1991 …2020

Research output per year

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Research Output

2020
2018

VEGFR1 and VEGFR2 in Alzheimer's Disease

Harris, R., Miners, J. S., Allen, S. & Love, S., 2018, In : Journal of Alzheimer's Disease. 61, 2, p. 741-752 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
367 Downloads (Pure)
2017

16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain

Emery, D., Shoemark, D., Batstone, T., Waterfall, C., Coghill, J., Cerajewska, T., Davies, M., West, N. & Allen-Birt, S., 20 Jun 2017, In : Frontiers in Aging Neuroscience. 9, 13 p., 195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
59 Citations (Scopus)
304 Downloads (Pure)

Bacterial burden in disease, aging and Alzheimer’s disease

Shoemark, D. & Allen-Birt, S., 1 Mar 2017, Handbook of Infection and Alzheimer’s Disease. Miklossy, J. (ed.). IOS Press, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
170 Downloads (Pure)

Chapter 2: Pathophysiology of Alzheimer's disease

Allen-Birt, S., 30 May 2017, Alzheimer's Disease. Waldemar, G. & Burns, A. (eds.). 2nd ed. Oxford University Press, 10 p. (Oxford Neurology Library).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
134 Downloads (Pure)

Relación entre enfermedad periodontal y enfermedad de Alzheimer: ¿El cepillado de los dientes puede influir en la enfermedad de Alzheimer?

West, N., Shoemark, D., Davies, M. & Allen-Birt, S., 23 May 2017, In : Periodoncia Clinica. 2017, 8, p. 63-76 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
69 Downloads (Pure)

Renin-angiotensin system microRNAs: special focus on the brain

Gerardo-Aviles, J., Allen-Birt, S. & Kehoe, P., 12 Jul 2017, Renin-angiotensin system : past, present and future. Croatia: InTech

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
247 Downloads (Pure)
2016

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

Kailainathan, S., Piers, T. M., Yi, J. H., Choi, S. M., Fahey, M. S., Borger, E., Gunn-Moore, F. J., O'Neill, L., Lever, M., Whitcomb, D. J., Cho, K. & Allen, S. J., Feb 2016, In : Pharmacological Research. 104, p. 97-107 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
239 Downloads (Pure)
2015

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
232 Downloads (Pure)

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

Shoemark, D. K. & Allen, S. J., 2015, In : Journal of Alzheimer's Disease. 43, 3, p. 725-38 14 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)

Frias, B., Santos, J., Morgado, M., Sousa, M. M., Gray, S. M. Y., McCloskey, K. D., Allen, S., Cruz, F. & Cruz, C. D., 4 Feb 2015, In : Journal of Neuroscience. 35, 5, p. 2146-60 15 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)
11 Downloads (Pure)
2013

Brain Derived Neurotrophic Factor (BDNF), acting at the spinal cord level, participates in bladder hyperactivity in and referred pain chronic bladder inflammation

Frias, B., Allen-Birt, S. J., Dawbarn, D., Charrua, A., Cruz, F. & Cruz, C. D., 27 Mar 2013, In : BMC Neuroscience. 234, p. 88-102 15 p.

Research output: Contribution to journalArticle (Academic Journal)

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U. & Patel, N. K., May 2013, In : Pharmacology and Therapeutics. 138, 2, p. 155 21 p., JPT-06525.

Research output: Contribution to journalArticle (Academic Journal)

369 Citations (Scopus)

Identification of novel small molecule TGF-β antagonists using structure-based drug design

Wang, H., Sessions, R. B., Prime, S. S., Shoemark, D. K., Allen-Birt, S. J., Hong, W., Narayanan, S. & Paterson, I. C., 2013, In : Journal of Computer Aided Design. 27, 0920-654X, p. 365-372 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling

Crompton, L. A., Byrne, M. L., Taylor, H., Kerrigan, T. L., Bru-Mercier, G., Badger, J. L., Barbuti, P. A., Jo, J., Tyler, S. J., Allen-Birt, S. J., Kunath, T., Cho, K. & Caldwell, M. A., 9 Aug 2013, In : Stem Cell Research. 11, 3, p. 1206-1221 16 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2011

The neurotrophins and their role in Alzheimer's disease

Allen, SJ., Watson, JJ. & Dawbarn, D., Dec 2011, In : Current Neuropharmacology. 9, p. 559 - 573 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Towards a model of sporadic Alzheimer’s disease: aiding design of small molecule TrkA agonists

Watson, J., Shoemark, D., Hemmings, J. L., Tyler, S., Fahey, M., Williams, C., Bailey, C., McArdle, C., Caunt, J., Jane, D., Sessions, R., Crump, M., Willis, C. & Allen-Birt, S., 1 Jul 2011, Alzheimer's & Dementia. Amsterdam:Elsevier, Vol. 7. p. S802 1 p. P4-274

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2010

Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis

Pinto, R., Frias, B., Allen, SJ., Dawbarn, D., McMahon S., B., Cruz, F. & Cruz C., D., 31 Mar 2010, In : Neuroscience. 166, 3, p. 907 - 916 10 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

McNamee K., E., Burleigh, A., Gompels L., L., Feldmann, M., Allen, SJ., Williams R., O., Dawbarn, D., Vincent T., L. & Inglis J. J., N. V., May 2010, In : PAIN. 149, 2, p. 386 - 392 6 p.

Research output: Contribution to journalArticle (Academic Journal)

83 Citations (Scopus)
2009

Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors

Masoudi, R., Ioannou M., S., Coughlin M., D., Pagadala, P., Neet K., E., Clewes, O., Allen, SJ., Dawbarn, D. & Fahnestock, M., 3 Jul 2009, In : Journal of Biological Chemistry. 284, 27, p. 18424 - 18433 10 p.

Research output: Contribution to journalArticle (Academic Journal)

96 Citations (Scopus)

Chapter 4: Pathophysiology of Alzheimer's Disease

Allen, S. J. & Dawbarn, D., 1 Mar 2009, Alzheimer's Disease. Waldemar, G. & Burns, A. (eds.). 1st ed. Oxford University Press, p. 27-35 8 p. (Oxford Neurology Library).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2008

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

Clewes, O., Fahey, MS., Tyler, SJ., Watson, JJ., Seok, H., Catania, C., Cho, K., Dawbarn, D. & Allen, S. J., Nov 2008, In : Journal of Neurochemistry. 107, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

Targeting nerve growth factor in pain: what is the therapeutic potential?

Watson, JJ., Allen, SJ. & Dawbarn, D., Nov 2008, In : Biodrugs. 22, p. 349 - 359 10 p.

Research output: Contribution to journalArticle (Academic Journal)

125 Citations (Scopus)
2007

Alzheimer's disease: a hundred years of investigation

Allen, SJ., 2007, Neurobiology of Alzheimer's disease 3rd edition. D., D. & Allen S., J. (eds.). Oxford University Press, p. 1 - 36 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro

Hatchett, CS., Tyler, SJ., Armstrong, D., Dawbarn, D. & Allen, SJ., May 2007, In : Brain Research. 1147, p. 248 - 255 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Neurobiology of Alzheimer's disease 3rd edition

Dawbarn, D. & Allen, SJ., 2007, Oxford University Press. 456 p.

Research output: Book/ReportEdited book

2006

Clinical relevance of the neurotrophins and their receptors

Allen, SJ. & Dawbarn, D., Feb 2006, In : Clinical Science. 110, p. 175 - 191 16 p.

Research output: Contribution to journalArticle (Academic Journal)

219 Citations (Scopus)

NGF receptor TrkAd5: Therapeutic agent and drug design target

Dawbarn, D., Fahey, MS., Watson, JJ., Tyler, SJ., Shoemark, DK., Zhang, R., Brady, L., Willis, CL. & Allen, SJ., Aug 2006, In : Biochemical Society Transactions. 34 (4), p. 587 - 590 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Premorbid effects of APOE on synaptic proteins in human temporal neocortex

Love, S., Siew, LK., Dawbarn, D., Wilcock, GK., Ben-Shlomo, Y. & Allen, SJ., Jun 2006, In : Neurobiology of Aging. 27 (6), p. 797 - 803 7 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma

Nassenstein, C., Dawbarn, D., Pollock, K., Allen, SJ., Erpenbeck, VJ., Spies, E., Krug, N. & Braun, A., Sep 2006, In : Journal of Allergy and Clinical Immunology. 118 (3), p. 597 - 605 9 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma

Watson, JJ., Fahey, MS., van den Worm, E., Engels, F., Nijkamp, FP., Stroemer, P., McMahon, S., Allen, SJ. & Dawbarn, D., Mar 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316 (3), p. 1122 - 1129 8 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)
2005

Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis

Hu, VY., Zvara, P., Dattilio, A., Redman, TL., Allen, SJ., Dawbarn, D., Stroemer, RP. & Vizzard, MA., Mar 2005, In : Journal of Urology. 173 (3), p. 1016 - 1021 5 p.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)
2004

Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay

Siew, LK., Love, S., Dawbarn, D., Wilcock, GK. & Allen, SJ., 30 Oct 2004, In : Journal of Neuroscience Methods. 139 (2), p. 153 - 159 7 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
2003

Changes in apha and beta secretase activity

Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., 2003, British Pharmacological Society.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Comparison of the binding of NGF, BDNF, NT-3 and NT4/5 to the TrkA immunoglobulin-like domain (Ig2)

Nurmahomed, K., Naylor, RL., Robertson, AGS., Burston, JJ., Dawbarn, D. & Allen, SJ., 2003, IBRO congress, Prague.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Expression, purification, and biological activity of the TrkAIg2 domain

Burston, JJ., Fahey, MS., Nurmahomed, K., Dawbarn, D. & Allen, SJ., 2003, IBRO congress, Prague.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Neurotrophins and Neurodegeneration

Dawbarn, D. & Allen, SJ., May 2003, In : Neuropathology and Applied Neurobiology. 29, p. 211 - 230 19 p.

Research output: Contribution to journalArticle (Academic Journal)

170 Citations (Scopus)

Secretase activity in Alzheimer's disease

Armstrong, D., Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., 2003, 6th International Conference of Alzheimer's and Parkinson's disease. Seville.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Therapeutic applications of neurotrophins

Dawbarn, D. & Allen, SJ., 2003, Recent Research Developments in Biophysics and Biochemistry. Pandalai, S. G. (ed.). Research Signpost, Vol. 3. p. 763 - 789 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2002

Achieving specificity in Trk-neurotrophin interactions: The crystal structure of TrkB-d5 bound to NT-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Brady, RL. & Dawbarn, D., 2002, Soc. Neuroscience, San Diego.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4

Naylor, RL., Robertson, AGS., Allen, SJ., Sessions, RB., Clarke, AR., Mason, GGF., Burston, JJ., Tyler, SJ., Wilcock, GK. & Dawbarn, D., 1 Mar 2002, In : Biochemical and Biophysical Research Communications. 291 (3), p. 501 - 507 7 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Alpha- and beta-secretase: profound changes in Alzheimer's disease

Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., Dec 2002, In : Biochemical and Biophysical Research Communications. 299 (3), p. 373 - 376 4 p.

Research output: Contribution to journalArticle (Academic Journal)

146 Citations (Scopus)

The second immunoglobulin domain of the human TrkB receptor defines the binding sites for BDNF and NT4

Allen, SJ., Naylor, RL., Sessions, RB., Burston, JJ. & Dawbarn, D., 2002, Federation of European Neuroscience. Vol. 27. p. 686 - 686 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2001

1HE7 - Human Nerve Growth Factor Receptor TrkA

Banfield, MJ., Robertson, AGS., Allen, SJ., Dando, JA., Tyler, SJ., Bennett, GS., Brain, SD., Mason, GGF., Holden, PH., Clarke, AR., Naylor, RL., Wilcock, GK., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Alzheimer's disease: past, present and future themes

Allen, SJ., 2001, Neurobiology of Alzheimer's Disease, 2nd edition. D. D. & S. J. A. (eds.). Oxford University Press, p. 1 - 32

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Crystal Structure Of Trkb-D5 Bound To Neurotrophin-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Expression of recombinant extracellular domain of the type II transforming growth factor-β receptor: utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-β agonists and antagonists

Fahey, MS., Dawbarn, D., Allen, SJ., Paterson, IC. & Prime, SS., Mar 2001, In : Analytical Biochemistry. 290 (2), p. 272 - 276 5 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Identification and structure of the nerve growth factor binding site on TrkA

Robertson, AGS., Banfield, MJ., Allen, SJ., Dando, JA., Mason, GGF., Tyler, SJ., Bennett, GS., Brain, SD., Clarke, AR., Naylor, RL., Wilcock, GK., Brady, RL. & Dawbarn, D., 23 Mar 2001, In : Biochemical and Biophysical Research Communications. 282 (1), p. 131 - 141 11 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Neurobiology of Alzheimer's disease

Dawbarn, D. & Allen, SJ., 2001, xii ed. Oxford University Press. 404 p.

Research output: Book/ReportEdited book

Neurobiology of Alzheimer's Disease, 2nd edition

Dawbarn, D. & Allen, SJ., 2001, xii ed. Oxford University Press. 404 p.

Research output: Book/ReportEdited book