Professor Simon C Satchell

Search results

• 2023

  Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

  Crompton, M., Ferguson, J. K., Ramnath, R. D., Onions, K. L., Ogier, A. S., Gamez, M., Down, C. J., Skinner, L., Wong, K. H., Dixon, L. K., Sutak, J., Harper, S. J., Pontrelli, P., Gesualdo, L., Heerspink, H. L., Toto, R. D., Welsh, G. I., Foster, R. R., Satchell, S. C. & Butler, M. J., 8 Mar 2023, In: JCI Insight. 8, 5, 17 p., e154164.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Glycocalyx 100%
  • Albuminuria 69%
  • Mineralocorticoid Receptor 60%
  • Diabetes 30%
  • Matrix Metalloproteinase 30%
• 2022

  Cerebral microvascular endothelial glycocalyx damage, its implications on the blood–brain barrier and a possible contributor to cognitive impairment

  Stoddart, P., Satchell, S. C. & Ramnath, R. D., 1 Apr 2022, In: Brain Research. 1780, 12 p., 147804.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Cognitive Defect 36%
  • Blood Brain Barrier 36%
  • Cognitive Disorders 36%
  • Research 36%
  131 Downloads (Pure)

• Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state

  Lawrence-Mills, S., Hezzell, M. J., Adamantos, S. E., Chan, I., Borgeat, K., Payne, J. R., Satchell, S. C., Welsh, G. I., Foster, R. R. & Finch, N. C., 31 May 2022, In: Veterinary Journal. 285, 4 p., 105845.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dog 100%
  • Echocardiography 9%
  7 Downloads (Pure)

• Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

  Qiu, Y., Buffonge, S., Ramnath, R., Jenner, S., Fawaz, S., Arkill, K. P., Neal, C., Verkade, P., White, S. J., Hezzell, M., Salmon, A. H. J., Suleiman, M-S., Welsh, G. I., Foster, R. R., Madeddu, P. & Satchell, S. C., 1 May 2022, In: Diabetologia. 65, 5, p. 879–894 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Endothelial Cell 26%
  • Diastolic Dysfunction 26%
  • Mouse 21%
  • Enzyme 17%
  8 Citations (Scopus)

  32 Downloads (Pure)

• Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations

  Finch, N. C., Fawaz, S., Neal, C. R., Butler, M. J., Salmon, A., Lay, A. C., Stevens, M., Mellor, H. H., Harper, S. J., Welsh, G. I., Foster, R. & Satchell, S. C., 15 Mar 2022, (E-pub ahead of print) In: Journal of the American Society of Nephrology. 33, 6, p. 1120-1136 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Fenestration 100%
  • Endothelial Cell 58%
  • Synapsin II 50%
  • Filtration 41%
  • Diabetes 33%
  5 Citations (Scopus)

  132 Downloads (Pure)

• Visualising the endothelial glycocalyx in dogs

  Lawrence-Mills, S., Neal, C. R., Satchell, S. C., Welsh, G. I., Foster, R. R. & Finch, N. C., 1 Jul 2022, In: Veterinary Journal. 285, 4 p., 105844.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dog 100%
  • Uterine Artery 25%
  • Testicular Artery 25%
  6 Downloads (Pure)
• 2021

  CRISPR/Cas9-Engineered HLA-Deleted Glomerular Endothelial Cells as a Tool to Predict Pathogenic Non-HLA Antibodies in Kidney Transplant Recipients

  et al., 30 Nov 2021, (E-pub ahead of print) In: Journal of the American Society of Nephrology. 32, 12, p. 3231-3251 21 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Immunoassay 100%
  • Transplantation 100%
  • Antibody 71%
  • Donor 71%
  • Histology 71%
  82 Downloads (Pure)

• Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

  Urban, A., Kowalska, D., Stasiłojć, G., Kuźniewska, A., Skrobińska, A., Arjona, E., Alonso, E. C., Fenollosa Segarra, M. Á., Jongerius, I., Spaapen, R., Satchell, S., Thiel, M., Ołdziej, S., Rodriguez de Córdoba, S. & Okrój, M., 25 Nov 2021, In: Frontiers in Immunology. 12, 8 p., 724361.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Gain of Function Mutation 100%
  • C-Reactive Protein 75%
  • Monospecific Antibody 50%
  • Mutation 50%
  • Complement Component 2 50%
  5 Citations (Scopus)

  18 Downloads (Pure)

• GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening

  Tuffin, J., Chesor, M., Kuzmuk, V., Johnson, T., Satchell, S. C., Welsh, G. I. & Saleem, M., 2 Dec 2021, In: Communications Biology. 4, 1, 1351.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Podocyte 100%
  • Glomerulus 50%
  • Drug Screening 50%
  • Tumor Spheroid 50%
  • Patient 33%
  6 Citations (Scopus)

  28 Downloads (Pure)
• 2020

  A role for NPY-NPY2R signaling in albuminuric kidney disease

  Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A., & 2 othersWelsh, G. I. & Coward, R. J. M., 19 Jun 2020, (E-pub ahead of print) In: Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15862-15873 12 p., 202004651.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Neuropeptide Y 100%
  • Podocyte 44%
  • Mouse 22%
  • Insulin 22%
  • Electric Potential 11%
  78 Downloads (Pure)

• Cystatin C and alpha-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome

  Hansson, M. J., Gustafsson, R., Jacquet, C., Chebaane, N., Satchell, S. C., Thunberg, T., Ahlm, C. & Fors Connolly, A-M., 18 Aug 2020, In: Pathogens. 9, 8, 14 p., 666.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Kidney 100%
  • Acute Kidney Failure 66%
  • Hemorrhagic Fever with Renal Syndrome 58%
  • Hemorrhagic Fever 58%
  • Cystatin C 41%
  13 Citations (Scopus)

  40 Downloads (Pure)

• Effect of endothelial cell heterogeneity on nanoparticle uptake

  Aliyandi, A., Satchell, S. C., Unger, R. E., Bartosch, B., Parent, R., Zuhorn, I. S. & Salvati, A., 29 Jul 2020, (E-pub ahead of print) In: International Journal of Pharmaceutics. 587, 10 p., 119699.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Silica 100%
  • Nanomedicine 100%
  • Organ 83%
  • Differences 66%
  • Serums 66%
  21 Downloads (Pure)

• Mineralocorticoid receptor antagonism in diabetes limits albuminuria by preserving endothelial glycocalyx

  Crompton, M., Ferguson, J. K., Ramnath, R. D., Onions, K. L., Ogier, A. S., Down, C. J., Skinner, L. J. S., Dixon, L., Sutak, J., Harper, S. J., Pontrelli, P., Gesualdo, L., Welsh, G. I., Foster, R. R., Satchell, S. C. & Butler, M. J., 1 Sep 2020, (In preparation) In: Journal of the American Society of Nephrology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx 100%
  • Albuminuria 41%
  • Diabetes 33%
  • Mineralocorticoid Receptor 33%
  • Spironolactone 25%

• Response to There is little evidence that the endothelial glycocalyx has a specific role in glomerular permeability of albumin

  Ramnath, R. D., Butler, M. N., Foster, R. R. & Satchell, S. C., 1 May 2020, In: Kidney International. 97, 5, p. 1057–1058 2 p.

  Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

  Open Access

  File

  • Albumin 100%
  • Glomerulus Filtration 100%
  • Glycocalyx 100%
  • Selectivity 50%
  • Observation 50%
  76 Downloads (Pure)

• The pathological relevance of increased endothelial glycocalyx permeability

  Butler, M., Down, C. J., Foster, R. R. & Satchell, S. C., 6 Feb 2020, (E-pub ahead of print) In: American Journal of Pathology. 190, 4, p. 742-751 10 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Protein 40%
  • Reading 20%
  • Comprehension 20%
  • Diseases 20%
  57 Downloads (Pure)
• 2019

  A Composite Hydrogel Scaffold Permits Self‐Organization and Matrix Deposition by Cocultured Human Glomerular Cells

  Tuffin, J., Burke, M., Richardson, T., Johnson, T., Saleem, M. A., Satchell, S., Welsh, G. I. & Perriman, A., 5 Sep 2019, In: Advanced Healthcare Materials. 8, 17, 11 p., 1900698.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Scaffold 100%
  • Cells 100%
  • Morphology 100%
  • Environment 66%
  • Culture 66%
  11 Citations (Scopus)

  224 Downloads (Pure)

• Aldosterone induces albuminuria via matrix metalloproteinase–dependent damage of the endothelial glycocalyx

  Butler, M. J., Ramnath, R., Kadoya, H., Desposito, D., Riquier-Brison, A., Ferguson, J. K., Onions, K. L., Ogier, A. S., ElHegni, H., Coward, R. J., Welsh, G. I., Foster, R. R., Peti-Peterdi, J. & Satchell, S. C., 1 Jan 2019, In: Kidney International. 95, 1, p. 94-107 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Gelatinase Inhibitor 100%
  39 Citations (Scopus)

  167 Downloads (Pure)

• Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease: Syndecan 4 in diabetic kidney disease

  Ramnath, R. D., Butler, M. J., Newman, G., Desideri, S., Russell, A., Lay, A. C., Neal, C. R., Qiu, Y., Fawaz, S., Onions, K. L., Gamez, M., Crompton, M., Michie, C., Finch, N., Coward, R. J., Welsh, G. I., Foster, R. R. & Satchell, S. C., 2 Nov 2019, (E-pub ahead of print) In: Kidney International.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Syndecan 4 100%
  • Glycocalyx 100%
  • Plasma 50%
  • Diabetes 50%
  • Diabetic Nephropathy 50%
  30 Citations (Scopus)

  245 Downloads (Pure)

• Developing methods to study the endothelial glycocalyx in cats

  Hillyer, S. J., Neal, C. R., Hibbert, A., Tasker, S., Welsh, G. I., Satchell, S. C. & Finch, N. C., Apr 2019.

  Research output: Contribution to conference › Conference Abstract

  Open Access

  • Cat 100%
  • Kidney 35%
  • Hyperthyroidism 35%
  • Uterine Artery 14%

• Early acute microvascular kidney transplant rejection in the absence of anti-HLA antibodies is associated with preformed IgG antibodies against diverse glomerular endothelial cell antigens

  Delville, M., Lamarthée, B., Pagie, S., See, S. B., Rabant, M., Burger, C., Gatault, P., Giral, M., Thaunat, O., Arzouk, N., Hertig, A., Hazzan, M., Matignon, M., Mariat, C., Caillard, S., Kamar, N., Sayegh, J., Westeel, P-F., Garrouste, C., Ladrière, M., & 15 othersVuiblet, V., Rivalan, J., Merville, P., Bertrand, D., Le Moine, A., Duong Van Huyen, J. P., Cesbron, A., Cagnard, N., Alibeu, O., Satchell, S. C., Legendre, C., Zorn, E., Taupin, J-L., Charreau, B. & Anglicheau, D., 1 Apr 2019, In: Journal of the American Society of Nephrology. 30, 4, p. 692-709 18 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • HLA Antibody 100%
  • Transplantation 100%
  • Cells 80%
  • Antibody 60%
  • Assay 60%
  68 Citations (Scopus)

  374 Downloads (Pure)

• Endothelial glycocalyx restoration by growth factors in diabetic nephropathy

  Desideri, S., Onions, K., Baker, S., Gamez, M., El Hegni, H. E. H., Russell, A., Satchell, S. & Foster, B., 21 May 2019, (E-pub ahead of print) In: Biorheology. 17 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Albumin 66%
  • Growth Factor 50%
  • Diabetes 50%
  • Growth Factors 50%
  11 Citations (Scopus)

  449 Downloads (Pure)

• Glomerular Endothelial Cells: Assessment of Barrier Properties In Vitro

  Ramnath, R. D. & Satchell, S. C., 8 Nov 2019, (E-pub ahead of print) Diabetic Nephropathy: Methods and Protocols. Humana Press Inc., p. 145-151 7 p. (Methods in Molecular Biology; vol. 2067).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  • Endothelial Cell 100%
  • Measurement 50%
  • In Vitro 50%
  • Permeability 50%
  • Electric Resistance 50%
  7 Citations (Scopus)

• Investigating the endothelial glycocalyx in health and disease in dogs

  Hillyer, S. J., Hezzell, M. J., Neal, C. R., Adamantos, S. E., Welsh, G. I., Foster, R. R., Satchell, S. C. & Finch, N. C., Apr 2019.

  Research output: Contribution to conference › Conference Abstract

  Open Access

  • Dog 100%
  • Uterine Artery 14%
  • Testicular Artery 14%
  • Echocardiography 7%

• Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells

  Reine, T. M., Lanzalaco, F., Kristiansen, O., Enget, A. R., Satchell, S., Jenssen, T. G. & Kolset, S. O., 20 May 2019, In: Microcirculation. 26, 4, e12534.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Syndecan 100%
  • Hyperglycemia 30%
  • MMP9 30%
  • Gene Expression 20%
  • Glycocalyx 20%
  17 Citations (Scopus)

  108 Downloads (Pure)

• Poly(ethylene glycol)-crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior

  Su, J., Satchell, S. C., Wertheim, J. A. & Shah, R. N., 1 May 2019, In: Biomaterials. 201, p. 99-112 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Peptide 100%
  • Endothelial Cell 75%
  • Cells 50%
  • Human Umbilical Vein Endothelial Cell 37%
  • Gelatin 37%
  35 Citations (Scopus)

  110 Downloads (Pure)

• The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis

  Dimou, P., Wright, R. D., Budge, K. L., Midgley, A., Satchell, S. C., Peak, M. & Beresford, M. W., 1 Dec 2019, In: Scientific Reports. 9, 1, 17 p., 8348.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Nephritis 100%
  • Lupus Erythematosus 100%
  • Cells 66%
  • Systemic Lupus Erythematosus 50%
  • Tumor Necrosis Factor 50%
  15 Citations (Scopus)

  153 Downloads (Pure)

• VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy

  Onions, K. L., Gamez, M., Buckner, N. R., Baker, S. L., Betteridge, K. B., Desideri, S., Dallyn, B. P., Ramnath, R. D., Neal, C. R., Farmer, L. K., Mathieson, P. W., Gnudi, L., Alitalo, K., Bates, D. O., Salmon, A. H. J., Welsh, G. I., Satchell, S. C. & Foster, R. R., 1 Jan 2019, In: Diabetes. 68, 1, p. 172-187 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vasculotropin Receptor 100%
  • Diabetic Nephropathy 100%
  • Vascular Endothelial Growth Factor 100%
  • Growth Factor Receptor 100%
  • Glomerulus 75%
  35 Citations (Scopus)

  317 Downloads (Pure)
• 2018

  A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli

  Desideri, S., Onions, K. L., Qiu, Y., Ramnath, R. D., Butler, M. J., Neal, C. R., King, M. L. R., Salmon, A. E., Saleem, M. A., Welsh, G. I., Michel, C. C., Satchell, S. C., Salmon, A. H. J. & Foster, R. R., 1 May 2018, In: Kidney International. 93, 5, p. 1086-1097 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Albumin 100%
  • Assay 75%
  • Glomerulus 75%
  • Glomerulus Filtration 37%
  • Plasma 25%
  26 Citations (Scopus)

  250 Downloads (Pure)

• Association of Elevated Urinary miR-126, miR-155, and miR-29b with Diabetic Kidney Disease

  Beltrami, C., Simpson, K., Jesky, M., Wonnacott, A., Carrington, C., Holmans, P., Newbury, L., Jenkins, R., Ashdown, T., Dayan, C., Satchell, S., Corish, P., Cockwell, P., Fraser, D. & Bowen, T., 2 Sep 2018, In: American Journal of Pathology. 188, 9, p. 1982-1992 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Diabetic Nephropathies 100%
  • ROC Curve 12%
  • Epithelial Cells 9%
  47 Citations (Scopus)

  210 Downloads (Pure)

• Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

  May, O., Merle, N. S., Grunenwald, A., Gnemmi, V., Leon, J., Payet, C., Robe-Rybkine, T., Paule, R., Delguste, F., Satchell, S. C., Mathieson, P. W., Hazzan, M., Boulanger, E., Dimitrov, J. D., Fremeaux-Bacchi, V., Frimat, M. & Roumenina, L. T., 20 Dec 2018, In: Frontiers in Immunology. 9, 17 p., 3008.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Endothelial Cell 100%
  • Cells 89%
  • Heme 80%
  • Hemolysis 50%
  • Heme Oxygenase 1 40%
  27 Citations (Scopus)

  226 Downloads (Pure)

• Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells

  Bakrania, B. A., Spradley, F. T., Satchell, S. C., Stec, D. E., Rimoldi, J. M., Gadepalli, R. S. V. & Granger, J. P., 1 Mar 2018, In: AJP - Regulatory, Integrative and Comparative Physiology. 314, 3, p. R427-R432

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelin 1 100%
  • Heme Oxygenase 1 54%
  • Heme Oxygenase 54%
  • Placental Mammal 45%
  • Perfusion Pressure 45%
  14 Citations (Scopus)

• Imaging the placental glycocalyx with transmission electron microscopy

  Fabre-Gray, A., Down, C., Neal, C., Foster, B., Satchell, S. & Bills, V., 15 Dec 2018, In: Placenta. 74, p. 59-61 3 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Transmission Electron Microscopy 40%
  • Placenta 40%
  • Tissues 20%
  • Diseases 20%
  9 Citations (Scopus)

  218 Downloads (Pure)

• Kidney decellularized extracellular matrix hydrogels: Rheological characterization and human glomerular endothelial cell response to encapsulation

  Su, J., Satchell, S. C., Shah, R. N. & Wertheim, J. A., 1 Sep 2018, In: Journal of Biomedical Materials Research Part A. 106, 9, p. 2448-2462 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Kidney 100%
  • Extracellular Matrix 100%
  • Endothelial Cell 100%
  • Tissues 66%
  • Cell Culture 66%
  36 Citations (Scopus)

• MicroRNA-532 regulates pericyte function through targeting the transcription regulator BACH1 and Angiopoietin-1

  Slater, S., Jover, E., Martello, A., Rodriguez-Arabaolaza, I., Alvino, V. V., Satchell, S., Madeddu, P., Spinetti, G., Caporali, A., Vono, R. & Mitić, T., 1 Sep 2018, (E-pub ahead of print) In: Molecular Therapy. 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • MicroRNA 100%
  • microRNA 100%
  • Pericyte 53%
  • Angiopoietin 1 46%
  • BACH1 40%
  21 Citations (Scopus)

  273 Downloads (Pure)

• Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

  Li, Z., Tuffin, J., Lei, I. M., Ruggeri, F. S., Lewis, N. S., Gill, E. L., Savin, T., Huleihel, L., Badylak, S. F., Knowles, T., Satchell, S., Welsh, G., Saleem, M. & Shery Huang, Y. Y., 15 Sep 2018, In: Acta Biomaterialia. 78, p. 111-122 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Matrix 100%
  • Fibers 75%
  • Membrane 68%
  • Extracellular Matrix 62%
  • Protein 37%
  23 Citations (Scopus)

  393 Downloads (Pure)

• The Authors Reply: [Glomerular Permeability Changes of Albumin in Isolated Glomeruli Do Not Mimic Changes in Albumin Excretion In Vivo in Diseased States]

  Desideri, S., Onions, K. L., Butler, M. J., Michel, C. C., Satchell, S. C., Salmon, A. H. J. & Foster, R. R., 1 Jul 2018, In: Kidney International. 94, 1, 1 p.

  Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review
  2 Citations (Scopus)
• 2017

  Adhesion of Escherichia coli under flow conditions reveals potential novel effects of FimH mutations

  Feenstra, T., Thøgersen, M. S., Wieser, E., Peschel, A., J Ball, M., Brandes, R., Satchell, S. C., Stockner, T., Aarestrup, F. M., Rees, A. J. & Kain, R., Mar 2017, In: European Journal of Clinical Microbiology and Infectious Diseases. 36, 3, p. 467-478 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Adhesion 100%
  • Flow 50%
  • Escherichia coli 40%
  • Cells 30%
  • Mutation 30%
  17 Citations (Scopus)

  294 Downloads (Pure)

• Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease

  Kelly, P., Denver, P., Satchell, S. C., Ackermann, M., Konerding, M. A. & Mitchell, C. A., 25 Jul 2017, (E-pub ahead of print) In: Angiogenesis. 20, 4, p. 567-580 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Brain 100%
  • Plaque 66%
  • Recognition 50%
  • Pathology 50%
  • Alzheimer's Disease 50%
  36 Citations (Scopus)

  308 Downloads (Pure)

• Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition

  Pieterse, E., Rother, N., Garsen, M., Hofstra, J. M., Satchell, S. C., Hoffmann, M., Loeven, M. A., Knaapen, H. K., van der Heijden, O. W. H., Berden, J. H. M., Hilbrands, L. B. & van der Vlag, J., 10 Jul 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 7, p. 1371-1379 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Neutrophil 100%
  • Extracellular Trap 100%
  • Endothelial Cell 40%
  • Elastase 20%
  • Catenin 13%
  128 Citations (Scopus)

• Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

  Betteridge, K., Arkill, K., Neal, C., Harper, S., Foster, B., Satchell, S., Bates, D. & Salmon, A., Aug 2017, In: Journal of Physiology. 595, 15, p. 5015-5035 21 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx 100%
  • Sialic Acid 30%
  • Microvessel 23%
  • Albumin 15%
  • Analysis 7%
  80 Citations (Scopus)

  351 Downloads (Pure)

• The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling

  Riu, F., Slater, S. C., Garcia, E. J., Rodriguez-Arabaolaza, I., Alvino, V., Avolio, E., Mangialardi, G., Cordaro, A., Satchell, S., Zebele, C., Caporali, A., Angelini, G. & Madeddu, P., 14 Jul 2017, In: Scientific Reports. 7, 13 p., 5443.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Pericyte 100%
  • Leptin 89%
  • Hypoxia 30%
  • Adipocytokine 30%
  • Adipokine 30%
  10 Citations (Scopus)

  523 Downloads (Pure)

• VEGF regulates local inhibitory complement proteins in the eye and kidney

  Keir, L. S., Firth, R., Aponik, L., Feitelberg, D., Sakimoto, S., Aguilar, E., Welsh, G. I., Richards, A., Usui, Y., Satchell, S. C., Kuzmuk, V., Coward, R. J., Goult, J., Bull, K. R., Sharma, R., Bharti, K., Westenskow, P. D., Michael, I. P., Saleem, M. A. & Friedlander, M., 3 Jan 2017, In: Journal of Clinical Investigation. 127, 1, p. 199-214 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vasculotropin 100%
  • Vascular Endothelial Growth Factor 100%
  • Complement Factor H 40%
  • Factor H 40%
  • Age Related Macular Degeneration 30%
  101 Citations (Scopus)

  327 Downloads (Pure)
• 2016

  Renal endothelial protein C receptor expression and shedding during diabetic nephropathy

  Lattenist, L., Ochodnický, P., Ahdi, M., Claessen, N., Leemans, J. C., Satchell, S. C., Florquin, S., Gerdes, V. E. & Roelofs, J. J. T. H., Jun 2016, In: Journal of Thrombosis and Haemostasis. 14, 6, p. 1171-1182 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelial Protein C Receptor 100%
  • Diabetic Nephropathy 64%
  • Patient 17%
  • Phenotype 17%
  • Diabetes Mellitus 17%
  20 Citations (Scopus)

• Transport of gold nanoparticles by vascular endothelium from different human tissues

  Gromnicova, R., Kaya, M., Romero, I. A., Williams, P., Satchell, S., Sharrack, B. & Male, D., 25 Aug 2016, In: PLoS ONE. 11, 8, 17 p., e0161610.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Endothelium 100%
  • Nanoparticle 55%
  • Kidney 44%
  • Tissues 33%
  • Brain 33%
  36 Citations (Scopus)

  281 Downloads (Pure)
• 2015

  Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

  Lobo, D. P., Wemyss, A. M., Smith, D. J., Straube, A., Betteridge, K. B., Salmon, A. H. J., Foster, R. R., Elhegni, H. E., Satchell, S. C., Little, H. A., Pacheco-Gómez, R., Simmons, M. J., Hicks, M. R., Bates, D. O., Rodger, A., Dafforn, T. R. & Arkill, K. P., Oct 2015, In: Nano Research. 8, 10, p. 3307-3315 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Shear Stress 100%
  • Procedure 57%
  • Microfluidics 57%
  • Surface 28%
  • Nanosensors 28%
  6 Citations (Scopus)

• Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines

  Ma, L., Shelness, G. S., Snipes, J. A., Murea, M., Antinozzi, P. A., Cheng, D., Saleem, M. A., Satchell, S. C., Banas, B., Mathieson, P. W., Kretzler, M., Hemal, A. K., Rudel, L. L., Petrovic, S., Weckerle, A., Pollak, M. R., Ross, M. D., Parks, J. S. & Freedman, B. I., Feb 2015, In: Journal of the American Society of Nephrology. 26, 2, p. 339-48 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Apolipoprotein L1 100%
  • Podocyte 77%
  • Messenger RNA 55%
  • Cells 44%
  • Cell Line 44%
  99 Citations (Scopus)

• Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy

  Oltean, S., Qiu, Y., Ferguson, J. K., Stevens, M., Neal, C., Russell, A., Kaura, A., Arkill, K. P., Harris, K., Symonds, C., Lacey, K., Wijeyaratne, L., Gammons, M., Wylie, E., Hulse, R. P., Alsop, C., Cope, G., Damodaran, G., Betteridge, K. B., Ramnath, R., & 9 othersSatchell, S. C., Foster, R. R., Ballmer-Hofer, K., Donaldson, L. F., Barratt, J., Baelde, H. J., Harper, S. J., Bates, D. O. & Salmon, A. H. J., Aug 2015, In: Journal of the American Society of Nephrology. 26, 8, p. 1889-1904

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Vasculotropin 100%
  • Diabetic Nephropathy 100%
  • Vasculotropin A 50%
  • Nephropathy 25%
  • Glycocalyx 25%
  105 Citations (Scopus)

  36 Downloads (Pure)
• 2014

  Glomerular Cell Cross-Talk Influences Composition and Assembly of Extracellular Matrix

  Byron, A., Randles, M. J., Humphries, J. D., Mironov, A., Hamidi, H., Harris, S., Mathieson, P. W., Saleem, M. A., Satchell, S. C., Zent, R., Humphries, M. J. & Lennon, R., 27 Feb 2014, In: Journal of the American Society of Nephrology. 25, 5, p. 953-966 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerulus Basement Membrane 100%
  • Coculture 50%
  • Podocyte 50%
  • Proteome 50%
  • Protein 25%
  79 Citations (Scopus)

• Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction

  Ramnath, R., Foster, R. R., Qiu, Y., Cope, G., Butler, M. J., Salmon, A. H., Mathieson, P. W., Coward, R. J., Welsh, G. I. & Satchell, S. C., 13 Aug 2014, In: FASEB Journal.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Tumor Necrosis Factors 100%
  • Syndecan 100%
  • Glycocalyx 60%
  • Heparan Sulfate 50%
  • Surface Property 30%
  87 Citations (Scopus)

• Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk

  Kuravi, S. J., McGettrick, H. M., Satchell, S. C., Saleem, M. A., Harper, L., Rainger, G. E. & Savage, C. O. S., 1 Jul 2014, In: Journal of Immunology. 193, 1, p. 234-43 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Interleukin-6 100%
  • Cells 100%
  • Endothelial Cell 89%
  • Podocyte 69%
  • Chemokine 60%
  32 Citations (Scopus)