1991 …2020

Research output per year

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Research Output

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Article (Academic Journal)
2020
Open Access
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5 Downloads (Pure)
2018

VEGFR1 and VEGFR2 in Alzheimer's Disease

Harris, R., Miners, J. S., Allen, S. & Love, S., 2018, In : Journal of Alzheimer's Disease. 61, 2, p. 741-752 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
391 Downloads (Pure)
2017

16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain

Emery, D., Shoemark, D., Batstone, T., Waterfall, C., Coghill, J., Cerajewska, T., Davies, M., West, N. & Allen-Birt, S., 20 Jun 2017, In : Frontiers in Aging Neuroscience. 9, 13 p., 195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
61 Citations (Scopus)
317 Downloads (Pure)

Relación entre enfermedad periodontal y enfermedad de Alzheimer: ¿El cepillado de los dientes puede influir en la enfermedad de Alzheimer?

West, N., Shoemark, D., Davies, M. & Allen-Birt, S., 23 May 2017, In : Periodoncia Clinica. 2017, 8, p. 63-76 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
71 Downloads (Pure)
2016

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

Kailainathan, S., Piers, T. M., Yi, J. H., Choi, S. M., Fahey, M. S., Borger, E., Gunn-Moore, F. J., O'Neill, L., Lever, M., Whitcomb, D. J., Cho, K. & Allen, S. J., Feb 2016, In : Pharmacological Research. 104, p. 97-107 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
251 Downloads (Pure)
2015

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
240 Downloads (Pure)

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

Shoemark, D. K. & Allen, S. J., 2015, In : Journal of Alzheimer's Disease. 43, 3, p. 725-38 14 p.

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)

Frias, B., Santos, J., Morgado, M., Sousa, M. M., Gray, S. M. Y., McCloskey, K. D., Allen, S., Cruz, F. & Cruz, C. D., 4 Feb 2015, In : Journal of Neuroscience. 35, 5, p. 2146-60 15 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
11 Downloads (Pure)
2013

Brain Derived Neurotrophic Factor (BDNF), acting at the spinal cord level, participates in bladder hyperactivity in and referred pain chronic bladder inflammation

Frias, B., Allen-Birt, S. J., Dawbarn, D., Charrua, A., Cruz, F. & Cruz, C. D., 27 Mar 2013, In : BMC Neuroscience. 234, p. 88-102 15 p.

Research output: Contribution to journalArticle (Academic Journal)

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U. & Patel, N. K., May 2013, In : Pharmacology and Therapeutics. 138, 2, p. 155 21 p., JPT-06525.

Research output: Contribution to journalArticle (Academic Journal)

373 Citations (Scopus)

Identification of novel small molecule TGF-β antagonists using structure-based drug design

Wang, H., Sessions, R. B., Prime, S. S., Shoemark, D. K., Allen-Birt, S. J., Hong, W., Narayanan, S. & Paterson, I. C., 2013, In : Journal of Computer Aided Design. 27, 0920-654X, p. 365-372 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling

Crompton, L. A., Byrne, M. L., Taylor, H., Kerrigan, T. L., Bru-Mercier, G., Badger, J. L., Barbuti, P. A., Jo, J., Tyler, S. J., Allen-Birt, S. J., Kunath, T., Cho, K. & Caldwell, M. A., 9 Aug 2013, In : Stem Cell Research. 11, 3, p. 1206-1221 16 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2011

The neurotrophins and their role in Alzheimer's disease

Allen, SJ., Watson, JJ. & Dawbarn, D., Dec 2011, In : Current Neuropharmacology. 9, p. 559 - 573 15 p.

Research output: Contribution to journalArticle (Academic Journal)

2010

Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis

Pinto, R., Frias, B., Allen, SJ., Dawbarn, D., McMahon S., B., Cruz, F. & Cruz C., D., 31 Mar 2010, In : Neuroscience. 166, 3, p. 907 - 916 10 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

McNamee K., E., Burleigh, A., Gompels L., L., Feldmann, M., Allen, SJ., Williams R., O., Dawbarn, D., Vincent T., L. & Inglis J. J., N. V., May 2010, In : PAIN. 149, 2, p. 386 - 392 6 p.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)
2009

Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors

Masoudi, R., Ioannou M., S., Coughlin M., D., Pagadala, P., Neet K., E., Clewes, O., Allen, SJ., Dawbarn, D. & Fahnestock, M., 3 Jul 2009, In : Journal of Biological Chemistry. 284, 27, p. 18424 - 18433 10 p.

Research output: Contribution to journalArticle (Academic Journal)

96 Citations (Scopus)
2008

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

Clewes, O., Fahey, MS., Tyler, SJ., Watson, JJ., Seok, H., Catania, C., Cho, K., Dawbarn, D. & Allen, S. J., Nov 2008, In : Journal of Neurochemistry. 107, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Targeting nerve growth factor in pain: what is the therapeutic potential?

Watson, JJ., Allen, SJ. & Dawbarn, D., Nov 2008, In : Biodrugs. 22, p. 349 - 359 10 p.

Research output: Contribution to journalArticle (Academic Journal)

125 Citations (Scopus)
2007

Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro

Hatchett, CS., Tyler, SJ., Armstrong, D., Dawbarn, D. & Allen, SJ., May 2007, In : Brain Research. 1147, p. 248 - 255 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)
2006

Clinical relevance of the neurotrophins and their receptors

Allen, SJ. & Dawbarn, D., Feb 2006, In : Clinical Science. 110, p. 175 - 191 16 p.

Research output: Contribution to journalArticle (Academic Journal)

220 Citations (Scopus)

NGF receptor TrkAd5: Therapeutic agent and drug design target

Dawbarn, D., Fahey, MS., Watson, JJ., Tyler, SJ., Shoemark, DK., Zhang, R., Brady, L., Willis, CL. & Allen, SJ., Aug 2006, In : Biochemical Society Transactions. 34 (4), p. 587 - 590 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Premorbid effects of APOE on synaptic proteins in human temporal neocortex

Love, S., Siew, LK., Dawbarn, D., Wilcock, GK., Ben-Shlomo, Y. & Allen, SJ., Jun 2006, In : Neurobiology of Aging. 27 (6), p. 797 - 803 7 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma

Nassenstein, C., Dawbarn, D., Pollock, K., Allen, SJ., Erpenbeck, VJ., Spies, E., Krug, N. & Braun, A., Sep 2006, In : Journal of Allergy and Clinical Immunology. 118 (3), p. 597 - 605 9 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma

Watson, JJ., Fahey, MS., van den Worm, E., Engels, F., Nijkamp, FP., Stroemer, P., McMahon, S., Allen, SJ. & Dawbarn, D., Mar 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316 (3), p. 1122 - 1129 8 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)
2005

Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis

Hu, VY., Zvara, P., Dattilio, A., Redman, TL., Allen, SJ., Dawbarn, D., Stroemer, RP. & Vizzard, MA., Mar 2005, In : Journal of Urology. 173 (3), p. 1016 - 1021 5 p.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)
2004

Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay

Siew, LK., Love, S., Dawbarn, D., Wilcock, GK. & Allen, SJ., 30 Oct 2004, In : Journal of Neuroscience Methods. 139 (2), p. 153 - 159 7 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
2003

Neurotrophins and Neurodegeneration

Dawbarn, D. & Allen, SJ., May 2003, In : Neuropathology and Applied Neurobiology. 29, p. 211 - 230 19 p.

Research output: Contribution to journalArticle (Academic Journal)

170 Citations (Scopus)
2002

A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4

Naylor, RL., Robertson, AGS., Allen, SJ., Sessions, RB., Clarke, AR., Mason, GGF., Burston, JJ., Tyler, SJ., Wilcock, GK. & Dawbarn, D., 1 Mar 2002, In : Biochemical and Biophysical Research Communications. 291 (3), p. 501 - 507 7 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Alpha- and beta-secretase: profound changes in Alzheimer's disease

Tyler, SJ., Dawbarn, D., Wilcock, GK. & Allen, SJ., Dec 2002, In : Biochemical and Biophysical Research Communications. 299 (3), p. 373 - 376 4 p.

Research output: Contribution to journalArticle (Academic Journal)

147 Citations (Scopus)
2001

1HE7 - Human Nerve Growth Factor Receptor TrkA

Banfield, MJ., Robertson, AGS., Allen, SJ., Dando, JA., Tyler, SJ., Bennett, GS., Brain, SD., Mason, GGF., Holden, PH., Clarke, AR., Naylor, RL., Wilcock, GK., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Crystal Structure Of Trkb-D5 Bound To Neurotrophin-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brady, RL., 2001, In : RCSB Protein Data Bank.

Research output: Contribution to journalArticle (Academic Journal)

Expression of recombinant extracellular domain of the type II transforming growth factor-β receptor: utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-β agonists and antagonists

Fahey, MS., Dawbarn, D., Allen, SJ., Paterson, IC. & Prime, SS., Mar 2001, In : Analytical Biochemistry. 290 (2), p. 272 - 276 5 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Identification and structure of the nerve growth factor binding site on TrkA

Robertson, AGS., Banfield, MJ., Allen, SJ., Dando, JA., Mason, GGF., Tyler, SJ., Bennett, GS., Brain, SD., Clarke, AR., Naylor, RL., Wilcock, GK., Brady, RL. & Dawbarn, D., 23 Mar 2001, In : Biochemical and Biophysical Research Communications. 282 (1), p. 131 - 141 11 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Recombinant human nerve growth factor for clinical trials: Protein expression, purification, stability and characterisation of binding to infusion pumps

Allen, SJ., Robertson, AGS., Tyler, SJ., Wilcock, GK. & Dawbarn, D., Feb 2001, In : Journal of Biochemical and Biophysical Methods. 47 (3), p. 239 - 255 17 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Specificity in Trk Receptor:Neurotrophin Interactions: The Crystal Structure of TrkB-d5 in Complex with Neurotrophin-4/5

Banfield, MJ., Naylor, RL., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brady, RL., Dec 2001, In : Structure. 9 (12), p. 1191 - 1199 9 p.

Research output: Contribution to journalArticle (Academic Journal)

71 Citations (Scopus)
2000

Galanin regulates the post-natal survival of a sub-set of basal forebrain cholinergic neurons

O'Meara, G., Coumis, U., Ma, S., Kehr, J., Mahoney, SA., Bacon, A., Allen, SJ., Holmes, FE., Kahl, U., Wang, F., Kearns, I., Ove-Ogren, S., Dawbarn, D., Mufson, E., Davies, C., Dawson, G. & Wynick, D., 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, p. 11569 - 11574

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

Identification of Syntaxin 1A as a novel binding protein for Presenilin-1

Smith, SKF., Anderson, HA., Yu, G., Robertson, AGS., Allen, SJ., Tyler, SJ., Naylor, RL., Mason, GGF., Wilcock, GK., Roche, PA., Fraser, PE. & Dawbarn, D., 2000, In : Molecular Brain Research. 78, p. 100 - 107

Research output: Contribution to journalArticle (Academic Journal)

1999

Profound and Selective Loss of Catalytic TrkB Immunoreactivity in Alzheimer's Disease

Allen, SJ., Wilcock, GK. & Dawbarn, D., 1999, In : Biochemical and Biophysical Research Communications. 264, p. 648 - 651

Research output: Contribution to journalArticle (Academic Journal)

1997

Immunoglobulin-like domains define the nerve growth factor binding site of the TrKA receptor

Holden, PH., Asopa, V., Robertson, AGS., Clarke, AR., Tyler, SJ., Bennett, GS., Brain, SD., Wilcock, GK., Allen, SJ., Smith, SKF. & Dawbarn, D., 1997, In : Nature Biotechnology. 15, p. 668 - 672

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Inhibition of nerve growth factor induced plasma extravasation in rat skin by Ig like domains of NGF receptor TrKA

Bennett, GS., Holden, PH., Asopa, AV., Robertson, AGS., Allen, SJ., Dawbarn, D. & Brain, SD., 1997, In : British Journal of Pharmacology. 122, p. 78 - 78 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype

Allen, SJ., MacGowan, SH., Tyler, SJ., Wilcock, GK., Robertson, AGS., Holden, PH., Smith, SKF. & Dawbarn, D., 1997, In : Neuroscience Letters. 239, p. 33 - 36

Research output: Contribution to journalArticle (Academic Journal)

1996

The expression, purification, refolding and characterization of the immunoglobulin like subdomains of the nerve growth factor receptor (TrkA)

Asopa, V., Holden, PH., Robertson, AGS., Tyler, SJ., Allen, SJ., Smith, SKF. & Dawbarn, D., 1996, In : British Journal of Pharmacology. 119, p. 273 - 273 1 p.

Research output: Contribution to journalArticle (Academic Journal)

1994

Cloning of a non-catalytic form of human Trkb and distribution of mRNA for Trkb in human brain

Allen, SJ., Dawbarn, D., Eckford, SD., Wilcock, GK., Ashcroft, M., Colebrook, SM., Feeney, R. & MacGowan, SH., 1994, In : Neuroscience. 60 (No3), p. 825 - 834 9 p.

Research output: Contribution to journalArticle (Academic Journal)

1991

Distribution and characterisation of Beta-nerve growth factor receptors in Alzheimer's disease

Allen, SJ., Treanor, JJS., Macgowan, SH., Wilcock, GK. & Dawbarn, D., 1991, In : Growth Factors and Alzheimer's Disease. p. 81 - 97 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain

Treanor, JJS., Dawbarn, D., Allen, SJ., Macgowan, SH. & Wilcock, GK., 1991, In : Neuroscience Letters. 121, p. 73 - 76 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Normal NGF content in Alzheimer's disease basal formation

Allen, SJ., MacGowan, SH., Treanor, JJS., Feeney, R., Wilcock, GK. & Dawbarn, D., 1991, In : Neuroscience Letters. 131, p. 135 - 139 4 p.

Research output: Contribution to journalArticle (Academic Journal)