 Citations (Scopus)

• Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade

  Patel, N., Toth, T., Jones, C., Lin, H., Ray, P., George, SJ., Welsh, G., Satchell, SC., Sleeman, PA., Angelini, G. & Murphy, GJ., Apr 2011, In: Critical Care Medicine. 39, 4, p. 793 - 802 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cardiopulmonary Bypass 100%
  • Endothelin A Receptor Antagonist 42%
  • Acute Kidney Injury 28%
  • Endothelial Dysfunction 21%
  • Serositis 14%
  31 Citations (Scopus)

• Regulation of VSMC behavior by the cadherin-catenin complex

  Lyon, C., Mill, C., Tsaousi, A., Williams, H. & George, S., 1 Jan 2011, In: Frontiers in Bioscience. 16, p. 644-657 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Vascular Smooth Muscle Cell 100%
  • Programmed Cell Death 50%
  • Catenin 50%
  • Vascular Disease 33%
  • Cell Proliferation 33%
  25 Citations (Scopus)

• Sustained Reduction of Vein Graft Neointima Formation by Ex Vivo TIMP-3 Gene Therapy

  George, S. J., Wan, S., Hu, J., MacDonald, R., Johnson, J. L. & Baker, A. H., 13 Sep 2011, In: Circulation. 124, 11, Supplement 1, p. s135 - s142 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Artery Intima Proliferation 100%
  • Tissue Inhibitor of Metalloproteinase 3 100%
  • Vein Graft 83%
  • Adenoviridae 83%
  • Metalloprotease Inhibitor 66%
  64 Citations (Scopus)