1991 …2020

Research output per year

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Research Output

16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain

Emery, D., Shoemark, D., Batstone, T., Waterfall, C., Coghill, J., Cerajewska, T., Davies, M., West, N. & Allen-Birt, S., 20 Jun 2017, In : Frontiers in Aging Neuroscience. 9, 13 p., 195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
61 Citations (Scopus)
317 Downloads (Pure)

1HE7 - Human Nerve Growth Factor Receptor TrkA

Banfield, MJ., Robertson, AGS., Allen, SJ., Dando, JA., Tyler, SJ., Bennett, GS., Brain, SD., Mason, GGF., Holden, PH., Clarke, AR., Naylor, RL., Wilcock, GK., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Achieving specificity in Trk-neurotrophin interactions: The crystal structure of TrkB-d5 bound to NT-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Brady, RL. & Dawbarn, D., 2002, Soc. Neuroscience, San Diego.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

Kailainathan, S., Piers, T. M., Yi, J. H., Choi, S. M., Fahey, M. S., Borger, E., Gunn-Moore, F. J., O'Neill, L., Lever, M., Whitcomb, D. J., Cho, K. & Allen, S. J., Feb 2016, In : Pharmacological Research. 104, p. 97-107 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
251 Downloads (Pure)

A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4

Naylor, RL., Robertson, AGS., Allen, SJ., Sessions, RB., Clarke, AR., Mason, GGF., Burston, JJ., Tyler, SJ., Wilcock, GK. & Dawbarn, D., 1 Mar 2002, In : Biochemical and Biophysical Research Communications. 291 (3), p. 501 - 507 7 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Alpha- and beta-secretase: profound changes in Alzheimer's disease

Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., Dec 2002, In : Biochemical and Biophysical Research Communications. 299 (3), p. 373 - 376 4 p.

Research output: Contribution to journalArticle (Academic Journal)

147 Citations (Scopus)

Alzheimer's disease: a hundred years of investigation

Allen, SJ., 2007, Neurobiology of Alzheimer's disease 3rd edition. D., D. & Allen S., J. (eds.). Oxford University Press, p. 1 - 36 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Alzheimer's disease: past, present and future themes

Allen, SJ., 2001, Neurobiology of Alzheimer's Disease, 2nd edition. D. D. & S. J. A. (eds.). Oxford University Press, p. 1 - 32

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Alzheimer's disease - Current controversies - an overview

Allen, SJ. & Dawbarn, D., 1995, Neurobiology of Alzheimer's disease. Dawbarn, D. & Allen, SJ. (eds.). BIOS Scientific Publishers , p. 1 - 8

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Analysis of the major loop of presenilin 1

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ., Wilcock, GK. & Darbarn, D., 1998, Unknown. S188-S188 ed. Vol. 19 4S. p. 188 - 188 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Bacterial burden in disease, aging and Alzheimer’s disease

Shoemark, D. & Allen-Birt, S., 1 Mar 2017, Handbook of Infection and Alzheimer’s Disease. Miklossy, J. (ed.). IOS Press, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
171 Downloads (Pure)

Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors

Masoudi, R., Ioannou M., S., Coughlin M., D., Pagadala, P., Neet K., E., Clewes, O., Allen, SJ., Dawbarn, D. & Fahnestock, M., 3 Jul 2009, In : Journal of Biological Chemistry. 284, 27, p. 18424 - 18433 10 p.

Research output: Contribution to journalArticle (Academic Journal)

96 Citations (Scopus)

Brain Derived Neurotrophic Factor (BDNF), acting at the spinal cord level, participates in bladder hyperactivity in and referred pain chronic bladder inflammation

Frias, B., Allen-Birt, S. J., Dawbarn, D., Charrua, A., Cruz, F. & Cruz, C. D., 27 Mar 2013, In : BMC Neuroscience. 234, p. 88-102 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Changes in apha and beta secretase activity

Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., 2003, British Pharmacological Society.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Chapter 2: Pathophysiology of Alzheimer's disease

Allen-Birt, S., 30 May 2017, Alzheimer's Disease. Waldemar, G. & Burns, A. (eds.). 2nd ed. Oxford University Press, 10 p. (Oxford Neurology Library).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
142 Downloads (Pure)

Chapter 4: Pathophysiology of Alzheimer's Disease

Allen, S. J. & Dawbarn, D., 1 Mar 2009, Alzheimer's Disease. Waldemar, G. & Burns, A. (eds.). 1st ed. Oxford University Press, p. 27-35 8 p. (Oxford Neurology Library).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Characterisation of Presenilin 1 (PS-1) major loop

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ. & Dawbarn, D., 1997, Unknown. Vol. 23(11).

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Clinical relevance of the neurotrophins and their receptors

Allen, SJ. & Dawbarn, D., Feb 2006, In : Clinical Science. 110, p. 175 - 191 16 p.

Research output: Contribution to journalArticle (Academic Journal)

220 Citations (Scopus)

Cloning of a non-catalytic form of human Trkb and distribution of mRNA for Trkb in human brain

Allen, SJ., Dawbarn, D., Eckford, SD., Wilcock, GK., Ashcroft, M., Colebrook, SM., Feeney, R. & MacGowan, SH., 1994, In : Neuroscience. 60 (No3), p. 825 - 834 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Comparison of Beta-nerve growth factor content in normal and Alzheimer brain

Allen, SJ., Macgowan, SJ., Treanor, JJS., Feeney, R., Wilcock, GK. & Dawbarn, D., 1991, Third IBRO World Congress of Neuroscience.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Comparison of Beta-nerve growth factor content in normal and schizophrenic hippocampus

Dawbarn, D., Allen, SJ., Macgowan, SH., Everall, IA. & Kerwin, RW., 1991, Unknown. Vol. 5. p. 441 - 441 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Comparison of the binding of NGF, BDNF, NT-3 and NT4/5 to the TrkA immunoglobulin-like domain (Ig2)

Nurmahomed, K., Naylor, RL., Robertson, AGS., Burston, JJ., Dawbarn, D. & Allen, SJ., 2003, IBRO congress, Prague.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Construction of NGF/BDNF chimeric genes and expression of recombinent proteins

Colebrook, SM., Feeney, R., Macgowan, S., Allen, SJ., Ashcroft, M. & Dawbarn, D., 1993, Unknown. Vol. 108S. p. 304 - 304 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Crystal Structure Of Trkb-D5 Bound To Neurotrophin-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis

Hu, VY., Zvara, P., Dattilio, A., Redman, TL., Allen, SJ., Dawbarn, D., Stroemer, RP. & Vizzard, MA., Mar 2005, In : Journal of Urology. 173 (3), p. 1016 - 1021 5 p.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
240 Downloads (Pure)

Distribution and characterisation of Beta-nerve growth factor receptors in Alzheimer's disease

Allen, SJ., Treanor, JJS., Macgowan, SH., Wilcock, GK. & Dawbarn, D., 1991, In : Growth Factors and Alzheimer's Disease. p. 81 - 97 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Distribution of trkB in rat-brain by in situ hybridization

Allen, SJ., Ashcroft, M., Colebrook, SM., Feeney, R., Macgowan, SH. & Dawbarn, D., 1993, Unknown. Vol. 108 S. p. 303 - 303 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Expression, purification, and biological activity of the TrkAIg2 domain

Burston, JJ., Fahey, MS., Nurmahomed, K., Dawbarn, D. & Allen, SJ., 2003, IBRO congress, Prague.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Expression, purification and refolding of the extracellular domains of Trk receptors in E. coli

Holden, PH., Allen, SJ., Drake, T., MacGowan, SH., Robertson, AGS. & Dawbarn, D., 1995, Unknown. Vol. Supp 8. p. 34 - 34 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

5 Citations (Scopus)

Expression of recombinant extracellular domain of the type II transforming growth factor-β receptor: utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-β agonists and antagonists

Fahey, MS., Dawbarn, D., Allen, SJ., Paterson, IC. & Prime, SS., Mar 2001, In : Analytical Biochemistry. 290 (2), p. 272 - 276 5 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Expression of recombinant TrkA extracellular domains a soluble IgG HFc fusion protein

Drake, T., Allen, SJ., MacGowan, SH., Holden, PH., Robertson, AGS. & Dawbarn, D., 1995, Unknown. Vol. 8 Supp. p. 17 - 17 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro

Hatchett, CS., Tyler, SJ., Armstrong, D., Dawbarn, D. & Allen, SJ., May 2007, In : Brain Research. 1147, p. 248 - 255 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Further characterisation of the major loop of Presenilin 1

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ., Wilcock, GK. & Dawbarn, D., 1998, Unknown. 181.8-181.8 ed. Vol. 24. p. 181 - 181 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Galanin regulates the post-natal survival of a sub-set of basal forebrain cholinergic neurons

O'Meara, G., Coumis, U., Ma, S., Kehr, J., Mahoney, SA., Bacon, A., Allen, SJ., Holmes, FE., Kahl, U., Wang, F., Kearns, I., Ove-Ogren, S., Dawbarn, D., Mufson, E., Davies, C., Dawson, G. & Wynick, D., 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, p. 11569 - 11574

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U. & Patel, N. K., May 2013, In : Pharmacology and Therapeutics. 138, 2, p. 155 21 p., JPT-06525.

Research output: Contribution to journalArticle (Academic Journal)

373 Citations (Scopus)

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

Clewes, O., Fahey, MS., Tyler, SJ., Watson, JJ., Seok, H., Catania, C., Cho, K., Dawbarn, D. & Allen, S. J., Nov 2008, In : Journal of Neurochemistry. 107, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Identification and structure of the nerve growth factor binding site on TrkA

Robertson, AGS., Banfield, MJ., Allen, SJ., Dando, JA., Mason, GGF., Tyler, SJ., Bennett, GS., Brain, SD., Clarke, AR., Naylor, RL., Wilcock, GK., Brady, RL. & Dawbarn, D., 23 Mar 2001, In : Biochemical and Biophysical Research Communications. 282 (1), p. 131 - 141 11 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Identification of novel small molecule TGF-β antagonists using structure-based drug design

Wang, H., Sessions, R. B., Prime, S. S., Shoemark, D. K., Allen-Birt, S. J., Hong, W., Narayanan, S. & Paterson, I. C., 2013, In : Journal of Computer Aided Design. 27, 0920-654X, p. 365-372 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Identification of Syntaxin 1A as a novel binding protein for Presenilin-1

Smith, SKF., Anderson, HA., Yu, G., Robertson, AGS., Allen, SJ., Tyler, SJ., Naylor, RL., Mason, GGF., Wilcock, GK., Roche, PA., Fraser, PE. & Dawbarn, D., 2000, In : Molecular Brain Research. 78, p. 100 - 107

Research output: Contribution to journalArticle (Academic Journal)

Identification of the NGF binding site of the TrkA receptor

Robertson, AGS., Bennett, GS., Tyler, SJ., Holden, PH., Allen, SJ., Smith, SKF., Wilcock, GK., Brain, SD. & Dawbarn, D., 1998, Unknown. Vol. 19 4S. p. 5268 - 5268 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Immunoglobulin-like domains define the nerve growth factor binding site of the TrKA receptor

Holden, PH., Asopa, V., Robertson, AGS., Clarke, AR., Tyler, SJ., Bennett, GS., Brain, SD., Wilcock, GK., Allen, SJ., Smith, SKF. & Dawbarn, D., 1997, In : Nature Biotechnology. 15, p. 668 - 672

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Inhibition of nerve growth factor induced plasma extravasation in rat skin by Ig like domains of NGF receptor TrKA

Bennett, GS., Holden, PH., Asopa, AV., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brain, SD., 1997, In : British Journal of Pharmacology. 122, p. 78 - 78 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Large scale production of recombinant human nerve growth factor expressed by baculovirus in insect cells

Robertson, AGS., MacGowan, SH., Holden, PH., Allen, SJ., Drake, T. & Dawbarn, D., 1995, Unknown. Vol. Suppl No 8. p. 70 - 70 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay

Siew, LK., Love, S., Dawbarn, D., Wilcock, GK. & Allen, SJ., 30 Oct 2004, In : Journal of Neuroscience Methods. 139 (2), p. 153 - 159 7 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
Open Access
File
5 Downloads (Pure)

Nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain

Treanor, JJS., Dawbarn, D., Allen, SJ., Macgowan, SH. & Wilcock, GK., 1991, In : Neuroscience Letters. 121, p. 73 - 76 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Neurobiology of Alzheimer's disease

Dawbarn, D. & Allen, SJ., 2001, xii ed. Oxford University Press. 404 p.

Research output: Book/ReportEdited book

Neurobiology of Alzheimer's Disease, 2nd edition

Dawbarn, D. & Allen, SJ., 2001, xii ed. Oxford University Press. 404 p.

Research output: Book/ReportEdited book

Neurobiology of Alzheimer's disease 3rd edition

Dawbarn, D. & Allen, SJ., 2007, Oxford University Press. 456 p.

Research output: Book/ReportEdited book