Research output per year
Research output per year
Research output
- 1 - 50 out of 293 results
Search results
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2024
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease
Tsartsalis, S., Sleven, H., Fancy, N., Wessely, F., Smith, A. M., Willumsen, N., Cheung, T. K. D., Rokicki, M. J., Chau, V., Ifie, E., Khozoie, C., Ansorge, O., Yang, X., Jenkyns, M. H., Davey, K., McGarry, A., Muirhead, R. C. J., Debette, S., Jackson, J. S. & Montagne, A. & 6 others, , 12 Mar 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 19 p., 2243.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access23 Citations (Scopus) -
Correction: Is later‑life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post‑mortem human brain tissue?
Sinclair, L. I., Mohr, A., Morisaki, M., Edmondson, M., Chan, S., Bone-Connaughton, A., Turecki, G. & Love, S., 13 Feb 2024, In: Alzheimer's Research & Therapy. 16, 1 p., 33.Research output: Contribution to journal › Article (Academic Journal)
Open Access -
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Van Hulle, C., Ince, S., Okonkwo, O. C., Bendlin, B. B., Johnson, S. C., Carlsson, C. M., Asthana, S., Love, S., Blennow, K., Zetterberg, H. & Miners, J. S., 5 Jan 2024, (E-pub ahead of print) In: Translational Psychiatry. 14, 1, 8 p., 3.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access10 Citations (Scopus) -
2023
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
van Hulle, C., Ince, S., Jonaitis, E., Okonkwo, O. C., Bendlin, B., Johnson, S., Carlsson, C., Asthana, S., Love, S., Blennow, K., Zetterberg, H. & Miners, J. S., 18 Apr 2023, (Research square).Research output: Working paper › Preprint
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Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage
Tayler, H. M., MacLachlan, R., Güzel, Ö., Miners, J. S. & Love, S., 4 Apr 2023, In: Brain Communications. 5, 2, fcad112.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access8 Citations (Scopus) -
Is later-life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post-mortem human brain tissue?
Sinclair, L. I., Mohr, A., Morisaki, M., Edmondson, M., Chan, S., Bone-Connaughton, A., Turecki, G. & Love, S., 12 Sept 2023, (E-pub ahead of print) In: Alzheimer's Research and Therapy. 15, 15 p., 153.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access10 Citations (Scopus) -
SARS-CoV-2 targets pericytes to restrict blood flow within the brain
Miners, J. S., Fisher, R. A. & Love, S., 1 Feb 2023, In: Brain. 146, 2, p. 418-420 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)43 Downloads (Pure) -
2022
APOE ε4, Alzheimer's disease neuropathology, and sleep disturbance, in individuals with and without dementia
Blackman, J., Love, S., Sinclair, L. I., Cain, R. J. & Coulthard, E. J., 30 Mar 2022, In: Alzheimer's Research and Therapy. 14, 1, 11 p., 47 .Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)77 Downloads (Pure) -
DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
Shireby, G., Dempster, E. L., Policicchio, S., Smith, R. G., Pishva, E., Chioza, B., Davies, J. P., Burrage, J., Lunnon, K., Seiler Vellame, D., Love, S., Thomas, A., Brookes, K., Morgan, K., Francis, P., Hannon, E. & Mill, J., 24 Sept 2022, In: Nature Communications. 13, 1, p. 5620 5620.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access44 Citations (Scopus) -
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
Pihlstrøm, L., Shireby, G., Geut, H., Henriksen, S. P., Rozemuller, A. J. M., Tunold, J.-A., Hannon, E., Francis, P., Thomas, A. J., Love, S., Mill, J., van de Berg, W. D. J. & Toft, M., 22 Aug 2022, In: Nature Communications. 13, 1, 10 p., 4932.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile21 Citations (Scopus)32 Downloads (Pure) -
Iron Deposition in the Brain After Aneurysmal Subarachnoid Hemorrhage
Galea, I., Durnford, A., Glazier, J., Mitchell, S., Kohli, S., Foulkes, L., Norman, J., Darekar, A., Love, S., Bulters, D. O., Nicoll, J. A. R. & Boche, D., 24 Feb 2022, (E-pub ahead of print) In: Stroke. 53, 5, p. 1633-1642 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
38 Citations (Scopus) -
Late-life blood pressure and markers of vascular and disease pathology in Alzheimer’s, vascular, and mixed dementia
Tayler, H. M., Guzel, O., MacLachlan, R. A., Miners, J. S. & Love, S., 9 Jun 2022, (Unpublished).Research output: Contribution to conference › Conference Poster › peer-review
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New insights into the genetic etiology of Alzheimer's disease and related dementias
EADB, 4 Apr 2022, In: Nature Genetics. 54, 4, p. 412-436 25 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1058 Citations (Scopus)55 Downloads (Pure) -
Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives
Fisher, R. A., Miners, J. S. & Love, S., 28 Oct 2022, In: Brain Pathology. 32, 6, e13061.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile60 Citations (Scopus)271 Downloads (Pure) -
2021
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
Smith, R. G., Pishva, E., Shireby, G., Smith, A. R., Roubroeks, J. A. Y., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Riemenschneider, M., Giese, A., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., van den Hove, D. L. A., Weedon, M., Brokaw, D., Francis, P. T., Love, S. & Morgan, K. & 5 others, , 10 Jun 2021, In: Nature Communications. 12, 1, 13 p., 3517 (2021).Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile79 Citations (Scopus)55 Downloads (Pure) -
Brain arteriolosclerosis
Blevins, B. L., Vinters, H. V., Love, S., Wilcock, D. M., Grinberg, L. T., Schneider, J. A., Kalaria, R. N., Katsumata, Y., Gold, B. T., Wang, D. J. J., Ma, S. J., Shade, L. M. P., Fardo, D. W., Hartz, A. M. S., Jicha, G. A., Nelson, K. B., Magaki, S. D., Schmitt, F. A., Teylan, M. A. & Ighodaro, E. T. & 5 others, , 1 Jan 2021, In: Acta Neuropathologica. 141, 1, p. 1-24 24 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile118 Citations (Scopus)151 Downloads (Pure) -
Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia
McAleese, K. E., Colloby, S. J., Thomas, A. J., Al-Sarraj, S., Ansorge, O., Neal, J., Roncaroli, F., Love, S., Francis, P. T. & Attems, J., Jul 2021, In: Alzheimer's and Dementia. 17, 7, p. 1121-1133 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile62 Citations (Scopus)80 Downloads (Pure) -
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Chia, R., Palmer, L., Love, S., Scholz, S. & American Genome Center, Mar 2021, In: Nature Genetics. 53, 3, p. 294-303 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile234 Citations (Scopus)56 Downloads (Pure) -
Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in Alzheimer's disease, vascular dementia and mixed dementia
Tayler, H., Miners, J. S., Güzel, Ö., MacLachlan, R. & Love, S., 1 Jul 2021, In: Brain Pathology. 31, 4, 12 p., e12935.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile61 Citations (Scopus)169 Downloads (Pure) -
Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study
Attems, J., Toledo, J. B., Walker, L., Gelpi, E., Gentleman, S., Halliday, G., Hortobagyi, T., Jellinger, K., Kovacs, G. G., Lee, E. B., Love, S., McAleese, K. E., Nelson, P. T., Neumann, M., Parkkinen, L., Polvikoski, T., Sikorska, B., Smith, C., Grinberg, L. T. & Thal, D. R. & 2 others, , Feb 2021, In: Acta Neuropathologica. 141, 2, p. 159-172 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile163 Citations (Scopus)72 Downloads (Pure) -
Neuropathology associated with SARS-CoV-2 infection
Egervari, K., Thomas, C., Lobrinus, A., Kuhlmann, T., Brück, W., Love, S., Crary, J., Stadelmann, C., Paulus, W. & Merkler,, D., 23 Jan 2021, In: Lancet. 397, p. 276 277 p.Research output: Contribution to journal › Letter (Academic Journal)
Open Access -
Pericyte Contractile Responses to Endothelin-1 and Aβ Peptides: Assessment by Electrical Impedance Assay
Hibbs, E., Love, S. & Miners, J. S., 20 Aug 2021, In: Frontiers in Cellular Neuroscience. 15, p. 723953 723953.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)66 Downloads (Pure) -
Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease
Asby, D., Boche, D., Allan, S., Love, S. & Miners, J. S., 28 Jul 2021, In: Brain. 144, 6, p. 1869-1883 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile53 Citations (Scopus)153 Downloads (Pure) -
2020
A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population
Love, S., Delgado-Saborit, J. M., Valentina, V., Gowers, A., Shaddick, G. & Fox, N., 25 Nov 2020, (E-pub ahead of print) In: Science of The Total Environment. 757, 27 p., 143734.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile156 Citations (Scopus)305 Downloads (Pure) -
Alemtuzumab-related eosinophilic central nervous system vasculitis
Leach, O. A., Hilton, D. A., Adams, W., Love, S. & Straukiene, A., 1 Oct 2020, In: Multiple Sclerosis Journal. 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)213 Downloads (Pure) -
Brain biopsy before or after treatment with corticosteroids
Rice, C. M., Renowden, S. A., Urankar, K., Love, S. & Scolding, N. J., 28 Apr 2020, In: Neuroradiology. 2 p.Research output: Contribution to journal › Letter (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)134 Downloads (Pure) -
Brain Pathology moves to open access
Glatzel, M. & Love, S., 17 Dec 2020, In: Brain Pathology. p. 1011-1011 1 p.Research output: Contribution to journal › Article (Academic Journal)
Open AccessFile34 Downloads (Pure) -
Cognitive impact of COVID-19: looking beyond the short term
Miners, S., Kehoe, P. G. & Love, S., 30 Dec 2020, In: Alzheimer's Research and Therapy. 12, 1, 16 p., 170 (2020).Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile162 Citations (Scopus)182 Downloads (Pure) -
Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates
Ling, H., Gelpi, E., Davey, K., Jaunmuktane, Z., Mok, K. Y., Jabbari, E., Simone, R., R'Bibo, L., Brandner, S., Ellis, M., Attems, J., Mann, D., Halliday, G. M., Al-Sarraj, S., Hedreen, J., Ironside, J. W., Kovacs, G. G., Kovari, E., Love, S. & Vonsattel, J. P. G. & 10 others, , 16 Jan 2020, In: Acta Neuropathologica. 18 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)145 Downloads (Pure) -
Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways
Hannon, E., Shireby, G. L., Brookes, K., Attems, J., Sims, R., Cairns, N., Love, S., Thomas, A., Francis, P. & Mill, J., 12 Oct 2020, In: Brain Communications. 2, 2, 13 p., fcaa167.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile9 Citations (Scopus)81 Downloads (Pure) -
Mixed neuropathology in frontotemporal lobar degeneration
Pennington, C., Marini, L., Coulthard, E. & Love, S., 2 Apr 2020, In: Amyotrophic lateral sclerosis & frontotemporal degeneration. p. 1-8 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Citations (Scopus)131 Downloads (Pure) -
Potential human transmission of amyloid beta pathology: surveillance and risks
Lauwers, E., Lalli, G., Brandner, S., Collinge, J., Compernolle, V., Duyckaerts, C., Edgren, G., Haik, S., Hardy, J., Helmy, A., Ivinson, A., Jaunmuktane, Z., Jucker, M., Knight, R., Lemmens, R., Love, S., Mead, S. & de Strooper, B., 1 Oct 2020, In: Lancet Neurology. 19, 10, p. 872-878 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile59 Citations (Scopus)97 Downloads (Pure) -
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
Shireby, G. L., Davies, J. P., Francis, P. T., Burrage, J., Walker, E. M., Neilson, G. W. A., Dahir, A., Thomas, A. J., Love, S., Smith, R. G., Lunnon, K., Kumari, M., Schalkwyk, L. C., Morgan, K., Brookes, K., Hannon, E. & Mill, J., 29 Oct 2020, In: Brain. 13 p., awaa334.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile106 Citations (Scopus)126 Downloads (Pure) -
Zibotentan, an endothelin A receptor antagonist, prevents Amyloid-β-induced hypertension and maintains cerebral perfusion
Palmer, J. C., Tayler, H. M., Dyer, L., Kehoe, P. G., Paton, J. F. R. & Love, S., 2 Jan 2020, In: Journal of Alzheimer's Disease. 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile9 Citations (Scopus)146 Downloads (Pure) -
2019
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)
GERAD, 28 Feb 2019, In: Nature Genetics.Research output: Contribution to journal › Article (Academic Journal) › peer-review
53 Citations (Scopus) -
Biochemical Evidence Of Cerebral Hypoperfusion in Dementia: Associated With β-Secretase, Endothelin-1 And Arteriolosclerosis
Tayler, H., MacLachlan, R., Miners, S. & Love, S., 8 Jun 2019, (Unpublished).Research output: Contribution to conference › Conference Abstract
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CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology
Miners, J. S., Kehoe, P. G., Love, S., Zetterberg, H. & Blennow, K., 14 Sept 2019, In: Alzheimer's Research and Therapy. 11, 6 p., 81.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile91 Citations (Scopus)176 Downloads (Pure) -
Dear Reader: Data Citation in Changing Times
Glatzel, M. & Love, S., 1 Mar 2019, In: Brain Pathology. 29, 2, p. 153-154 2 p.Research output: Contribution to journal › Article (Academic Journal)
Open AccessFile1 Citation (Scopus)125 Downloads (Pure) -
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy
Kiely, A. P., Miners, S., Courteny, R., Strand, C., Love, S. & Holton, J. L., 1 Jun 2019, In: Neuropathology and Applied Neurobiology. 45, 4, p. 347-360 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile16 Citations (Scopus)181 Downloads (Pure) -
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Alzheimer Disease Genetics Consortium (ADGC), 28 Feb 2019, In: Nature Genetics. 51, 3, p. 414-430 22 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1868 Citations (Scopus)403 Downloads (Pure) -
KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences
Hares, K. M., Miners, S., Scolding, N., Love, S. & Wilkins, A., 19 Feb 2019, In: AMRC Open Research. 1, 22 p., 1.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile259 Downloads (Pure) -
Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease
Nicoll, J. A. R., Buckland, G. R., Harrison, C. H., Page, A., Harris, S., Love, S., Neal, J. W., Holmes, C. & Boche, D., 3 Jun 2019, (E-pub ahead of print) In: Brain. 142, 7, p. 2113–2126 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile146 Citations (Scopus)365 Downloads (Pure) -
Primum non nocere: a call for balance when reporting on CTE
Stewart, W., Allinson, K., Al-Sarraj, S., Bachmeier, C., Barlow, K., Belli, A., Burns, M. P., Carson, A., Crawford, F., Dams-O'Connor, K., Diaz-Arrastia, R., Dixon, C. E., Edlow, B. L., Ferguson, S., Fischl, B., Folkerth, R. D., Gentleman, S., Giza, C. C., Grady, M. S. & Helmy, A. & 40 others, , 1 Mar 2019, In: Lancet Neurology. 18, 3, p. 231-233 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile57 Citations (Scopus)172 Downloads (Pure) -
Vascular dysfunction—The disregarded partner of Alzheimer's disease
Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S. & Bath, P. M. & 47 others, , Jan 2019, In: Alzheimer's and Dementia. 15, 1, p. 158-167 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile515 Citations (Scopus)575 Downloads (Pure) -
Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas
Sinclair, L., Kumar, A., Taher, D.-S. & Love, S., 12 Sept 2019, In: Alzheimer's Research and Therapy. 11, 1, 15 p., 80 (2019).Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Citations (Scopus)269 Downloads (Pure) -
Zibotentan, an endothelin AD receptor antagonist, prevents Aβ-induced hypertension and maintains cerebral perfusion
Tayler, H., Palmer, J., Dyer, L., Kehoe, P., Paton, J. & Love, S., 19 Jun 2019, (Submitted) In: Journal of Alzheimer's Disease.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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2018
A broader view of dementia: Multiple co-pathologies are the norm
Coulthard, E. J. & Love, S., Jul 2018, In: Brain. 141, 7, p. 1894-1897 4 p., awy153.Research output: Contribution to journal › Comment/debate (Academic Journal)
Open AccessFile27 Citations (Scopus)203 Downloads (Pure) -
Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease
Miners, J. S., Schulz, I. & Love, S., 1 Jan 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 103-115 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile164 Citations (Scopus)491 Downloads (Pure) -
Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism
Hull, J., Usmari Moraes, M., Brookes, E., Love, S. & Conway, M. E., 1 Jan 2018, In: Neurochemistry International. 112, p. 49-58 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)497 Downloads (Pure) -
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology
Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & Joutel, A. & 20 others, , 30 Apr 2018, In: Clinical Science. 132, 8, p. 851-868 18 p.Research output: Contribution to journal › Review article (Academic Journal)
Open AccessFile49 Citations (Scopus)356 Downloads (Pure)