1991 …2020

Research output per year

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Research Output

2001

Recombinant human nerve growth factor for clinical trials: Protein expression, purification, stability and characterisation of binding to infusion pumps

Allen, SJ., Robertson, AGS., Tyler, SJ., Wilcock, GK. & Dawbarn, D., Feb 2001, In : Journal of Biochemical and Biophysical Methods. 47 (3), p. 239 - 255 17 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Secretase activity in Alzheimer's disease

Armstrong, D., Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., 2001, 6th International Conference of Alzheimer's and Parkinson's disease. Seville.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Specificity in Trk Receptor:Neurotrophin Interactions: The Crystal Structure of TrkB-d5 in Complex with Neurotrophin-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brady, RL., Dec 2001, In : Structure. 9 (12), p. 1191 - 1199 9 p.

Research output: Contribution to journalArticle (Academic Journal)

71 Citations (Scopus)

TrkAIg2 purification method

Allen, SJ., Dawbarn, D. & Robertson, AGS., 2001, Patent No. Application number 0122400.5 D

Research output: Patent

2000

Galanin regulates the post-natal survival of a sub-set of basal forebrain cholinergic neurons

O'Meara, G., Coumis, U., Ma, S., Kehr, J., Mahoney, SA., Bacon, A., Allen, SJ., Holmes, FE., Kahl, U., Wang, F., Kearns, I., Ove-Ogren, S., Dawbarn, D., Mufson, E., Davies, C., Dawson, G. & Wynick, D., 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, p. 11569 - 11574

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

Identification of Syntaxin 1A as a novel binding protein for Presenilin-1

Smith, SKF., Anderson, HA., Yu, G., Robertson, AGS., Allen, SJ., Tyler, SJ., Naylor, RL., Mason, GGF., Wilcock, GK., Roche, PA., Fraser, PE. & Dawbarn, D., 2000, In : Molecular Brain Research. 78, p. 100 - 107

Research output: Contribution to journalArticle (Academic Journal)

Pancreatic Cancer Therapy

Dawbarn, D., Allen, SJ. & Robertson, AGS., 2000, Patent No. 0020504.7

Research output: Patent

Structure of TrkAIg2 and molecular modelling of the neurotrophin binding sites of the Trk receptors

Robertson, AGS., Sessions, RB., Banfield, MJ., Dando, JA., Mason, GGF., Holden, PH., Allen, SJ., Tyler, SJ., Burston, JJ., Naylor, RL., Wilcock, GK., Brady, RL. & Dawbarn, D., 2000, European Journal of Neuroscience. Vol. 12, S11. p. 239 - 239 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Syntaxin 1A is a novel binding protein for Presenilin 1

Allen, SJ., Smith, SKF., Anderson, HA., Yu, G., Robertson, AGS., Tyler, SJ., Naylor, RL., Mason, GGF., Wilcock, GK., Roche, PA., Fraser, PE. & Dawbarn, D., 2000, European Journal of Neuroscience. Vol. 12, S11. p. 213 - 213 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

25 Citations (Scopus)
1999

Profound and Selective Loss of Catalytic TrkB Immunoreactivity in Alzheimer's Disease

Allen, SJ., Wilcock, GK. & Dawbarn, D., 1999, In : Biochemical and Biophysical Research Communications. 264, p. 648 - 651

Research output: Contribution to journalArticle (Academic Journal)

Therapeutic agent for NGF

Robertson, AGS., Allen, SJ. & Dawbarn, D., 1999, Patent No. PCT/GB99/01108

Research output: Patent

1998

Analysis of the major loop of presenilin 1

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ., Wilcock, GK. & Darbarn, D., 1998, Unknown. S188-S188 ed. Vol. 19 4S. p. 188 - 188 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Further characterisation of the major loop of Presenilin 1

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ., Wilcock, GK. & Dawbarn, D., 1998, Unknown. 181.8-181.8 ed. Vol. 24. p. 181 - 181 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Identification of the NGF binding site of the TrkA receptor

Robertson, AGS., Bennett, GS., Tyler, SJ., Holden, PH., Allen, SJ., Smith, SKF., Wilcock, GK., Brain, SD. & Dawbarn, D., 1998, Unknown. Vol. 19 4S. p. 5268 - 5268 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

1997

Characterisation of Presenilin 1 (PS-1) major loop

Smith, SKF., Robertson, AGS., Allen, SJ., Holden, PH., Tyler, SJ. & Dawbarn, D., 1997, Unknown. Vol. 23(11).

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Immunoglobulin-like domains define the nerve growth factor binding site of the TrKA receptor

Holden, PH., Asopa, V., Robertson, AGS., Clarke, AR., Tyler, SJ., Bennett, GS., Brain, SD., Wilcock, GK., Allen, SJ., Smith, SKF. & Dawbarn, D., 1997, In : Nature Biotechnology. 15, p. 668 - 672

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Inhibition of nerve growth factor induced plasma extravasation in rat skin by Ig like domains of NGF receptor TrKA

Bennett, GS., Holden, PH., Asopa, AV., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brain, SD., 1997, In : British Journal of Pharmacology. 122, p. 78 - 78 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype

Allen, SJ., MacGowan, SH., Tyler, SJ., Wilcock, GK., Robertson, AGS., Holden, PH., Smith, SKF. & Dawbarn, D., 1997, In : Neuroscience Letters. 239, p. 33 - 36

Research output: Contribution to journalArticle (Academic Journal)

1996

The expression, purification, refolding and characterization of the immunoglobulin like subdomains of the nerve growth factor receptor (TrkA)

Asopa, V., Holden, PH., Robertson, AGS., Tyler, SJ., Allen, SJ., Smith, SKF. & Dawbarn, D., 1996, In : British Journal of Pharmacology. 119, p. 273 - 273 1 p.

Research output: Contribution to journalArticle (Academic Journal)

1995

Alzheimer's disease - Current controversies - an overview

Allen, SJ. & Dawbarn, D., 1995, Neurobiology of Alzheimer's disease. Dawbarn, D. & Allen, SJ. (eds.). BIOS Scientific Publishers , p. 1 - 8

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Expression, purification and refolding of the extracellular domains of Trk receptors in E. coli

Holden, PH., Allen, SJ., Drake, T., MacGowan, SH., Robertson, AGS. & Dawbarn, D., 1995, Unknown. Vol. Supp 8. p. 34 - 34 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

5 Citations (Scopus)

Expression of recombinant TrkA extracellular domains a soluble IgG HFc fusion protein

Drake, T., Allen, SJ., MacGowan, SH., Holden, PH., Robertson, AGS. & Dawbarn, D., 1995, Unknown. Vol. 8 Supp. p. 17 - 17 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Large scale production of recombinant human nerve growth factor expressed by baculovirus in insect cells

Robertson, AGS., MacGowan, SH., Holden, PH., Allen, SJ., Drake, T. & Dawbarn, D., 1995, Unknown. Vol. Suppl No 8. p. 70 - 70 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

The Neurobiology of Alzheimer's Disease

Dawbarn, D. & Allen, SJ., 1995, BIOS Scientific Publishers . 326 p.

Research output: Book/ReportEdited book

1994

Cloning of a non-catalytic form of human Trkb and distribution of mRNA for Trkb in human brain

Allen, SJ., Dawbarn, D., Eckford, SD., Wilcock, GK., Ashcroft, M., Colebrook, SM., Feeney, R. & MacGowan, SH., 1994, In : Neuroscience. 60 (No3), p. 825 - 834 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Production of the extracellular domains of p140TrkA and p145TrkB neurotrophin receptors in a baculovirus expression system

Ashcroft, M., MacGowan, SH., Holden, PH., Allen, SJ., Colebrook, SM. & Dawbarn, D., 1994, Unknown. Vol. 11. p. 44 - 44 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

1993

Construction of NGF/BDNF chimeric genes and expression of recombinent proteins

Colebrook, SM., Feeney, R., Macgowan, S., Allen, SJ., Ashcroft, M. & Dawbarn, D., 1993, Unknown. Vol. 108S. p. 304 - 304 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Distribution of trkB in rat-brain by in situ hybridization

Allen, SJ., Ashcroft, M., Colebrook, SM., Feeney, R., Macgowan, SH. & Dawbarn, D., 1993, Unknown. Vol. 108 S. p. 303 - 303 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Neurotrophins and neurodegeneration

Dawbarn, D., Allen, SJ. & Macgowan, SH., 1993, Cambridge University Press. 234 p.

Research output: Book/ReportAuthored book

1992

Neurotrophic Factors: Therapeutic Implications in Alzheimer's Disease

Dawbarn, D., Allen, SJ., Treanor, JJS., Wilcock, GK., Feeney, R. & Macgowan, SH., 1992, Alzheimer's Disease, Potential Therapeutic Strategies. Copeland, J. R. M. (ed.). IBC Technical Services Ltd., p. 122 - 140 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1991

Comparison of Beta-nerve growth factor content in normal and Alzheimer brain

Allen, SJ., Macgowan, SJ., Treanor, JJS., Feeney, R., Wilcock, GK. & Dawbarn, D., 1991, Third IBRO World Congress of Neuroscience.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Comparison of Beta-nerve growth factor content in normal and schizophrenic hippocampus

Dawbarn, D., Allen, SJ., Macgowan, SH., Everall, IA. & Kerwin, RW., 1991, Unknown. Vol. 5. p. 441 - 441 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Distribution and characterisation of Beta-nerve growth factor receptors in Alzheimer's disease

Allen, SJ., Treanor, JJS., Macgowan, SH., Wilcock, GK. & Dawbarn, D., 1991, In : Growth Factors and Alzheimer's Disease. p. 81 - 97 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain

Treanor, JJS., Dawbarn, D., Allen, SJ., Macgowan, SH. & Wilcock, GK., 1991, In : Neuroscience Letters. 121, p. 73 - 76 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Normal NGF content in Alzheimer's disease basal formation

Allen, SJ., MacGowan, SH., Treanor, JJS., Feeney, R., Wilcock, GK. & Dawbarn, D., 1991, In : Neuroscience Letters. 131, p. 135 - 139 4 p.

Research output: Contribution to journalArticle (Academic Journal)