Siang Boon Koh

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Dr Siang Boon Koh

BSc (Pharm), PhD

 https://orcid.org/0000-0002-5494-3800

  • BS8 1TD

Personal profile

Research interests

The Koh Laboratory is interested in exploring and exploiting molecular aberrations in cancer. Through collaborative use of omics profiling, imaging, molecular biology, pharmacology and computational approaches, we study how deregulated biological pathways, such as the DNA Damage Response and RAS signalling network, mediate tumour proliferation and progression. We leverage these mechanistic insights to identify actionable cancer-specific vulnerabilities. Our goal is to develop selective, synergistic treatment strategies that enable maximal tumour-cell killing and minimal host toxicity.

Enquiries from prospective graduate students and postdoctoral researchers are welcome.

Education/Academic qualification

Harvard Medical School, Massachusetts General Hospital

National University of Singapore

University of Cambridge

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  • 18 Article (Academic Journal)
  • 1 Review article (Academic Journal)

  • Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

    Wang, Y., Gao, B., Zhang, L., Wang, X., Zhu, X., Yang, H., Zhang, F., Zhu, X., Zhou, B., Yao, S., Nagayama, A., Lee, S., Ouyang, J., Koh, S.-B., Eisenhauer, E. L., Zarrella, D., Lu, K., Rueda, B. R., Zou, L. & Su, X. A. & 4 others, Yeku, O., Ellisen, L. W., Wang, X.-S. & Lan, L., 21 Feb 2024, In: Nature Communications. 15, 17 p., 1568.

    Research output: Contribution to journal › Article (Academic Journal) › peer-review

    Open Access
    2 Citations (Scopus)

  • Regulation of RNA methylation by therapy treatment, promotes tumor survival

    Bukhari, S. I., Truesdell, S. S., Datta, C., Choudhury, P., Wu, K. Q., Shrestha, J., Maharjan, R., Plotsker, E., Elased, R., Laisa, S., Bhambhani, V., Lin, Y., Kreuzer, J., Morris, R., Koh, S.-B., Ellisen, L. W., Haas, W., Ly, A. & Vasudevan, S., 20 May 2023, In: bioRxiv.

    Research output: Contribution to journal › Article (Academic Journal)

  • The expanding role of WEE1

    Koh, S.-B., 1 Jun 2022, In: Cellular Signalling. 94, 110310.

    Research output: Contribution to journal › Review article (Academic Journal) › peer-review

    8 Citations (Scopus)
View all 19 research outputs